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| 1 | Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities显示文摘Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins,and has also been used for the treatment of severe acute respiratory syndrome(SARS). In vitro, the crude H. cordata polysaccharides(CHCP) exhibited potent anti-complementary activity through both the classical and alternative pathways by acting on components C3 and C4 of the complement system without interfering with the coagulation system. This study was to investigate the preventive effects of CHCP on acute lung injury(ALI) induced by hemorrhagic shock plus lipopolysaccharide(LPS) instillation(two-hit)and LPS-induced fever in rats. CHCP significantly attenuated pulmonary injury in the 'two-hit' ALI model by reducing pulmonary edema and protein exudation in bronchoalveolar lavage fluid(BALF). In addition, it reduced the deposit of complement activation products in the lung and improved oxidantantioxidant imbalance. Moreover, CHCP administration inhibited fever in rats, reduced the number of leukocytes and restored serum complement levels. The inhibition on the inappropriate activation of complement system by CHCP may play an important role in its beneficial effects on inflammatory diseases. The anti-complementary polysaccharides are likely to be among the key substances for the heatclearing function of H. cordata. | Yan Lu Yun Jiang Lijun Ling Yunyi Zhang Hong Li Daofeng Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 18 |
| 2 | Effects of salidroside on glioma formation and growth inhibition together with improvement of tumor microenvironment显示文摘Objective:To test the effects of salidroside on formation and growth of glioma together with tumor microenvironment.Methods:Salidroside extracted from Rhodiola rosea was purified and treated on human glioma cells U251 at the concentration of 20μg/mL.3-(4,5-dimethylthiazol-2-yl)-2,5-dephenyltetrazolium bromide(MTT)assay for cytotoxicity and flow cytometry(FCM)for cell cycle analysis were performed.Then for in vivo study,xenotransplantation tumor model in nude mice was generated and treated with salidroside at the concentration of 50 mg/kg.d for totally 20 d.Body weight and tumor size were detected every 2 d after the treatment.The levels of 8-isoprostane,superoxide dismutase(SOD)and malondialdehyde(MDA),special markers for oxidative stress,were detected while immunofluoresence staining was performed for astrocyte detection.Results:For in vitro study,salidroside could decrease the viability of human glioma cells U251 and the growth of U251 cells at G0/G1checkpoint during the cell cycle.For in vivo study,salidroside could also inhibit the growth of human glioma tissue in nude mice.The body weight of these nude mice treated with salidroside did not decrease as quickly as control group.In the tumor xenotransplantation nude mice model,mice were found of inhibition of oxidative stress by detection of biomarkers.Furthermore,overgrowth of astrocytes due to the stimulation of oxidative stress in the cortex of brain was inhibited after the treatment of salidroside.Conclusions:Salidroside could inhibit the formation and growth of glioma both in vivo and in vitro and improve the tumor microenvironment via inhibition of oxidative stress and astrocytes. | Yanshan Zhang Yunyi Yao Huijuan Wang Yanqin Guo Hui Zhang Liang Chen | 2013 | Chinese Journal of Cancer Research2013，25，5： | 14 |
| 3 | Current status of pediatric kidney transplantation in China: data analysis of Chinese Scientific Registry of Kidney Transplantation显示文摘 | Liu Longshan Zhang Huanxi Fu Qian Chen Liping Sun Chuanhou Xiong Yunyi Shi Bingyi Wang Changxi | 2014 | Chinese Medical Journal2014，，3： | 10 |
| 4 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 5 | Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601显示文摘稀释毒力的螺旋体 interrogans serovar Lai 紧张 IPAV 被延长实验室经过从在中国孤立的高度剧毒的祖先的紧张导出。我们学习了 IPAV 的基因变化对病原的 L 经由比较分析使它变为无毒害。interrogans serovar Lai 紧张 56601。IPAV 紧张的完全的染色体顺序决心、使用与作比较,然后修正并且重新注解紧张 56601 的染色体顺序。除了他们的高度类似的 genomic,结构和基因顺序, 33 插入的一个总数, 53 删除和 301 个单个核苷酸的变化(SNV ) 在整个直接影响 101 基因的 IPAV 的染色体被检测,在他们的 5 ′ 的任何一个;在上游的区域或在他们的编码区域以内。在他们之中, 44 功能的基因的多数涉及信号 transduction,压力反应, transmembrane 运输和氮新陈代谢。基于量的液体,层析(LC )-MS/MS 数据揭示了的比较 proteomic 分析在 orthologs 的 1 627 选择的对之中,在 IPAV 的 174 基因拉紧,这是 upregulated,与主要在精力的班上的丰富生产和类脂化合物新陈代谢。相反,在紧张 56601 的 228 基因是 upregulated,与在蛋白质翻译和 DNA 复制 / 修理的范畴充实的多数。 genomic 和 proteomic 途径的联合在批评基因说明了那改变的表情或变化,例如编码 Ser/Thr kinase ,碳饥饿蛋白质 CstA ,夫酸安合成酶,GTP有约束力的蛋白质 BipA , ribonucleotide-diphosphate reductase 和磷酸盐 transporter 的那些,并且在脂蛋白或外部膜蛋白质的翻译侧面的改变是可能的在紧张 IPAV 说明毒力变细。 | Yi Zhong Xiao Chang Xing-Jun Cao Yan Zhang Huajun Zheng Yongzhang Zhu Chengsong Cai Zelin Cui Yunyi Zhang Yuan-Yuan Li Xiu-Gao Jiang Guo-Ping Zhao Shengyue Wang Yixue Li Rong Zeng Xuan Li Xiao-Kui Guo | 2011 | Cell Research2011，21，8： | 10 |
| 6 | Cloning and characterization of three cheB genes in Leptospira interrogans显示文摘活动性和趋化性系统为 leptospires 的毒力是批评的。有在 leptospires 定位的通常认为的趋化性相当或相同的事物的多重拷贝大染色体。从螺旋体 interrogans 紧张 Lai 的 CheB1 和 CheB3 被预言有一个全球象 CheB 一样领域,但是 CheB2 被预言仅仅有一个 C 终端受动器领域。以便验证三通常认为的 cheB 基因的功能,他们被克隆进 pQE31 向量然后分别地,在野类型的 Escherichia coli 紧张 RP437 和 cheB 有缺陷者紧张 RP4972 表示了。聚集的试金的结果和 CheB1 的预言的第三的结构和 L 的 CheB3。interrogans 紧张 Lai 建议一个 N 终端规章的领域的缺席可以是原因之一让 CheB2 的失败补充 E。coli cheB 异种。而且, CheB2 在 leptospires 的相互作用网络完全连接到 CheR1 和 CheR3。一起拿,这些结果显示 CheB2 不能独自工作,并且在某些生理的条件下面,工作可以要求 CheB3 和 CheR1。趋化性基因相当或相同的事物的多重拷贝的存在建议了那 L。interrogans 紧张 Lai 可能有一条更复杂的化学感应的小径。 | Ke Dong Qingtian Li Chang Liu Yunyi Zhang Guoping Zhao Xiaokui Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 5 |
| 7 | Action mechanisms of a new erythrocyte-derived depressing factor显示文摘To investigate the action mechanisms of a new erythrocyte-derived depressing factor(EDDF), the focus is placed on the effect of EDDF on both cytosolic and nuclear free calcium (Ca2+) transportation in vascular smooth muscle cell (VSMC), as well as the apoptosis and cell cycle of VSMC of rats. EDDF has been extracted from human erythrocytes. The changes of Ca2+ levels in cytoplasm ([Ca2+],) and nucleus ([Ca2+]n) have been observed using a laser scanning confocal microscope together with fluo-3/AM as a calcium indicator. Flow cytometric technique was used to study the effect of EDDF on cell cycle and apoptosis of VSMC. [Ca2+]j and [Ca2+]n were significantly decreased through several different pathways: ( i) it reduced the Ca2+ influx by blocking L-type voltage-dependent calcium channel (L-VDC) and R-type voltage-dependent calcium channel (R-VDC); (ii) it inhibited the Ca2+ release from inositol 1, 4, 5-trisphosphate (IP3) sensitive calcium store; and (iii) activated Ca2+-ATPase of sarcoplasmic reticulum ( | Yunyi Wen Xiaochun Zhang Xiaorong Xu Guiqing Zhao Fang Wan | 2000 | Chinese Science Bulletin2000，45，23： | 4 |
| 8 | Fabrication of niobium doped titanate nanoflakes with enhanced visible-light-driven photocatalytic activity for efficient ibuprofen degradation显示文摘In this study,a novel class of niobium(Nb) doped titanate nanoflakes(TNFs) are fabricated through a onestep hydrothermal method.Nb doping affects the curving of titanate nanosheet,leading to the formation of nanoflake structure.In addition,Nb5+ filled in the interlayers of [TiO6] alters the light adsorption property of pristine titanate.The band gap of Nb-TNFs is narrowed to 2.85 eV,while neat titanate nano tubes(TNTs) is 3.4 eV.The enhanced visible light adsorption significantly enhances the visible-lightdriven activity of Nb-TNFs for ibuprofen(IBP) degradation.The pseudo-first order kinetics constant for Nb-TNFs is calculated to be 1.04 h^-1,while no obvious removal is observed for TNTs.Photo-generated holes(h^+) and hydroxyl radicals(·OH) are responsible for IBP degradation.The photocatalytic activity of Nb-TNFs depends on pH condition,and the optimal pH value is found to be 5.In addition,Nb-TNFs exhibited superior photo-stability during the reuse cycles.The results demonstrated Nb-TNFs are very promising in photocatalytic water purification. | Wen Liu Wei Zhang Mushi Liu Penghui Du Chenyuan Dang Jialiang Liang Yunyi Li | 2019 | Chinese Chemical Letters2019，30，12： | 3 |
| 9 | Toward High Carrier Mobility and Low Contact Resistance:Laser Cleaning of PMMA Residues on Graphene Surfaces显示文摘Poly(methyl methacrylate)(PMMA) is widely used for graphene transfer and device fabrication.However,it inevitably leaves a thin layer of polymer residues after acetone rinsing and leads to dramatic degradation of device performance.How to eliminate contamination and restore clean surfaces of graphene is still highly demanded.In this paper,we present a reliable and position-controllable method to remove the polymer residues on graphene films by laser exposure.Under proper laser conditions,PMMA residues can be substantially reduced without introducing defects to the underlying graphene.Furthermore,by applying this laser cleaning technique to the channel and contacts of graphene fieldeffect transistors(GFETs),higher carrier mobility as well as lower contact resistance can be realized.This work opens a way for probing intrinsic properties of contaminant-free graphene and fabricating high-performance GFETs with both clean channel and intimate graphene/metal contact. | Yuehui Jia Xin Gong Pei Peng Zidong Wang Zhongzheng Tian Liming Ren Yunyi Fu Han Zhang | 2016 | Nano-Micro Letters2016，8，4： | 2 |
| 10 | Heavy ion micro-beam study of single-event transient(SET) in Si Ge heterjunction bipolar transistor显示文摘Silicon-germainum heterojunction bipolar transistor(Si Ge HBT)has been demonstrated to be suitable in extreme environment because of its superior temperature characteristics which can operate from 43 K to 400 K[1].In addition,outstanding hardness to both total ionizing dose(TID)radiation and displacement damage make Si Ge HBT technology particularly attractive for | Jinxin ZHANG Hongxia GUO Fengqi ZHANG Chaohui HE Pei LI Yunyi YAN Hui WANG Linxia ZHANG | 2017 | Science China(Information Sciences)2017，60，12： | 2 |
| 11 | Catalytic Hydrogenation of Acetic Acid to Acetaldehyde: Synergistic Effect of Bifunctional Co/Ce-Fe Oxide Solid Solution Catalysts显示文摘The large-scale industrial production of acetic acid (HAc) from carbonylation of methanol has enabled intense research interest from direct hydrogenation of HAc to acetaldehyde (AA).Herein,a series of cerium-iron oxide solid solution supported metallic cobalt catalysts were prepared by modified sol-gel method and were applied in gas-phase hydrogenation of HAc to AA.A synergistic effect between the hydrogenation metal cobalt and Ce-Fe oxide solid solution is revealed.Specifically,oxygen vacancies provide the active sites for adsorption of HAc,while highly uniformly dispersed metallic Co adsorbs H2 and activates the reduction of HAc into AA.Moreover,the metallic Co can also assist the cyclical conversion between Fe3+/Fe2+ and Ce3+/Ce4+ on the surface of Ce1.xFexO2-δ supports.The unique effect substantially enhances the ability of the support material to rapidly capture oxygen atoms from HAc.It is found that the catalyst of 5% Co/Ce0.8Fe0.2O2-δ with the highest concentration of oxygen vacancy presents the best catalytic performance (i.e.acetaldehyde yield reaches 49.9%) under the optimal reaction conditions (i.e.623 K and H2 flow rate =10 mL/min).This work indicates that the Co/Ce-Fe oxide solid solution catalyst can be potentially used for the selective hydrogenation from HAc to AA.The synergy between the metallic Co and Ce1-xFexO2-δ revealed can be extended to the design of other composite catalysts. | Naixu Li Qi Zhang Rehana Bibi Quanhao Shen Richard Ngulube Yunyi Liu Jiancheng Zhou | 2019 | Chinese Journal of Chemistry2019，37，7： | 2 |
| 12 | Leptospira interrogans encodes an ROK family glucokinase involved in a cryptic glucose utilization pathway显示文摘尽管螺旋体 interrogans 是不能的作为它的碳 / 精力利用葡萄糖,采购原料, L 的 LA_1437 基因。interrogans serovar Lai 潜在地编码组 III glucokinase (GLK ) 。L。interrogans GLK (LiGLK ) 不同类地在 Escherichia 表示了 coli 被净化并且证明了是有它 12.3 的特定的活动的 homodimeric 酶 ? 桴 ? 慰瑲慩?? 潤慭湩愠摮渠牯慭?? 整浲湩獵? 獩猠潨瑲牥琠慨 ? 偁 ? 湡 ??? 戠 ? 桴 ? 敲獡湯漠 ? 敧敮映慲敭桳晩 ? 畭慴楴湯搠牵湩? | Qing Zhang Yunyi Zhang Yi Zhong Jun Ma Nanqiu Peng Xingjun Cao Chen Yang RongZeng Xiaokui Guo Guoping Zhao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 1 |
| 13 | Development of the Miniature NMR Apparatus for Edible Oil Quality Control显示文摘 | Rongsheng Lu Xinlong Zhou Weiping Wu Yunyi Zhang Zhonghua Ni | 2014 | Applied Magnetic Resonance2014，，5： | 1 |
| 14 | Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides显示文摘Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall function of the complement system. The main objective of our study was to develop a specific enzyme-linked immunosorbent assay(ELISA) as an alternative method to assess the anti-complement activity, particularly against the lectin pathway. By using respective coating substrates against different activation pathways, followed by capturing the stable C3c fragments, our ELISA method can be used to screen complement inhibitors against the classical pathway and the lectin pathway. The inhibitory effect of suramin on the classical pathway, as measured by our hemolytic assay is consistent with previous reports. Further assessment of suramin and Bupleurum polysaccharides against the lectin pathway showed a good reproducibility of the method. Comparison of the lectin pathway IC50 between Bupleurum smithii var. parvifolium polysaccharides(1.055 mg/mL) and Bupleurum chinense polysaccharides(0.98 mg/mL) showed that, similar to the classical and alterative pathway, these two Bupleurum polysaccharides had comparable anti-complementary properties against the lectin pathway. The results demonstrate that the described ELISA assay can compensate for the shortcomings of the hemolytic assay in lectin pathway. | Mulu Wu Hong Li Yunyi Zhang Daofeng Chen | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 1 |
| 15 | Chemical and pharmacological research progress of Chinese drug 'Jiang Xiang'显示文摘 | Zhao Qian Guo Jixian Zhang Yunyi | 2000 | J Chin Pharmac Sci2000，9，1： | 1 |
| 16 | Low-field NMR micro coils based on printed circuit board technology显示文摘Radiofrequency coil is one of the most important components for a nuclear magnetic resonance(NMR)instrument.In this article,some planar micro coils with an inner diameter of 2 mm and number of turns that varied from 1 to 11 were investigated based on the printed circuit board(PCB)technology.The electrical characterization of micro coils show that self-resonant frequencies are larger than 200 MHz.Then,an NMR measurement platform with a static magnetic field of 0.66 T was constructed and the signal to noise ratio(SNR)values of the NMR were analyzed.It was found that the SNR is optimal when the turn number of the micro coils is six and the excitation time of a 90°pulse is 0.8?s.Finally,we used the micro coil with six turns to study the transverse relaxation rate of copper sulfate pentahydrate aqueous solution with different concentrations.It was found that the transverse relaxation rate is proportional to the solution concentration.Results from the micro coil were verified by measurements using a Bruker Minispec MQ60. | WU WeiPing LU RongSheng ZHOU XinLong ZHANG YunYi NI ZhongHua | 2014 | Science China(Technological Sciences)2014，57，10： | 1 |
| 17 | Chemieal and pharmacologi cal research progress of Chinese drug'Jiang Xiang'显示文摘 | Zhao Qian Guo Jixian Zhang Yunyi | 2000 | J Clin Pharmac Sci2000，9，1： | 1 |
| 18 | The relationship between air gap sizes and clothing heat transfer performance显示文摘 | Jun Li Zhaohua Zhang Yunyi Wang | 2013 | The Journal of the Textile Institute2013，104，12： | 1 |
| 19 | Genetic and molecular biological characterization of two homologous cheR genes from Leptospira interrogans显示文摘螺旋体 interrogans 染色体编码 cheR 基因的二个拷贝,他们中的每能为 Escherichia coli cheR 0 异种 RP1254 的聚集的有缺点的显型补充到某些程度,当他们的也的在表示上禁止趋化性的野类型的 E 聚集时。coli 紧张, RP437。因此, CheR1 和 CheR2 应该忍受 methyltransferase 活动,尽管 CheR1 有仅仅而不是位于 2 螺旋的断然控告的脸的二保存基本氨基酸残余。当象 CheR2 的 Lys48 和 Arg55 一样的这残余被变异时,任何一个 CheRs 都不能维持上述的互补功能,建议他们考虑到类似于 E 的接受甲基的趋化性蛋白质的关键角色。coli。由 microarray 试金示威了,在 L 的 cheR1 的表情。在 28 点有教养的 | Yunyi Zhang Ke Dong Lingbing Zeng Qingtian Li Chang Liu Jin Wang Xiaokui Guo Guo-Ping Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 1 |
| 20 | Isolation and characterization of an anti-complementary protein-bound polysaccharide from the stem barks of Eu commia ulmoides显示文摘 | ZHU Hongwei ZHANG Yunyi ZHANG Jianwen | 2008 | International fmmunopharmacology2008，8，12： | 1 |
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