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| 1 | Gold nanorods and nanohydroxyapatite hybrid hydrogel for preventing bone tumor recurrence via postoperative photothermal therapy and bone regeneration promotion显示文摘Osteosarcoma is a malignant bone tumor,which often occurs in adolescents.However,surgical resection usually fails to completely remove the tumor clinically,which has been the main cause of postoperative recurrence and metastasis,resulting in the high death rate of patients.At the same time,osteosarcoma invades a large area of the bone defect,which cannot be self-repaired and seriously affects the life quality of the patients.Herein,a bifunctional methacrylated gelatin/methacrylated chondroitin sulfate hydrogel hybrid gold nanorods(GNRs)and nanohydroxyapatite(nHA),which possessed excellent photothermal effect,was constructed to eradicate residual tumor after surgery and bone regeneration.In vitro,K7M2wt cells(a mouse bone tumor cell line)can be efficiently eradicated by photothermal therapy of the hybrid hydrogel.Meanwhile,the hydrogel mimics the extracellular matrix to promote proliferation and osteogenic differentiation of mesenchymal stem cells.The GNRs/nHA hybrid hydrogel was capable of photothermal treatment of postoperative tumors and bone defect repair in a mice model of tibia osteosarcoma.Therefore,the hybrid hydrogel possesses dual functions of tumor therapy and bone regeneration,which shows great potential in curing bone tumors and provides a new hope for tumor-related bone complex disease. | Jinfeng Liao Kun Shi Yanpeng Jia Yanting Wu Zhiyong Qian | 2021 | Bioactive Materials2021，6，8： | 3 |
| 2 | Sustained co-delivery of gemcitabine and cis-platinum via biodegradable thermo-sensitive hydrogel for synergistic combination therapy of pancreatic cancer显示文摘Pancreatic cancer is one of the most devastating cancers with poor prognosis and no significant change in the survival rate over the past decades.Localized targeted drug delivery through interventional endoscopic ultrasonography-guided fine-needle injection (EUS-FNI) is an attractive and minimally invasive strategy for inoperable pancreatic cancer.An injectable in-situ formed long-lasting drug delivery system is a promising alternative for the localized treatment of pancreatic cancer via EUS-FNI.Here,a biodegradable thermo-sensitive copolymer hydrogel for the co-delivery of anticancer agents gemcitabine (GEM) and cis-platinum (DDP) was developed.This hydrogel is a free flowable liquid at room temperature that changes into a semi-solid hydrogel following injection in response to the physiological temperature.Both in vitro and in vivo drug release behaviors indicate sustained drug release of this delivery system.Synergistic cellular proliferation inhibition and desirable apoptosis promotion have been found when pancreatic cancer Bxpc-3 cells were co-cultured with this GEM-DDP/hydrogel system.After a single intratumoral injection,the dual-drug loaded hydrogel formulation exhibited superior anti-tumor efficacy and minimized systemic side effect on pancreatic cancer xenograft mouse model in comparison to the intravenously injected free GEM and DDP combination.In addition,a strong synergistic therapeutic effect of the GEM-DDP/hydrogel system against pancreatic cancer has been found in vitro and in vivo compared to the single-drug loaded hydrogel composites.The obtained findings suggest this developed thermo-sensitive copolymer hydrogel system as a potential universal carrier for the localized targeted delivery of multi-drugs,for use in a variety of inoperable solid tumors. | Kun Shi Bingxin Xue Yanpeng Jia Liping Yuan Ruxia Han Fan Yang Jinrong Peng Zhiyong Qian | 2019 | Nano Research2019，12，6： | 3 |
| 3 | Cyclophosphamide loaded thermo-responsive hydrogel system synergize with a hydrogel cancer vaccine to amplify cancer immunotherapy in a prime-boost manner显示文摘Although neoantigen-based cancer vaccines show great potential in cancer immunotherapy due to their ability to induce effective and long-lasting anti-tumor immunity,their development is hindered by the limitations of neoantigens identification,low immunogenicity,and weak immune response.Cyclophosphamide(CTX)not only directly kills tumors but also causes immunogenic cell death,providing a promising source of antigens for cancer vaccines.Herein,a combined immunotherapy strategy based on temperature-sensitive PLEL hydrogel is designed.First,CTX-loaded hydrogel is injected intratumorally into CT26 bearing mice to prime anti-tumor immunity,and then 3 days later,PLEL hydrogels loaded with CpG and tumor lysates are subcutaneously injected into both groins to further promote anti-tumor immune responses.The results confirm that this combined strategy reduces the toxicity of CTX,and produces the cytotoxic T lymphocyte response to effectively inhibit tumor growth,prolong survival,and significantly improve the tumor cure rate.Moreover,a long-lasting immune memory response is observed in the mice.About 90%of the cured mice survive for at least 60 days after being re-inoculated with tumors,and the distant tumor growth is also well inhibited.Hence,this PLEL-based combination therapy may provide a promising reference for the clinical promotion of chemotherapy combined with cancer vaccines. | Fan Yang Kun Shi Ying Hao Yanpeng Jia Qingya Liu Yu Chen Meng Pan Liping Yuan Yongyang Yu Zhiyong Qian | 2021 | Bioactive Materials2021，6，10： | 2 |
| 4 | A fabrication method for adaptive dielectric gradient insulating components显示文摘Dielectric gradient components have advantages in electric field mitigation and insulation improvement.In this paper,we propose a fabrication method for adaptive dielectric gradient components using in situ AC electric field,including the mechanism and the corresponding operational procedures for industrial applications.Based on the electric polarisation and self-assembly effect of the filler particles in the liquid matrix,the chainlike structure in the high field strength region is constructed to enhance the local permittivity and mitigate the maximum of the spatial electric field.The dielectric gradient basin insulator is prepared by this method,and its flashover voltage is increased by 12.8%compared with that of a homogeneous dielectric basin insulator,and the improvement is 20.8%when metal particles are present on the surface.The more non-uniform the initial electric field is,the greater the improvement in flashover voltage.This method is expected to promote the industrial application of dielectric gradient insulating components. | Zikui Shen Zhidong Jia Yanpeng Hao Zhenyu Xin Xilin Wang | 2023 | High Voltage2023，8，1： | 2 |
| 5 | Heat Transfer Performance of Microgroove Back Plate Heat Pipes with Working Fluid and Heating Power显示文摘Micro heat pipes(MHP) cooling is one of the most efficient solutions to radiate heat for high heat flux electronic components in data centers. It is necessary to improve heat transfer performance of microgroove back plate heat pipes. This paper discusses about influence on thermal resistance through experiments and numerical simulation with different working fluids, filling ratio and heat power. Thermal resistance of the CO2 filled heat pipe is 14.8% lower than the acetone filled heat pipe. In the meantime, at the best filling ratio of 40%, the CO2 filled heat pipe has the optimal heat transfer behavior with the smallest thermal resistance of 0.123 K/W. The thermal resistance continues to decline but the magnitude of decreases is going to be minor. In addition, this paper illustrates methods about how to enhance heat pipe performance from working fluids, filling ratio and heat power, which provides a theoretical basis for practical applications. | WU Yanpeng JIA Jie TIAN Dongmin CHUAH Yew Khoy | 2020 | Journal of Thermal Science2020，29，4： | 2 |
| 6 | Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer显示文摘The synergistic therapy of chemotherapy and photothermal therapy(PTT)has been reported as a promising antitumor strategy.To achieve effective combination therapy,developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary.Herein,a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin(DOX)loading.We further designed PtPd-ethylene glycol(PEG)-folic acid(FA)-doxorubicin(DOX)nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting.Moreover,excellent photoacoustic(PA)imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’targeting effect.The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor. | Yanpeng Jia Yang Song Ying Qu Jinrong Peng Kun Shi Dan Du He Li Yuehe Lin Zhiyong Qian | 2020 | Nano Research2020，13，6： | 2 |
| 7 | Camptothecin@HMSNs/thermosensitive hydrogel composite for applications in preventing local breast cancer recurrence显示文摘Camptothecin has a strong tumor killing ability for a variety of tumor cells with its special anti-cancer mechanism including the breast cancer. However, because of its infinite hydrophobic property, its clinical application has been greatly limited. Early prevention of loco regional recurrence for the breast cancer is critical for patients who have undergone breast-conserving therapy. In the study,CPT was used for the inhibition of the recurrence after the operation. The hollow mesoporous silica nanoparticles were used as the carrier to improve the hydrophilic property and increase its bioavailability with the high loading capacity. The ability of the cellular uptake and antitumor activity was increased. Hydrogel was the ideal carrier for local therapy, so the CPT@HMSNs were loaded into the PLEL thermo sensitive hydrogel to be injected into the tumor sites after the tumor was resected. The recurrence was reduced in the group of CPT-HMSNs-PLEL and the side effect of CPT was decreased. They exhibit distinguished potential as drug carrier for local delivery. | Jing Wu Ying Qu Kun Shi Bingyang Chu Yanpeng Jia Xue Xiao Qianjun He Zhiyong Qian | 2018 | Chinese Chemical Letters2018，29，12： | 2 |
| 8 | Application of ultrasonic pulse-echo method to insulation condition diagnosis for large generators显示文摘 | Hao Yanpeng Wang Guoli Jia Zhidong | 2005 | IEEE Transactions on Dielectrics and Electrical Insulation2005，12，1： | 1 |
| 9 | As- sessment of insulation condition of generator stator bars based on velocity of ultrasonic waves 显示文摘 | Yanpeng Hao Hengkun Xie Guoli Wang Zhidong Jia | 2003 | IEEE Trans on Di- electrics and Electrical Insulation2003，10，3： | 1 |
| 10 | Ag2S nanoparticles as an emerging single-component theranostic agent显示文摘Last two decades,with the rapid changes and development of nanotechnology and biological materials,diverse multi-functional nanomaterials emerging,which offers a novel way to treat and diagnose diseases,and therefore spawned the new biomedical technology of theranostics,which integrates the treatment and diagnosis or monitoring of diseases into one.Ag2S as a bio-nanomaterial with low biotoxicity has attracted more and more attention due to its good photoluminescence properties and fluorescence imaging of small animals in the second near-infrared region(NIR-Ⅱ).Meanwhile,Ag2S has the ability to absorb near-infrared light strongly because of its local surface plasma resonance(LSPR)effect and had become a kind of photothermal conve rters with good photothermal conve rsion efficiency.More interestingly,both photothermal effect and fluorescence characteristics of Ag2S nanoparticles(NPs)are closely related to their particle sizes.However,the relationship between photothermal effect and fluorescence characteristics of Ag2S NPs and their sizes has not been reviewed so far.Herein,the synthesis methods and influencing factors of synthesize Ag2S NPs with different sizes were compared firstly,and then the photothermal effect and fluorescence characte ristics of Ag2S NPs with different sizes were summarized.Finally,the possibilities and challenges of using Ag2S NPs to construct theranostic agent were discussed in the end. | Ruxia Han Jinrong Peng Yao Xiao Ying Hao Yanpeng Jia Zhiyong Qian | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 11 | Application of ultrasonic pulse-echo method to insulation condition diagnosis for large generators 显示文摘 | Hao Yanpeng Wang Guoli Jia Zhidong | 2005 | IEEE Transactions on Dielectrics and Electrical Insulation2005，12，1： | 1 |
| 12 | Structured Controller Design for Interconnected Systems via Nonlinear Programming显示文摘Dear Editor,This letter deals with the structural controller design problem of interconnected systems with unknown feedback topology.Firstly,under a cardinality constraint on the directed communication links among sub-controllers,a distributed controller’s feedback gain and feedback topology are incorporated in a unified co-design framework.Secondly,the cardinality constraint introduced in the distributed control is represented by a binary integer programming.To deal with the complementary constraint,a nonlinear programming(NLP)is proposed to relax the binary integer programming.Finally,incorporating the NLP into the standard distributed event-triggered control method,an algorithm is developed for interconnected systems to simultaneously design the feedback topology and controller gain.An interconnected system is composed of several coupling subsystems,which usually coordinate with each other to accomplish a common task. | Yanpeng Guan Junpeng Du Xinchun Jia | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，7： | 0 |
| 13 | Development of a model-based flood emergency management system in Yujiang River Basin, South China显示文摘泛滥是在中国的最经常的灾难。它影响人的生活和性质,引起可观的经济损失。水库的洪水预报和操作在洪水紧急情况管理是重要的。尽管大进步直用计算机在洪水预报和水库操作被获得了,在中国联网技术,和地理信息系统技术,模型的预言精确性不由于即时监视的 unavailability 是令人满意的数据。另外,即时洪水控制情形分析不在许多区域是有效的并且能很少提供联机决定支持功能。在这研究,为即时洪水在 Yujiang 河盆预报的一个决定支持系统,华南(DSS-YRB ) 在这篇论文被介绍。这个系统基于水文学和水力的数学模型。概念的框架和建议 DSS-YRB 的详细部件被说明,它采用即时降雨数据变换,预报的模型驱动的 hydrologic,模型刻度,数据吸收方法,和水库运作的情形分析。Multi-tiered 建筑学提供大灵活性,可移植性,可重用性,和可靠性。应用案例研究结果显示出一个决定支持系统的开发和应用程序因为即时洪水预报和操作为洪水控制是有益的[出版摘要] | Yong ZENG Yanpeng CAI Peng JIA Jiansu MAO | 2014 | Frontiers of Earth Science2014，8，2： | 0 |
| 14 | Seamlessly Merging the Capacity of P into Sb at Same Voltage with Maintained Superior Cycle Stability and Low-temperature Performance for Li-ion Batteries显示文摘Among the alloying-type anodes,elemental Sb possesses the suitable yet safe plateau,simple lithiation pathway,small voltage polarization,high conductivity,and superior cycle stability.However,challenge is that its intrinsic capacity is rather low(660 mAh g^(-1)),<1/6 of silicon.Herein,we propose a seamless integration strategy by merging the voltage and capacity of phosphorus and antimony into a solid solution alloy.Interestingly,the enlistment of P is found greatly enlarge the capacity from 660 to 993 mAh g^(-1) for such Sb_(30)P_(30) solid solution,while maintaining a single and stable discharge plateau(~0.79 V)similar to elemental Sb.Various experimental characterizations including XPS,PDF,Raman,and EDS mapping reveal that in such a material the P and Sb atoms have interacted with each other to form a homogenous solid solution alloy,rather than a simple mixing of the two substances.Thus,the Sb_(30)P_(30) exhibits superior rate performances(807 mAh g^(-1) at 5000 mA g^(-1))and cyclability(821 mAh g^(-1) remained after 300 cycles).Furthermore,such Sb_(60-x)P_(x) alloys can even deliver 621 mAh g^(-1) at30℃,which can be served as the alternative anode materials for high-energy and low-temperature batteries.This unique seamless integration strategy based on solid solution chemistry can be easily leveraged to manipulate the capacity of other electrode materials at similar voltage. | Yaqing Wei Jun He Jie Zhang Mingyang Ou Yanpeng Guo Jiajun Chen Cheng Zeng Jia Xu Jiantao Han Tianyou Zhai Huiqiao Li | 2023 | Energy & Environmental Materials2023，6，2： | 0 |
| 15 | Remediation of preservative ethylparaben in water using natural sphalerite:Kinetics and mechanisms显示文摘As a typical class of emerging organic contaminants(EOCs), the environmental transformation and abatement of preservative parabens have raised certain environmental concerns. However, the remediation of parabens-contaminated water using natural matrixes(such as, naturally abundant minerals) is not reported extensively in literature. In this study, the transformation kinetics and the mechanism of ethylparaben using natural sphalerite(NS) were investigated. The results show that around 63% of ethylparaben could be absorbed onto NS within 38 hr, whereas the maximum adsorption capacity was 0.45 mg/g under room temperature. High temperature could improve the adsorption performance of ethylparaben using NS. In particular, for the temperature of 313 K, the adsorption turned spontaneous. The well-fitted adsorption kinetics indicated that both the surface adsorption and intra-particle diffusion contribute to the overall adsorption process. The monolayer adsorption on the surface of NS was primarily responsible for the elimination of ethylparaben. The adsorption mechanism showed that hydrophobic partitioning into organic matter could largely govern the adsorption process, rather than the Zn S that was the main component of NS. Furthermore, the ethylparaben adsorbed on the surface of NS was stable, as only less than 2% was desorbed and photochemically degraded under irradiation of simulated sunlight for 5 days. This study revealed that NS might serve as a potential natural remediation agent for some hydrophobic EOCs including parabens, and emphasized the significant role of naturally abundant minerals on the remediation of EOCs-contaminated water bodies. | Yanpeng Gao Teng Guo Xiaolin Niu Na Luo Jia Chen Junlang Qiu Yuemeng Ji Guiying Li Taicheng An | 2022 | Journal of Environmental Sciences2022，34，3： | 0 |
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