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| 1 | Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese显示文摘Single-nucleotide polymorphisms (SNPs) of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus (T2DM), but there are many conflicting results especially in Chinese populations. To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects. rs16861194 (-11426 A>G) in the putative promoter of ADIPOQ was associated with T2DM (P = 0.007; OR = 1.29, 95% CI 1.08-1.55). None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. There was also no significant difference found from the ADIPOQ haplotype analysis, which contains rs16861194. In addition, we also assessed potential gene-gene interactions in three genes and no interactions were found. In conclusion, our results supported the ADIPOQ gene as a possible risk factor for type 2 diabetes in Han Chinese population. | Yabing Wang Di Zhang Yun Liu Yifeng Yang Teng Zhao Jie Xu Sheng Li Zuofeng Zhang Guoyin Feng Lin He He Xu | 2009 | Journal of Genetics and Genomics2009，36，7： | 7 |
| 2 | Organic photovoltaic cell with 17% efficiency and superior processability显示文摘The development of organic photoactive materials,especially the newly emerging non-fullerene electron acceptors(NFAs),has enabled rapid progress in organic photovoltaic(OPV)cells in recent years.Although the power conversion efficiencies(PCEs)of the top-performance OPV cells have surpassed 16%,the devices are usually fabricated via a spin-coating method and are not suitable for large-area production.Here,we demonstrate that the fine-modification of the flexible side chains of NFAs can yield 17%PCE for OPV cells.More crucially,as the optimal NFA has a suitable solubility and thus a desirable morphology,the high efficiencies of spin-coated devices can be maintained when using scalable blade-coating processing technology.Our results suggest that optimization of the chemical structures of the OPV materials can improve device performance.This has great significance in larger-area production technologies that provide important scientific insights for the commercialization of OPV cells. | Yong Cui Huifeng Yao Ling Hong Tao Zhang Yabing Tang Baojun Lin Kaihu Xian Bowei Gao Cunbin An Pengqing Bi Wei Ma Jianhui Hou | 2020 | National Science Review2020，7，7： | 7 |
| 3 | Is new American Thyroid Association risk classification for hereditary medullary thyroid carcinoma applicable to Chinese patients? A single-center study显示文摘Objective: The American Thyroid Association(ATA) proposed a new risk classification for hereditary medullary thyroid carcinoma(MTC) in 2015. This study aimed to assess whether the new guidelines are suitable for the Chinese population, and reported our experience on prophylactic thyroidectomy.Methods: A total of 73 patients from 22 families were screened as rearranged during transfection(RET) mutation carriers from 2010 to 2016 in Cancer Hospital, Chinese Academy of Medical Science; the medical history for each patient was collected. Based on the initial treatment, we identified the risk factors for poor prognosis by univariate and multivariate logistic regression. Then, 4 RET mutation carriers were enrolled for prophylactic thyroidectomy,and their pathological data and follow-up outcomes were recorded.Results: In univariate and multivariate logistic regression analyses, age at initial surgery and risk classification were significant risk factors for stage Ⅲ/Ⅳ hereditary MTC at initial diagnosis. The likelihood was increased by 11.6% per year of age at initial surgery [95% confidence interval(95% CI), 1.040–1.198; P=0.002). It was 7.888 times more likely to have Ⅲ/Ⅳ stage disease for ATA highest risk patients, compared to ATA moderate risk individuals(95% CI, 1.607–38.717; P=0.003). Postoperative pathological results showed all 4 multiple endocrine neoplasia type 2A(MEN2A) patients had C-cell hyperplasia(CCH); multifocal malignancies were detected in 3 of them. All 4 patients were cured biochemically, and none developed permanent hypoparathyroidism.Conclusions: In Chinese individuals, hereditary MTC aggressiveness is in line with the new ATA risk classification. Germline RET gene mutation carriers should undergo prophylactic thyroidectomy according to basal serum calcitonin levels. | Xiwei Zhang Dangui Yan Junyi Wang Hanfeng Wan Yongxia Zhang Yabing Zhang Yuqin He Wensheng Liu Bin Zhang | 2017 | Chinese Journal of Cancer Research2017，29，3： | 5 |
| 4 | Image of Landscapes in Ancient Water Towns——Case Study on Zhouzhuang and Tongli of Jiangsu Province显示文摘Researchers in several disciplines and fields agree that the image establishing has both perceptual and affec-tive evaluations.The paper comparatively analyzes the image of landscapes in ancient water towns held by 1619 tourists after the investigations of Zhouzhuang and Tongli of Jiangsu Province.Based on the elements of the image of urban landscapes,the perceptual/cognitive image of tourist landscapes in water towns is developed including path,node,landmark,important courtyard,district and edge.Particularly the important courtyard plays the great role on the per-ceptive image of tourists,however,the perceptual/cognitive images of the district and the edge are obviously weak.Meanwhile,the finding showed that the affective images of tourist landscapes in Zhouzhuang differ with those of Tongli by the method of paired comparison.The main reason is that the affective images are influenced by the impressive scenery spots.Furthermore,the commercialization of streets and pollution of rivers are easy to be functioned negatively. | LI Yabing ZHANG Jie CHEN Youjun | 2006 | Chinese Geographical Science2006，16，4： | 4 |
| 5 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 6 | The Main Progress of Perovskite Solar Cells in 2020-2021显示文摘Perovskite solar cells(PSCs)emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from all over the world.Both the efficiency and stability of PSCs have increased steadily in recent years,and the research on reducing lead leakage and developing eco-friendly lead-free perovskites pushes forward the commercialization of PSCs step by step.This review summarizes the main progress of PSCs in 2020 and 2021 from the aspects of efficiency,stability,perovskite-based tandem devices,and lead-free PSCs.Moreover,a brief discussion on the development of PSC modules and its challenges toward practical application is provided. | Tianhao Wu Zhenzhen Qin Yanbo Wang Yongzhen Wu Wei Chen Shufang Zhang Molang Cai Songyuan Dai Jing Zhang Jian Liu Zhongmin Zhou Xiao Liu Hiroshi Segawa Hairen Tan Qunwei Tang Junfeng Fang Yaowen Li Liming Ding Zhijun Ning Yabing Qi Yiqiang Zhang Liyuan Han | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 7 | Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats显示文摘 | Liang Xi Zhiyu Qian Guanglin Xu Shuguo Zheng Sai Sun Na Wen Liang Sheng Yun Shi Yabing Zhang | 2007 | The Journal of Nutritional Biochemistry2007，，1： | 1 |
| 8 | Genetic diversity in the mtDNA control region and population structure in the small yellow croaker Larimichthys polyactis显示文摘 | Yongshuang Xiao Yan Zhang Tianxiang Gao Takashi Yanagimoto Mamoru Yabe Yasunori Sakurai | 2009 | Environmental Biology of Fishes2009，，4： | 1 |
| 9 | Active control of phase change from supercooled water to ice by ultrasonic vibration 显示文摘 | INADA T ZHANG Xu YABE A | 2001 | International Journal of Heat and Mass Transfer2001，44，23： | 1 |
| 10 | Comparative study of the stoichiometric characteristics of karst and non-karst forests in Guizhou, China显示文摘Carbon (C), nitrogen (N), and phosphorous (P) levels and their stoichiometry in plant components (leaves, branch trunks, roots) of trees in a karst forest and non-karst forest are compared. The results show that the C contents, C:N and C:P ratios of dominant species in the karst forest were lower than those in the non-karst forest, but the N and P and the N:P ratio were higher;C:N:P ratios in plant organs of trees in the karst forest were in the order of trunks>roots>branches>leaves. However, C:N:P ratio in the non-karst forest trees were trunks>branches>roots>leaves. Moreover, ratio of C:N:P in trunks was highest and lowest in leaves in both forests. In non-karst forest trees, N:P was in the order of leaves> roots>branches>trunks. There were no significant differences in the ratio of N:P in different plant components of trees in the karst forest. However, in karst and non-karst forest trees, the ratio of N:P in leaves was highest;positive correlations between N and P contents, and N and N:P ratios were observed in both karst and non-karst forests (p<0.001). Negative correlations between P and N:P ratios (p<0.05) were observed in karst forest trees, while positive correlations were observed in non-karst forest trees. | Yabing Zhang Chuanyan Zhou Wenqiang Lv Lihua Dai Jingang Tang Shaoqi Zhou Lihua Huang Anding Li Jianli Zhang | 2019 | Journal of Forestry Research2019，30，3： | 1 |
| 11 | Tumor neoantigens: Novel strategies for application of cancer immunotherapy显示文摘Neoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for treating cancer.The recognition of antigens by immune cells is a crucial step in tumor-specific killing,and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells,making them an attractive therapeutic target.Currently,neoantigens find utility in various domains,primarily in the realm of neoantigen vaccines such as DC vaccines,nucleic acid vaccines,and synthetic long peptide vaccines.Additionally,they hold promise in adoptive cell therapy,encompassing tumor-infiltrating cells,T cell receptors,and chimeric antigen receptors which are expressed by genetically modified T cells.In this review,we summarized recent progress in the clinical use of tumor vaccines and adoptive cell therapy targeting neoantigens,discussed the potential of neoantigen burden as an immune checkpoint in clinical settings.With the aid of state-of-the-art sequencing and bioinformatics technologies,together with significant advancements in artificial intelligence,we anticipated that neoantigens will be fully exploited for personalized tumor immunotherapy,from screening to clinical application. | HANYANG GUAN YUE WU LU LI YABING YANG SHENGHUI QIU ZHAN ZHAO XIAODONG CHU JIASHUAI HE ZUYANG CHEN YIRAN ZHANG HUI DING JINGHUA PAN YUNLONG PAN | 2023 | Oncology Research2023，31，4： | 1 |
| 12 | Active control of phase change from supercooled water to ice by ultrasonic vibration 1 control of freezing temperature 显示文摘 | Nada T Zhang X Yabe A | 2001 | International Journal of Mass Transfer2001，44，23： | 1 |
| 13 | Active control of phase change from super cooled water to ice by ultrasonic vibration显示文摘 | Inada T Zhang X Yabe A | 2001 | International Journal of Heat and Mass Transfer2001，44，23： | 1 |
| 14 | Active Control of Phase Change from Supercooled Water to Ice by Ultrasonic Vibration Control of Freezing Temperature显示文摘 | INADA T ZHANG X YABE A | 2001 | International Journal of Heat and Mass Transfer2001，44，12： | 1 |
| 15 | The involvement of hepa-ran sulfate(HS)in FGF1/HS/FGFR1signaling tomplex显示文摘 | Wu ZL Zhang L Yabe T | 2003 | Biol Chem2003，278，17： | 1 |
| 16 | Active control of phase change from supercooled water to ice by ultrasonic vibration 1显示文摘 | Inada T Zhang X Yabe A | 2001 | International Journal of Heat and Mass Transfer2001，，44： | 1 |
| 17 | Active control of phase change from supercooled water to ice by ultrasonic vibration 2显示文摘 | Zhang X Inada T Yabe A | 2001 | International Journal of Heat and Mass Transfer2001，，44： | 1 |
| 18 | Registra- tion of images with affine geometric distortion based on maximally stable extremal regions and phase congruen- cy显示文摘 | ZHANG Qing WANG Yabing WANG Lin | 2015 | Image and Vision Computing2015，36，12： | 1 |
| 19 | Statistical study of “trunk-like” heavy ion structures in the inner magnetosphere显示文摘We present a statistical study of“trunk-like”structures observed in He+and O+in the inner magnetosphere.The main characteristic of these structures is that the energy of the peak flux decreases earthward.Using observations from the Helium Oxygen Proton Electron(HOPE)instrument onboard Van Allen Probe A,we identify the trunks observed from November 2012 to June 2019 and obtain the universal time,L shell,magnetic local time(MLT),and energy information of each trunk’s root and tip.We then investigate the behavior of trunks in terms of their frequency of occurrence,temporal evolution,spatial and energy distribution,and trunk dependence on different geomagnetic indices.We find that(1)the trunks are always located at L=1.5−4.0 and have a preferential location mainly concentrated at MLT=18−24,(2)the sector within MLT=14−16 is a forbidden zone without trunk roots,and(3)the energy of He+ trunks is the largest near dusk and gradually decreases in the counterclockwise direction,whereas the energy of O+ trunks is relatively evenly distributed with MLT and L.The differences between He+ and O+ trunks are probably due to the different charge exchange and Coulomb collision lifetime.The dependence on different geomagnetic indices indicates that the trunk structures occur more frequently during relatively quiet periods. | Hao Zhang YaBing Wang JianYong Lu | 2022 | Earth and Planetary Physics2022，6，4： | 0 |
| 20 | Identification of floral fragrance components in an F_(1) population derived from Paeonia ostii 'Fengdan' × P. suffruticosa 'Chunguihuawu' Cross显示文摘Tree peony(Paeonia suffruticosa Andr.)is a unique aromatic plant famous for its huge flowers,bright colors and strong fragrance,having high ornamental,medicinal,and edible value.Research on tree peony's flower fragrance has mainly focused on the comparative analysis among its varieties,leaving the inheritance of aroma compounds in this plant an overlooked area of study.Here,the volatile components of flowers at three different flowering stages of the light fragrance-type cultivar P.ostii'Fengdan'and the strong fragrance-type cultivar P.suffruticosa'Chunguihuawu',as well as the half-opening stage flowers of 109 F_(1) progeny,were collected and characterized in-depth by dynamic headspace sampling technique combined with gas chromatography-mass spectrometry(GC-MS).Diverse profiles of volatiles that included alcohols,esters,aldehydes,terpenes,benzenes,and hydrocarbons were identified from the evaluated accessions.These results revealed that the volatile components and content of parents were significantly different,and that hybridization generated more complex volatile components.Most volatile compounds in the hybrids,especially the main aromatic components,existed in at least one of the parents,being characterized by intermediate or transgressive inheritance for the floral trait;this demonstrated that volatile compounds can be inherited from parents to progeny.Further,seven de novo aroma compounds—those present in progeny yet absent in their parents—were found in progeny.This study preliminarily clarified the segregation performance of aroma traits in tree peony hybrids,which might provide a theoretical basis for selecting breeding parents and the breeding of new varieties for aroma traits. | Tongfei Niu Chenjie Zhang Can Wang Xian Xue Yabing Zhang Lili Guo Xiaogai Hou | 2022 | Ornamental Plant Research2022，2，1： | 0 |
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