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| 1 | Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey显示文摘AIM: To investigate and compare frequencies of serum positive cagA in patients from two separate regions of Turkey who were grouped according to the presence of peptic ulcer disease or non-ulcer dyspepsia.METHODS: One hundred and eighty Helicobacter pyloripositive patients with peptic ulcer disease or non-ulcer dyspepsia were included in the study. One hundred and fourteen patients had non-ulcer dyspepsia and 66 had peptic ulcer disease (32 with gastric ulcers and/or erosions and 34with duodenal ulcers). Each patient was tested for serum antibody to H. pylori cagA protein by enzyme immunoassay.RESULTS: The total frequency of serum positive cagA in the study group was 97.2 %. The rates in the patients with peptic ulcers and in those with non-ulcer dyspepsia were 100% and 95.6%, respectively. These results were similar to those reported in Asian studies, but higher than those that have been noted in other studies from Turkey and Western countries.CONCLUSION: The high rates of serum positive cagA in these patients with peptic ulcer disease and non-ulcer dyspepsia were similar to results reported in Asia. The fact that there was high seroum prevalence regardless of ulcer status suggests that factors other than cagA might be responsible for ulceration or other types of severe pathology in H. pylori-positive individuals. | Ender Serin Uur Yilmaz Ganiye Künefeci Birol zer Yüksel Gümürdülü Mustafa Gülü Fazilet Kayaseluk Sedat Boyaciolu | 2003 | World Journal of Gastroenterology2003，9，4： | 10 |
| 2 | Glutamine analogs promote cytoophidium assembly in human and Drosophila cells显示文摘CTP synthase is compartmentalized within a subcellular structure,termed the cytoophidium,in a range of organisms including bacteria, yeast,fruit fly and rat.Here we show that CTP synthase is also compartmentalized into cytoophidia in human cells.Surprisingly,the occurrence of cytoophidia in human cells increases upon treatment with a glutamine analog 6-diazo-5-oxo-L-norleucine(DON),an inhibitor of glutamine-dependent enzymes including CTP synthase.Experiments in flies confirmed that DON globally promotes cytoophidium assembly.Clonal analysis via CTP synthase RNA interference in somatic cells indicates that CTP synthase expression level is critical for the formation of cytoophidia.Moreover,DON facilitates cytoophidium assembly even when CTP synthase level is low.A second glutamine analog azaserine also promotes cytoophidum formation.Our data demonstrate that glutamine analogs serve as useful tools in the study of cytoophidia. | mr Yilmaz Tastan Zillah Anne Deussen Mayte Yu-Yin Siswick | 2011 | Journal of Genetics and Genomics2011，38，9： | 10 |
| 3 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 4 | 不同单色光照饲养条件下肉鸡生长性能和肉品质特性的研究显示文摘试验选用480只罗斯母肉仔鸡,研究其在不同单色光照饲养条件下腿肌和胸肌的品质特性。鸡孵化后,随机分为3个光照组,对照组:微型白炽灯光照;G-B光照组:先由绿色单色光照3周,后为蓝色单色光照3周;G-GB混合光照组:先由绿色单色光照3周,后为蓝色单色光+绿色单色光照3周。试验结果表明,G-B光照组和G-GB混合光照组肉鸡的耗料量、体重和总肌重显著高于对照组;与G-B光照组和G-GB混合光照组相比,对照组肉鸡的胸肌和腿肌有较低的pH和持水性能,但是有较高滴水损失;与其他两组相比,G-GB混合光照组肉鸡的肌肉组织更为松软。本试验证明了G-B光照和G-GB混合光照的饲养条件可以改善母肉鸡肌体和肌肉的生长性能及其肉品质特性。 | Karakaya M ParlatS S Yilmaz M T Yildirim I Ozalp B | 2009 | 饲料博览2009，，7： | 3 |
| 5 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 6 | Bone mineral density in children with neurofibromatosis l显示文摘 | Yilmaz K Ozmen M Goksan SB | 2007 | Acta Padiatrica2007，96，8： | 1 |
| 7 | Zinc deficiency as critical problem in wheat production in Central Anatolia显示文摘 | Cakmak I Yilmaz A Kalayci M | 1996 | Plant and Soil1996，180，： | 1 |
| 8 | Beneficial effects of intraperitoneally administered alpha-tocopheryl acetate on the levels of lipid peroxide and activity of glutathione peroxidase and superoxide dismutase in skin,blood and liver显示文摘 | Naziroglu M Kokcam I Yilmaz S | 2003 | Skin Pharmacol Appl Skin Physiol2003，16，1： | 1 |
| 9 | Zinc deficiency as a critical problem in wheat production in Central Anatolia 显示文摘 | Cakmak I Yilmaz A Kalayci M | 1996 | Plant Soil1996，180，16： | 1 |
| 10 | Comparison of in-sulin monotherapy and combination therapy with insulinand metformin or insulin and rosiglitazone or insulin andacarbose in type 2 diabetes显示文摘 | Yilmaz H Gursoy A Sahin M | 2007 | Acta Diabetol2007，44，4： | 1 |
| 11 | Urotensin-II Immunoreactivity in children with chronic glomerulonephritis显示文摘 | BALAT A KARAKOK M YILMAZ K | 2007 | Renal Failure2007，29，： | 1 |
| 12 | Compari- son of electrorheological properties of some polyaniline derivatives 显示文摘 | GERCEK B YAVUZ M YILMAZ H | 2007 | Colloids and Surfaces A2007，299，： | 1 |
| 13 | EMT, the cytoskeleton, and cancer cell in- vasion 显示文摘 | Yilmaz M Chfistofori G | 2009 | CancerMetastRev2009，28，12： | 1 |
| 14 | The impact of strict volume control strategy on patient suivival and technique failure in peritoneal dialysis patients 显示文摘 | Kircelli F Asci G Yilmaz M ct al | 2011 | Blood Purification2011，32，1： | 1 |
| 15 | Comparison of calcium acetate and sevelamer on vascular function and fibroblast growth factor 23 in CKD patients:a randomized clinical trial显示文摘 | Yilmaz MI Sonmez A Saglam M | | 0，，： | 1 |
| 16 | Serum level of vitamin D and trace elements in children with recurrent wheezing: a cross- sectional study显示文摘 | Uysalol M Uysalol EP Yilmaz Y | 2014 | BMC Pediatr2014，14，： | 1 |
| 17 | Is there any relationship between asthma and asthma attack in children and atypical bacterial infections; Chlamydia pneumoniae, Mycoplasma pneumoniae and Helicobacter pylori 显示文摘 | Annagur A Kendirli SG Yilmaz M | 2007 | J Trop Pediatr2007，53，： | 1 |
| 18 | Serum vitamin BI2, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis 显示文摘 | Kocer B Engur S Ak F Yilmaz M | 2009 | J Clin Neurosci2009，16，3： | 1 |
| 19 | Gas permeation characteristics of polymer - zeolite mixed matrix membrames显示文摘 | SUER M G BAS N YILMAZ L | 1994 | J Membrane Sci1994，91，： | 1 |
| 20 | Terazosin in the treatment of premature ejaculation:a short-term follow-up显示文摘 | Basar MM Yilmaz E Ferhat M Basar H Batislam E | 2005 | Int Urol Nephrol2005，37，4： | 1 |
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