|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor I in Arabidopsis thaliana显示文摘RGF1,分泌的肽荷尔蒙,戏在 Arabidopsis 在根分裂组织开发给角色调音。以前的研究显示功能的 RGF1 需要是在由 tyrosylprotein sulfotransferase 的酷氨酸残余的 sulfated 并且 RGF1 主要经由二个下游的抄写因素调整根分裂组织活动,过多 1 (PLT1 ) 并且 PLT2。然而,细胞外的 RGF1 怎么被一个植物房间察觉,是不清楚的。用基因途径,我们发现了充满白氨酸的重复的 clade 像受体的 kinases,指定了为 RGF1 感觉迟钝 1 (RGI1 ) 到 RGI5,用作 RGF1 的受体。二独立 rgi1 rgi2 rgi3 rgi4 rgi5 五倍的异种与分裂组织的一种小尺寸显示一致的短主要的根显型。四倍的异种显示出的 rgi1 rgi2 rgi3 rgi4 到 RGF1 的显著地减少的敏感,和五倍的异种对 RGF1 完全感觉迟钝。PLT1 和 PLT2 的表示在五倍的异种是几乎无法发现的。一个 RGI2 倡导者极大地在五倍的异种驾驶的 PLT2 的宫外的表示救了它的根分裂组织缺点。RGI 之一, RGI1,随后详细生物化学地被分析。在 vitro 点弄污和下拉,分析显示 RGI1 能身体上与 RGF1 交往。RGF1 的外长的申请能快速并且同时导致 RGI1 的 phosphorylation 和 ubiquitination,显示 RGI1 能察觉并且 transduce RGF1 肽信号。然而,激活的 RGI1 多半很快被翻。这些结果表明那 RGI,充当 RGF1 的受体,在在 Arabidopsis thaliana 的 RGF1-PLT-mediated 根分裂组织开发的戏必需品角色。 | Yang Ou Xiaoting Lu Quaner Zi Qingqing Xun Jingjie Zhang Yujun Wu Hongyong Shi Zhuoyun Wei Baolin Zhao Xiaoyue Zhang Kai He Xiaoping Gou Chuanyou Li Jia Li | 2016 | Cell Research2016，26，6： | 18 |
| 2 | Compound Zhebei granules combined with chemotherapy for the treatment of refractory acute leukemia: a randomized clinical trial显示文摘OBJECTIVE: To observe the effect of compound Zhebei granules(CZBG) with chemotherapy in the treatment of refractory acute leukemia.METHODS: In this multicenter, double-blind, placebo-controlled clinical trial, we used a central(online) randomization system to assign 235 patients to two treatment groups. A total of 118 patients received chemotherapy combined with CZBG(4 g,twice daily) and 117 patients received chemotherapy plus placebo. The clinical efficacy was evaluated at the end of one chemotherapeutic cycle.RESULTS: In the full analysis set, in which deaths due to disease progression were regarded as inefficacy, the rates of complete remission(CR) and partial remission(CR + PR) were 32.35% and 50.00%,respectively, for the chemotherapy combined with CZBG group, and 23.08% and 35.58%, respectively,for the chemotherapy plus placebo group. There was a statistically significant difference between the two groups according to a ysis set(PPχ2test(P < 0.05). In the per protocol analS), the CR(33.67%),CR+PR(52.04%) response rates for the chemotherapy plus CZBG group were significantly different from the response rates of the control group(CR:24.24% and CR+PR: 37.37%), respectively(P < 0.05).CONCLUSION: CZBG plus chemotherapy can improve the clinical remission rate of refractory acute leukemia after one just one therapeutic cycle. | Hou Li Yang Shulian Yang Wenhua Zhou Yuhong Liu Feng Yang Hongyong Sun Weizheng Li Dongyun Xu Yamei Chen Xinyi | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 13 |
| 3 | TPX2 knockdown suppressed hepatocellular carcinoma cell invasion via inactivating AKT signaling and inhibiting MMP2 and MMP9 expression显示文摘Objective: Targeting protein for Xenopus kinesin-like protein 2(TPX2) is a nuclear proliferation-related protein that plays a critical role in the formation of mitotic spindle. High expression of TPX2 has been observed in several types of tumors. However, the role of TPX2 in hepatocellular carcinoma(HCC) remains unclear. Our study aimed to investigate the effect of TPX2 on HCC cell invasion.Methods: The immortalized normal human liver cell line L02 and six HCC cell lines including SMMC-7721, BEL-7402, Huh-7, HepG2, Hep3 B and SKHep1 were subjected to qRT-PCR and western blot for TPX2 mRNA and protein, respectively. Furthermore, TPX2 small interfering RNA(siRNA) was used to knock down TPX2 expression in SMMC-7721 and HepG2 cells. Cell proliferation and invasion were determined by MTT and transwell assays. Otherwise, expression of p-AKT, MMP2 and MMP9 were evaluated by western blot in SMMC-7721 cells.Results: The expression of TPX2 in HCC cell lines was markedly higher than that in normal human liver cell line. TPX2 knockdown using a specific TPX2-siRNA reduced the number of invaded cells and inhibited cell proliferation in SMMC-7721 and HepG2 cells. Furthermore, TPX2 knockdown resulted in inactivation of AKT signaling and down-regulation of MMP2 and MMP9 expression in SMMC-7721 cells.Conclusions: Our study identified that TPX2 might contribute to tumor cell invasion through activating AKT signaling and subsequently increasing MMP2 and MMP9 in HCC. | Qingquan Liu Pinghua Yang Kangsheng Tu Hongyong Zhang Xin Zheng Yingmin Yao Qingguang Liu | 2014 | Chinese Journal of Cancer Research2014，26，4： | 11 |
| 4 | Online condition diagnosis for a two-stage gearbox machinery of an aerospace utilization system using an ensemble multi-fault features indexing approach显示文摘China manned space station is designed to operate for over ten years. Long-term and sustainable research on space science and technology will be conducted during its operation. The application payloads must meet the ‘‘long life and high reliability' mission requirement. Gearbox machinery is one of the essential devices in an aerospace utilization system, failure of which may lead to downtime loss even during some disastrous catastrophes. A fault diagnosis of gearbox has attracted attentions for its significance in preventing catastrophic accidents and guaranteeing sufficient maintenance. A novel fault diagnosis method based on the Ensemble Multi-Fault Features Indexing(EMFFI) approach is proposed for the condition monitoring of gearboxes. Different from traditional methods of signal analysis in the one-dimensional space, this study employs a supervised learning method to determine the faults of a gearbox in a two-dimensional space using the classification model established by training the features extracted automatically from diagnostic vibration signals captured. The proposed method mainly includes the following steps. First, the vibration signals are transformed into a bi-spectrum contour map utilizing bi-spectrum technology,which provides a basis for the following image-based feature extraction. Then, Speeded-Up Robustness Feature(SURF) is applied to automatically extract the image feature points of the bi-spectrum contour map using a multi-fault features indexing theory, and the feature dimension is reduced by Linear Discriminant Analysis(LDA). Finally, Random Forest(RF) is introduced to identify the fault types of the gearbox. The test results verify that the proposed method based on the multi-fault features indexing approach achieves the target of high diagnostic accuracy and can serve as a highly effective technique to discover faults in a gearbox machinery such as a two-stage one. | Min ZHOU Ke WANG Yang WANG Kaiji LUO Hongyong FU Liang SI | 2019 | Chinese Journal of Aeronautics2019，32，5： | 6 |
| 5 | Containment Control of Fractional Order Multi-Agent Systems With Time Delays显示文摘In complex environments, many distributed multiagent systems are described with the fractional-order dynamics.In this paper, containment control of fractional-order multiagent systems with multiple leader agents are studied. Firstly,the collaborative control of fractional-order multi-agent systems(FOMAS) with multiple leaders is analyzed in a directed network without delays. Then, by using Laplace transform and frequency domain theorem, containment consensus of networked FOMAS with time delays is investigated in an undirected network, and a critical value of delays is obtained to ensure the containment consensus of FOMAS. Finally, numerical simulations are shown to verify the results. | Hongyong Yang Fuyong Wang Fujun Han | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，3： | 6 |
| 6 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 7 | Distributed Finite-Time Integral Sliding-Mode Control for Multi-Agent Systems with Multiple Disturbances Based on Nonlinear Disturbance Observers显示文摘This paper proposes a finite-time consensus control algorithm based on nonlinear integral sliding-mode control for second-order multi-agent systems(MASs)with mismatched and matched disturbances.Firstly,a nonlinear finite-time disturbance observer is established to estimate the states and mismatched disturbances of the agent.Secondly,a dynamic integral sliding-mode(ISM)surface is designed by employing the estimates of mismatched disturbances.Then,based on the designed ISM and disturbance observer,the discontinuous or continuous campsite control protocols are respectively developed to guarantee the consensus for MASs in finite time with active anti-disturbance control.Finally,numerical simulation results illustrate the effectiveness of the proposed consensus control algorithm. | YANG Yize LIU Fan YANG Hongyong LI Yuling LIU Yuanshan | 2021 | Journal of Systems Science & Complexity2021，34，3： | 4 |
| 8 | Photodegradation of benzene by TiO_2 nanoparticles prepared by flame CVD process显示文摘Photodegradation of benzene at ppb levels by mixed-phase TiO 2 nanoparticles, synthesized by the oxidation of TiCl 4 in propane/air turbulent flame chemical vapor deposition (CVD) process, is investigated experimentally by using a tubular photoreactor with thin TiO 2 films coated on the reactor wall by sedimentation. Effects of inlet benzene concentration from 10 to 300 g/m 3 , rutile mass fraction from about 20 to 50% and photoluminescence (PL) intensity of TiO 2 nanoparticles on degradation degree are examined under the conditions of 70% relative humidity, 38 g/cm 2 catalyst loading, 24 mW/cm 2 UV irradiation of 254 nm and 5.7 s residence time in the reactor. Based on experimental results, separation of photo-induced electron (e- ) and hole (h + ) pairs by rutile phase is discussed as photo-induced electron (e- ) in anatase phase will migrate to rutile surface due to that the potential of conductive band of rutile is lower than that of anatase, leading to more holes ready on anatase surface for oxidation reactions. | Hongyong Xie Luping Zhu Lingling Wang Shengwen Chen Dandan Yang Lijun Yang Guilan Gao Hao Yuan | 2011 | Particuology2011，9，1： | 3 |
| 9 | RGF1-RGI1,a Peptide-Receptor Complex,Regulates Arabidopsis Root Meristem Development via a MAPK Signaling Cascade显示文摘Root growth is maintained by the continuous division of cells in the apical meristem.ROOT MERISTEM GROWTH FACTOR 1(RGF1)is a critical peptide hormone regulating root stem cell niche maintenance.Previous studies discovered that five closely related leucine-rich repeat receptor-like protein kinases(LRRRLKs),named RGF1 INSENSITIVES(RGIs)or RGF1 RECEPTORS(RGFRs),are able to perceive the RGF1 signal and redundantly control root stem cell niche maintenance.RGF1 regulates root meristem activity mainly via two downstream transcription factors,PLETHORA 1(PLT1)and PLT2.Regulatory proteins connecting cell surface RGF1-RGI1 and nuclear PLTs,however,were not identified.Here,we report that the mitogen-activated protein(MAP)kinase kinase 4(MKK4)and MAP kinase 3(MPK3)were coimmunoprecipitated with RGI1-FLAG after Arabidopsis seedlings were treated with RGF1.Genetic and biochemical assays confirmed that MKK4 and MKK5,and their downstream targets MPK3 and MPK6,are essential RG卜dependent regulators of root meristem development.In addition,we found that the MKK4/MKK5-MPK3/MPK6 module functions downstream of YDA,a MAPKKK.Our results demonstrate that RGF1-RGI1 regulate the expression of PLT1/PLT2 via a YDA-MKK4/MKK5-MPK3/MPK6 signaling cascade. | Xiaoting Lu Hongyong Shi Yang Ou Yanwei Cui Jinke Chang Liang Peng Xiaoping Gou Kai He Jia Li | 2020 | Molecular Plant2020，13，11： | 3 |
| 10 | Consensus of Second- Order Multi - Agent Systems with Exogenous Disturb- ances 显示文摘 | Yang Hongyong Zhang Zhenxing Zhang Siying | 2011 | International Journal of Robust and Nonlinear Control2011，21，9： | 1 |
| 11 | Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages显示文摘Myocardial dysfunction is the most serious complication of sepsis.Sepsis-induced myocardial dysfunction(SMD)is often associated with gastrointestinal dysfunction,but its pathophysiological significance remains unclear.The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD.In mice,knockdown of the gastrin receptor,cholecystokinin B receptor(Cckbr),aggravated lipopolysaccharide(LPS)-induced cardiac dysfunction and increased inflammation in the heart,whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury.Macrophage infiltration plays a significant role in SMD because depletion of macrophages by the intravenous injection of clodronate liposomes,48 h prior to LPS administration,alleviated LPSinduced cardiac injury in Cckbr-deficient mice.The intravenous injection of bone marrow macrophages(BMMs)overexpressing Cckbr reduced LPS-induced myocardial dysfunction.Furthermore,gastrin treatment inhibited toll-like receptor 4(TLR4)expression through the peroxisome proliferator-activated receptor a(PPAR-a)signaling pathway in BMMs.Thus,our findings provide insights into the mechanism of the protective role of gastrin/CCKBR in SMD,which could be used to develop new treatment modalities for SMD. | Dandong Fang Yu Li Bo He Daqian Gu Mingming Zhang Jingwen Guo Hongmei Ren Xinyue Li Ziyue Zhang Ming Tang Xingbing Li Donghai Yang Chunmei Xu Yijie Hu Hongyong Wang Pedro AJose Yu Han Chunyu Zeng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 12 | Consensus of second - order delayed multi - agent systems with leader - following显示文摘 | Yang Hongyong Zhu Xunlin Zhang Siying | 2010 | European Journal of Control2010，16，2： | 1 |
| 13 | Revocable Broadcast Encryption with Constant Ciphertext and Private Key Size显示文摘In a revocable broadcast encryption scheme,the group manager can flexibly set revoked users who cannot decrypt the ciphertext.Many applications of the revocable broadcast encryption have been found in the secure cloud data sharing.An adaptively secure revocable broadcast encryption system with constant ciphertext and private key size under standard assumptions is more suitable for use in the cloud environment.Few existing revocable broadcast encryption schemes meet such a requirement.We propose a revocable broadcast encryption scheme with constant size ciphertext and private key by combining the RSA cryptographic accumulator with an efficient identity based encryption system.We prove it to be adaptively secure under standard assumptions using dual system encryption techniques. | JIA Hongyong CHEN Yue YANG Kuiwu GUO Yuanbo WANG Zhiwei | 2019 | Chinese Journal of Electronics2019，28，4： | 1 |
| 14 | Construction of biorthogonal multiwavelets显示文摘 | Yang Shouzhi Cheng Zhengxing Wang Hongyong | 2002 | J Math Anal Appl2002，276，： | 1 |
| 15 | Preparation and preliminary biological evaluation of ^(99)Tc^m-TADP as bone imaging agent显示文摘TADP, 2-(1H-1,2,4-triazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid, was synthesized by three step reactions from the raw material 1H-1,2,4-triazole. Tcm-TADP was prepared with 5 mg TADP at pH 7.0 by joining 99 99TcmO4 with SnCl2·2H2O in aqueous solution for 10 min at room temperature. Both labeling yield and radiochemical - purity of Tcm-TADP were more than 95%. The biodistribution in rats and bone scan in rabbits were also studied. The 99 uptake of organ was expressed as %ID/g. The results showed that the bone uptake is up to 17.17%ID/g which is the maximum of bone uptake at 30 min after injection of Tcm-TADP in rats, bone-to-muscle and bone-to-blood uptake 99 ratios were 61.32 and 13.21, respectively. The clear bone image of rabbit was obtained at 120 min after injection of 99Tcm-TADP and clearance in soft tissue was visible. The preparation of 99Tcm-TADP was convenient and 99Tcm-TADP exhibited high uptake in bone, and it would be a potential new bone imaging agent. | YAN Xiaohong LUO Shineng NIU Guosai YE Wanzhong YANG Min WANG Hongyong XIA Yongmei | 2008 | Nuclear Science and Techniques2008，19，3： | 1 |
| 16 | Construction of biorthogonal multiwavelets显示文摘 | Yang Shouzhi Cheng Zhengxing Wang Hongyong | 2002 | Journal of Mathematical Analysis and Applications2002，276，1： | 1 |
| 17 | High-order balanced multiwavelets with dilation factor显示文摘 | Yang Shouzhi Wang Hongyong | 2006 | Applied Mathematics and Computation2006，，8： | 1 |
| 18 | An improved approach to calculate the dynamic characteristics of permanent magnetic actuator of vacuum circuit breaker显示文摘 | Liu Fugui Guo Hongyong Yang Qingxin | 2004 | IEEE Transactions on Applied Superconductivity2004，14，2： | 1 |
| 19 | Construction of biorthogonal multiwavelets显示文摘 | YANG Shouzhi CHENG Zhengxing WANG Hongyong | 2002 | J Math Anal Appl2002，276，： | 1 |
| 20 | Consensus of multiagent systems based on disturbance observer显示文摘The objectives of this work are the development and design of disturbance observers (DO’s) for a team of agents that accomplish consensus on agents’ states in the presence of exogenous disturbances. A pinning control strategy is designed for a part of agents of the multiagent systems without disturbances, and this pinning control can bring multiple agents’ states to reaching an expected consensus value. Under the effect of the disturbances, nonlinear disturbance observers are developed for disturbances generated by an exogenous system to estimate the disturbances. Asymptotical consensus of the multiagent systems with disturbances under the composite controller can be achieved. Finally, by applying an example of multiagent systems with switching topologies and exogenous disturbances, the design of the parameters of DO’s are illuminated. | Hongyong YANG 1 , Fucai WANG 2 , Zhenxing ZHANG 3 , Guangdeng ZONG 4 (1.School of Information Science and Engineering, Ludong University, Yantai Shandong 264025, China 2.School of Electronic and Electrical Engineering, Ludong University, Yantai Shandong 264025, China 3.School of Automation, Southeast University, Nanjing Jiangsu 210096, China 4.Institute of Automation, Qufu Normal University, Qufu Shandong 273165, China) | 2010 | 控制理论与应用(英文版)2010，8，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员