|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis显示文摘 | Yongting Luo Hongxia Duan Yining Qian Liqun Feng Zhenzhen Wu Fei Wang Jing Feng Dongling Yang Zhihai Qin Xiyun Yan | 2017 | Cell Research2017，27，3： | 18 |
| 3 | CD146 is essential for PDGFRβ-induced pericyte recruitment显示文摘 | Jianan Chen Yongting LUO Hongxin Huang Shuilong Wu Jing Feng Jingjing Zhang Xiyun Yan | 2018 | Protein & Cell2018，9，8： | 9 |
| 4 | Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy显示文摘Diabetic mellitus(DM) is a common degenerative chronic metabolic disease often accompanied by severe cardiovascular complications(DCCs) as major causes of death in diabetic patients with diabetic cardiomyopathy(DCM) as the most common DCC. The metabolic disturbance in DCM generates the conditions/substrates and inducers/triggers and activates the signaling molecules and death executioners leading to cardiomyocyte death which accelerates the development of DCM and the degeneration of DCM to heart failure.Various forms of programmed active cell death including apoptosis, pyroptosis, autophagic cell death, autosis,necroptosis, ferroptosis and entosis have been identified and characterized in many types of cardiac disease.Evidence has also been obtained for the presence of multiple forms of cell death in DCM. Most importantly,published animal experiments have demonstrated that suppression of cardiomyocyte death of any forms yields tremendous protective effects on DCM. Herein, we provide the most updated data on the subject of cell death in DCM, critical analysis of published results focusing on the pathophysiological roles of cell death, and pertinent perspectives of future studies. | Jinjing Wei Yongting Zhao Haihai Liang Weijie Du Lihong Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 5 | Purification and Characterization of a Mannose-binding Lectin from the Rhizomes of Aspidistra elatior Blume with Antiproliferative Activity显示文摘有一个新奇 N 终端氨基酸序列的凝集素被硫酸铵降水,离子交换层析 ondiethylaminoethyl-Sepharose 和 carboxymethyl-Sepharose 和凝胶过滤层析 onSephacryl S-100 从蜘蛛抱蛋 elatior 布鲁坶的根茎净化。A。elatior 布鲁坶凝集素(AEL ) 是有 56kDa 的一个分子的团的 heterotetramer 并且一起由 13.5 kDa 和 14.5 kDaheld 的二不同多肽组成由的二 homodimers 创作非共有原子价相互作用。Hapten 抑制试金显示向兔子红血球的 AEL 的那项 hemagglutinating 活动能被 D 甘露糖禁止,甘露聚糖, thyroglobulinand ovomucoid。凝集素是稳定的直到 70 ° C,并且在 7.0-8.0 的一个狭窄的 pH 范围显示出最大的活动。化学修正和光谱分析显示色氨酸,精氨酸,半胱氨酸和 carboxyl 组织残余为它的 hemagglutinating 活动是必要的。然而,他们可能不在活跃中心是在场的,除了一些 carboxyl 组残余。AEL 也出现了在向 Bre-04 (66%) 的 antiproliferative 活动, Lu-04 (60%) 和人的癌症房间的 HepG2 (56%) 衬里的 vitro 重要。 | Xiaochao XU Chuanfang WU Chao LIU Yongting LUO Jian LI Xinping ZHAO Els Van DAMME Jinku BAO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 8 |
| 6 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 7 | CD146:a potential therapeutic target For systemic sclerosis显示文摘Dear Editor, Systemic sclerosis (scleroderma,SSc)is a chronic disease of connective tissues,and is clinically characterized by persistent fibrosis in the skin as well as in a variety of organs (Katsumoto et al.,2011).The pathogenesis of SSc is com- plex and involves vasculopathy,autoimmunity and fibrosis. The hallmarks of late-stage SSc are the excessive secretion and accumulation of extracellular matrix (ECM)by aberrantly activated fibroblasts (myofibroblasts)in the skin and internal organs (Bhattacharyya et al.,2012). | Lingling Zhang Yongting Luo Xiao Teng Zhenzhen Wu Mengtao Li Dong Xu Qian Wang Fei Wang Jing Feng Xiaofeng Zeng Xiyun Yan | 2018 | Protein & Cell2018，9，12： | 4 |
| 8 | Constitutive Modeling of Slip, Twinning and Detwinning for Mg Alloy and Inhomogeneous Evolution of Microstructure显示文摘 | Yuan Chen Guijuan Hu Yongting Lan Keshi Zhang Ganwei Cai | 2018 | Acta Mechanica Solida Sinica2018，31，4： | 3 |
| 9 | A Light Space Manipulator with High Load-to-Weight Ratio: System Development and Compliance Control显示文摘In order to meet the requirements of the space environment for the lightweight and load capacity of the manipulator,this paper designs a lightweight space manipulator with a weight of 9.23 kg and a load of 2 kg.It adopts the EtherCAT communication protocol and has the characteristics of high load-to-weight ratio.In order to achieve constant force tracking under the condition of unknown environmental parameters,an integral adaptive admittance control method is proposed.The control law is expressed as a third-order linear system equation,the operating environment is equivalent to a spring model,and the control error transfer function is derived.The control performance under the step response is further analyzed.The simulation results show that the proposed integral adaptive admittance control method has better performance than the traditional method.It has no steady-state error,overcomes the problems caused by nonlinear discrete compensation,and can facilitate analysis in the frequency domain,realize parameter optimization,and improve calculation accuracy. | Zhiwei Wu Yongting Chen Wenfu Xu | 2021 | Space(Science & Technology)2021，，1： | 3 |
| 10 | Synthesis and characteriza-tion of two new types of oxovanadium complexes with pyrazole as ligand显示文摘At room temperature, two new different oxovanadium complexes with simple pyrazole (C3H4N2) as ligand were synthesized. VO(pz)4(SO4)? H2O (1) (pz: pyrazole) is a mono-nuclear oxovana- dium complex with pyrazole as terminal ligands. V2O2(μ-pz)(μ-OOSO2)(μ-OCH3)(pz)4 (2) is bi-nuclear oxovanadium complex containing three different bridges, which are pyrazolate, sulphate and methoxy, respectively. The two complexes were characterized by IR, elemental analyses, thermal analyses and X-ray diffraction. The crystal structural data of the complexes 1 and 2 are given as follows: Complex 1, orthorhombic, Pna21, a = 14.547(2) ?, b =10.895(2) ?, c =11.835(2) ?; α=β=γ=90°, V=1875.8(5) ?3, Z = 4, R1 = 0.0485, WR2 = 0.1092. Complex 2, triclinic, P1 , a =8.377(2) ?, b =9.928(2) ?, c = 16.527(3) ?, α = 85.54(3)°, β = 80.92(3)°, γ = 87.92(3)°, R1 = 0.1461, WR2 = 0.4444. The study of non-thermal kinetic de- composition shows that, for complex 1, the possible reaction mechanisms of the two steps are nucleation and growth n=1/3, and three-dimensional pervasion n=2, respectively, and the kinetic equations may be expressed as dα/dT = (A/β)exp(?E/RT){1/3(1?α) [?In(1?α)]?2} and dα/dT = (A/β)exp(?E/RT){3/2(1?α)2/3 [1?(1?α)1/3] ?1}, respectively; for complex 2, the pos- sible reaction mechanisms of the two steps are chemical reaction, and three-dimensional pervasion n=2, respectively; the kinetic equations may be ex- pressed as dα/dT = (A/β)exp(?E/RT)[(1?α)2], anddα/dT = (A/β)exp(?E/RT){3/2(1?α)2/3[1?(1?α)1/3] ?1}, respectively. | XING Yongheng ZHANG Yuanhong XU Yongting ZHANG Baoli NIU Shuyun BAI Fengying | 2006 | Chinese Science Bulletin2006，51，18： | 3 |
| 11 | Hypoxia-controlled matrix metalloproteinase-9 hyperexpression promotes behavioral recovery after ischemia显示文摘Matrix metalloproteinase-9(MMP-9) plays a beneficial role in the sub-acute phase after ischemic stroke.However,unrestrained MMP-9 may disrupt the blood-brain barrier(BBB),which has limited its use for the treatment of brain ischemia.In the present study,we constructed lentivirus mediated hypoxiacontrolled MMP-9 expression and explored its role after stroke.Hypoxia response element(HRE)was used to confine MMP-9 expression only to the hypoxic region of mouse brain after 120-min transient middle cerebral artery occlusion.Lentiviruses were injected into the peri-infarct area on day 7 after transient ischemia.We found hyperexpression of exogenous HRE-MMP-9 under the control of hypoxia,and its expression was mainly located in neurons and astrocytes without aggravation of BBB damage compared to the CMV group.Furthermore,mice in the HRE-MMP-9 group showed the best behavioral recovery compared with the normal saline,GFP,and SB-3CT groups.Therefore,hypoxia-controlled MMP-9 hyperexpression during the sub-acute phase of ischemia may provide a novel promising approach of gene therapy for stroke. | Hongxia Cai Zhihao Mu Zhen Jiang Yongting Wang Guo-Yuan Yang Zhijun Zhang | 2015 | Neuroscience Bulletin2015，31，5： | 3 |
| 12 | Density-functional-theory predictions of mechanical behaviour and thermal properties as well as experimental hardness of the Ga-bilayer Mo_(2)Ga_(2)C显示文摘Mo_(2)Ga_(2)C is a new MAX phase with a stacking Ga-bilayer as well as possible unusual properties.To understand this unique MAX phase structure and promote possible future applications,the structure,chemical bonding,and mechanical and thermodynamic properties of Mo_(2)Ga_(2)C were investigated by first-principles.Using the“bond stiffness”model,the strongest covalent bonding(1162 GPa)was formed between Mo and C atoms in Mo_(2)Ga_(2)C,while the weakest Ga–Ga(389 GPa)bonding was formed between two Ga-atomic layers,different from other typical MAX phases.The ratio of the bond stiffness of the weakest bond to the strongest bond(0.33)was lower than 1/2,indicating the high damage tolerance and fracture toughness of Mo_(2)Ga_(2)C,which was confirmed by indentation without any cracks.The high-temperature heat capacity and thermal expansion of Mo_(2)Ga_(2)C were calculated in the framework of quasi-harmonic approximation from 0 to 1300 K.Because of the metal-like electronic structure,the electronic excitation contribution became more significant with increasing temperature above 300 K. | Xinxin QI Weilong YIN Sen JIN Aiguo ZHOU Xiaodong HE Guangping SONG Yongting ZHENG Yuelei BAI | 2022 | Journal of Advanced Ceramics2022，11，2： | 2 |
| 13 | Delving noble metal and semiconductor nanomaterials into enantioselective analysis显示文摘With growing interests paid to the enantioselective analysis of chiral molecules, roles played by noble metal and semiconductor nanomaterials surface gradually. Given the unique physicochemical properties of noble metal and semiconductor nanomaterials, the enantioselective analyses are classified into three categories: fluorescence-based, colorimetry-based, and circular dichroism-based ones. In this paper, we review the existing progresses on enantioselective analysis, thanks to noble metal and semiconductor nanomaterials. Finally, the prospect of enantioselective analysis based on noble metal and semiconductor are discussed. | Yongting Wen Zheng Li Jianhui Jiang | 2019 | Chinese Chemical Letters2019，30，9： | 2 |
| 14 | Studies on the enhancement of flue gas desulfurization with oxidation reaction 显示文摘 | Zhi Yongting Zheng Juanjuan Zhou Yaping Sun Yan Su Wei Zhou Li | 2011 | Energy& Fuels2011，25，： | 1 |
| 15 | Microstructure and mechanical properties of Al2O3/ZrO 2eutectic ceramic composites prepared by explosion synthesis显示文摘 | Yongting Zheng Hongbo Li Tao Zhou | 2013 | Journal of Alloys and Compounds2013，551，25： | 1 |
| 16 | Neuroprotection and Sensorimotor Functional Improvement by Curcumin after Intracerebral Hemorrhage in Mice显示文摘 | Yuhao Sun Minchao Dai Yongting Wang | 2011 | Neurotrau ma2011，28，12： | 1 |
| 17 | Vascular remodeling after ischemic stroke: Mechanisms and therapeutic potentials显示文摘 | Jialing Liu Yongting Wang Yosuke Akamatsu Chih Cheng Lee R. Anne Stetler Michael T. Lawton Guo-Yuan Yang | 2013 | Progress in Neurobiology2013，，： | 1 |
| 18 | Morphologic and genetic identification of Taenia tapeworms in Tanzania and DNA genotyping of Taenia solium显示文摘 | Eom KS ChaiJ Y YongTS | | 0，，04： | 1 |
| 19 | Fuzzy quality and analysis on fuzzy probability 显示文摘 | CEN Yongting | 1996 | Fuzzy Sets and Systems1996，83，2： | 1 |
| 20 | A self-similarity model for effective thermal conductivity of porous media 显示文摘 | Ma Yongting Yu Boming Zhang Duanming Zou Mingqing | 2003 | Journal of Physics D: Applied Physics2003，36，17： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员