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| 1 | Synthesis of Porous NiO Nanocrystals with Controllable Surface Area and Their Application as Supercapacitor Electrodes显示文摘We report a facile way to grow various porous NiO nanostructures including nanoslices,nanoplates,and nanocolumns,which show a structure-dependence in their specific charge capacitances.The formation of controllable porosity is due to the dehydration and re-crystallization of β-Ni(OH)_(2) nanoplates synthesized by a hydrothermal process.Thermogravimetric analysis shows that the decomposition temperature of the β-Ni(OH)_(2) nanostructures is related to their morphology.In electrochemical tests,the porous NiO nanostructures show stable cycling performance with retention of specific capacitance over 1000 cycles.Interestingly,the formation of nanocolumns by the stacking of β-Ni(OH)_(2) nanoslices/plates favors the creation of small pores in the NiO nanocrystals obtained after annealing,and the surface area is over five times larger than that of NiO nanoslices and nanoplates.Consequently,the specific capacitance of the porous NiO nanocolumns(390 F/g)is significantly higher than that of the nanoslices(176 F/g)or nanoplates(285 F/g)at a discharge current of 5 A/g.This approach provides a clear illustration of the process-structure-property relationship in nanocrystal synthesis and potentially offers strategies to enhance the performance of supercapacitor electrodes. | Xiaojun Zhang Wenhui Shi Jixin Zhu Weiyun Zhao Jan Ma Subodh Mhaisalkar Tuti Lim Maria Yanhui Yang Hua Zhang Huey Hoon Hng Qingyu Yan | 2010 | Nano Research2010，3，9： | 24 |
| 2 | Using Fuzzy Theory and Variable Weights for Water Quality Evaluation in Poyang Lake, China显示文摘Achieving water purity in Poyang Lake has become a major concern in recent years, thus appropriate evaluation of spatial and temporal water quality variations has become essential. Variations in 11 water quality parameters from 15 sampling sites in Poyang Lake were investigated from 2009 to 2012. An integrative fuzzy variable evaluation(IFVE) model based on fuzzy theory and variable weights was developed to measure variations in water quality. Results showed that: 1) only chlorophyll-a concentration and Secchi depth differed significantly among the 15 sampling sites(P < 0.01), whereas the 11 water quality parameters under investigation differed significantly throughout the seasons(P < 0.01). The annual variations of all water quality variables except for temperature, electrical conductivity, suspended solids and total phosphorus were considerable(P < 0.05). 2) The IFVE model was reasonable and flexible in evaluating water quality status and any possible ′bucket effect′. The model fully considered the influences of extremely poor indices on overall water quality. 3) A spatial analysis indicated that anthropogenic activities(particularly industrial sewage and dredging) and lake bed topography might directly affect water quality in Poyang Lake. Meanwhile, hydrological status and sewage discharged into the lake might be responsible for seasonal water quality variations. | LI Bing YANG Guishan WAN Rongrong ZHANG Lu ZHANG Yanhui DAI Xue | 2017 | Chinese Geographical Science2017，27，1： | 15 |
| 3 | Ecological studies on Prochlorococcus in China seas显示文摘Prochlorococcus, a tiny oxygenic photosynthetic picoplankton with unique pigment composition, has been found to be ubiquitous and abundant in the world oceans, and has been recognized to be closely related to living resources and environmental issues. It has attracted the interest of marine biologists since its discovery, and field data on it over global oceans have accumulated rapidly in the past 10 years. In China, we have studied Prochlorococcus for 8 years, achieving a basic ecological understanding. The presence of Prochlorococcus in China seas, marginal seas of the west Pacific, was confirmed, and its distribution patterns were also brought to light. Prochlorococcus is very abundant in the South China Sea and the offshore regions of the East China Sea. It is seasonally present in the southeast part of the Yellow Sea and absent in the Bohai Sea. Temporal and spatial variations of the abundance of Prochlorococcus and their affecting factors, physiological and ecological characteristics of | Nianzhi Jiao Yanhui Yang | 2002 | Chinese Science Bulletin2002，47，15： | 12 |
| 4 | PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma(PDAC),and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC显示文摘High expression of PD-L1 marks the poor prognosis of pancreatic ductal adenocarcinomas(PDAC).However,the regulatory mechanism of PD-L1 remains elusive.We recently reported that cancer Forkhead box protein 3(Cancer-FOXP3 or C-FOXP3)promoted immune evasion of PDAC by recruiting Treg cells into PDAC via upregulation of CCL5.In this study,we confirmed that PD-L1 was overexpressed in PDAC samples from two independent cohorts of patients with radical resection.Moreover,C-FOXP3 was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels,and this finding was confirmed by the The Cancer Genome Atlas(TCGA)database.Chromatin immunoprecipitation(ChIP)revealed that C-FOXP3 directly bound to the promoter region of PD-L1 in pancreatic cancer cells.Furthermore,overexpression of C-FOXP3 activated the luciferase reporter gene under the control of the PD-L1 promoter.However,mutation of the binding motif-a completely reversed the luciferase activity.In addition,C-FOXP3-induced upregulation of PD-L1 effectively inhibited the activity of CD8+T cells.Based on our recent finding that the CCL-5 antibody achieved a better response to PDAC models with high C-FOXP3 levels,we further demonstrated that the PD-L1 antibody strengthened the antitumor effect of CCL-5 blockade in xenograft and orthotopic mouse models with high C-FOXP3 levels.In conclusion,C-FOXP3 directly activates PD-L1 and represents a core transcription factor that mediates the immune escape of PDAC.Combined blockade of PD-L1 and CCL-5 may provide an effective therapy for patients with PDAC that have high C-FOXP3 levels. | Xiuchao Wang Xin Li Xunbin Wei Haiping Jiang Chungen Lan Shengyu Yang Han Wang Yanhui Yang Caijuan Tian Zanmei Xu Jiangyan Zhang Jihui Hao He Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 5 | Plate tectonic control on the formation and tectonic migration of Cenozoic basins in northern margin of the South China Sea显示文摘The tectonic evolution history of the South China Sea(SCS) is important for understanding the interaction between the Pacific Tectonic Domain and the Tethyan Tectonic Domain,as well as the regional tectonics and geodynamics during the multi-plate convergence in the Cenozoic.Several Cenozoic basins formed in the northern margin of the SCS,which preserve the sedimentary tectonic records of the opening of the SCS.Due to the spatial non-uniformity among different basins,a systematic study on the various basins in the northern margin of the SCS constituting the Northern Cenozoic Basin Group(NCBG) is essential.Here we present results from a detailed evaluation of the spatial-temporal migration of the boundary faults and primary unconformities to unravel the mechanism of formation of the NCBG.The NCBG is composed of the Beibu Gulf Basin(BBGB),Qiongdongnan Basin(QDNB),Pearl River Mouth Basin(PRMB) and Taixinan Basin(TXNB).Based on seismic profiles and gravity-magnetic anomalies,we confirm that the NE-striking onshore boundary faults propagated into the northern margin of the SCS.Combining the fault slip rate,fault combination and a comparison of the unconformities in different basins,we identify NE-striking rift composed of two-stage rifting events in the NCBG:an early-stage rifting(from the Paleocene to the Early Oligocene) and a late-stage rifting(from the Late Eocene to the beginning of the Miocene).Spatially only the late-stage faults occurs in the western part of the NCBG(the BBGB,the QDNB and the western PRMB),but the early-stage rifting is distributed in the whole NCBG.Temporally,the early-stage rifting can be subdivided into three phases which show an eastward migration,resulting in the same trend of the primary unconformities and peak faulting within the NCBG.The late-stage rifting is subdivided into two phases,which took place simultaneously in different basins.The first and second phase of the early-stage rifting is related to back-arc extension of the Pacific subduction retreat system.The third phase of the earlystage rifting resulted from the joint effect of slab-pull force due to southward subduction of the proto-SCS and the back-arc extension of the Pacific subduction retreat system.In addition,the first phase of the late-stage faulting corresponds with the combined effect of the post-collision extension along the Red River Fault and slab-pull force of the proto-SCS subduction.The second phase of the late-stage faulting fits well with the sinistral faulting of the Red River Fault in response to the Indochina Block escape tectonics and the slab-pull force of the proto-SCS. | Pengcheng Wang Sanzhong Li Yanhui Suo Lingli Guo Guangzeng Wang Gege Hui M.Santosh Ian D.Somerville Xianzhi Cao Yang Li | 2020 | Geoscience Frontiers2020，11，4： | 10 |
| 6 | Superhydrophobic modification of ceramic membranes for vacuum membrane distillation显示文摘The hydrophobically modi fied ceramic membranes have great potential for energy-ef ficient membrane distillation.In this work,flat-sheet ceramic membranes with a superhydrophobic surface were fabricated by grafting 1H,1H,2H,2H-per fluorooctyltrichlorosilane or 1H,1H,2H,2H-per fluorodecyltriethoxysilane and followed by ultraviolet irradiation.The surface water contact angle was improved from 46° of original ceramic membrane to 159°,which exhibited a stable and excellent superhydrophobic effect.The modi fied membranes showed a high flux of 27.28 kg·m^(-2)·h^(-1) and simultaneously maintained an excellent retention rate of 99.99%,when used in vacuum membrane distillation process for treatment of a 1 wt% NaCl(75 °C) aqueous solution.These results suggested that superhydrophobic modi fication of ceramic surface is a facile and cost-effective way to achieve higher membrane distillation performance.The superhydrophobically-modi fied ceramic membrane with an excellent desalination capacity would show considerable potential in practical membrane distillation utilizations. | Yanhui Yang Qianqian Liu Haizhi Wang Fusheng Ding Guoshan Jin Chunxi Li Hong Meng | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 9 |
| 7 | Neural substrates of data-driven scientific discovery:An fMRI study during performance of number series completion task显示文摘Although much has been known about how humans psychologically perform data-driven scientific discovery,less has been known about its brain mechanism.The number series completion is a typical data-driven scientific discovery task,and has been demonstrated to possess the priming effect,which is attributed to the regularity identification and its subsequent extrapolation.In order to reduce the heterogeneities and make the experimental task proper for a brain imaging study,the number magnitude and arithmetic operation involved in number series completion tasks are further restricted.Behavioral performance in Experiment 1 shows the reliable priming effect for targets as expected.Then,a factorial design (the priming effect:prime vs.target;the period length:simple vs.complex) of event-related functional magnetic resonance imaging (fMRI) is used in Experiment 2 to examine the neural basis of data-driven scientific discovery.The fMRI results reveal a double dissociation of the left DLPFC (dorsolateral prefrontal cortex) and the left APFC (anterior prefrontal cortex) between the simple (period length=1) and the complex (period length=2) number series completion task.The priming effect in the left DLPFC is more significant for the simple task than for the complex task,while the priming effect in the left APFC is more significant for the complex task than for the simple task.The reliable double dissociation may suggest the different roles of the left DLPFC and left APFC in data-driven scientific discovery.The left DLPFC (BA 46) may play a crucial role in rule identification,while the left APFC (BA 10) may be related to mental set maintenance needed during rule identification and extrapolation. | ZHONG Ning LIANG PeiPeng QIN YuLin LU ShengFu YANG YanHui LI KunCheng | 2011 | Science China(Life Sciences)2011，54，5： | 8 |
| 8 | Cryo-EM structure of human mTOR complex 2显示文摘 | Xizi Chen Mengjie Liu Yuan Tian Jiabei Li Yilun Qi Dan Zhao Zihan Wu Min Huang Catherine C. L. Wong Hong-Wei Wang Jiawei Wang Huirong Yang Yanhui Xu | 2018 | Cell Research2018，28，5： | 8 |
| 9 | Optimization on cooperative feed strategy for radial–axial ring rolling process of Inco718 alloy by RSM and FEM显示文摘During radial–axial ring rolling process,cooperative strategy of the radial–axial feed is critical for dimensional accuracy and thermo mechanical parameters distribution of the formed ring.In order to improve the comprehensive quality of the ring parts,response surface method(RSM) is employed for the first time to optimize the cooperative feed strategy for radial–axial ring rolling process by combining it with an improved and verified 3D coupled thermo-mechanical finite element model.The feed trajectory is put forward to describe cooperative relationship of the radial–axial feed and three variables are designed based on the feed trajectory.In order to achieve multiobjective optimization,four responses including thermo mechanical parameters distribution and rolling force are proposed.Based on the FEM results,RSM is used to establish a response model to depict the function relationship between the objective response and design variables.Through this approximate model,effects of different variables on ring rolling process are analyzed connectedly and optimal feed strategy is obtained by resorting to the optimal chart specific to a constraint condition. | Zhu Xinglin Liu Dong Yang Yanhui Hu Yang Zheng Yong | 2016 | Chinese Journal of Aeronautics2016，29，3： | 7 |
| 10 | 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1显示文摘 | Huirong Yang Jia Wang Mengjie Liu Xizi Chen Min Huang Dan Tan Meng-Qiu Dong Catherine C. L, Wong Jiawei Wang Yanhui Xu Hong-Wei Wang | 2016 | Protein & Cell2016，7，12： | 7 |
| 11 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 12 | Engineering Ruthenium-Based Electrocatalysts for Effective Hydrogen Evolution Reaction显示文摘The investigation of highly effective,durable,and cost-effective electrocatalysts for the hydrogen evolution reaction(HER)is a prerequisite for the upcoming hydrogen energy society.To establish a new hydrogen energy system and gradually replace the traditional fossil-based energy,electrochemical water-splitting is considered the most promising,environmentally friendly,and efficient way to produce pure hydrogen.Compared with the commonly used platinum(Pt)-based catalysts,ruthenium(Ru)is expected to be a good alternative because of its similar hydrogen bonding energy,lower water decomposition barrier,and considerably lower price.Analyzing and revealing the HER mechanisms,as well as identifying a rational design of Ru-based HER catalysts with desirable activity and stability is indispensable.In this review,the research progress on HER electrocatalysts and the relevant describing parameters for HER performance are briefly introduced.Moreover,four major strategies to improve the performance of Ru-based electrocatalysts,including electronic effect modulation,support engineering,structure design,and maximum utilization(single atom)are discussed.Finally,the challenges,solutions and prospects are highlighted to prompt the practical applications of Rubased electrocatalysts for HER. | Yingjie Yang Yanhui Yu Jing Li Qingrong Chen Yanlian Du Peng Rao Ruisong Li Chunman Jia Zhenye Kang Peilin Deng Yijun Shen Xinlong Tian | 2021 | Nano-Micro Letters2021，13，10： | 5 |
| 13 | USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer显示文摘Dear Editor,The Hippo tumor suppressor pathway plays an important role in development and tumorigenesis.Yes-associated protein(YAP)is a major effector of the Hippo pathway regulating the expression of genes involved in cell proliferation,cell death,and cell differentiation(Pan,2010;Johnson and Haider,2014;Piccolo etal.,2014;Yu etal.,2015).In intestine,YAP is mainly expressed in leucine rich repeat containing G protein-coupled receptor 5(LGR5)marked stem cells,and is required for regeneration following tissue damage and the development of colon cancer in mice(Cai etal.,2010;Barry etal.,2013;Wang etal.,2017).Moreover,in colorectal cancer(CRC)specimens,elevated YAP expression and activity is frequently observed(Steinhardt et al.,2008).It has been shown that high YAP expression is associated with cancer metastasis,poor prognosis,resistance to chemotherapy,and greater possibility of relapse(Johnson and Haider,2014;Yu etal.,2015). | Beiqing Pan Yi Yang Jian Li Yu Wang Chuantao Fang Fa-Xing Yu Yanhui Xu | 2020 | Protein & Cell2020，11，2： | 4 |
| 14 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 15 | Epidemiological and Virological Surveillance of Seasonal Influenza Viruses—China,2020–2021显示文摘Introduction:During the coronavirus disease 2019(COVID-19)pandemic,the circulation of seasonal influenza virus declined globally and remained below previous seasonal levels.We analyzed the results of the epidemiology,antigenic,and genetic characteristics,and antiviral susceptibilities of seasonal influenza viruses isolated from the mainland of China during October 5,2020 through September 5,2021,to better assess the risk of influenza during subsequent influenza season in 2021–2022.Methods:Positive rates of influenza virus detection during this period were based on real-time polymerase chain reaction(PCR)detection by the Chinese National Influenza Surveillance Network laboratories,and isolated viruses from influenza positive samples were submitted to the Chinese National Influenza Center.Antigenic analyses for influenza viruses were conducted using the hemagglutination inhibition assay.Next-generation sequencing was used for genetic analyses.Viruses were tested for resistance to antiviral medications using a phenotypic assay and next-generation sequencing.Results:In southern China,the influenza positivity rate was elevated especially after March 2021 and was higher than the same period the previous year with the COVID-19 pandemic.In northern China,influenza positive rate peaked at Week 18 in 2021 and has declined since then.Nearly all isolated viruses were B/Victoria lineage viruses during the study period,and 37.3%of these viruses are antigenically similar to the reference viruses representing the vaccine components for the 2020–2021 and 2021–2022 Northern Hemisphere influenza season.All seasonal influenza viruses were susceptible to neuraminidase inhibitors and endonuclease inhibitors.Conclusions:Influenza activity has gradually increased in the mainland of China in 2021,although the intensity of activity is still lower than before the COVID-19 pandemic.The diversity of circulating influenza types/subtypes decreased,with the vast majority being B/Victoria lineage viruses.The surveillance data from this study suggest that we should strengthen influenza surveillance during the upcoming traditional influenza season.It also provided evidence for vaccine recommendations and prevention and control of influenza and clinical use of antiviral drugs. | Weijuan Huang Xiyan Li Minju Tan Yanhui Cheng Tao Chen Hejiang Wei Xiaoxu Zeng Yiran Xie Jia Liu Ning Xiao Lei Yang Dayan Wang | 2021 | China CDC weekly2021，3，44： | 4 |
| 16 | The use of Career Growth Scale in Chinese nurses:Validity and reliability显示文摘Purpose:To test the validity and reliability of a modified Career Growth Scale(CGS)to assess nurse career growth.Method:A cross-sectional design was used to analyze the use of the CGS to survey 600 fulltime registered nurses from Grade A hospitals in Tianjin.Results:A modified scale we called Career Growth of Nurse Scale(CGNS)is acceptable,valid,and reliable for the evaluation of nurse career growth in Chinese hospitals.This scale measured three main factors(career goal,career capacity,and career opportunity)and showed that nurse career growth differed across age,work seniority,and professional title.Conclusions:A three-dimensional scale of nurse career growth was presented.The results revealed CGNS has good validity and reliability. | Jingying Liu Jipeng Yang Yanhui Liu Yang Yang Hongfu Zhang | 2015 | International Journal of Nursing Sciences2015，2，1： | 4 |
| 17 | Polymer matrix mediated solvation of LiNO3 in carbonate electrolytes for quasi-solid high-voltage lithium metal batteries显示文摘Lithium(Li)metal is one of the most promising anodes for next-generation energy storage systems.However,the Li dendrite formation and unstable solid-electrolyte interface(SEI)have hindered its further application.Lithium nitrate(LiNO3)is extensively used as an effective electrolyte additive in ether-based electrolytes to improve the stability of lithium metal.Nevertheless,it is rarely utilized in carbonate electrolytes due to its low solubility.Here,a novel gel polymer electrolyte(GPE)consisting of poly(vinylidene fluoride)(PVDF),poly(methyl methacrylate)(PMMA),poly(ethylene oxide)(PEO)with LiN03 additive is proposed to solve this issue.In this GPE,polyether-based PEO serves as a matrix for dissolving LiNO3 which can be decomposed into a fast Li-ion conductor(Li3N)in conventional carbonate electrolytes to enhance the stability and Li^+conductivity of the SEI film.As a result,dendrite formation is effectively suppressed,and a significantly improved average Coulombic efficiency(CE)of 97.2%in Li-Cu cell is achieved.By using this novel GPE coupled with Li anode and LiNi0.5Mn0.3Co0.2O2(NMC532),excellent capacity retention of 94.1%and high average CE of over 99.2%are obtained after 200 cycles at 0.5 C.This work presents fresh insight into practical modification strategies on high-voltage Li metal batteries. | Zijian Wang Kai Yang Yongli Song Hai Lin Ke Li Yanhui Cui Luyi Yang Feng Pan | 2020 | Nano Research2020，13，9： | 3 |
| 18 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 19 | The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B显示文摘KDM5B 是 histone H3K4me2/3 demethylase。KDM5B 的 PHD1 领域为 demethylation 是批评的,但是位于这个领域的行动下面的机制是不清楚的。在这份报纸,我们观察了那 PHD1 < 潜水艇 class= “ a-plus-plus ” > KDM5B 与 unmethylated H3K4me0 交往。我们 PHD1 的 NMR 结构 < 潜水艇 class= “ a-plus-plus ” > 在有 H3K4me0 的建筑群的 KDM5B 表明有约束力的模式与另外的报导哲学博士手指的稍微不同。由在接口(L325A/D328A ) 的残余上的两倍变化的这个相互作用的混乱减少在在约 50% 的房间和增加的 KDM5B 的 H3K4me2/3 demethylation 活动肿瘤 suppressor 基因由的 transcriptional 压抑近似双重。这些调查结果暗示那 PHD1 < 潜水艇 class= “ a-plus-plus ” > KDM5B 可以帮助在目标基因维持 KDM5B 调停 KDM5B 的 demethylation 活动。 | Yan Zhang Huirong Yang Xue Guo Naiyan Rong Yujiao Song Youwei Xu Wenxian Lan Xu Zhang Maili Liu Yanhui Xu Chunyang Cao | 2014 | Protein & Cell2014，5，11： | 3 |
| 20 | The research of space-time coupled spectral element method for acoustic wave equations显示文摘A space-time coupled spectral element method based on Chebyshev polynomials is presented for solving time-dependent wave equations.Acoustic propagation problems in1+1,2+1,3+1 dimensions with the Dirichlet boundary conditions are simulated via space-time coupled spectral element method using quadrilateral,hexahedral and tesseractic elements respectively.Space-time coupled spectral element method can obtain high-order precision over time.With the same total number of nodes,higher numerical precision is obtained if the higher-order Chebyshev polynomials in space directions and lower-order Chebyshev polynomials in time direction are adopted.Numerical illustrations have indicated that the space-time algorithm provides higher precision than the semi-discretization.When space-time coupled spectral element method is used,time subdomain-by-subdomain approach is more economical than time domain approach. | GENG Yanhui QIN Guoliang WANG Yang HE Wei | 2016 | Chinese Journal of Acoustics2016，35，1： | 3 |
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