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| 1 | Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients显示文摘In late December 2019,the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),was identified in Wuhan,China,and the ensuing pandemic has led to more than 50 million infected individuals and more than one million deaths by November 10,2020(http://gffzze7c39cdc9e894ca6s6ncv5fq5x9pk6kkn.ffgz.tsg.suse.edu.cn/).Pathologic investigations of autopsy tissue have focused primarily on the lung,heart,and kidney,whereas morphologic data on testis injury and the effects of SARS-CoV-2 infection on spermatogenesis are limited.Although two groups did not detect SARS-CoV-2 in the semen or testes of recovered COVID-19 patients,1,2 another group confirmed SARS-CoV-2 in the semen of patients.3 Therefore,it is currently unknown whether SARS-CoV-2 infection impacts spermatogenesis and male fertility.In the present study,we evaluated the effects of SARS-CoV-2 infection on spermatogenesis by examining the pathophysiology and molecular features of testes obtained from five male COVID-19 patients at autopsy. | Xixiang Ma Chuhuai Guan Rong Chen Yunyun Wang Shenglei Feng Rongshuai Wang Guoqiang Qu Sijia Zhao Fengli Wang Xiaoli Wang Dingyu Zhang Liang Liu Aihua Liao Shuiqiao Yuan | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 2 | miR-200b and miR-200c as Prognostic Factors and Mediators of Gastric Cancer Cell Progression显示文摘 | Hailin Tang Min Deng Yunyun Tang Xinhua Xie Jiaoli Guo Yanan Kong Feng Ye Qi Su Xiaoming Xie | 2013 | Clinical Cancer Research2013，，20： | 4 |
| 3 | Examining effective use of data sources and modeling algorithms for improving biomass estimation in a moist tropical forest of the Brazilian Amazon显示文摘Previous research has explored the potential to integrate lidar and optical data in aboveground biomass(AGB)estimation,but how different data sources,vegetation types,and modeling algorithms influence AGB estimation is poorly understood.This research conducts a comparative analysis of different data sources and modeling approaches in improving AGB estimation.RapidEye-based spectral responses and textures,lidar-derived metrics,and their combination were used to develop AGB estimation models.The results indicated that(1)overall,RapidEye data are not suitable for AGB estimation,but when AGB falls within 50–150 Mg/ha,support vector regression based on stratification of vegetation types provided good AGB estimation;(2)Lidar data provided stable and better estimations than RapidEye data;and stratification of vegetation types cannot improve estimation;(3)The combination of lidar and RapidEye data cannot provide better performance than lidar data alone;(4)AGB ranges affect the selection of the best AGB models,and a combination of different estimation results from the best model for each AGB range can improve AGB estimation;(5)This research implies that an optimal procedure for AGB estimation for a specific study exists,depending on the careful selection of data sources,modeling algorithms,forest types,and AGB ranges. | Yunyun Feng Dengsheng Lu Qi Chena Michael Keller Emilio Moran Maiza Nara dos-Santos Edson Luis Bolfe Mateus Batistella | 2017 | International Journal of Digital Earth2017，10，10： | 2 |
| 4 | Assessing the genetic diversity of the critically endangered Chinese sturgeon Acipenser sinensis using mitochondrial markers and genome-wide single-nucleotide polymorphisms from RAD-seq显示文摘As a living fossil, the endangered Chinese sturgeon(Acipenser sinensis) has been considered a national treasure in China. Here,the famous Gezhouba Dam and Three Gorges Dam on the Yangtze River were built in 1988 and 2006, for economic purposes.The natural population of Chinese sturgeon has declined since then, as these dams block its migratory route to the original spawning grounds in the middle reaches of the Yangtze River. In 2013 and 2014, there was an absence of spawning where it typically happened near the Gezhouba Dam. Nevertheless, from April to June in 2015, over 1,000 larvae with different body lengths(10–35 cm) were detected along the Shanghai Yangtze Estuary; but only little is currently known about the population genetic structure of the Chinese sturgeon. Herein, we inferred population genetic parameters from 462 available Chinese sturgeon specimens based on a 421-bp fragment of the mitochondrial DNA(mtDNA) D-loop region and 1,481,620 SNPs(singlenucleotide polymorphisms) generated by restriction site-associated DNA sequencing(RAD-seq). For the D-loop dataset, 15 haplotypes were determined. Randomly picked 23 individuals, representing the 15 D-loop haplotype groups, were subsequently used for further RAD-seq validation. The average nucleotide diversity calculated from the mtDNA and RAD datasets was 0.0086 and 0.000478, respectively. The overall effective female population size was calculated to be 1,255 to 2,607, and the long-term effective population size was estimated to range from 11,950 to 119,500. We observed that the genetic variability and the effective female population size of the current population in the Yangtze River are severely low, which are similar to the data reported over 10 years ago. The deduced relatively small effective population of female fish, limiting the genetic connectivity among Chinese sturgeon, should be considered a serious threat to this endangered species. | Jian Liu Xinxin You Pao Xu Ping Zhuang Yueping Zheng Kai Zhang Min Wang Yunyun Lv Gangchun Xu Feng Zhao Jianhui Wu Houyong Fan Jianan Xu Zhiqiang Ruan Chao Bian Kai Liu Dongpo Xu Jinhui Chen Junmin Xu Qiong Shi | 2018 | Science China(Life Sciences)2018，61，9： | 2 |
| 5 | MDG-1, a polysaccharide from Ophiopogon japonicus , prevents high fat diet-induced obesity and increases energy expenditure in mice显示文摘 | Yuan Wang Yunyun Zhu Kefeng Ruan Hai Wei Yi Feng | 2014 | Carbohydrate Polymers2014，，： | 1 |
| 6 | The Application of the Campus Experimental Project Management System Based on Intranet Technology显示文摘 | Zhou Shandan Feng Dan Chen Li Xu Yunyun | 2012 | Procedia Engineering2012，，： | 1 |
| 7 | Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice显示文摘 | Yu Luo Ying Liu Meng Liu Jie Wei Yunyun Zhang Jinpao Hou Weifeng Huang Tao Wang Xun Li Ying He Feng Ding Li Yuan Jianchun Cai Feng Zheng James Y. Yang | 2014 | BBA - Gene Regulatory Mechanisms2014，，2： | 1 |
| 8 | Achieving both large piezoelectric constant and low dielectric loss in BiScO_(3)-PbTiO_(3)-Bi(Mn_(2/3)Sb_(1/3))O_(3)high-temperature piezoelectric ceramics显示文摘BiScO_(3)-PbTiO_(3)binary ceramics own both high Curie temperature and prominent piezoelectric properties,while the high dielectric loss needs to be reduced substantially for practical application especially at high temperatures.In this work,a ternary perovskite system of(1-x-y)BiScO3-yPbTiO3-xBi(Mn_(2/3)Sb_(1/3))O_(3)(BS-yPT-xBMS)with x=0.005,y=0.630-0.645 and x=0.015,y=0.625-0.640 was prepared by the traditional solid-state reaction method.The phase structure,microstructure,dielectric/piezoelectric/ferroelectric properties were studied.Among BS-yPT-xBMS ceramic series,the BS-0.630PT-0.015BMS at morphotropic phase boundary possesses the reduced dielectric loss factor(tanδ=1.20%)and increased mechanical quality factor(Qm=84),and maintains a high Curie temperature(TC=410°C)and excellent piezoelectric properties(d_(33)=330 pC/N)simultaneously.Of particular importance,at elevated temperature of 200°C,the value of tanδis only increased to 1.59%.All these properties indicate that the BS-0.630PT-0.015BMS ceramic has great potential for application in high-temperature piezoelectric devices. | Yunyun Feng Changhong Yang Xiaoying Guo Wei Sun Wenxuan Wang Xiujuan Lin Shifeng Huang | 2022 | Journal of Advanced Dielectrics2022，12，6： | 0 |
| 9 | Comparison of pathological findings between patients with relapsed and non-relapsed immunoglobin G4-related disease显示文摘Immunoglobin(Ig)G4-related disease(IgG4-RD)is an immune-mediated fibroinflammatory condition characterized by elevated serum IgG4 levels and multi-organ involvement.The characteristic histological findings of IgG4-RD are dense lymphoplasmacytic infiltration,fibrosis,and massive IgG4 positive plasma cells infiltrating the affected tissues.[1]Previous studies have demonstrated various relapse predictors corresponding to demographic,clinical characteristics,laboratory test results,and treatment agents.However,no study has revealed the risk factors of flares in pathology.This study aimed to ascertain whether the pathological characteristics are related to therapeutic outcomes. | Hui Lu Shan Wang Mu Wang Xiaowei Liu Linyi Peng Jiaxin Zhou Jieqiong Li Zheng Liu Xuan Luo Yu Peng Yunyun Fei Yan Zhao Xiaofeng Zeng Ruie Feng Wen Zhang | 2022 | Chinese Medical Journal2022，，4： | 0 |
| 10 | Synthesis of fluorinated CaCO_(3)-based oxygen-supplying nanophotosensitizers to potentiate photodynamic immunotherapy by reversing tumor hypoxia and immunosuppression显示文摘Photodynamic therapy is a noninvasive type of phototherapy with a high capacity to boost specific antitumor immunity by causing immunogenic cell death.However,the photodynamic therapeutic potency toward solid tumors is dampened by tumor hypoxia that negatively impairs the generation of cytotoxic singlet oxygen and promotes the formation of tumor immunosuppression.Herein,fluorinated CaCO_(3)(CaF)nanoparticles are prepared with the addition of dopamine-conjugated perfluorosebacic acid and ferric chloride into a calcium chloride ethanol solution via an ammonium bicarbonate-mediated gas-diffusion process.After being coated with commercial lipids and hexadecylamin conjugated chlorin e6(hCe6)via a templated self-assembly process,the yielded PEGylated nanophotosensitizer(hCe6@CaF-PEG)exhibits an effective loading efficiency to perfluoro-15-crown-5-ether(PFCE),a model perfluorocarbon molecule,and thus oxygen molecules.Upon intravenous administration,the obtained PFCE/hCe6@CaF-PEG can alleviate tumor hypoxia by working as an oxygen nanoshuttle.Together with local light emitting diode light exposure,photodynamic treatment with PFCE/hCe6@CaF-PEG can suppress the growth of primary CT26 tumors and unirradiated distant tumors,particularly when synergized with anti-PD-1(aPD-1)immunotherapy to collectively reverse tumor immunosuppression.This work presents an effective strategy to potentiate photodynamic immunotherapy by concurrently reversing tumor hypoxia and immunosuppression. | Yunyun Zhang Ziliang Dong Yu Hao Yimou Gong Chunjie Wang Yifan Yan Minming Chen Yumin Wu Quguang Li Zhuang Liu Liangzhu Feng | 2023 | Nano Research2023，16，7： | 0 |
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