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| 1 | MicroRNAs and prostate cancer显示文摘MicroRNAs (miRNAs ) 是否定地调整基因表示由的小、非编码的、搁浅单人赛的 RNA 的一个类对在 post-transcriptional 水平的目标 mRNAs 的 3 untranslated 区域(UTR ) 主要有约束力。最近的研究证明了 miRNAs 的异常表情仔细包括前列腺癌症(PCa ) 与各种各样的癌症的发展,侵略,转移和预后被联系。位于 miRNAs 的异常表示下面的建议分子的机制源于基因变化, epigenetic 修正和 Dicer 丰富的改变。尽管多达 50 miRNAs 被报导了显著地在人的 PCa 被表示,仅仅他们的一个小数字试验性地被显示做贡献到 PCa 的致病。这评论的目的是描述几已知的 miRNAs 的机制,在 oncogenic miRNAs 的改变的表示的关联上总结最近的研究(例如 miR-221/-222 , miR-21 ,和 miR-125b )并且肿瘤 suppressor miRNAs (例如 miR-101 , miR-126 *, miR-146a , miR-330 , miR-34 簇,并且 miR-200 家庭)为 PCa 。另外,他们在 PCa 的潜在的临床的应用和前景例如 biomarkers 和临床的治疗,简短也被讨论。 | Yingxin Pang Charles Y.F. Young Huiqing Yuan | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 15 |
| 2 | Optimization of an in vitro method to measure the bioaccessibility of polybrominated diphenyl ethers in dust using response surface methodology显示文摘To more reasonably evaluate human intake of PBDEs via dust ingestion,bioaccessibility should be taken into account.Previously,we developed an in vitro method to determine the bioaccessibility of PBDEs in food.Here,this method was adapted to determine the bioaccessibility of PBDEs in dust and the digestion conditions that influenced the bioaccessibility of PBDEs were optimized.The digestion conditions included the incubation time of dust in the intestinal digestion solution (T),the bile concentration in the intestinal digestion solution (C bile),and the ratio of the volume of the intestinal digestion solution to dust (R).The influence of the concentrations of individual PBDE congeners (C PBDE) on the bioaccessibility of PBDEs was also investigated.Central composite design was used to build an experimental model and set experimental parameters,and response surface methodology was used to analyze the obtained data.The results showed that the bioaccessibility of PBDEs increased with the increases of C bile and R,and was independent of T and C PBDE.Under the digestion conditions with C bile and R being at 4.0-7.0 g/L and 150-250,respectively,the bioaccessibility of PBDEs in the method-dust varied from 39.2% to 72.8%,which were comparable with the bioaccessibility or bioavailability of PBDEs in dust/soil in the literature.Thus,the in vitro method to measure the bioaccessibility of PBDEs in dust was established and validated.Finally,the bioaccessibility of PBDEs in four natural dust samples,which ranged from 36.1% to 43.3%,were determined using the adapted method. | Yingxin Yu Yuping Pang Xinyu Zhang Chen Li Zhiqiang Yu Jiamo Fu | 2011 | Journal of Environmental Sciences2011，23，10： | 2 |
| 3 | Roles of NPAS2 in circadian rhythm and disease显示文摘NPAS2,a circadian rhythm gene encoding the neuronal PAS domain protein 2(NPAS2),has received widespread attention because of its complex functions in cells and diverse roles in disease progression,especially tumorigenesis.NPAS2 binds with DNA at E-box sequences and forms heterodimers with another circadian protein,brain and muscle ARNT-like protein 1(BMAL1).Nucleotide variations of the NPAS2 gene have been shown to influence the overall survival and risk of death of cancer patients,and differential expression of NPAS2 has been linked to patient outcomes in breast cancer,lung cancer,non-Hodgkin’s lymphoma,and other diseases.Here,we review the latest advances in our understanding of NPAS2 with the aim of drawing attention to its potential clinical applications and prospects. | Lu Peng Gaigai Bai Yingxin Pang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 1 |
| 4 | Induction of systemic resistance, root colonisation and biocontrol activities of the rhizospheric strain of Serratia plymuthica are dependent on N-acyl homoserine lactones显示文摘 | Yandong Pang Xiaoguang Liu Yingxin Ma Leonid Chernin Gabriele Berg Kexiang Gao | 2009 | European Journal of Plant Pathology2009，，2： | 1 |
| 5 | Route-specific daily uptake of organochlorine pesticides in food, dust, and air by Shanghai residents, China显示文摘 | Yingxin Yu Chunlei Li Xiaolan Zhang Xinyu Zhang Yuping Pang Shaohuan Zhang Jiamo Fu | 2012 | Environment International2012，，： | 1 |
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