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| 1 | Th e role of ferroptosis in ionizing radiation-induced cell death and tumor suppression显示文摘Ferroptosis,a form of regulated cell death caused by lipid peroxidation,was recently identified as a natural tumor suppression mechanism.Here,we show that ionizing radiation(IR)induces ferroptosis in cancer cells.Mechanistically,IR induces not only reactive oxygen species(ROS)but also the expression of ACSL4,a lipid metabolism enzyme required for ferroptosis,resulting in elevated lipid peroxidation and ferroptosis.ACSL4 ablation largely abolishes IR-induced ferroptosis and promotes radioresistance.IR also induces the expression of ferroptosis inhibitors,including SLC7A11 and GPX4;as an adaptive response.IR-or KEAP1 deficiencyinduced SLC7A11 expression promotes radioresistance through inhibiting ferroptosis.Inactivating SLC7A11 or GPX4 with ferroptosis inducers(FINs)sensitizes radioresistant cancer cells and xenograft tumors to IR.Furthermore,radiotherapy induces ferroptosis in cancer patients,and increased ferroptosis correlates with better response and longer survival to radiotherapy in cancer patients.Our study reveals a previously unrecognized link between IR and ferroptosis and indicates that further exploration of the combination of radiotherapy and FINs in cancer treatment is warranted. | Guang Lei Yilei Zhang Pranavi Koppula Xiaoguang Liu Jie Zhang Steven HLin Jaffer AAjani Qin Xiao Zhongxing Liao Hui Wang Boyi Gan | 2020 | Cell Research2020，30，2： | 88 |
| 2 | IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice显示文摘Strigolactones (SL ) ,一组类胡萝卜素导出 terpenoid 内酯,是压制射击由禁止腋的芽的长出分叉的 root-to-shoot 植物激素。矮子 53 (D53 ) ,表明小径的 SL 的关键抑压者,被推测调整 SL 反应的下游的 transcriptional 网络。然而, D53 指向的下游的抄写因素还都没被报导。这里,我们报导那理想的植物体系结构 1 (IPA1 ) ,在米饭的植物体系结构的一个关键管理者,在调整 tiller 数字和导致 SL 的基因表示作为 D53 的一个直接下游的部件工作。我们证明 D53 在 vivo 并且在 vitro 与 IPA1 交往并且压制 IPA1 的 transcriptional 激活活动。我们进一步证明 IPA1 能直接绑在 D53 倡导者并且在导致 SL 的 D53 表示的反馈规定起一个关键作用。这些调查结果表明 IPA1 是可能的与 D53 行动到的长推测的抄写因素之一调停在米饭的调整 SL 的 tiller 发展。 | Xiaoguang Song Zefu Lu Hong Yu Gaoneng Shao Jinsong Xiong Xiangbing Meng Yanhui Jing Guifu Liu Guosheng Xiong Jingbo Duan Xue-Feng Yao Chun-Ming Liu Hongqing Li Yonghong Wang Jiayang Li | 2017 | Cell Research2017，27，9： | 48 |
| 3 | Construction of a Genome-Wide Mutant Library in Rice Using CRISPR/Cas9显示文摘 | Meng, Xiangbing Yu, Hong Zhang, Yi Zhuang, Fengfeng Song, Xiaoguang Gao, Songsong Gao, Caixia Li, Jiayang | 2017 | Molecular Plant2017，10，9： | 46 |
| 4 | Wheat straw burning and its associated impacts on Beijing air quality显示文摘Based on MODIS images, large-scale flow field charts and environmental monitoring data, we thor- oughly analyzed the spatial distribution of wheat straw burning in North China, with focus on its envi- ronmental impacts on the air quality of Beijing and pollution transport paths. And we anatomized changes of air quality in Beijing under the impacts of pollution generated by wheat straw burning around. The results indicate that: (1) The North China Plain, a winter-wheat growing area, is the main source of pollutants induced by wheat straw burning in Beijing. The direction of south-west is the dominant heavy pollution transport path. (2) Impacts of wheat straw burning on air quality are mainly manifested by significantly increasing CO concentration. (3) Precursors of O3 generated by wheat straw burning, combining with favorable meteorological conditions, can induce increasing O3 concentration greatly. NO concentration will be greatly increased due to decreasing O3 concentration at night. (4) Atmospheric particles, especially the fine ones, from wheat straw burning exert considerable influ- ence on Beijing air quality. (5) Different contributions of wheat straw burning to pollutants are identified. Ratios of PM10/SO2, CO/SO2, etc., can be applied to indicate pollution extent of wheat straw burning. High ratios of PM10/SO2 and CO/SO2 show that the air quality was heavily impacted by wheat straw burning and these ratios can be employed as indicators of contribution of wheat straw burning to the degradation of Beijing air quality. (6) Randomness of wheat straw burning activities renders random outbreak of air pollution of this type. Regional and extensive wheat straw burning activities can cause serious air pollution event. | LI LingJun WANG Ying ZHANG Qiang LI JinXiang YANG XiaoGuang JIN Jun | 2008 | Science China Earth Sciences2008，51，3： | 37 |
| 5 | Recent developments in plastic forming technology of titanium alloys显示文摘Titanium alloys have been used extensively in industry fields including aviation,aerospace and automobile due to their excellent comprehensive properties.Research and development of advanced plastic forming technology are of great importance to manufacturing titanium products of high performance and lightweight with low cost and short cycle.This paper analyzes the development tendencies of titanium alloy forming technology.Recent achievements in precision forming,microstructure control and multi-scale simulation of titanium alloys are reviewed.The forming techniques of large-sale integral complex components are presented. | YANG He FAN XiaoGuang SUN ZhiChao GUO LiangGang ZHAN Mei | 2011 | Science China(Technological Sciences)2011，54，2： | 33 |
| 6 | Laser cleaning of steel structure surface for paint removal and repaint adhesion显示文摘Paint removal from steel structure is executed for shipyards of marine and offshore engineering.Due to environmental unfriendliness and unhealthy drawbacks of sand blasting technique, laser ablation technique is proposed as a substituting method.By absorbing high energy of the 1064 nm pulsed laser, the paint is vaporized quickly.The ablated debris is then collected by using a suction pump.Initial metal surface of the steel is exposed when laser beam irradiates perpendicularly and scans over it.The cleaned surface fulfills the requirements of surface preparation standards ISO 8501 of SA2.The adhesion is further characterized with pull-off test after carrying out painting with Jotamastic 87 aluminum paint.The repainting can be embedded onto the laser cleaned surface to bond much more tightly.The excellent adhesion strength of 20 MPa between repainted coating and the substrate is achieved, which is higher than what is required by shipyards applications. | Xiaoguang Li Tingting Huang Ang Wei Chong Rui Zhou Yoo Sang Choo Minghui Hong | 2017 | 光电工程2017，44，3： | 24 |
| 7 | Validation of quantitative computed tomography-derived areal bone mineral density with dual energy X-ray absorptiometry in an elderly Chinese population显示文摘 | Cheng Xiaoguang Wang Ling Wang Qianqian Ma Yimin Su Yongbin Li Kai | 2014 | Chinese Medical Journal2014，，8： | 22 |
| 8 | Feature Extraction and Recognition for Rolling Element Bearing Fault Utilizing Short-Time Fourier Transform and Non-negative Matrix Factorization显示文摘Due to the non-stationary characteristics of vibration signals acquired from rolling element bearing fault, the time-frequency analysis is often applied to describe the local information of these unstable signals smartly. However, it is difficult to classify the high dimensional feature matrix directly because of too large dimensions for many classifiers. This paper combines the concepts of time-frequency distribution(TFD) with non-negative matrix factorization(NMF), and proposes a novel TFD matrix factorization method to enhance representation and identification of bearing fault. Throughout this method, the TFD of a vibration signal is firstly accomplished to describe the localized faults with short-time Fourier transform(STFT). Then, the supervised NMF mapping is adopted to extract the fault features from TFD. Meanwhile, the fault samples can be clustered and recognized automatically by using the clustering property of NMF. The proposed method takes advantages of the NMF in the parts-based representation and the adaptive clustering. The localized fault features of interest can be extracted as well. To evaluate the performance of the proposed method, the 9 kinds of the bearing fault on a test bench is performed. The proposed method can effectively identify the fault severity and different fault types. Moreover, in comparison with the artificial neural network(ANN), NMF yields 99.3% mean accuracy which is much superior to ANN. This research presents a simple and practical resolution for the fault diagnosis problem of rolling element bearing in high dimensional feature space. | GAO Huizhong LIANG Lin CHEN Xiaoguang XU Guanghua | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 21 |
| 9 | Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 in lung tissue显示文摘 | Jin Xiaoguang | 2014 | Chinese Medical Journal2014，，7： | 20 |
| 10 | Microstructure control techniques in primary hot working of titanium alloy bars:A review显示文摘How to control the microstructure of titanium alloy bars is important to fabricating high-performance aerial forgings. This paper gives a thorough survey of the manufacturing methods and microstructure control techniques for titanium alloy bars. It summarizes the effects of processing parameters on the mechanisms and laws of microstructure evolution during b working and(a + b) working, including the kinetics and grains size of dynamic recrystallization(DRX) during b deformation and the kinetics and grains size of spheroidization during(a + b) deformation. The trends in microstructure control techniques are presented for fabricating titanium alloy bars with high efficiency, low cost, and high quality by means of b/(a + b) working, and the puzzles and challenges in the future are also pointed out. | Guo Lianggang Fan Xiaoguang Yu Gaofeng Yang He | 2016 | Chinese Journal of Aeronautics2016，29，1： | 19 |
| 11 | Investigation of quality of life in patients with lung cancer by the EORTC QLQ-C30(V3.0) Chinese version显示文摘Objective To explore quality of life(QOL) and its influencing factors in patients with lung cancer.Methods A QOL questionnaire(European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire-Core 30 [QLQ-C30] Chinese version) was used with 138 patients with lung cancer participating in the study. A statistical description of the general characteristics of the patients with lung cancer was performed. The patients' QLQ-C30 scores were compared with the reference value for each dimension. To analyze the influence of QOL in different genders, age groups, and cancer stages, ttests and rank sum tests were used to compare the differences in QOL using a 5% significance level. Results The QLQ-C30 function scores in PF(physical functioning), EF(emotional functioning), SF(social functioning), and GH(global functioning), and symptom scales in NV(nausea and vomiting), DY(dyspnea), SL(insomnia), and FI(financial difficulties) were significantly different(P < 0.05) in comparison to the reference values. Female patients were worse than males(P < 0.05) in EF, NV, and DI(diarrhea). The later the stage of lung cancer, the worse the quality of life became; the functional scales in RF(role functioning), EF, CF, SF, and GH, and symptom scales in PA(pain), AP(appetite), and SL differences were statistically significant(P < 0.05). Conclusion This study aids understanding of the status of the quality of life of Chinese patients with cancer and might be useful for clinical work, theory research, and health policymakers. | Jun Li Xiaoguang Xiao Yao Wei Yang Li Man Zou Shiying Yu Yuan Chen Qian Chu | 2015 | Oncology and Translational Medicine2015，1，3： | 18 |
| 12 | Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription显示文摘为 histone crotonylation 的酶和读者蛋白质上的最近的研究在抄写支持 histone crotonylation 的功能。然而,为 histone decrotonylation (HDCR ) 负责的酶仍然保持糟糕定义。而且,如果 histone crotonylation 从生理地重要、机能上地不同或对 histone acetylation 冗余,它尚待坚定。这里我们一级 histone deacetylases (HDAC ) 而非 sirtuin 家庭 deacetylases (SIRT ) 是主要 histone decrotonylases 的现在的证据,和那 histone crotonylation 象在哺乳动物的房间的 histone acetylation 一样动态。尤其是,我们与损害 HDAC 产生了新奇 HDAC1 和 HDAC3 异种但是未经触动的 HDCR 活动。用这些异种,我们证明在哺乳动物的房间的选择 HDCR 与宽广 transcriptional 压抑和 crotonylation 然而并非 acetylation 读者蛋白质的减少的倡导者协会相关。而且,我们证明那 histone crotonylation 被充实在并且为老鼠的自强要求了胚胎的干细胞。 | Wei Wei Xiaoguang Liu Jiwei Chen Shennan Gao Lu Lu Huifang Zhang Guangjin Ding Zhiqiang Wang Zhongzhou Chen Tieliu Shi Jiwen Li Jianjun Yu Jiemin Wong | 2017 | Cell Research2017，27，7： | 18 |
| 13 | Activity criterion of pre-existing fabrics in non-homogeneous deformation domain显示文摘The Anderson's model can be applied only to elastic homogeneous deformation and cannot explain complicated phenomena of natural faults, which to a large degree limits the model to practical application. By combing the Coulomb-Mohr Criterion with the sandbox modeling and considering non-homogeneous deformation, mechanisms of how basement pre-existing fabrics control fault formation and evolution are analyzed and a mechanical factor, activation-coefficient (faS) of pre-existing fabrics, is proposed. It is determined by the attitude and mechanical properties of pre-existing fabric, and the stress state (the magnitudes and directions of the three principal stresses). The coefficient has taken the heterogeneity of rocks into account and may serve as a criterion for evaluating the activity of a pre-existing fabric. The Mohr-Coulomb Criterion is expanded to non-homogeneous deformation domain in terms of activation-coefficient (faS) of pre-existing fabrics, the general law of the activity of a pre-existing fabric is predicted, the fault complexity real of rift basin is revealed in theory, and the controlling law of basement pre-existing faults to fault formation and evolution is determined, and checked with sandbox modeling. A new way is provided for in-depth study of faulting. | TONG HengMao CAI DongSheng WU YongPing LI XiaoGuang LI XuShen MENG LingJian | 2010 | Science China Earth Sciences2010，53，8： | 17 |
| 14 | Breast milk macronutrient composition and the associated factors in urban Chinese mothers显示文摘 | Yang Titi Zhang Yumei Ning Yibing You Lili Ma Defu Zheng Yingdong Yang Xiaoguang Li Wenjun Wang Junkuan Wang Peiyu | 2014 | Chinese Medical Journal2014，，9： | 17 |
| 15 | A landscape shape index-based sampling approach for land cover accuracy assessment显示文摘Spatial sampling design is one of the key steps in land cover accuracy assessment,and many traditional sampling approaches may not achieve credible spatial sampling due to the high spatial heterogeneity of land cover.This paper characterizes the spatial heterogeneity with three-level LSIs and determines the subsequent sample sizes and their spatial distributions.The three-level LSIs are rLSI in a region,cLSI for each land cover class and uLSI in each geographic sampling unit in the region.The rLSIs are used to derive appropriate sample sizes in the target regions.The cLSIs are used to assure that larger sample numbers are allocated to land cover classes with higher spatial heterogeneity.The uLSIs provide useful measures for selecting optimal geographic units in which sample sites will be located.This LSI-based sampling approach can derive the sample sizes and determine their distributions in an adaptive way according to the spatial heterogeneity.An experimental case study further demonstrates that the LSI-based sampling approach obtains more appropriate sample sizes for each region,sufficient sample numbers for rare classes,and optimal sample distributions in the geographical space. | CHEN Fei CHEN Jun WU Hao HOU DongYang ZHANG WeiWei ZHANG Jun ZHOU XiaoGuang CHEN LiJun | 2016 | Science China(Information Sciences)2016，59，12： | 17 |
| 16 | Recent progress in methane dehydroaromatization: From laboratory curiosities to promising technology显示文摘Direct conversion of methane to benzene or other valuable chemicals is a very promising process for the efficient application of natural gas. Compared with conversion processes that require oxidants, non-oxidative direct conversion is more attractive due to high selectivity to the target product. In this paper, an alternative route for methane dehydrogenation and selective conversion to benzene and hydrogen without the participation of oxygen is discussed. A brief review of the catalysts used in methane dehydroaromatization (MDA) is first given, followed by our current understanding of the location and the active phase of Mo species, the reaction mechanism, the mechanism of carbonaceous deposit and the deactivation of Mo/zeolite catalysts are systematically discussed. Ways to improve the catalytic activity and stability are described in detail based on catalyst and reaction as well as reactor design. Future prospects for methane dehydroaromatization process are also presented. | Shuqi Ma Xiaoguang Guo Lingxiao Zhao Susannah Scott Xinhe Bao | 2013 | Journal of Energy Chemistry2013，22，1： | 17 |
| 17 | Landslide Developmental Characteristics and Response to Climate Change since the Last Glacial in the Upper Reaches of the Yellow River, NE Tibetan Plateau显示文摘The upper reaches of the Yellow River in northeastern Tibetan Plateau are geohazards areas. The evolution of the Yellow River, chronology of some landslides, and spatiotemporal distribution characteristics of super large scale and giant landslides within the region are summarized using paleoclimate evidence, and the relationship between the intensive landslide period and climatic changes since the Last Glacial period is analyzed. It is concluded that(1) Super large scale and giant landslides are distributed widely within the region, particularly in the Qunke-Jianzha basin.(2) The chronological sequence of landslides is established by dating the slip zones of landslides and analyzing the relations between landslides and their overlying or underlying loess formations. Five landslide development periods are determined: 53–49 ka BP, 33–24 ka BP, 10–8 ka BP, 5–3.5 ka BP, and the present.(3) These correspond closely to warm and wet periods during the last 100,000 years, i.e., two weak paleosol development stages of Malan loess deposited during the last Glacial period in the Chinese loess Plateau, L1-4 and L1-2 that belong to the marine oxygen isotope stage 3, the last deglacial period, the Holocene Optimum, and the modern global warming period.(4) Landslide triggers may be closely linked to warm and wet periods related to rapid climatic transitions. | YIN Zhiqiang QIN Xiaoguang YIN Yueping ZHAO Wuji WEI Gang | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 16 |
| 18 | 基于多传感器融合的无人机精准自主飞行控制方法显示文摘为解决我国植保无人机实际作业过程中普遍存在的由空间位置定位精度不足和飞行参数不稳定造成的雾滴分布不均匀、重喷、漏喷等问题,以多旋翼无人机系统为平台,基于ROS(Robot operating system)和MAVROS构建了由协同计算机与开源飞行控制器组成的二级控制系统,结合基于RTK-GPS的绝对位置测量和基于激光雷达的相对距离探测方法,融合外部传感器与飞行控制器板载传感器数据对无人机状态估计进行修正,提高了无人机飞行参数和飞行轨迹的稳定性。为进一步提高植保无人机自主作业性能,基于ROS设计了飞行任务管理系统,实现了无人机精准自主任务点之间的直线飞行。真实飞行试验结果表明:无人机自主飞行过程中水平方向平均定位误差为0.145 m,垂直方向平均定位误差为0.053 m。 | 王大帅 LIU Xiaoguang 李伟 张俊雄 袁挺 张春龙 | 2019 | 农业机械学报2019，50，12： | 15 |
| 19 | Bioptical microcycles of laminated speleothems from China and their chronological significance显示文摘Interfaces of microlayers, in most stalagmites from China, consist of opaque and organic materials. Observed with microscope, the interfaces seem dark under transmitted light and luminiferous under reflected fluorescent light. Stalagmites in which the two optical characters are unified spatially would be most suitable for cross-dating use, and can play an important role in the study on speleochronology and speleoclimatology. | Ming Tan Xiaoguang Qin Linmei Shen Xianfeng Wang Yongjin Wang Tieying Li Linhua Song Laihong Wang Dongsheng Liu | 1999 | Chinese Science Bulletin1999，44，17： | 14 |
| 20 | 微波场中甲烷部分氧化制合成气 Ⅱ.Co/ZrO_2催化剂在微波场中的升温行为及催化活性显示文摘近年来,甲烷部分氧化制合成气(POM)的研究一直十分活跃[1,2].前文报道了用于甲烷部分氧化制合成气的镍基催化剂(Ni/La2O3)在微波场中的升温行为和催化活性[3],发现在达到相同的CH4转化率时,微波活化方式下的催化剂床层温度比常规加热低得多... | Bi Xianjun 1, Xie Xiaoguang 2, Duan Aihong 1, Wang Zhen 3, Hong Pinjie 3, Dai Shushan 3 (1 Department of Chemistry, Yunnan Normal University, Kunming 650092 2 Modern Biological Center, Yunnan University, Kunming 650091 3 Department of Chemi | 1998 | 催化学报1998，19，5： | 13 |
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