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| 1 | Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B显示文摘AIM: To investigate whether there was a relationship between the liver functions and fibrosis scores of hepatitis B patients and their TNF-α, IFN-γ, IL-4, and TGF-β1 serum levels based on the studies of liver biopsies. METHODS: Thirty patients with chronic hepatitis B (CHB)receiving no treatment and 30 healthy individuals with negative hepatitis serology and normal values of liver biochemistry were studied. After serum samples of the patients were collected, liver needle biopsy was performed on each patient. Cytokine levels were studied by ELISA.The biopsy materials were scored based on Knodell's histological activity index.RESULTS: In comparison of cytokine levels between CHB patients and control group, TNF-α, IL-4, and TGF-β1 levels of the patients were higher in CHB patients than in the controls, while IFN-γ level was lower in the patients than in the controls. There were significant differences between the groups in TNF-α, IL-4, TGF-β1, and IFN-γ (P<0.005,0.03, 0.002, 0.0001, respectively). There was a negativecorrelation between TGF-β1 and IL-4 and IFN-γ (P<0.05),TNF-α and the other cytokines and IFN-γ and IL-4 were not correlated (P>0.05). TGF-β1 was correlated with fibrosis (P<0.05). Liver necroinflammatory activity and fibrosis and TNF-α, IL-4, and IFN-γ were not correlated (P>0.05).CONCLUSION: In the course of HBV infection and its chronic progress, cytokines play an important role. IL-4and IFN-γ are effective in the chronic progression, whileTGF-β1 is effective in the development of fibrosis. Serum cytokine levels may be effective tools in the estimation of chronic progression and fibrosis development. | Nusret Akpolat Seyfettin Yahsi Ahmet Godekmerdan Kutbettin Demirbag Mehmet Yalniz | 2005 | World Journal of Gastroenterology2005，11，21： | 46 |
| 2 | Tumors of the spine显示文摘Spine tumors comprise a small percentage of reasons for back pain and other symptoms originating in the spine.The majority of the tumors involving the spinal column are metastases of visceral organ cancers which are mostly seen in older patients.Primary musculoskeletal system sarcomas involving the spinal column are rare.Benign tumors and tumor-like lesions of the musculoskeletal system are mostly seen in young patients and often cause instability and canal compromise.Optimal diagnosis and treatment of spine tumors require a multidisciplinary approach and thorough knowledge of both spine surgery and musculoskeletal tumor surgery.Either primary or metastatic tumors involving the spine are demanding problems in terms of diagnosis and treatment.Spinal instability and neurological compromise are the main and critical problems in patients with tumors of the spinal column.In the past,only a few treatment options aiming short-term control were available for treatment of primary and metastatic spine tumors.Spine surgeons adapted their approach for spine tumors according to orthopaedic oncologic principles in the last 20 years.Advances in imaging,surgical techniques and implant technology resulted in better diagnosis and surgical treatment options,especially for primary tumors.Also,modern chemotherapy drugs and regimens with new radiotherapy and radiosurgery options caused moderate to long-term local and systemic control for even primary sarcomas involving the spinal column. | Mert Ciftdemir Murat Kaya Esref Selcuk Erol Yalniz | 2016 | World Journal of Orthopedics2016，7，2： | 13 |
| 3 | Diuretic effect of frusemide in patients with nephrotic syndrome:is it potentiated by intravenous albumin?显示文摘 | Akcicek F Yalniz T Basci A | 1995 | BMJ1995，310，： | 1 |
| 4 | Diabetes mellitus:a risk factor for pancreatic cancer显示文摘 | Yalniz M Pour PM | 2005 | Langenbecks Arch Surg2005，390，1： | 1 |
| 5 | Clinical reviewof23 patients with tuberculous pertonit is:Presenting features anddiagnosis显示文摘 | Poyraz oglu OK Tim urkaan M Yalniz M | 2008 | J Dig Dis2008，9，3： | 1 |
| 6 | The Levels of Ghrelin, Leptin, TNF- α , and IL-6 in Liver Cirrhosis and Hepatocellular Carcinoma due to HBV and HDV Infection显示文摘 | Huseyin Ataseven Ibrahim Halil Bahcecioglu Nalan Kuzu Mehmet Yalniz Selman Celebi Ahmet Erensoy Bilal Ustundag | 2006 | Mediators of Inflammation2006，，： | 1 |
| 7 | Short term effects of valsartan on portal blood flow in cirrhotic patients显示文摘 | Yalniz M Demir A Arslan A | 2003 | Turk J Gastroenterol2003，14，1： | 1 |
| 8 | Diabetes mellitus:a risk factor for pancreatic cancer显示文摘 | Yalniz M Pour PM | 2005 | Langenbeck Arch Surg2005，390，1： | 1 |
| 9 | A typical tuberculosis of the spine显示文摘 | Yalniz E Pekindil G Aktas S | 2000 | Yonsei Med J2000，41，： | 1 |
| 10 | Correlation between computerized tomographic findings and histopathologic grade/stage in non-alcoholic steatohepatitis 显示文摘 | Ataseven H Yildrim M H Yalniz M | 2003 | J Hepatol2003，38，2： | 1 |
| 11 | Atypical tuberculosis of the spine 显示文摘 | Yalniz E Pekindil G Aktas S | 2000 | Yonsei Med J2000，41，： | 1 |
| 12 | Clinical review of 23 patients with tuberculous peritonitis:presenting features and diagnosis显示文摘 | Poyrazoglu OK Timurkaan M Yalniz M | 2008 | J Dig Dis2008，9，3： | 1 |
| 13 | A typical tuberculosis of the spine 显示文摘 | Yalniz E Pekindil G Akta S | 2000 | Yonsei MED J2000，41，： | 1 |
| 14 | Diabetes mellitus:a risk factor for pancreatic cancer显示文摘 | Yalniz M Pour PM | 2005 | Langenbecks Arch Surg2005，390，1： | 1 |
| 15 | Pancreatic islet cell amy- loidosis manifesting as a large pancreas显示文摘 | Onur MR Yalniz M Poyraz AK | 2012 | Korean Journal of Radiology2012，13，1： | 1 |
| 16 | Clinical review of 23 patients with tuberculous peritonitis: presenting features and diagnosis显示文摘 | Poyrazoglu OK Timurkaan M Yalniz M | 2008 | J Dig Dis2008，9，3： | 1 |
| 17 | Serumadipokine and ghrelin levels in nonalcoholicsteatohepatitis显示文摘 | Yalniz M Bahcecioglu IH Ataseven H UstundagB Ilhan F Poyrazoglu OK Erensoy A | 2006 | Mediators Inflamm2006，，34： | 1 |
| 18 | Clinical re- view of 23 patients with tuberculous peritonitis: presenting features and diagnosis显示文摘 | Poyrazoglu OK Timurkaan M Yalniz M | 2008 | J Dig Dis2008，9，3： | 1 |
| 19 | Atypical tuberculosis of the spine显示文摘 | Yalniz E Pekindil G Aktas S | | 0，，05： | 1 |
| 20 | Short term effects of valsartan on portal blood flow in cirrhotic patients显示文摘 | Yalniz M Demir A Arslan A | 2003 | Turk J Gastroenterol2003，14，1： | 1 |
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