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| 1 | Metamodel-based Global Optimization Using Fuzzy Clustering for Design Space Reduction显示文摘High fidelity analysis are utilized in modern engineering design optimization problems which involve expensive black-box models.For computation-intensive engineering design problems,efficient global optimization methods must be developed to relieve the computational burden.A new metamodel-based global optimization method using fuzzy clustering for design space reduction(MGO-FCR) is presented.The uniformly distributed initial sample points are generated by Latin hypercube design to construct the radial basis function metamodel,whose accuracy is improved with increasing number of sample points gradually.Fuzzy c-mean method and Gath-Geva clustering method are applied to divide the design space into several small interesting cluster spaces for low and high dimensional problems respectively.Modeling efficiency and accuracy are directly related to the design space,so unconcerned spaces are eliminated by the proposed reduction principle and two pseudo reduction algorithms.The reduction principle is developed to determine whether the current design space should be reduced and which space is eliminated.The first pseudo reduction algorithm improves the speed of clustering,while the second pseudo reduction algorithm ensures the design space to be reduced.Through several numerical benchmark functions,comparative studies with adaptive response surface method,approximated unimodal region elimination method and mode-pursuing sampling are carried out.The optimization results reveal that this method captures the real global optimum for all the numerical benchmark functions.And the number of function evaluations show that the efficiency of this method is favorable especially for high dimensional problems.Based on this global design optimization method,a design optimization of a lifting surface in high speed flow is carried out and this method saves about 10 h compared with genetic algorithms.This method possesses favorable performance on efficiency,robustness and capability of global convergence and gives a new optimization strategy for engineering design optimization problems involving expensive black box models. | LI Yulin LIU Li LONG Teng DONG Weili | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 13 |
| 2 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 3 | Periodic Solution and Ergodic Stationary Distribution of Stochastic SIRI Epidemic Systems with Nonlinear Perturbations显示文摘This paper formulates two stochastic nonautonomous SIRI epidemic systems with nonlinear perturbations.The main aim of this study is to investigate stochastic dynamics of the two SIRI epidemic systems and obtain their thresholds.For the nonautonomous stochastic SIRI epidemic system with white noise,the authors provide analytic results regarding the stochastic boundedness,stochastic permanence and persistence in mean.Moreover,the authors prove that the system has at least one nontrivial positive T-periodic solution by using Lyapunov function and Hasminskii’s theory.For the system with Markov conversion,the authors establish sufficient conditions for positive recurrence and existence of ergodic stationary distribution.In addition,sufficient conditions for the extinction of disease are obtained.Finally,numerical simulations are introduced to illustrate the main results. | ZHANG Weiwei MENG Xinzhu DONG Yulin | 2019 | Journal of Systems Science & Complexity2019，32，4： | 6 |
| 4 | Facile one-step synthesis of graphitic carbon nitride-modified biochar for the removal of reactive red 120 through adsorption and photocatalytic degradation显示文摘Converting waste biomass into value-added biochar has been considered as a green and sustainable strategy for resource management and pollution control.In this study,graphitic carbon nitride(g-C_(3)N_(4))modified biochars(BCs)were produced through one-pot pyrolysis of urea and hickory chips in differential ratios at 520℃.The resulting BC/g-C_(3)N_(4)composites were evaluated in laboratory for their physicochemical,adsorptive,and photocatalytic properties.The characterization tests showed the successful synthesis of the BC/g-C_(3)N_(4)composites that introduced g-C_(3)N_(4)structure,N-containing surface func-tional groups,reduced surface area,and better thermal stability to the biochar.After modification,the BC/g-C_(3)N_(4)composites showed better adsorption ability to reactive red 120(RR120)than the pristine BC,due to the strong electrostatic attrition between N-containing functional groups of g-C_(3)N_(4)on biochar surface and anionic RR120.The BC/g-C_(3)N_(4)composites also inherited g-C_(3)N_(4)’s photocatalytic activity,which is visible light responsive to generate free radicals for RR120 degradation.In addition,the composites with higher urea modification ratios were more effective in the degradation of RR120.Overall,this study demonstrates the feasibility and promising potential of combining biochar and photocatalyst for the removal of aqueous dye.Because of the synergistic adsorption and photodegradation ability,BC/g-C_(3)N_(4)composites present a novel and cost-effective solution for the removal of aqueous dye and other photodegradable contaminants under natural conditions. | Yulin Zheng Yichen Yang Yue Zhang Weixin Zou Yidan Luo Lin Dong Bin Gao | 2019 | Biochar2019，1，1： | 5 |
| 5 | Effects of urban street trees on human thermal comfort and physiological indices: a case study in Changchun city, China显示文摘Planting trees along urban streets is one of the most important strategies to improve the urban thermal environment.However,the net impacts of urban street trees on human thermal comfort and physiological parameters are still less clear.On three similar east-west orientated streets with different degrees of tree cover-low(13%),medium(35%),and high(75%),urban microclimatic parameters and human physiological indices for six male students were simultaneously measured on three cloudless days in summer 2018.The results show that the differences in tree cover were predominant in influencing urban thermal environment and comfort.The street with the highest tree cover had significantly lower physiological equivalent temperature(PET) and more comfortable than the other two streets.The frequency of strong heat stress(PET> 35℃) was 64%,11 %,and 0%,respectively,for streets with low,medium,and high tree cover.For the six male university students,human physiological indices varied greatly across the three streets with different tree cover.Systolic blood pressure,diastolic blood pressure,and pulse rate increased with decreasing tree cover.The results also suggest that urban thermal environment and comfort had considerable impact on human physiological parameters.Our study provides reasons for urban planners to plant trees along streets to improve the thermal environment and promote urban sustainability. | Zhibin Ren Hongbo Zhao Yao Fu Lu Xiao Yulin Dong | 2022 | Journal of Forestry Research2022，33，3： | 4 |
| 6 | Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout显示文摘 | Dong, Zheng Li, Yuan Zhou, Jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia Pang, Yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun | 2017 | Protein & Cell2017，8，6： | 3 |
| 7 | A vacuum ultraviolet laser with a submicrometer spot for spatially resolved photoemission spectroscopy显示文摘Vacuum ultraviolet(VUV)lasers have demonstrated great potential as the light source for various spectroscopies,which,if they can be focused into a small beam spot,will not only allow investigation of mesoscopic materials and structures but also find application in the manufacture of nano-objects with excellent precision.In this work,we report the construction of a 177 nm VUV laser that can achieve a record-small(〜0.76 μm)focal spot at a long focal length(~45 mm)by using a flat lens without spherical aberration.The size of the beam spot of this VUV laser was tested using a metal grating and exfoliated graphene flakes,and we demonstrated its application in a fluorescence spectroscopy study on pure and Tm3+-doped NaYF4 microcrystals,revealing a new emission band that cannot be observed in the traditional up-conversion process.In addition,this laser system would be an ideal light source for spatially and angleresolved photoemission spectroscopy. | Yuanhao Mao Dong Zhao Shen Yan Hongjia Zhang Juan Li Kai Han Xiaojun Xu Chuan Guo Lexian Yang Chaofan Zhang Kun Huang Yulin Chen | 2021 | Light(Science & Applications)2021，10，3： | 3 |
| 8 | Carbon inputs regulate the temperature sensitivity of soil respiration in temperate forests显示文摘Litter and root activities may alter the temperature sensitivity(Q_(10))of soil respiration.However,existing studies have not provided a comprehensive understanding of the effects of litter and root carbon inputs on the Q_(10)of soil respiration in different seasons.In this study,we used the trench method under in situ conditions to measure the total soil respiration(R_(total)),litter-removed soil respiration(R_(no-litter)),root-removed soil respiration(R_(no-root)),and the decomposition of soil organic matter(i.e.,both litter and root removal;R_(SOM))in different seasons of pioneer(Populus davidiana Dode)and climax(Quercus liaotungensis Mary)forests on the Loess Plateau,China.Soil temperature,soil moisture,litter biomass,fine root biomass,litter carbon,and root carbon were analyzed to obtain the drive mechanism of the Q_(10)of soil respiration in the two forests.The results showed that the Q_(10)of soil respiration exhibited seasonality,and the Q_(10)of soil respiration was higher in summer.The litter enhanced the Q_(10)of soil respiration considerably more than the root did.Soil temperature,soil moisture,fine root biomass,and litter carbon were the main factors used to predict the Q_(10)of different soil respiration components.These findings indicated that factors affecting the Q_(10)of soil respiration highly depended on soil temperature and soil moisture as well as related litter and root traits in the two forests,which can improve our understanding of soil carbon–climate feedback in global warming.The results of this study can provide reference for exploring soil respiration under temperate forest restoration. | LIU Yulin LI Jiwei HAI Xuying WU Jianzhao DONG Lingbo PAN Yingjie SHANGGUAN Zhouping WANG Kaibo DENG Lei | 2022 | Journal of Arid Land2022，14，9： | 3 |
| 9 | The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway显示文摘Polyphyllin I(PPI)and polyphyllin II(PII)are the main active substances in the Paris polyphylla.However,liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated.In this work,we found that PPI and PII exposure could induce significant hepatotoxicity in human liver cell line L-02 and zebrafish in a dose-dependent manner.The results of the proteomic analysis in L-02 cells and transcriptome in zebrafish indicated that the hepatotoxicity of PPI and PII was associated with the cholesterol biosynthetic pathway disorders,which were alleviated by the cholesterol biosynthesis inhibitor lovastatin.Additionally,3-hydroxy-3-methy-lglutaryl CoA reductase(HMGCR)and squalene epoxidase(SQLE),the two rate-limiting enzymes in the cholesterol synthesis,selected as the potential targets,were confirmed by the molecular docking,the overexpression,and knockdown of HMGCR or SQLE with siRNA.Finally,the pull-down and surface plasmon resonance technology revealed that PPI could directly bind with SQLE but not with HMGCR.Collectively,these data demonstrated that PPI-induced hepatotoxicity resulted from the direct binding with SQLE protein and impaired the sterol-regulatory element binding protein 2/HMGCR/SQLE/lanosterol synthase pathways,thus disturbing the cholesterol biosynthesis pathway.The findings of this research can contribute to a better understanding of the key role of SQLE as a potential target in drug-induced hepatotoxicity and provide a therapeutic strategy for the prevention of drug toxic effects with similar structures in the future. | Zhiqi Li Qiqi Fan Meilin Chen Ying Dong Farong Li Mingshuang Wang Yulin Gu Simin Guo Xianwen Ye Jiarui Wu Shengyun Dai Ruichao Lin Chongjun Zhao | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 10 | Compression Properties of Ti-Al-X Alloys in Relation to Site Occupancies of Alloying Elements in TiAl and Ti_3Al显示文摘 | Yulin HA O Rui YANG, Yuyou CUI and Dong LI(Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110015, China)Wanfu GAO(Fushun Petroleum Institute, Dandong Road, Fushun 113001, China) | 1999 | Journal of Materials Science & Technology1999，15，6： | 2 |
| 11 | Astrocyte reactivity in related brain regions in a mouse model of MPTP-induced Parkinson's disease显示文摘BACKGROUND:Severe injury to dopaminergic neuronal cell bodies and their axon terminals in the substantia nigra pars compacta(SNC) has been observed in both Parkinson's disease(PD) patients or in 1-methy-4-phenyl-1,2,3,6-tetrahydropyrindine(MPTP)-induced PD animal models, but only slight injury occurs in the adjacent ventral tegmental area(VTA).The mechanisms underlying this selective injury remain poorly understood. OBJECTIVE:To comparatively observe astrocyte reactivity in the SNC,caudate putamen(CPu), VTA,and frontal association cortex(FrA). DESIGN,TIME AND SETTING:A cellular and molecular biology,randomized,controlled experiment was performed at the Institute of Neurobiology,Department of Human Anatomy, Medical School of Nantong University,between December 2006 and September 2008. MATERIALS:A total of 80 healthy adult male C57BL/6 mice were included in this study.MPTP was purchased from Sigma,USA. METHODS:Mice were randomly divided into a model group(n=64) and a sham-operated group (n=16).PD was induced in the mice from the model group by intraperitoneal injection of 20 mg/kg MPTP,once every three hours,for a total of 4 times. MAIN OUTCOME MEASURES:Tyrosine hydroxylase(TH)-immunoreactive neurons and glial fibrillary acidic protein(GFAP)-immunoreactive astrocytes were examined by dual immunofluorescence labeling.GFAP-immunoreactive astrocytes in the CPu and FrA were determined by immunofluorescent staining.GFAP mRNA expression in the SNC,CPu,VTA,and FrA was detected using real-time polymerase chain reaction.TH protein levels in the TH-immunoreactive axon terminals of the CPu and FrA were detected by Western blotting. RESULTS:Numbers of TH-immunoreactive neurons in the SNC,and TH protein level in the CPu, markedly decreased(by approximately 68%) 1 day after MPTP injection,and gradually increased at 3 days.Simultaneously,astrocyte reactivity was strengthened,in particular at 7 days.However, after MPTP injection,decreases in the numbers of TH-immunoreactive neurons in the VTA,and TH protein levels in the FrA,were less apparent(approximately 15%).Also,no obvious astrocyte reactivity was observed. CONCLUSION:In a mouse model of PD,astrocyte reactivity was apparent in the SNC and CPu, but not the VTA or FrA.In addition,astrocyte reactivity was greater in regions where injury to dopaminergic neurons was more severe. | Zhijun Zhang Chunlin Xia Yulin Dong Guangming Lü Juan Liu Lin Ding Hengjian Ni | 2009 | Neural Regeneration Research2009，4，2： | 1 |
| 12 | Preparation and characterization of antibacterial viscose-based activated carbon fiber supporting silver显示文摘 | Wang Yulin Wan Yizao Dong Xianghong | 1998 | Carbon1998，36，11： | 1 |
| 13 | Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration显示文摘 | Ling Zhao Jixin Liu Xilin Dong Yulin Peng Kai Yuan Fumei Wu Jinbo Sun Qiyong Gong Wei Qin Fanrong Liang | 2013 | The Journal of Headache and Pain2013，，1： | 1 |
| 14 | Association between the Apolipoprotein E4 and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Intravenous Anesthesia and Inhalation Anesthesia显示文摘 | Yingmin Cai Haitao Hu Pengbin Liu Gaifeng Feng Weijiang Dong Bing Yu Yulin Zhu Jinxin Song Minggang Zhao | 2012 | Anesthesiology2012，，1： | 1 |
| 15 | New Discovery of the 341 Ma Gabbro at Xiongcun District in the Southern Margin of Lhasa Terrane, Tibet显示文摘Objective Lhasa terrane has recorded the geologic history concerning the formation and evolution of Paleo-Tethys and the intra-continental convergence in Qinghai–Tibet Plateau(Yin and Harrison,2000).Previous investigations have focused on the initial timing of the India-Asia collision and the Cretaceous–Cenozoic magmatism and sedimentation(Wang Tianyang et al.,2017),however, | LANG Xinghai LIU Dong DENG Yulin TANG Juxing XIE Fuwei YANG Zongyao CUI Zhiwei WANG Xuhui LI Zhijun ZHANG Zhong ZHANG Jinshu HUANG Yong | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 1 |
| 16 | Enhanced expressions of lysozyme,SLPI and glycoprotein 340in biofilm-associated chronic rhinosinusitis显示文摘 | DONG D YULIN Z YAN X | 2014 | Eur Arch Otorhinolaryngol2014，271，： | 1 |
| 17 | Electrochemically Reduced Graphene Oxide as Modified Electrode Material for Determination of Dihydroxybenzenes显示文摘A simple and green method was introduced to fabricate the electrochemical sensor based on the electrochemically reduced graphene oxide(ERGO) modified electrode. It was found that the ERGO modified electrode exhibited an excellent catalytic activity toward the oxidation of dihydroxybenzenes isomers. Under the optimum conditions, in the simultaneous determination of the dihydroxybenzene isomers, the currents were linear with the concentrations of the isomers from 5 to 550 μmol/L for hydroquinone(HQ), from 6 to 400 μmol/L for catechol(CT) and from 5 to 350 μmol/L for resorcinol(RS), respectively. In addition, the proposed sensor has good stability and reproducibility. The developed method has been applied to the simultaneous determination of dihydroxybenzene isomers in real samples with a satisfactory recovery from 98% to 103%. | 王梦梦 李曦 LIU Jing XU Wenjing DONG Yulin LIU Peng 张超灿 | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，5： | 1 |
| 18 | Particle swarm optimization for determining fuzzy measures form data 显示文摘 | WANG Xizhao HE Yulin DONG Lingeai | 2001 | Information Science2001，181，19： | 1 |
| 19 | Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag显示文摘 | Yoshiaki Yamaguchi Toru Suzuki Yasutaka Mizoro Hiroshi Kori Kazuki Okada Yulin Chen Jean-Michel Fustin Fumiyoshi Yamazaki Naoki Mizuguchi Jing Zhang Xin Dong Gozoh Tsujimoto Yasushi Okuno Masao Doi Hitoshi Okamura | 2013 | Science2013，，6154： | 1 |
| 20 | The microgravity enhanced polymer-mediated siRNA gene silence by improving cellular uptake显示文摘Microgravity(MG)effect is a weightlessness phenomenon caused by the distance from the ground or low gravity of other planets outside the earth's atmosphere.The various effects of MG have been corroborated in human and animal studies and modeled in cell-based analogs.However,the impact of MG on siRNA performance remains to be elucidated,which is crucial for aerospace medicine.In this study,we prepared nucleic acid nanomicelles(EAASc/siRNA)by using tri-block copolymer of PEG45-PAMA40-P(C7A36-DBA37)(EAASc)and siRNA and explored its working mechanism under simulated microgravity(SMG)condition generated by a random positioning machine(RPM).The binding ability of EAASc to siRNA and silence activity were firstly confirmed in normal gravity(NG)environment.Evaluation of PLK1 mRNA expression revealed that gene inhibition efficiencies were increased by 28.7%(HepG2)and 28.9%(A549)under SMG condition,compared with those under NG condition.In addition,mechanism exploration indicated that morphology and migration capability of cancer cells were significantly changed,the internalization of EAASc/siRNA by cells was magnified when the cells were incubated with RPM.No significant difference was observed regarding the expression profiles of genes involved in RNA interference(RNAi)pathway,including Ago2,Dicer,TRBP,and so on.Taken together,siRNA activity was elevated under SMG condition owning to increased cellular internalization.This study,for the first time to our knowledge,provides valuable theory for development and application of siRNA therapeutic in space in the future. | Tongren Yang Chanchan Yu Changrong Wang Chunhui Li Mengjie Zhang Xiaofan Luo Yuhua Weng Anjie Dong Xiaoqiong Li Yulin Deng Yuanyu Huang | 2020 | Biophysics Reports2020，6，6： | 1 |
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