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| 1 | Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test显示文摘AIM: To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay. METHODS: This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration. RESULTS: Using the UBT as the standard, the sensitivity, specif icity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were signif icantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A450/630) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099). | Masaaki Kodama Kazunari Murakami Tadayoshi Okimoto Yoshihiro Fukuda Tadashi Shimoyama Masumi Okuda Chieko Kato Intetsu Kobayashi Toshio Fujioka | 2012 | World Journal of Gastroenterology2012，18，1： | 7 |
| 2 | Immediate detection of endoscopic retrograde cholangiopancreatographyrelated periampullary perforation: Fluoroscopy or endoscopy?显示文摘AIM:To investigate the causes and intraoperative detection of endoscopic retrograde cholangiopancreatography(ERCP)-related perforations to support immediate or early diagnosis.METHODS:Consecutive patients who underwent ERCP procedures at our hospital between January2008 and June 2013 were retrospectively enrolled in the study(n=2674).All procedures had been carried out using digital fluoroscopic assistance with the patient under conscious sedation.For patients showing alterations in the gastrointestinal anatomy,a short-type double balloon enteroscope had been applied.Cases of perforation had been identified by the presence of air in or leakage of contrast medium into the retroperitonealspace,or upon endoscopic detection of an abdominal cavity related to the perforated lumen.For patients with ERCP-related perforations,the data on medical history,endoscopic findings,radiologic findings,diagnostic methods,management,and clinical outcomes were used for descriptive analysis.RESULTS:Of the 2674 ERCP procedures performed during the 71-mo study period,only six(0.22%)resulted in perforations(male/female,2/4;median age:84 years;age range:57-97 years).The cases included an endoscope-related duodenal perforation,two periampullary perforations related to endoscopic sphincterotomy,two periampullary perforations related to endoscopic papillary balloon dilation,and a periampullary or bile duct perforation secondary to endoscopic instrument trauma.No cases of guidewire-related perforation occurred.The video endoscope system employed in all procedures was only able to immediately detect the endoscope-related perforation;the other five perforation cases were all detected by subsequent digital fluoroscope applied intraoperatively(at a median post-ERCP intervention time of 15 min).Three out of the six total perforation cases,including the single case of endoscope-related duodenal injury,were surgically treated;the remaining three cases were treated with conservative management,including trans-arterial embolization to control the bleeding in one of the cases.All patients recovered without further incident.CONCLUSION:ERCP-related perforations may be difficult to diagnose by video endoscope and digital fluoroscope detection of retroperitoneal free air or contrast medium leakage can facilitate diagnosis. | Yasuaki Motomura Kazuya Akahoshi Junya Gibo Kenji Kanayama Shinichiro Fukuda Shouhei Hamada Yoshihiro Otsuka Masaru Kubokawa Kiyoshi Kajiyama Kazuhiko Nakamura | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 3 | Diagnostic utility of peroral cholangioscopy for various bile-duct lesions显示文摘 | Yoshihiro Fukuda Toshio Tsuyuguchi Yuji Sakai Shin Tsuchiya Hiromitsu Saisyo | 2005 | Gastrointestinal Endoscopy2005，，3： | 3 |
| 4 | Adsorptive granulocyte and monocyte apheresis for refractory Crohn’s disease: an open multicenter prospective study显示文摘 | Yoshihiro Fukuda Toshiyuki Matsui Yasuo Suzuki Kazunari Kanke Takayuki Matsumoto Masakazu Takazoe Takayuki Matsumoto Satoshi Motoya Terasu Honma Koji Sawada Tsuneyoshi Yao Takashi Shimoyama Toshifumi Hibi | 2004 | Journal of Gastroenterology2004，，12： | 1 |
| 5 | Localized type 1 autoimmune pancreatitis superimposed upon preexisting intraductal papillary mucinous neoplasms显示文摘A 70-year-old woman was found to have 2 cystic lesions in the head of the pancreas on abdominal ultrasonography during a routine medical examination.Endoscopic ultrasonography(EUS)and magnetic resonance cholangiopancreatography showed multilocular cysts in the head of the pancreas without dilation of the main pancreatic duct.The patient was followed-up semiannually with imaging studies for suspected branch duct-type intraductal papillary mucinous neoplasm(IPMN).At 3 years after initial presentation,hypoechoic lesions were observed around each pancreatic cyst by EUS.Diffusion-weighted imaging showed high-intensity regions corresponding to these lesions.Therefore,a diagnosis of invasive carcinoma derived from IPMN could not be excluded,and subtotal stomach-preserving pancreaticoduodenectomy was performed.The macroscopic examination of the surgical specimen showed whitish solid masses in the head of the pancreas,with multilocular cysts within each mass.Microscopically,each solid mass consisted of inflammatory cells such as lymphocytes and plasma cells.Furthermore,immunochemical staining revealed immunoglobulin G4-positive cells,and many obliterating phlebitides were observed.The cysts consisted of mucus-producing epithelial cells and showed a papillary growth pattern.Based on these findings,we diagnosed multiple localized type 1 autoimmune pancreatitis occurring only in the vicinity of the branch ducttype IPMN. | Takahiro Urata Yoshiki Naito Yoshihiro Izumi Yoshi Takekuma Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Kenji Notohara Michio Hifumi | 2013 | World Journal of Gastroenterology2013，19，47： | 1 |
| 6 | Low Prevalence and Incidence of H elicobacter pylori Infection in Children: A Population‐Based Study in J apan显示文摘 | Masumi Okuda Takako Osaki Yingsong Lin Hideo Yonezawa Kohei Maekawa Shigeru Kamiya Yoshihiro Fukuda Shogo Kikuchi | 2015 | Helicobacter2015，，2： | 1 |
| 7 | Comparison of monoclonal antibody-based stool antigen tests to determine the results of Helicobacter pylori eradication therapy显示文摘 | Tadashi Shimoyama Intetsu Kobayashi Chieko Kato Masaaki Kodama Yoshihiro Fukuda | 2010 | Scandinavian Journal of Gastroenterology2010，，12： | 1 |
| 8 | Evaluation of a Novel Stool Native Catalase Antigen Test for Helicobacter pylori Infection in Asymptomatic North American Children显示文摘 | Victor M Cardenas Delfina C Dominguez Flor A Puentes Corinne C Aragaki Karen J Goodman David Y Graham Yoshihiro Fukuda | 2008 | Journal of Pediatric Gastroenterology and Nutrition2008，，4： | 1 |
| 9 | Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn’s disease, respectively显示文摘 | Hiroko Sashio Kazuo Tamura Reiko Ito Yoshihiro Yamamoto Hiroko Bamba Tadashi Kosaka Shin Fukui Koji Sawada Yoshihiro Fukuda Kazutami Tamura Masamichi Satomi Takashi Shimoyama Jun-ichi Furuyama | 2002 | Immunogenetics2002，，12： | 1 |
| 10 | A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease显示文摘 | Hiroaki Ito Masakazu Takazoe Yoshihiro Fukuda Toshifumi Hibi Kazuo Kusugami Akira Andoh Takayuki Matsumoto Takehira Yamamura Junichi Azuma Norihiro Nishimoto Kazuyuki Yoshizaki Takashi Shimoyama Tadamitsu Kishimoto | 2004 | Gastroenterology2004，，4： | 1 |
| 11 | Coexistence of metastatic lung cancer and pulmonary tuberculosis diagnosed in the same cavity显示文摘 | Yoshihiro Kobashi Minoru Fukuda Masao Nakata | 2005 | International Journal of Clinical Oncology2005，，： | 1 |
| 12 | Simultaneous detection of virulence factors from a colony in diarrheagenic Escherichia coli by a multiplex PCR assay with Alexa Fluor-labeled primers显示文摘 | Masaru Kuwayama Naoki Shigemoto Sachiko Oohara Yukie Tanizawa Hiroko Yamada Yoshihiro Takeda Takeshi Matsuo Shinji Fukuda | 2011 | Journal of Microbiological Methods2011，，1： | 1 |
| 13 | Influence of Helicobacter pylori infection on development of stress-induced gastric mucosal injury显示文摘 | Noriyasu Yamamoto Takashi Sakagami Yoshihiro Fukuda Hiromasa Koizuka Kazutoshi Hori Yukio Sawada Yutaka Hikasa Noritoshi Tanida Takashi Shimoyama | 2000 | Journal of Gastroenterology2000，，5： | 1 |
| 14 | Peroral cholangioscopy for the diagnosis and treatment of biliary diseases显示文摘 | Toshio Tsuyuguchi Yoshihiro Fukuda Hiromitsu Saisho | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，2： | 1 |
| 15 | Lower frequency of non-target lesion intervention in post-successful percutaneous coronary intervention patients with an LDL to HDL cholesterol ratio below 1.5显示文摘 | Yusuke Fukuda Shin-ichiro Miura Yoshihiro Tsuchiya Yukiko Inoue-Sumi Kazumitsu Kubota Yousuke Takamiya Takashi Kuwano Hitomi Ohishi Amane Ike Ken Mori Daizaburo Yanagi Hiroaki Nishikawa Kazuyuki Shirai Keijiro Saku Hidenori Urata | 2011 | International Journal of Cardiology2011，，1： | 1 |
| 16 | CO2 reduction potentials by utilizing waste plastics in steel works显示文摘 | Yu Sekine Koichi Fukuda Kenji Kato Yoshihiro Adachi Yasunari Matsuno | 2009 | The International Journal of Life Cycle Assessment2009，，2： | 1 |
| 17 | Wilms’ tumor gene WT1-shRNA as a potent apoptosis-inducing agent forsolid tumors显示文摘 | Naoya Tatsumi Yusuke Oji Naoko Tsuji Asako Tsuda Mari Higashio Sayaka Aoyagi Ikuyo Fukuda Ken Ito Junya Nakamura Satoshi Takashima Yayoi Kitamura Saori Miyai Tanyarat Jomgeow Zheyu Li Toshiaki Shirakata Sumiyuki Nishida Akihiro Tsuboi Yoshihiro Oka Haruo | 2008 | International Journal of Oncology2008，，： | 1 |
| 18 | ABC screening for gastric cancer is not applicable in a Japanese population with high prevalence of atrophic gastritis显示文摘 | Tadashi Shimoyama Masahiko Aoki Yoshihiro Sasaki Masashi Matsuzaka Shigeyuki Nakaji Shinsaku Fukuda | 2012 | Gastric Cancer2012，，3： | 1 |
| 19 | New canine spinal cord injury model free from laminectomy显示文摘 | Seijun Fukuda Tatsuo Nakamura Yoshihiro Kishigami Katsuaki Endo Takashi Azuma Takamitsu Fujikawa Sadami Tsutsumi Yasuhiko Shimizu | 2005 | Brain Research Protocols2005，，： | 1 |
| 20 | New canine spinal cord injury model free from laminectomy显示文摘 | Seijun Fukuda Tatsuo Nakamura Yoshihiro Kishigami Katsuaki Endo Takashi Azuma Takamitsu Fujikawa Sadami Tsutsumi Yasuhiko Shimizu | 2005 | Brain Research Protocols2005，，3： | 1 |
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