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| 1 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 2 | Modulation of evening complex activity enables north-to-south adaptation of soybean显示文摘Soybean,a typical short-day crop,is sensitive to photoperiod,which is a major limiting factor defining its north-to-south cultivation range.The long-juvenile(LJ)trait is controlled primarily by the J locus which has been used for decades by soybean breeders to delay flowering and improve grain yield in tropical regions.The J gene encodes an ortholog of the Arabidopsis Evening Complex(EC)component EARLY FLOWERING 3(ELF3).To identify modifiers of J,we conducted a forward genetic screen and isolated a mutant(eoj57)that in combination with j has longer flowering delay compared with j single mutant plants.Map-based cloning and genome re-sequencing identified eoj57(designated as GmLUX2)as an ortholog of the Arabidopsis EC component LUX ARRHYTHMO(LUX).To validate that GmLUX2 is a modifier of J,we used trans-complementation and identified a natural variant allele with a similar phenotype.We also show that GmLUX2 physically interacts with GmELF3a/b and binds DNA,whereas the mutant and natural variant are attenuated in both activities.Transcriptome analysis shows that the GmLUX2-GmELF3a complex co-regulates the expression of several circadian clock-associated genes and directly represses E1 expression.These results provide mechanistic insight into how GmLUX2-GmELF3 controls flowering time via synergistic regulation of gene expression.These novel insights expand our understanding of the regulation of the EC complex,and facilitate the development of soybean varieties adapted for growth at lower latitudes. | Xiaolong Fang Yapeng Han Mengshi Liu Jiacan Jiang Xiang Li Qichao Lian Xianrong Xie Yian Huang Qibin Ma Hai Nian Ji Qi Cunyi Yang Yingxiang Wang | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 3 | Zinc finger transcription factor ZAT family genes confer multi-tolerances in Gossypium hirsutum L.显示文摘ZAT(Zinc Finger of Arabidopsis thaliana)proteins are composed of a plant-specific transcription factor family,which play an important role in plant growth,development,and stress resista nee.To study the potential function of ZAT family in cotton,the whole genome identification,expression,and structure analysis of ZAT gene family were carried out.In this study,our analysis revealed the presenee of 115Z 56,59,and 115 ZAT genes in Gossypium hirsutum,G raimondii,G.arboreum and G barbadense,respectively.According to the number of domains and phylogenetic characteristics,we divided ZAT genes of four Gossypium species into 4 different clades,and further divided them into 11 subfamilies.The results of collinearity an alysis showed that segmental duplicati on was the main method to amplify the cotton ZAT genes family.Analysis of c/s-elements of promoters indicated that most GhZAT genes contained c/5-elements related to plant hormones and abiotic stress.According to heatmap analysis,the expression patterns of GhZAT genes under different stresses indicated that GhZAT genes were significantly involved in the response to cold,heat,salt,and PEG stress,possibly through different mechanisms.Among the highly expressed genes,we cloned a G hirsutum gene GhZAT67.Through virus-induced gene silencing(VIGS),we found that its expression level decreased significantly after being sileneed.Under alkaline treatment,the wilting degree of silenced plants was even greater than the wild type,which proved that GhZAT67 gene was involved in the response to alkaline stress. | FAN Yapeng ZHANG Yuexin RUI Cun XU Nan ZHANG Hong WANG Jing MALIK Waqar Afeal HAN Mingge ZHAO Lanjie LU Xuke CHEN Xiugui CHEN Chao YE Wuwei | 2021 | Journal of Cotton Research2021，4，3： | 0 |
| 4 | Bovine HSD17B8 gene and its relationship with growth and meat quality traits显示文摘17 b-Hydroxysteroid dehydrogenase type 8(HSD17B8) is an important regulator of lipid and steroid metabolism. In the present study, we aimed to assess the effects of HSD17B8 on growth and meat quality traits in cattle. Transcription profile analysis showed that HSD17B8 was primarily expressed in the salpinx, liver, and testis.Meanwhile, we identified three SNPs(SNP1: intron1-A91G; SNP2: exon 1-A90G; and SNP3: intron 8-A86G)of the bovine HSD17B8 gene and investigated its haplotype frequencies and linkage disequilibrium. The detected SNPs were found associated with growth traits(body weight,body length, height at withers, heart girth, hip width, and average daily gain) in native cattle populations(Nanyangand Jiaxian) as well as the meat quality traits(Warner–Bratzler shear force, rib area, dressing percentage, carcass weight, and backfat thickness) in commercial breeds(Angus, Hereford, Limousin, Luxi, Simmental, and Jinnan).Our results provided evidence that polymorphisms in the HSD17B8 gene were associated with growth traits and meat quality traits. Moreover, our findings might be used for marker-assisted selection in beef cattle breeding program. | Yun Ma Ningbo Chen Fen Li Weiwei Fu Yapeng Han Yanlin Chang Xiangxiang Jiang Junya Li Yueyu Bai Xuxin Tan | 2015 | Science Bulletin2015，60，18： | 0 |
| 5 | Effects of the vegetative propagation method on juvenility in Robinia pseudoacacia L.显示文摘Vegetative propagation is an important method of reproduction and rejuvenation in forestry.The growth and development of asexually propagated trees are influenced by the age and position of the propagule on the plant,effects referred to as cyclophysis and topophysis,respectively.Due to the long lifespans and large body sizes of woody trees,the selection of propagules is critically important.Here,we used three vegetative propagation methods(shoot cutting,root sprouting,and root cutting)to study the effect of different regeneration methods on juvenility of the resulting black locust plants,with seed-derived seedlings used as a control.Most characteristics of plantlets generated by rootsprouting were similar to those of seed-derived seedlings,including leaf traits and leaf anatomical structure.However,there were significant differences between the plantlets derived from shoot-cuttings and seedlings from seeds.Furthermore,the data showed that some of these agerelated small RNAs and genes differed in expression among propagation methods and between plantlets/seedlings and mature trees.These agerelated small RNAs,genes,and transcription factors may be used as molecular markers of juvenility and phase transitions in black locust.Our results provide useful information for the optimal propagation of woody trees and for further research into the mechanisms of root regeneration. | Jie Liu Zijie Zhang Yapeng Li Juan Han Huayu Si Yueqi Mi Shaoming Wang Xiaoning Wei Hao Yang Yuhan Sun Yun Li | 2022 | Forestry Research2022，2，1： | 0 |
| 6 | Functional structure analysis and genome‑wide identification of CNX gene family in cotton显示文摘Background:Under abiotic stress conditions,cotton growth is inhibited and yield losses are severe.Identification of calnexin family members and function analysis under abiotic stress laid the foundation for the screening of stressrelated candidate genes.Results:A total of 60 CNX family members have been identified in Gossypium hirsutum,G.barbadense,G.arboreum,and G.raimondii,and they were divided into two categories:CNX and CRT genes.Through the construction of a phylogenetic tree,they were subdivided into three classes.Further analysis of chromosome localization,conserved promoters,gene structure and selection under pressure showed that the family members were highly conserved in the evolution process.Analysis of cis-acting elements in the promoter regions showed that CNX family genes contain regulatory elements for growth and development,anaerobic,drought,defense and stress response,and plant hormones.Using RNA-seq data to study the expression pattern of GhCNX genes under cold,hot,salt stress and Polyethylene glycol,it was observed that the gene expression levels changed by different degrees under different stress conditions,indicating that GhCNX members were involved in the regulation of multiple biological stresses.Conclusion:This study provides an insight into the members of cotton CNX genes.The results of this study suggested that CNX family members play a role in defense against adversity and provide a foundation for the discovery of stress-related genes. | XU Nan ZHANG Hong ZHANG Yuexin FAN Yapeng WANG Jing MALIK Waqar Afzal RUI Cun HAN Mingge LU Xuke CHEN Xiugui WANG Junjuan WANG Delong WANG Shuai CHEN Chao GUO Lixue ZHAO Lanjie YE Wuwei | 2022 | Journal of Cotton Research2022，5，3： | 0 |
| 7 | Effects of spray adjuvants and operation modes on droplet deposition and elm aphid control using an unmanned aerial vehicle显示文摘A conventional spraying mode and a fully autonomous fruit tree operation mode using a model DJ T30 unmanned aerial vehicle(UAV)were used to control aphids control on elm trees and to clarify the distribution of droplets in elm trees sprayed by a UAV.The effects of six aviation spray adjuvants on elm canopy droplet deposition and aphid control were evaluated.ImageJ software was used to analyze and measure the droplet density and deposition of water sensitive paper in two modes;this was done to calculate the droplet uniformity,depositional penetration,and droplet penetration,and to verify the aphid control effect.The results showed that the droplet density increased by 79.7%-100.7% in the upper canopy and 0-394.1%in the lower canopy without adjuvants in the fully autonomous fruit tree operation mode.The upper canopy deposits increased by 65.7%-179.3%,and the lower canopy increased by 0-152.8%.When adjuvants were added,the droplet density in the upper canopy increased by 49.7-56.1%using Jiexiaofeng(JXF),and the lower canopy increased by 138.2%-177.8% using JXF,45.8%-141.3%using Beidatong(BDT),45.5%-92.9% using Gongbei(GB),0-93.5% using Maisi(MS),and 0-95.2%using Manniu(MN).The deposits of the upper canopy increased by 888.1-1154.2% using JXF,0-1298.3% using MN,0-343.9%using BDT,0-422.5% using GB,0-580.3% using MS.The lower canopy increased by 746.4%-1426.0%using JXF,226.2%-231.0% using BDT,435.8%-644.0% using GB,255.0%-322.4%using MS,and 249.3%-360.0%using MN.When JXF was added,the droplet uniformity,droplet penetration and depositional penetration were better than when using other adjuvants.The effects of JXF,BDT and GB in controlling aphids was significantly better than other adjuvants(p<0.05).The following control effects were observed;94.1% with JXF,93.1% with BDT,and 93.3% with GB after 3 d of application,and 97.9% with JXF,95.6% with BDT,and 97.1% with GB after 7 d of application.At the same time,the application of the fully autonomous fruit tree operation mode and JXF can effectively improve the density and deposits,which will produce a superposition optimization effect.Our study focuses on the prevention and control of elm aphid infestations based on the operation mode of a UAV and aviation spray adjuvants,which can provide a baseline for the control of diseases and insect pests using UAVs in agriculture and forestry. | Zechen Dou Zhihao Fang Xiaoqiang Han Muhammad Zeeshan Yapeng Liu Yubin Lan | 2023 | International Journal of Agricultural and Biological Engineering2023，16，2： | 0 |
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