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| 1 | Regulation of the cellular uptake of nanopartides by the orientation of helical polypeptides显示文摘Controlling the cellular interactio n and internal izatio n of polymer-modified nan oparticles (NPs) is of central importa nee to the developme nt of promisi ng nano medici nes. Here, we describe the use of synthetic polypeptides for NP surface coati ng and regulati on of their cellular uptake behaviors by simply switching the conformation and anchoring orientation. Our results show that gold NPs (AuNPs) coated with a helical poly(Y-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)esteryl「glutamate)(L-P(EG3Glu)5o) from the C-terminus ((L-C)-AuNPs) exhibit greater zeta potential and more cellular uptake (2.0-5.5 fold higher) than those coated with the same polypeptide but anchored from the N-terminus ((L-N)-AuNPs), or from both the C- and N-terminus at a 1/1 molar ratio ((L-C/L-N)-AuNPs). A similar orientation-regulated cellular internalization pattern is observed in D-P(EG3Glu)50 but not the unstructured DL-P(EG3Glu)5o-rnodified AuNPs, suggesting an important and universal role of the helix-derived macrodipole in cellular uptake. Moreover, this orientation-governed internalization is successfully reproduced in P(EG3Glu)50-coated gold nano rods (AuNRs), and applied to the desig n of doxorubici reloaded polypeptide micelles. Simulation study offers time-resolved in sights regarding the NP-membrane in teracti ons and membrane remodeling. Thus, our study provides a delicate way of regulating the surface chemistry of NPs and the subsequent NP-cell interactions. Moreover, the results highlight the uniqueness of polypeptides in NP surface engineering, and urge a more careful consideration on the polymer orientation effect. | Chong Zhang Jianhua Lu Falin Tian Lindong Li Yingqin Hou Yaoyi Wang Lingdong Sun Xinghua Shi Hua Lu | 2019 | Nano Research2019，12，4： | 4 |
| 2 | Resorption Efficiency of Four Cations in Different Tree Species in a Subtropical Common Garden显示文摘High rainfall in subtropical regions can leach cation elements from ecosystems,which may limit plant growth.Plants often develop efficient resorption patterns to recycle elements,but there is relatively little available information on this topic.In February 2012,a common garden was established in a subtropical forest by planting dominant trees from the area.Green and senescent leaves were sampled from 11 tree species.The concentrations of potassium(K),calcium(Ca),sodium(Na)and magnesium(Mg)were determined,and the resorption efficiencies were calculated.The results showed significant K,Na and Mg resorption in most of the investigated tree species,while Ca mainly displayed accumulation.Evergreen coniferous and evergreen broad-leaved trees(such as Cunninghamia lanceolata,Pinus massoniana,Cinnamomum camphora,and Michelia macclurei)exhibited relatively higher resorption efficiencies of K(39.0%-87.5%)and Na(18.3%-50.2%)than deciduous broad-leaved trees.Higher Mg resorption efficiencies(>50%)were detected in Liriodendron chinense,C.lanceolata and P.massoniana than in other trees.Overall,evergreen coniferous and evergreen broad-leaved trees could show higher cation resorption than deciduous broad-leaved trees.K and Mg resorption efficiencies and Ca accumulation decrease with increasing nutrient concentrations in green leaves.Our results emphasize that nutrient resorption patterns largely depend on elements and plant functions,which provides new insights into the nutrient use strategies of subtropical plants and a reference for the selection of suitable tree species in this region. | Yaoyi Zhang Xiangyin Ni Jing Yang Siyi Tan Shu Liao Dingyi Wang Kai Yue Fuzhong Wu | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 2 |
| 3 | Virtual design and analysis with multi-dimension coupling for engineering machinery cooling system显示文摘A good cooling circle should ensure that the system can work at an appropriate temperature in the requirements of power increase,engine compartment constraint and working demands for modern engineering machinery,which asks for a thorough understanding of system thermal loads before practical production.However,traditional experiment method spends a long time,costs a huge resource but lacks efficiency,whereas virtual design can avoid the shortcomings of traditional method and can analyze operating states adequately with variable loads on engine,generator,drives,battery pack and HVAC systems.Therefore,this paper focuses on a new virtual design method based on multi-dimension coupled simulation adopting Flowmaster software for initial prediction and CFX tool for further optimization.The simulation results in different operating conditions are compared and validated with experiments.Orthogonal experiment and range analysis are used to explore key parameters of cooling system.The research will be helpful in guiding future design and optimization of engineering machinery. | CAI HuiKun QIAN YaoYi HOU Liang WANG WenWu ZHANG EnLai YANG WeiPing | 2015 | Science China(Technological Sciences)2015，58，1： | 2 |
| 4 | Recognizing text in raster maps显示文摘 | CHIANG Yaoyi CRAIG A | 2015 | Geo Informatica2015，19，1： | 1 |
| 5 | Molecular modeling and structure studies of LARC-CPI semicrystalline polyimide显示文摘 | Mark V B Cheng Yaoyi Pradnya Nagarkart | 1997 | Polymer1997，38，12： | 1 |
| 6 | Minimized transient and steady-state cross regulation in 55-nm CMOS single-inductor dual-output(SIDO) step-down DC-DC converter显示文摘 | Lee Yu-huei Huang Tzu-chi Yang Yaoyi | 2011 | IEEE Journal of Solid-State Circuits2011，46，11： | 1 |
| 7 | Microgravimetric DNA sensor based on quartz crystal microbalance:comparison of oligonucleotide immobilization methods and the application in genetic diagnosis显示文摘 | Zhou Xichun Huang Liqun Samfong Yaoyi | 2001 | Biosensor & Bioelectronics2001，16，： | 1 |
| 8 | Complete Genome Sequences of the SARS-CoV: the BJ Group (Isolates BJ01-BJ04)显示文摘Beijing has been one of the epicenters attacked most severely by the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) since the first patient was diagnosed in one of the city's hospitals. We now report complete genome sequences of the BJ Group, including four isolates (Isolates B J01, B J02, B J03,and B J04) of the SARS-CoV. It is remarkable that all members of the BJ Group share a common haplotype, consisting of seven loci that differentiate the group from other isolates published to date. Among 42 substitutions uniquely identifled from the BJ group, 32 are non-synonymous changes at the amino acid level.Rooted phylogenetic trees, proposed on the basis of haplotypes and other sequence variations of SARS-CoV isolates from Canada, USA, Singapore, and China, gave rise to different paradigms but positioned the BJ Group, together with the newly discovered GD01 (GD-Ins29) in the same clade, followed by the H-U Group (from Hong Kong to USA) and the H-T Group (from Hong Kong to Toronto), leaving the SP Group (Singapore) more distant. This result appears to suggest a possible transmission path from Guangdong to Beijing/Hong Kong, then to other countries and regions. | ShengliBi E‘deQin ZuyuanXu WeiLi JingWang YongWuHu YongLiu ShuminDuan JianfeiHu YujunHan JingXu YanLi YaoYi YongdongZhou WeiLin1 JieWen HongXu RuanLi ZizhangZhang HaiyanSun JinguiZhu ManYu BaochangFan QingfaWu WeiLin2 LinTang Bao’anYang GuoqingLi WenmingPeng WenjieLi TaoJiang YajunDeng BohuaLiu JianpingShi YongqiangDeng WeiWei HongLiu ZongzhongTong FengZhang YuZhang Cui‘eWang YuquanLi JiaYe YonghuaGan JiaJi XiaoyuLi XiangjunTian FushuangLu GangTan RuifuYang BinLiu SiqiLiu SonggangLi JunWang JianWang WuchunCao JunYu XiaopingDong HuanmingYang | 2003 | Genomics, Proteomics & Bioinformatics2003，1，3： | 1 |
| 9 | Gemcimbine, oxaliplatin and dexame- thasone as salvage treatment for elderly patients with refractory and relapsed peripheral T-cell lymphoma 显示文摘 | YaoYY TangY Zhu Q | 2013 | Leuk Lymphoma2013，54，6： | 1 |
| 10 | Minimized transient and steady-state cross regulation in 55-nm CMOS Single-Inductor Dual-Output(SIDO) step-down DC-DC converter显示文摘 | LEE Yuhuei HUANG Tzuchi YANG Yaoyi | 2011 | IEEE Journal of Solid-State Circuits2011，46，11： | 1 |
| 11 | Co-delivery of Cisplatin and Chlorin e6 by Poly(phosphotyrosine)for Synergistic Chemotherapy and Photodynamic Therapy显示文摘Nanoscale drug delivery systems(NDDSs)have emerged as promising carriers for combinational therapy by co-delivery of multiple drugs and modalities.However,most co-delivery systems require the use of complicated materials and formulations.Herein,we report the single use of a polymeric material,namely mPEG-block-poly(phosphotyrosine)(mPEG-b-PpY),as a multi-functional carrier for the facile fabrication of NDDS Pt/Ce6@mPEG-b-PpY(PtCeNP)for the co-delivery of cisplatin and photosensitizer chlorin e6(Ce6)via phosphato-platinum coordination andπ-πstacking,respectively.PtCeNP improves the solubility,cellular uptake,and bioavailability of both parental drugs,and showed strong synergistic antitumor efficacy both in vitro and in vivo through combined chemo-photodynamic therapy.Our results indicate that PpY is a biocompatible,multifunctional,and promising carrier material suitable for a variety of drugs and may simplify the design for co-delivery systems. | Haisen Zhou Yaoyi Wang Yingqin Hou Zhengkui Zhang Qi Wang Xiaodong Tian Hua Lu | 2022 | Chinese Journal of Chemistry2022，40，20： | 1 |
| 12 | Memory and learningimpairment induced by dexamethasone in senescent but not young mice显示文摘 | YaoYY Liu D M Xu D F | 2007 | Eur J Pharmacol2007，574，1： | 1 |
| 13 | Erythropoietinattenuatescardiacdysfunctionbyincreasingmyocardialangiogenesisandinhibitinginterstitialfibrosisindiabeticrats显示文摘 | LuJ YaoYY DaiQM etal | 2012 | CardiovascDiabetol2012，11，： | 1 |
| 14 | Twoviewsofthetheoryofroughsetsinfiniteuniverses显示文摘 | YAOYY | 1996 | InternationalJournalofApproximateReaGsoning1996，15，： | 1 |
| 15 | Erythropoietin attenu-ates cardiac dysfunction by increasing myocardial angio-genesis and inhibiting interstitial fibrosis in diabetic rats显示文摘 | Lu J YaoYY Dai M Q | 2012 | Cardiovasc Diabetol2012，11，1： | 1 |
| 16 | Molecular beam epitaxy of superconducting PdTe_2 films on topological insulator Bi_2Te_3显示文摘Majorana fermions have been observed in topological insulator/s-wave superconductor heterostructures. To manipulate Majorana fermions, superconducting materials should be deposited on the surfaces of topological insulators. In this study, highquality superconducting PdTe_2 films are deposited on the topological insulator Bi_2Te_3 surface using molecular beam epitaxy. The surface topography and electronic properties of PdTe_2/Bi_2Te_3 heterostructures are investigated via in situ scanning tunneling microscopy/spectroscopy. Under Te-rich conditions, the Pd atoms presumably form PdTe_2 film on Bi_2Te_3 surface rather than diffuse into Bi_2Te_3. The superconductivity of the PdTe_2/Bi_2Te_3 heterostructure is detected at a transition temperature of ~1.4 K using the two-coil mutual inductance technique. This study proposes a method for fabricating superconducting materials on topological insulator surfaces at low doping levels, paving ways for designing nanodevices that can manipulate Majorana fermions. | HuanYi Xue Hao Yang YanFu Wu Gang Yao Dandan Guan ShiYong Wang Hao Zheng CanHua Liu YaoYi Li JinFeng Jia | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，7： | 1 |
| 17 | Kallikrein protects against ische-mic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis显示文摘 | Xia CF YinH YaoYY | 2006 | Hum Gene Ther2006，17，2： | 1 |
| 18 | Topological Defects Induced HighSpin Quartet State in Truxene-Based Molecular Graphenoids显示文摘Topological defects in graphene materials introduce exotic properties with both fundamental importance and technological implications,absent in their defect-free counterparts.Although individual topological defects have been widely studied,collective magnetic behaviors originating from well-organized multiple topological defects remain a great challenge.Here,we examined the collective magnetic properties originating from three pentagon topological defects in truxene-based molecular graphenoids using scanning tunneling microscopy(STM)and non-contact atomic force microscopy.Unpairedπelectrons were introduced into the aromatic topology of truxene molecular graphenoids one by one by dissociating hydrogen atoms at the pentagon defects via atom manipulation.STM measurements,together with density functional theory calculations,suggested that the unpaired electrons were ferromagnetically coupled,forming a collective highspin quartet state of S=3/2.Our work demonstrates that collective spin ordering could be realized through engineering regular patterned topological defects in molecular graphenoids,providing a new platform for designing one-dimensional ferromagnetic spin chains and two-dimensional ferromagnetic networks. | Can Li Yu Liu Yufeng Liu Fu-Hua Xue Dandan Guan Yaoyi Li Hao Zheng Canhua Liu Jinfeng Jia Pei-Nian Liu Deng-Yuan Li Shiyong Wang | 2023 | CCS Chemistry2023，5，3： | 0 |
| 19 | Erratum to:In situ construction of thiol-silver interface for selectively electrocatalytic CO_(2)reduction显示文摘Erratum to Nano Research 2022,15(4):3283−3289 http://gffzzd3cc09b8251d45dfsuwqf5ouw55of6vvw.ffgz.tsg.suse.edu.cn/10.1007/s12274-021-3978-7 One funding number in the Acknowledgements section was unfortunately mistakenly used.This error did not affect any of the conclusions from the published paper. | Ying Chen Feng Hu Yanan Hao Yonghan Wang Yaoyi Xie Hui Wang Lijie Yin Deshuang Yu Hongchao Yang Jun Ma Dan Kai Linlin Li Shengjie Peng | 2022 | Nano Research2022，15，8： | 0 |
| 20 | Endoscopic closure of a duodenal fistula caused by a deformable foreign body显示文摘Introduction We describe an elderly patient who suffered severe,intermittent mid-abdominal pain due to a duodenal fistula secondary to a rarely seen deformable foreign body Dendrobium officinale and achieved complete relief following endoscopic closure. | Xiujing Yu Yaoyi Wu Jianshan Mao | 2022 | Gastroenterology Report2022，10，1： | 0 |
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