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| 1 | Using balance of seasonal herbage supply and demand to inform sustainable grassland management on the Qinghai–Tibetan Plateau显示文摘To mitigate the impacts of grassland degradation on the Qinghai–Tibetan Plateau(QTP), in recent decades China has been implementing large-scale conservation programs and has invested about 42 billion CNY(7 billion USD). However, these programs are faced with major challenges involving trade-offs between ecological function, livestock production and income of pastoralists.Scientific assessments, as well as technical and policy issues, have not fully captured the complex ecological,social and economic dynamics of the challenges facing grassland management on the QTP. Pastoral livestock production on the QTP is characterized by imbalance in both quality and quantity between livestock seasonal nutrient requirements and herbage production, which forces pastoralists to keep larger numbers of livestock for longer periods, leading to overgrazing. To solve these problems, an integrated crop-livestock system is promoted to improve the efficiency of livestock production and conserve natural grassland as well for a sustainable system for the QTP. | Xinquan ZHAO Liang ZHAO Qi LI Huai CHEN Huakun ZHOU Shixiao XU Quanmin DONG Gaolin WU Yixin HE | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 11 |
| 2 | Construction of heparin-based hydrogel incorporated with Cu_(5.4)O ultrasmall nanozymes for wound healing and inflammation inhibition显示文摘Excessive production of inflammatory chemokines and reactive oxygen species(ROS)can cause a feedback cycle of inflammation response that has a negative effect on cutaneous wound healing.The use of wound-dressing materials that simultaneously absorb chemokines and scavenge ROS constitutes a novel‘weeding and uprooting’treatment strategy for inflammatory conditions.In the present study,a composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol(starPEG)and heparin for chemokine sequestration as well as Cu_(5.4)O ultrasmall nanozymes for ROS scavenging(Cu_(5.4)O@Hep-PEG)was developed.The material effectively adsorbs the inflammatory chemokines monocyte chemoattractant protein-1 and interleukin-8,decreasing the migratory activity of macrophages and neutrophils.Furthermore,it scavenges the ROS in wound fluids to mitigate oxidative stress,and the sustained release of Cu_(5.4)O promotes angiogenesis.In acute wounds and impaired-healing wounds(diabetic wounds),Cu_(5.4)O@Hep-PEG hydrogels outperform the standard-of-care product Promogram®in terms of inflammation reduction,increased epidermis regeneration,vascularization,and wound closure. | Yuan Peng Danfeng He Xin Ge Yifei Lu Yuanhao Chai Yixin Zhang Zhengwei Mao Gaoxing Luo Jun Deng Yan Zhang | 2021 | Bioactive Materials2021，6，10： | 7 |
| 3 | High-average-power, high-repetition-rate tunable terahertz difference frequency generation with GaSe crystal pumped by 2 μm dual-wavelength intracavity KTP optical parametric oscillator显示文摘We have demonstrated a high-average-power,high-repetition-rate optical terahertz(THz)source based on difference frequency generation(DFG)in the GaSe crystal by using a near-degenerate 2μm intracavity KTP optical parametric oscillator as the pump source.The power of the 2μm dual-wavelength laser was up to 12.33 W with continuous tuning ranges of 1988.0–2196.2 nm/2278.4–2065.6 nm for two waves.Different GaSe cystal lengths have been experimentally investigated for the DFG THz source in order to optimize the THz output power,which was in good agreement with the theoretical analysis.Based on an 8 mm long GaSe crystal,the THz wave was continuously tuned from 0.21 to 3 THz.The maximum THz average power of 1.66μW was obtained at repetition rate of 10 kHz under 1.48 THz.The single pulse energy amounted to 166 pJ and the conversion efficiency from 2 μm laser to THz output was 1.68×10^(-6).The signal-to-noise ratio of the detected THz voltage was 23 dB.The acceptance angle of DFG in the GaSe crystal was measured to be 0.16°. | DEXIAN YAN YUYE WANG DEGANG XU PENGXIANG LIU CHAO YAN JIA SHI HONGXIANG LIU YIXIN HE LONGHUANG TANG JIANCHEN FENG JIANQIN GUO WEI SHI KAI ZHONG YUEN H.TSANG JIANQUAN YAO | 2017 | Photonics Research2017，5，2： | 5 |
| 4 | β-catenin activation in hair follicle dermal stem cells in duces ectopic hair outgrowth and skin fibrosis显示文摘Hair follicle dermal sheath(DS)harbors hair follicle dermal stem cells(hfDSCs),which can be recruited to replenish DS and dermal papilla(DP).Cultured DS cells can differentiate into various cell lineages in vitro.However,it is unclear how its plasticity is modulated in vivo.Wnt/β-catenin signaling plays an important role in maintaining stem cells of various lineages and is required for HF development and regeneration.Here we report that activation ofβ-catenin in DS generates ectopic HF outgrowth(EF)by reprogramming HF epidermal cells and DS cells themselves,and endows DS cells with hair inducing ability.Epidermal homeostasis of pre-existing HFs is disrupted.Additionally,cell-autonomous progressive skin fibrosis is prominent in dermis,where the excessive fibroblasts largely originate from DS.Gene expression analysis of purified DS cells with activatedβ-catenin revealed significantly increased expression of Bmp,Fgf,and Notch ligands and administration of Bmp,Fgf,or Notch signaling inhibitor attenuates EF formation.In summary,our findings advance the current knowledge of high plasticity of DS cells and provide an insight into understanding how Wnt/β-catenin signaling controls DS cell behaviors. | Yixin Tao Qingchun Yang Lei Wang Jie Zhang Xuming Zhu Qianqian Sun Yunbin Han Qian Luo Yushu Wang Xizhi Guo Ji Wu Baojie Li Xiao Yang Lin He Gang Ma | 2019 | Journal of Molecular Cell Biology2019，11，1： | 4 |
| 5 | Intestinal OCTN2-and MCT1-targeted drug delivery to improve oral bioavailability显示文摘Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs,thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.In particular,intestinal carnitine/organic cation transporter 2(OCTN2)and mono-carboxylate transporter protein 1(MCT1)possess high transport capacities and complementary distributions.Therefore,we outline recent developments in transporter-targeted oral drug delivery with regard to the OCTN2 and MCT1 proteins in this review.First,basic information of the two transporters is reviewed,including their topological structures,characteristics and functions,expression and key features of their substrates.Furthermore,progress in transporter-targeting prodrugs and nanoparticles to increase oral drug delivery is discussed,including improvements in the oral absorption of anti-inflammatory drugs,antiepileptic drugs and anticancer drugs.Finally,the potential of a dual transporter-targeting strategy is discussed. | Gang Wang Lichun Zhao Qikun jiang Yixin Sun Dongyang Zhao Mengchi Sun Zhonggui He Jin sun Yang Wang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 3 |
| 6 | The adsorption properties of NaY zeolite for separation of ethylene glycol and 1,2-butanediol: Experiment and molecular modelling显示文摘The separation of ethylene glycol(EG)and 1,2-butanediol(1,2-BDO)azeotrope in the synthesis process of EG via coal and biomass is becoming of increasing commercial and environmental importance.Selective adsorption is deemed as the most promising methods because of energy saving and environment favorable.In this paper,NaY zeolite was used to separate 1,2-BDO from EG,and its adsorption properties was then investigated.The isotherms of EG and 1,2-BDO in vapor and liquid phases from 298 to 328 K indicated that they fitted Langmuir model quite well,and the NaY zeolite absorbent favored EG more than 1,2-BDO.The Grand Canonical Monte Carlo(GCMC)and molecular dynamics(MD)simulation techniques were conducted to investigate the competition adsorption and diffusion characteristics in different adsorption regions.It was observed that EG and 1,2-BDO molecules all have the most probable locations of the center of the 12-membered ring near the Na cations.The diffusivities of EG are lower than those of 1,2-BDO at the same adsorption concentration.At last,the breakthrough curves of the binary mixture regressed from the empirical Dose–Response model in fixed-bed column showed that the adsorption selectivity of EG could reach to as high as 2.43,verified that the NaY zeolite could effectively separate EG from 1,2-BDO.This work is also helpful for further separation of other dihydric alcohol mixtures from coal and biomass fermentation. | Pei Xiong Peng He Yixin Qu Liguo Wang Yan Cao Shuang Xu Jiaqiang Chen Muhammad Ammar Huiquan Li | 2021 | Green Energy & Environment2021，6，1： | 3 |
| 7 | Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy显示文摘Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia(AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor(G-CSF)(low-dose chemotherapy(LDC)/G-CSF). Complete response(CR) after two induction courses was attained in 87.0%(40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy(SDC) for induction(80/94(85.1%) of the patients attained CR after induction Ⅱ, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free(67.4 vs. 70.7%;P = 0.99)and overall(70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell(WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC(11.5 vs. 18.5 d for WBCs(P < 0.001);15.5 vs. 22.0 d for platelets(P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF(n = 9) or SDC(n = 11), all of the mutations were below the reference value(variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML. | Yixin Hu Aili Chen Xinchang Zheng Jun Lu Hailong He Jin Yang Ya Zhang Pinpin Sui Jingyi Yang Fuhong He Yi Wang Peifang Xiao Xin Liu Yinmei Zhou Deqing Pei Cheng Cheng Raul C. Ribeiro Shaoyan Hu Qian-fei Wang | 2019 | National Science Review2019，6，3： | 3 |
| 8 | Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 是世界范围的致命的肝恶意。在这研究,我们报导了那个蛋白质磷酸酶镁依赖者(PPM1D ) 1 高度在 HCC 案例(约 59%) 的多数被表示并且显著地把水平与高浆液 -fetoprotein (法新社) 联系了(P = 0.044 ) 。Kaplan- Meier 和考克斯回归数据显示 PPM1D overexpression 是 HCCspecific 全面幸存的一个独立预言者(HR, 2.799;95% CI, 1.346-5.818, P = 0.006 ) 。, Overexpressing PPM1D 支持了房间生存能力和侵略 RNA 调停干扰 PPM1D 击倒有教养的 HCC 房间的禁止的增长,侵略,和移植。另外,由小介入 RNA 的 PPM1D 抑制减少了在 vivo 的 HCC 房间的 tumorigenicity。总的来说,结果建议 PPM1D 为 HCC 是一个潜在的预示的标记和治疗学的目标。 | Zhi Xu Chunxiang Cao Haiyan Xia Shujing Shi Lingzhi Hong Xiaowei Wei Dongying Gu Jianmin Bian Zijun Liu Wenbin Huang Yixin Zhang Song He Nikki Pui-Yue Lee Jinfei Chen | 2016 | Frontiers of Medicine2016，10，1： | 3 |
| 9 | Electrical and Optical Properties of Nano Aluminum Film/Particle Structure显示文摘The electrical and optical effects of particles on the nano aluminum film deposited by thermal evaporation was investigated. From the characterization results of scanning electron microscope(SEM), the accumulation in tens of nanometers had been observed. The current-voltage(I-V) curve of the sample indicates its nonlinear electrical characters expecting the corresponding nonlinear optical properties. By the theoretical calculation, nonlinear conduction of the carrier transportation may result from the barrier-well-barrier structure, where negative resistance and Coulomb blockade effect appears. The simulation results are approximately matched with the experimental results. By testing the fluorescence emission spectrum of the sample, peaks were found to be located at 420 and 440 nm. In addition, the full width at half maximum(FWHM) had been obviously broadened by means of adding 2, 5-diphenyloxazole(DPO). Therefore, discrete energy levels could be estimated inside those particles. | 孟庆云 LI Siqi KANG Yixin ZHAI Xiaoyu WEI Sitao HE Huimei 王云 殷子文 | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，5： | 2 |
| 10 | Synergistic effect of EMS1-shRNA and sorafenib on proliferation, migration, invasion and endocytosis of SMMC-7721显示文摘 | Jiaming Zhou Li Chen Yixin Zhang Yuanyuan Wu Guilan Wang Song He Zhongying Guo Yingze Wei | 2014 | Journal of Molecular Histology2014，，： | 1 |
| 11 | Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma显示文摘 | Guofen Yang Weipeng He Muyan Cai Fei Luo Hsiangfu Kung Xinyuan Guan Yixin Zeng Dan Xie | 2011 | International Journal of Gynecological Cancer2011，，3： | 1 |
| 12 | Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma显示文摘 | Guofen Yang Weipeng He Muyan Cai Fei Luo Hsiangfu Kung Xinyuan Guan Yixin Zeng Dan Xie | 2011 | International Journal of Gynecological Cancer2011，，3： | 1 |
| 13 | Chaperonin containing TCP 1, subunit 8 ( CCT 8) is upregulated in hepatocellular carcinoma and promotes HCC proliferation显示文摘 | Xiaodong Huang Xingxiu Wang Chun Cheng Jing Cai Song He Hua Wang Fang Liu Changlai Zhu Zongmei Ding Xianting Huang Tianyi Zhang Yixin Zhang | 2014 | APMIS2014，，11： | 1 |
| 14 | Forum on frontiers of science and technology:Lifeomics and translational medicine显示文摘The Chinese Academy of Sciences held its 7th forum on frontiers of Science and Technology,April 12-13,2012,in the academy hall of the Chinese Academy of Sciences.The Forum was organized by the Life Science and Medicine Division and co-organized by Academy of Military Medical Sciences and Science China Press.The theme of the 7th Forum was 'Lifeomics and Translational Medicine',and the purpose was to discuss the significance of lifeomics(i.e., | QIANG BoQin HE FuChu ZENG YiXin | 2013 | Science China(Life Sciences)2013，56，3： | 1 |
| 15 | An Imaging Compounding Parabolic Concentrator 显示文摘 | HE Kaiyan ZHENG Hongfei LIU Yixin | 2007 | Proceeding of ISES Solar World Congress2007，2，： | 1 |
| 16 | Study on Intervention of Blood Sugar and Blood Lipid in Diabetic Mice by Abrus Cantoniensis and Armeniaca mume Sieb and Their Compatibility显示文摘Objective:The study aims to explore the interventional effect of Abrus cantonensis and Armeniaca mume Sieb and their compatibility on blood glucose and blood lipid in diabetic mice and to explore the optimal ratio of efficacy of their compatibility.Methods:SPF Kunming male mice were fed with high sugar and high fat diet for 6 weeks and then intraperitoneally injected with STZ solution to establish a diabetes model.The successfully modeled mice were randomly divided into 6 groups according to their body weight:model group,Abrus Cantoniensis group,Armeniaca mume Sieb group,as well as Abrus Cantoniensis and Armeniaca mume Sieb group divided into 1:2,1:1 and 2:1 groups according to volume ratio with 10 mice in each group.Another 10 healthy mice were taken as blank group and intraperitoneally injected with sodium citrate buffer.The corresponding solution was given intragastric administration by body mass once a day for 20 days.After the last administration,fasting was performed for 12 hours.Serum was collected by the method of eyeball blood collection to determine the contents of fasting blood glucose,total cholesterol Triacylglycerol,triglyceride,low density lipoprotein and high-density lipoprotein.Results:Compared with Abrus Cantoniensis and Armeniaca mume Sieb groups,Glu,TG,TC and LDL-C of the three compatibility groups significantly decreased,with the most significant decrease in the compatibility group 1:2,while there was no significant difference in HDL-C among all groups.Conclusion:Abrus Cantoniensis and Armeniaca mume Sieb and their combination have synergistic effects on the improvement of blood glucose and lipid levels in mice with high glucose and high fat combined with STZ-induced diabetes mellitus model.Among all the experimental groups,the compatibility 1:2 group had the best effect. | Yixin Zhang Shibo Zhao Sitong Lu Danni Lu Yedong Shen Changhuan He Zhonggang Wu Suoyi Huang | 2021 | TMR Pharmacology Research2021，1，4： | 1 |
| 17 | An imaging com- pounding parabolic concentrator 显示文摘 | He Kaiyan Zheng Hongfei Liu Yixin | 2007 | ISES Solar World Congress2007，2，3： | 1 |
| 18 | Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population显示文摘 | Jiang Chang Ying Huang Lixuan Wei Baoshan Ma Xiaoping Miao Yun Li Zhibin Hu Dianke Yu Weihua Jia Yu Liu Wen Tan Zhonghu He Yang Ke Tangchun Wu Hongbing Shen Yixin Zeng Chen Wu Dongxin Lin | 2013 | Carcinogenesis2013，，8： | 1 |
| 19 | AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma显示文摘Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma(HCC)in individuals infected with the hepatitis virus.However,the molecular pathways leading to its bioactivation and subsequent toxicity in hepatocytes have not been well-defined.Here,we carried out a genome-wide CRISPR-Cas9 genetic screen to identify aflatoxin B1(AFB1)targets.Among the most significant hits was the aryl hydrocarbon receptor(AHR),a ligand-binding transcription factor regulating cell metabolism,differentiation,and immunity. | Qing Zhu Yarui Ma Junbo Liang Zhewen Wei Mo Li Ying Zhang Mei Liu Huan He Chunfeng Qu Jianqiang Cai Xiaobing Wang Yixin Zeng Yuchen Jiao | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 20 | Multi-Modal Domain Adaptation Variational Autoencoder for EEG-Based Emotion Recognition显示文摘Traditional electroencephalograph(EEG)-based emotion recognition requires a large number of calibration samples to build a model for a specific subject,which restricts the application of the affective brain computer interface(BCI)in practice.We attempt to use the multi-modal data from the past session to realize emotion recognition in the case of a small amount of calibration samples.To solve this problem,we propose a multimodal domain adaptive variational autoencoder(MMDA-VAE)method,which learns shared cross-domain latent representations of the multi-modal data.Our method builds a multi-modal variational autoencoder(MVAE)to project the data of multiple modalities into a common space.Through adversarial learning and cycle-consistency regularization,our method can reduce the distribution difference of each domain on the shared latent representation layer and realize the transfer of knowledge.Extensive experiments are conducted on two public datasets,SEED and SEED-IV,and the results show the superiority of our proposed method.Our work can effectively improve the performance of emotion recognition with a small amount of labelled multi-modal data. | Yixin Wang Shuang Qiu Dan Li Changde Du Bao-Liang Lu Huiguang He | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 1 |
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