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| 1 | Incidence and mortality of thyroid cancer in China, 2008-2012显示文摘Objective: To analyze the incidence and mortality rates of thyroid cancer(TC) in China from 2008 to 2012.Methods: Incident and death cases of TC were retrieved from the National Central Cancer Registry(NCCR)database collecting from 135 cancer registries in China during 2008-2012. The crude incidence and mortality rates of TC were calculated by area(urban/rural), region(eastern, middle, western), gender and age group(0, 1-4, 5-9,…, 85+). China census in 2000 and world Segi's population were applied for age-standardized rates. Joinpoint(Version 4.6.0.0) model was used for time-trend analysis.Results: The crude incidence rate of TC was 7.56/100,000 which ranked the seventh in overall cancers. The agestandardized incidence rates by China population(ASIRC) and by World population(ASIRW) were 6.25/100,000 and 5.52/100,000, respectively. The crude mortality of TC in China was 0.52/100,000. The age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were0.34/100,000 and 0.32/100,000, respectively. Incidence and mortality rates of TC were higher in females than in males and higher in urban areas than in rural areas. Eastern areas had the highest incidence followed by middle and western areas. TC incidence increased dramatically after age of 15 years, then peaked at 14.08/100,000 in the group of 50-54 years and finally decreased sharply after 55 years old. TC mortality increased with age in population,reaching the peak of 5.09/100,000 in sub-population aged 85 years or older. TC incidence increased by 4.73 times from 2.40/100,000 in 2003 to 13.75/100,000 in 2012 with an average annual increase of 20%, while TC mortality only increased slightly around 0.32/100,000 from 0.26/100,000 to 0.36/100,000.Conclusions: Appropriate targeted prevention, early detection and treatment programs can be carried out to curb the rapid growth trend of TC and control the disease burden. | Lingbin Du Runhua Li Minghua Ge Youqing Wang Huizhang Li Wanqing Chen Jie He | 2019 | Chinese Journal of Cancer Research2019,31,1: | 31 |
| 2 | Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratioin predicting survival for patients with stage Ⅰ-Ⅱgastric cancer显示文摘Background:The preoperative neutrophil-to-lymphocyte ratio(NLR) and the platelet-to-lymphocyte ratio(PLR) are associated with poor prognosis of gastric cancer.We aimed to determine whether the combination of NLR and PLR(NLR-PLR) could better predict survival of patients after curative resection for stage Ⅰ-Ⅱ gastric cancer.Methods:We collected data from the medical records of patients with stage Ⅰ-Ⅱ gastric cancer undergoing curative resection between December 2000 and November 2012 at the Sun Yat-sen Cancer Center.The preoperative NLRPLR was calculated as follows:patients with both elevated NLR(≥2.1) and PLR(≥ 120) were given a score of 2,and patients with only one or neither were given a score of 1 or 0,respectively.Results:Kaplan-Meier analysis and log-rank tests revealed significant differences in overall survival(OS) among patients with NLR-PLR scores of 0,1 and 2(P < 0.001).Multivariate analysis showed that OS was independently associated with the NLR-PLR score[hazard ratio(HR) = 1.51,95%confidence interval(CI) 1.02-2.24,P = 0.039]and TNM stage(HR = 1.36,95%CI 1.01-1.83,P= 0.041).However,other systemic inflammation-based prognostic scores,including the modified Glasgow prognostic score,the prognostic nutritional index,and the combination of platelet count and NLR,were not.In TNM stage-stratified analysis,the prognostic significance of NLR-PLR was maintained in patients with stage Ⅰ(P < 0.001) and stage Ⅱ cancers(P= 0.022).In addition,the area under the receiver operating characteristic curve for the NLR-PLR score was higher than those of other systemic inflammation-based prognostic scores(P = 0.001).Conclusion:The preoperative NLR-PLR score is a useful predictor of postoperative survival in the patients with stage l-ll gastric cancer and may help identify high-risk patients for rational therapy and timely follow-up. | Xiaowei Sun Xuechao Liu Jianjun Liu Shangxiang Chen Dazhi Xu Wei Li Youqing Zhan Yuanfang Li Yingbo Chen Zhiwei Zhou | 2016 | Chinese Journal of Cancer2016,35,7: | 25 |
| 3 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018,61,12: | 19 |
| 4 | Improving uniform scattering device for straw-smashing,back-throwing,no-tillage planter under complete straw mulching condition显示文摘With the objective of obtaining a completely straw-mulched field,when no-tillage mechanical sowing is implemented with straw smashing,delivering,and back-throwing approaches,it may be difficult to scatter the smashed straw uniformly during a succeeding wheat sowing step.This is because the previous rice straw is substantial in quantity and has a high humidity and toughness,which may easily result in non-uniform straw mulching and thus sparse and weak seedlings of wheat.Therefore a force-dispersing and uniform-scattering device was designed.With the number of scattering impellers,impeller angle,and impeller rotation speed as the main factors and the percentage of pass for the scattering width and non-uniformity of the straw mulching as the assessment indices,single-factor experiments and orthogonal regressive tests were performed,and a dual-index(percentage of pass for the scattering width and non-uniformity of the straw mulching)fitted regression equation was established.The test results suggested that the main factors(from primary to secondary)that influence the indices were the impeller rotation speed,number of scattering impellers,and impeller angle.The optimal parameter combination for the uniform scattering device was four rows of impellers with an angle of 15°,rotation speed of 1015 r/min,percentage of pass of 72.65%for the scattering width,and a non-uniformity of 13.8%in the straw mulching.This combination can be used to realize a uniform scattering of the smashed straw along the seedling rows on the after-sowing ground.According to the field investigation of the wheat growth,the wheat emergence rate was 90.7%.The research results can provide a reference for improving the uniform scattering device for a straw-smashing,back-throwing,no-tillage planter for obtaining a completely straw-mulched field,enhancing the quality of the machinery operation,and ensuring good and strong seedlings after sowing. | Fengwei Gu Xuemei Gao Feng Wu Zhichao Hu Youqing Chen Chong Zhang | 2018 | International Journal of Agricultural and Biological Engineering2018,11,6: | 5 |
| 5 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022,65,6: | 2 |
| 6 | Determination of damaged wheat kernels with hyperspectral imaging analysis显示文摘Hyperspectral imaging was applied to classify the damaged wheat kernels and healthy kernels.The spectral information was extracted from damaged wheat kernels and healthy kernels samples.The effective wavelengths were obtained from spectral of 865-1711 nm by X-loadings of principal component analysis(PCA)and successive projection algorithm(SPA)method,respectively.Partial least square method(PLS)and least square-support vector machine(LS-SVM)were then used to build classification models on full spectral data and effective wavelengths dataset,respectively.The results showed that the classification accuracy of every LS-SVM model was the best,being 100%.While the accuracy of the PLS model was slightly lower,still over 97%.The confusion matrix showed that several damaged wheat kernels samples were misclassified as healthy samples,while all healthy samples were correctly classified.The overall results indicated that hyperspectral imaging could be used for discriminating the damaged wheat kernels and could provide a reference for detecting other grain kernels grading degrees.Further,this study can provide a research basis for the development of online or portable detectors on grain damaged kernels recognition,which will be beneficial for grain grading or post-harvest quality processing of other grains. | Yuanyuan Shao Chong Gao Guantao Xuan Xuemei Gao Youqing Chen Zhichao Hu | 2020 | International Journal of Agricultural and Biological Engineering2020,13,5: | 2 |
| 7 | Analysis of the Ecdysteroid UDP-Glucosyltransferase Gene of Heliothis armigera Single-Nucleocapsid Baculovirus显示文摘 | Xinwen Chen Zhihong Hu Johannes A. Jehle Youqing Zhang Just M. Vlak | 1997 | Virus Genes1997,,3: | 1 |
| 8 | Titanium dioxide coated zinc oxide nanostrawberry aggregates for dye-sensitized solar cell and self-powered UV-photodetector显示文摘 | Caitian Gao Xiaodong Li Youqing Wang Lulu Chen Xiaojun Pan Zhenxing Zhang Erqing Xie | 2013 | Journal of Power Sources2013,,: | 1 |
| 9 | Prospect of the upper limit of the energy demand in China from regional aspects显示文摘 | Toshihide Ito Youqing Chen Shoichi Ito Kaoru Yamaguchi | | 0,,12: | 1 |
| 10 | A fluorescent approach to the identification of grout injected into fissures and pore spaces显示文摘 | Chen Youqing | 2000 | Engineering Geology2000,56,34: | 1 |
| 11 | Identification of microRNAs regulating grain filling of rice inferior spikelets in response to moderate soil drying post-anthesis显示文摘The grain filling of inferior spikelets is much less complete than that of superior spikelets in rice cultivars with large panicles and numerous spikelets and is promoted by moderate soil drying(MD)post-anthesis.A growing body of evidence has shown that microRNAs function in regulating grain development.However,little is known about the mechanism of microRNA control of grain filling of inferior spikelets in response to MD.In this study,grain filling of inferior spikelets was promoted by MD treatment in Nipponbare.Small-RNA profiling at the most active grain-filling stage was conducted in inferior spikelets under control(CK)and MD treatment.Of 521 known and 128 novel miRNAs,38 known and 9 novel miRNAs were differentially expressed between the CK and MD treatments.Target genes of differentially expressed miRNAs were involved in multiple developmental and signaling pathways associated with catalytic activity,carbohydrate metabolism,and other functions.Both miR1861 and miR397 were upregulated by MD,leading to a decrease in OsSBDCP1 and OsLAC,two negative regulators of SSIIIa activity and BR signaling,respectively.In contrast,miR1432 abundance was reduced by MD,resulting in upregulation of OsACOT and thus an elevated content of both ABA and IAA.These results suggest that both starch synthesis and phytohormone biosynthesis are regulated by differentially expressed miRNAs in inferior spikelets in response to MD treatment.Our results suggest the molecular mechanisms by which miRNAs regulate grain filling in inferior spikelets of rice under moderate soil drying,providing potential application in agriculture to increase rice yields by genetic approaches. | Zhenning Teng Yinke Chen Youqing Yuan Yaqiong Peng Yake Yi Huihui Yu Zhenxie Yi Jianchang Yang Yan Peng Meijuan Duan Jianhua Zhang Nenghui Ye | 2022 | The Crop Journal2022,10,4: | 1 |
| 12 | PROTECTIVE EFFECT OF MOXIBUSTION AT SHENQUE(RN 8)ON GASTRIC MUCOSA显示文摘Male S.D rats weighing 200g were used(as experimental animals).Moxibus-tion at Shenque(RN 8)was performed for 15 minutes each day.The course lasted for weeks.In ratsundergoing oral infusion of taurocholate,index of gastric mucosal injury were 9.0±6.1 and 4.6±2.5 in two and four week groups respectively.Compared with control group(index:16.8±7.6),Pwas less than 0.05 and 0.01.This indicated that moxibustion had protective effect on gastric mucosalinjury.Time-effect relationship also existed.In experiment of analysis about mechanism of moxibustion,we found that moxibustion.1.stim-ulated the secretion of gastric mucus(P<0.001);2.increased the PGE 2 content in gastric mucosa(P<0.05);3.increased the number of β-endorphin-like immunoactive cells in gastric mucosa(P<0.05);4.enhanced the transformation of lymphocytes(P<0.01);5.reinforced the function of an-tibody-producing cells in the spleen.The results suggested that protective effect of moxibustion might result from the increase in mu-cus,the PGE 2 and the endogenous β-endorphin.It might also be related to the reinforcing effect ofmoxibustion on transformation of lymphocytes and antibody-producing function of spleen cells. | Chen Yanjiang Chen Yongchang Xiao Desheng Wang Fengwei Cao Youqing Zhenjiang Medical College,Zhenjiang,Jiangsu Province 212001,China | 1993 | World Journal of Acupuncture-Moxibustion1993,3,2: | 0 |
| 13 | A breathing A4 paper by in situ growth of green metal-organic frameworks for air freshening and cleaning显示文摘Surface modification of natural cellulose fibers with nanomaterials is an effective strategy for producing functional textiles for multiple applications.A4-sized printing paper is a commonly used,cheap,and easily acquirable office supply which is mainly made of cellulose fibers.Here,we report green and simple nanofabrication of A4 paper to endow it with high capability for fragrance encapsulation and sustained release,and strong adsorption to indoor air pollutants.The method utilizes the sugar molecule of cellulose for in-situ growth ofγ-cyclodextrin(γ-CD)metal-organic frameworks(MOFs)on A4 paper.The obtainedγ-CD-MOF/A4 nanocomposites have superior specific surface area and high porous structure.Theγ-CD-MOF/A4 nanocomposites can effectively encapsulate fragrant molecules through host-guest interaction.Theγ-CD-MOF/A4 nanocomposites also show strong absorption capability to formaldehyde and carbon dioxide through the formation of hydrogen bonding and chemical bonds.Theseγ-CD-MOF/A4nanocomposites combine the advantages of both A4 paper andγ-CD-MOF,which can be used in indoor air freshening and cleaning. | Bo Zhang Hongwen Chen Liming Jiang Youqing Shen Dan Zhao Zhuxian Zhou | 2022 | Chinese Journal of Chemical Engineering2022,,12: | 0 |
| 14 | The Mechanism of Cisplatin-induced Apoptosis in HeLa Cells显示文摘 | Youqing Uu Hui Xing Xiaobing Han Xiaoyan Shi Fengqi Liang Gang Chen Ding Ma | 2005 | Chinese Journal of Clinical Oncology2005,2,6: | 0 |
| 15 | Electron-distribution control via Pt/NC and MoC/NC dual junction:Boosted hydrogen electro-oxidation and theoretical study显示文摘The scarcity,high cost and susceptibility to CO of Platinum severely restrict its application in alkaline hydrogen oxidation reaction(HOR).Hybridizing Pt with other transition metals provides an effective strategy to modulate its catalytic HOR performance,but at the cost of mass activity due to the coverage of modifiers on Pt surface.Herein,we constructed dual junctions'Pt/nitrogen-doped carbon(Pt/NC)andδ-MoC/NC to modify electronic structure of Pt via interfacial electron transfer to acquire Pt-MoC@NC catalyst with electron-deficient Pt nanoparticles,simultaneously endowing it with high mass activity and durability of alkaline HOR.Moreover,the unique structure of Pt-MoC@NC endows Pt with a high COtolerance at 1,000 ppm CO/H_(2),a quality that commercial Pt-C catalyst lacks.The theoretical calculations not only confirm the diffusion of electrons from Pt/NC to Mo C/NC could occur,but also demonstrate the negative shift of Pt d-band center for the optimized binding energies of*H,*OH and CO. | Feng Zhou Xiaofeng Ke Yihuang Chen Mei Zhao Yun Yang Youqing Dong Chao Zou Xi’an Chen Huile Jin Lijie Zhang Shun Wang | 2024 | Journal of Energy Chemistry2024,88,1: | 0 |
| 16 | Optimization and experiment on key structural parameters of no-tillage planter with straw-smashing and strip-mulching显示文摘Accelerate the quality of smashed-straw laying and enhance the effect of seed-bed arranging for no-tillage planter with straw-smashing and strip-mulching in full stubble covered paddy have become imperative in implementing modern conservation tillage.Considering the perfect operating performance(passability and stability)of the developed no-tillageplanter,this study intends to optimize the structure design of smashed-straw diversion device and strip-rotary tillage device.Dynamics equations of smashed straw and kinematics models of rotary blades were established through theoretical analysis,and the principal factors that affecting straw strip-laying quality and seed-bed arranging effect were specified.The influence of out-enlarge angle(η)and slide-push angle(γ)of the diversion device on the coefficient of variation(ζ1)of cover-straw width,and the influence of rotary tillage-blade number(N)and configuration in a singlerotary plane on the broken rate(ζ2)of strip soil were completely analyzed.And then,based on the systematic analysis and integrated scheme,operating performance and field verification tests using the optimized no-tillage planter were thoroughly performed.The results of the performance tests indicated that the out-enlarge angle(η)had a highly significant influence on the coefficient of variation(ζ1),and the slide-push angle(γ)had a significant influence on(ζ1).The rotary tillage-blade number(N)had a highly significant influence on the broken rate(ζ2),and the slide-push angle(γ)had a significant influence on(ζ2).The obtained optimal combination of these key structure parameters through comprehensive analysis wasη=45°,γ=40°,and N=4.Field verification test results indicated that the optimized no-tillage planter achieved mean values of ζ1=10.47%and ζ2=90.95%,which satisfied the relevant operation quality and cultivation agricultural requirement of conservation tillage equipment,and provided technical references for developing the similar no-tillage planter of straw crushing and returning. | Yinyan Shi Xiaochan Wang Zhichao Hu Fengwei Gu Feng Wu Youqing Chen | 2021 | International Journal of Agricultural and Biological Engineering2021,14,3: | 0 |
| 17 | THE EFFECT OF MOXIBUSTION ON IMMUNITY IN RATS显示文摘Our previous works have proved that moxibustion at“Shenque(RN8)”playa role in protecting gastric mucosa in experimental gastric ulcer modal rats.The present studieswere designed to determine whether moxibustion affects immunity.The results showed that theactivity of bacteriolysin.the antibody forming cell.of the spleen,the titer of anti.SRBC antibodyand the transformation of lymphocytes were all significantly increased in moxibustion groups.andthe course of moxibustion must be longer than 14 days.The results suggested that moxibustioncould stimulate immunity in rats(including non-specific and specific immunity.cellular andhumoral immunity)and the course of moxibustion should not be less than two weeks. | Chen Yanjiang Chen Yongchang Wang Fengwei Li Liangjy Xu Wenrong Cao Youqing, Zhenjiang Medical College, Zhenjiang, Jiangsu 212001, China | 1992 | World Journal of Acupuncture-Moxibustion1992,2,1: | 0 |
| 18 | Tuning the release rate of volatile molecules by pore surface engineering in metal-organic frameworks显示文摘Encapsulation and controlled release of volatile molecules such as fragrances in a designed manner is important but challenging for the flavor and fragrance industry.Here,we report the tuning release of volatile molecules by postsynthetic modification of an amine-terminated metal-organic framework(MOF)MIL-101-NH_(2).By amidation,we obtained three MIL-101 MOFs,the trimethylacetamideterminated TC-MIL-101,the benzamide-terminated BC-MIL-101,and the oxalic acid monoamideterminated OC-MIL-101.All the MOFs can efficiently encapsulate volatile molecules.Moreover,we demonstrate that the release profile of volatiles can be widely tuned to sustain the release in several days to months and even over a year using different modified MIL-101 MOFs.We show that the release profiles are correlated with the binding energies between the guest volatiles and pores in MOFs.The pore diffusion and the synergistic transport are the rate-limiting step of the guest molecules from the modified MOFs. | Hongwen Chen Huaqiang Chen Bo Zhang Liming Jiang Youqing Shen Engang Fu Dan Zhao Zhuxian Zhou | 2021 | Chinese Chemical Letters2021,32,6: | 0 |
| 19 | Adaptabilities of different harvesters to peanut plants after cutting stalks显示文摘At present,there are no harvesters specifically adapted to process peanuts after cutting stalks.In particular,methods for harvesting peanuts after cutting stalks have not been reported thus far.Therefore,to utilize peanut stalks as feed when harvesting plastic-film-grown peanuts,and to improve industry benefits,a three-stage harvesting method is proposed herein.In view of the three-stage harvesting method,the peanut stalks are cut before digging,with the remaining peanut plants being shorter,thereby increasing the peanut pod-stalk ratio.To investigate the adaptabilities of existing harvesters in harvesting peanuts after cutting stalks,three types of peanut harvesters-the self-propelled pick-up combine harvester,trailed pick-up combine harvester,and peanut picker were used to conduct a comparative test on harvesting intact peanut plants and plants after cutting stalks.The loss,breakage and impurity rates were used as evaluation indicators.The loss rates of these three harvesters were 14.64%,16.44%and 1.33%;the breakage rates were 21.28%,21.92%and 20.00%,and impurity rates were 4.60%,8.76%and 9.06%.Analysis of variance showed that cutting stalks had a significant impact on the work qualities of the three harvesters(p<0.05).With regard to the loss rate,results revealed that:the two peanut combine harvesters could not be adapted to harvest peanut plants after cutting stalks.The three harvesters had good adaptability to harvest peanut plants after cutting stalks,considering the breakage rate;however,based on the impurity rate,the three harvesters could not be adapted to harvest peanut plants after cutting stalks.The losses of the two combine harvesters consisted mainly of dropped and missed picking,with the sum of the losses accounting for 99.87%and 97.99%of the total losses of the two harvesters,respectively;this suggests that the drum pickup of the combine harvesters could not adapt to harvesting the peanut after cutting stalks.The breakage rates of the three harvesters were considerably reduced,suggesting that the pod picking devices of the three harvesters were suitable for harvesting the peanut after cutting stalks;the impurity rates of the three harvesters were considerably increased,indicating that the pod picking and cleaning devices of the three harvesters were not suitable for harvesting peanut after cutting stalks.To improve the adaptabilities of the harvesters,it is suggested that the speed of pickup elastic tooth,lateral spacing between adjacent elastic teeth,concave screen hole size of pod picking device,the structure and motion parameters of cleaning device should be optimized.The results of this study provide a reference for the development and improvement of peanut harvesters suitable for harvesting peanuts after the cutting of stalks. | Youqing Chen Gongpu Wang Jiangtao Wang Peng Zhang Bing Wang Zhichao Hu | 2022 | International Journal of Agricultural and Biological Engineering2022,15,2: | 0 |