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| 1 | The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells显示文摘几研究证明了有自然产品和化疗代理人的联合治疗能改进化疗代理人的 sensitivityand cytotoxicity。Resveratrol,一个自然产品,包括 antitumor andantiviral 活动,以及脉管的保护的效果有许多生物效果。这研究的目的是与 cisplatin 和涉及 A549 房间的潜在的 anticancer 机制在联合调查 resveratrol 的 synergistic anticancereffect。从数 Kit-8 和 isobolographic 分析的房间的 resultsobtained 表明了 resveratrol 和 cisplatin resultedin synergistic 的那联合在 A549 房间的细胞毒素的效果。从染色的 Hoechst 的结果,流动 cytometry 和西方的污点分析 suggestedthat resveratrol 提高了调停 cisplatin 的 apoptosis。同时, LC3-II 和 P62 层次和在有 cisplatin 的联合的 resveratrol 触发了的 autophagosomesuggested 的形成的变化 autophagy。更重要地,由 3-methyladeninemarkedly 禁止 autophagy 稀释了 resveratrol 和 cisplatin 的联合在 A549 房间引起的 apoptosis。一起拿,我们的 studyprovides resveratrol synergistically 与 cisplatin 相结合的第一条证据在 A549 房间经由 modulating autophagiccell 死亡导致 apoptosis。这些调查结果也帮助我们在肺癌症与 chemotherapyagents 在联合理解自然产品的角色。 | Song Hu Xiaolin Li Rongrong Xu Lingyun Ye Hui Kong Xiaoning Zeng Hong Wang Weiping Xie | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 9 |
| 2 | Surface crack imaging based on delayed temperature difference at symmetric points by laser spot thermography显示文摘Laser spot thermography is a novel technique for the detection of surface cracks with a laser to heat sample locally and with an IR camera to record the surface temperature distribution. Common methods to characterize cracks are only suitable for the situation that the laser scanning path is vertical to the crack. But due to the randomness of cracks,when the scanning path is parallel to the crack,surface cracks cannot be detected by these methods. To tackle this problem,a method is presented which is suitable for the situation that the scanning path is parallel to crack. The main idea is to evaluate the crack-caused asymmetries of the surface temperature distribution. The effect of temperature gradient and the maximum scanning interval are analyzed by a 2D simulation. A new crack imaging technique is presented that is based on delayed temperature difference at symmetric points to characterize the crack in the thermal image. Compared well with those obtained by the spatial first derivative method,experimental results are shown to efficiently prove this method. | WANG Xiaona WANG Xiaoning HOU Dexin YE Shuliang | 2014 | Instrumentation2014，1，2： | 5 |
| 3 | The compensatory phenomenon of the functional connectome related to pathological biomarkers in individuals with subjective cognitive decline显示文摘Background Subjective cognitive decline(SCD)is a preclinical stage along the Alzheimer’s disease(AD)continuum.However,little is known about the aberrant patterns of connectivity and topological alterations of the brain functional connectome and their diagnostic value in SCD.Methods Resting-state functional magnetic resonance imaging and graph theory analyses were used to investigate the alterations of the functional connectome in 66 SCD individuals and 64 healthy controls(HC).Pearson correlation analysis was computed to assess the relationships among network metrics,neuropsychological performance and pathological biomarkers.Finally,we used the multiple kernel learning-support vector machine(MKL-SVM)to differentiate the SCD and HC individuals.Results SCD individuals showed higher nodal topological properties(including nodal strength,nodal global efficiency and nodal local efficiency)associated with amyloid-βlevels and memory function than the HC,and these regions were mainly located in the default mode network(DMN).Moreover,increased local and medium-range connectivity mainly between the bilateral parahippocampal gyrus(PHG)and other DMN-related regions was found in SCD individuals compared with HC individuals.These aberrant functional network measures exhibited good classification performance in the differentiation of SCD individuals from HC individuals at an accuracy up to 79.23%.Conclusion The findings of this study provide insight into the compensatory mechanism of the functional connectome underlying SCD.The proposed classification method highlights the potential of connectome-based metrics for the identification of the preclinical stage of AD. | Haifeng Chen Xiaoning Sheng Caimei Luo Ruomeng Qin Qing Ye Hui Zhao Yun Xu Feng Bai 无 | 2020 | Translational Neurodegeneration2020，9，2： | 5 |
| 4 | Rigid-Plastic Dynamic Response of Reinforced Concrete Bridge Pier Impacted by Automobile显示文摘Bridge piers are impacted by autos sometimes. The pier usually has not been destroyed after once impact by auto. But there are few research on damage which will affect pier's capability, and most relative studies have focused the problems on piers impacted by vessels. The methods involve mainly sutra experience theory, numerical analysis, and experimental method. Owing to the complicacy of the bridge pier impacted by a vessel, there are few research derived with the sutra mechanics model and the piers impacted by autos. The dynamic response is studied here under the assumption of the rigid-plastic small-deformation for the pier impacted by auto. According to the Parkes beam model, the rigid-plastic theoretical solution is deduced. The final deformation is calculated by a practical example for the pier impacted by auto. | ZHENG Xiaoning DIAO Bo YE Yinghua | 2006 | Transactions of Tianjin University2006，12，B09： | 4 |
| 5 | Study on the microstructure of 12%chromium low carbon stainless steel in a high temperature heat-affected zone显示文摘Coarsening,embrittlement and corrosion sensitization in a high temperature heat-affected zone(HTHAZ) are the major problems when 12%chromium low carbon stainless steel is being welded,which induce the deterioration of the impact toughness at a low temperature and intergranular corrosion resistance property.This study investigates the corresponding microstructures in HTHAZ with different chemical compositions and heat inputs through thermal simulation tests.The results show that the martensite content increases with the descending of ferrite factor(FF) when FF is below 9.0 and heat input influences the microstructure of high FF steel in HTHAZ.Martensite of 12%Cr stainless steel in HTHAZ with only Nb stabilization reticularly distributes at ferrite grain boundaries. | ZHENG Huaibei YE Xiaoning WANG Baosen JIANG Laizhu LIU Zhenyu WANG Guodong | 2010 | Baosteel Technical Research2010，4，1： | 4 |
| 6 | Colonic expression of Runx3 protein and TGF-β_1 and their correlation in patients with irritable bowel syndrome显示文摘Objective:To investigate the role of Runx3 protein and TGF-β1 in the pathogenesis of irritable bowel syndrome(IBS),as well as the correlation of these two proteins.Methods:Colonic tissue was collected from patients with IBS and normal persons.The colonic expression of Runx3 protein and TGF-β1 was detected with immunohislochemistry method.Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.Results:Compared with their counterparts,patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β1(P>0.05).Interestingly,there was a significant correlation between Runx3 protein and TGF-β1 in patients with IBS(P<0.05).Conclusions:The role of Runx3 protein and TGF-β1 in the pathogenesis of IBS remains to be further studied. | Xiaoning Sun Cheng Lan Yu An Ye Sun | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 2 |
| 7 | Neutron irradiation-induced effects on the reliability performance of electrochemical metallization memory devices显示文摘In this work,electrochemical metallization memory(ECM)devices with an Ag/AgInSbTe(AIST)/amorphous carbon(a-C)/Pt structure were irradiated with 14 MeV neutrons.The switching reliability performance before and after neutron irradiation was compared and analyzed in detail.The results show that the irradiated memory cells functioned properly,and the initial resistance,the resistance at the low-resistance state(LRS),the RESET voltage and the data retention performance showed little degradation even when the total neutron fluence was as high as 2.5×1011 n/cm2.Other switching characteristics such as the forming voltage,the resistance at the high-resistance state(HRS),and the SET voltage were also studied,all of which merely showed a slight parameter drift.Irradiation-induced Ag ions doping of the a-C layer is proposed to explain the damaging effects of neutron irradiation.The excellent hard characteristics of these Ag/AIST/a-C/Pt-based ECM devices suggest potential beneficial applications in the aerospace and nuclear industries. | Ye Tao Xuhong Li Zhongqiang Wang Gang Li Haiyang Xu Xiaoning Zhao Ya Lin Yichun Liu | 2021 | Journal of Semiconductors2021，42，1： | 2 |
| 8 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 9 | Effect of initial fluid resuscitation on subsequent treatment in uncontrolled hemorrhagic shock in rats 显示文摘 | XiaoN Wang XC Diao YE | 2004 | Shock2004，21，3： | 1 |
| 10 | Wide - band e - shaped patch antennas of wireless communication 显示文摘 | YANG F ZHANG Xuexia YE Xiaoning | 2011 | IEEE Transactions on Antennas and Propagation2011，49，7： | 1 |
| 11 | Cloning, expression, purification, and characterization of a glutamate-specific endopeptidase from Bacillus licheniformis显示文摘 | Wei Ye Jingwen Liu Haiying Wang Jufang Wang Xiaoning Wang | 2011 | Protein Expression and Purification2011，，1： | 1 |
| 12 | Effect of carbon content on mierostructure and mechanical properties of hot-rolled low carbon 12Cr-Ni stainless steel显示文摘 | Zheng Huaibei Ye Xiaoning Li Jiadong | 2010 | Material Science and Engineering A2010，527，： | 1 |
| 13 | Study on microstructure of low carbon 12% chromium stainless steel in high temperature heat-affected zone 显示文摘 | Zheng Huaibei Ye Xiaoning Jiang Laizhu | 2010 | Materials and Design2010，31，10： | 1 |
| 14 | Study on microstructure of low carbon 12% chromium stainless steel in high temperature heat-affected zone显示文摘 | Zheng Huaibei Ye Xiaoning Jiang Laizhu | 2010 | Materials and Design2010，31，10： | 1 |
| 15 | Signal integrity design for high- speed digital circuits: progress and directions 显示文摘 | FAN Jun YE Xiaoning KIM Jingook | 2010 | IEEE Transactions on Electromagnetic Compatibility2010，52，2： | 1 |
| 16 | Wide-Band E-shaped Patch Antennas for Wireless Communications显示文摘 | Yang Fng Zhang Xuexia Ye Xiaoning | 2001 | IEEE Trans on Antenna and Propagation2001，49，7： | 1 |
| 17 | Wide-band e-shaped patch antennas of wireless communication显示文摘 | Yang F Zhang Xuexia Ye Xiaoning etal | 2011 | IEEETransactions on Antennas and Propagation2011，49，7： | 1 |
| 18 | Wide- band e- shaped patch antennas for wireless communications 显示文摘 | YANG Fan ZHANG Xuexia YE Xiaoning | 2001 | IEEE Transactions on Antennas and Propagation2001，49，7： | 1 |
| 19 | Signal integrity design for high-speed digital circuits: progress and directions 显示文摘 | FAN Jun YE Xiaoning KIM Jingook | 2010 | IEEE Transactions on Electromagnetic Compatibility2010，52，2： | 1 |
| 20 | Signal integrity Design for Hign-Speed Digital Circuits:Progress and Directions显示文摘 | Jun Fan Xiaoning Ye Jingook Kim | 2010 | Electronmagnetec Compatibility2010，52，2： | 1 |
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