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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | The geochemical characteristics,geochronology and tectonic significance of the Carboniferous volcanic rocks of the Santanghu area in northeastern Xinjiang,China显示文摘The Santanghu area is located on the northeastern margin of the Junggar Basin,northern Xinjiang,Northwest China.The Carboniferous volcanic rocks in this area are widely distributed in Kaokesaiergaishan,Santanghu,Daheishan and Naomaohu districts,which are located to the north of the Kalameili Fault.These rocks,sourced from a cognate magma,consist of basic,intermediate,and acidic lavas,and pyroclastic rock.The basic volcanic rocks are enriched with large-ion lithophile elements(LILE),but are relatively depleted in high field strength elements(HFSE),and have an obvious negative Nb-Ta-Ti anomaly.They were most probably derived from a depleted mantle source,and during their ascent,these magmas were not contaminated by the crustal material as they underwent magma crystallization differentiation.Based on the Carboniferous volcanic assemblage and geochemical data,it is apparent that the early Carboniferous volcanism occurred in a subduction-related tectonic setting.New LA-ICP-MS zircon U-Pb analyses constrain the age of the andesite within the volcanic rocks as the early Carboniferous(328.9-331.3 Ma).Combined with the regional geological record,comprehensive analysis of the isotope geochronological data indicates that the subduction of the Junggar Ocean predates the early Carboniferous,and that the Santanghu island arc magmatism was induced by the subduction of the Junggar Ocean in the Carboniferous. | LI Wei LIU YiQun DONG YunPeng ZHOU XiaoHu LIU XiaoMing LI Hong FAN TingTing ZHOU DingWu XU XueYi CHEN JunLu | 2013 | Science China Earth Sciences2013，56，8： | 8 |
| 3 | Geology and geochemistry of the Bingdaban ophiolitic mélange in the boundary fault zone on the northern Central Tianshan Belt,and its tectonic implications显示文摘The properties and tectonic significance of the fault bound zone on the northern margin of the Central Tianshan belt are key issues to understand the tectonic framework and evolutionary history of the Tianshan Orogenic Belt. Based on the geological and geochemical studies in the Tianshan orogenic belt, it is suggested that the ophiolitic slices found in the Bingdaban area represent the remaining oceanic crust of the Early Paleozoic ocean between the Hazakstan and Zhungaer blocks. Mainly com-posed of basalts, gabbros and diabases, the ophiolites were overthrust onto the boundary fault be-tween the Northern Tianshan and Central Tianshan belts. The major element geochemistry is charac-terized by high TiO2 (1.50%-2.25%) and MgO (6.64%-9.35%), low K2O (0.06%-0.41%) and P2O5 (0.1%-0.2%), and Na2O>K2O as well. Low ΣREE and depletion in LREE indicate that the original magma was derived from a depleted mantle source. Compared with a primitive mantle, the geochemistry of the basalts from the Bingdaban area is featureded by depletion in Th, U, Nb, La, Ce and Pr, and unfrac-tionated in HFS elements. The ratios of Zr/Nb, Nb/La, Hf/Ta, Th/Yb and Hf/Th are similar to those of the typical N-MORB. It can be interpreted that the basalts in the Bingdaban area were derived from a de-pleted mantle source, and formed in a matured mid-oceanic ridge setting during the matured evolu-tionary stage of the Northern Tianshan ocean. In comparison with the basalts, the diabases from the Bingdaban area show higher contents of Al2O3, ∑REE and HFS elements as well as unfractionated incompatible elements except Cs, Rb and Ba, and about 10 times the values of the primitive mantle. Thus, the diabases are thought to be derived from a primitive mantle and similar to the typical E-MORB. The diabases also have slight Nb depletion accompanying no apparent Th enrichment compared with N-MORB. From studies of the regional geology and all above evidence, it can be suggested that the diabases from the Bingdaban area were formed in the mid-oceanic ridge of the Northern Tianshan ocean during the initial spreading stage. | DONG YunPeng ZHANG GuoWei ZHOU DingWu LUO JinHai ZHANG ChengLi XIA LinQi XU XueYi LI XiangMin | 2007 | Science China Earth Sciences2007，50，1： | 5 |
| 4 | Geochemistry, geochronology and Hf isotope of granitoids in the Chinese Altai: Implications for Paleozoic tectonic evolution of the Central Asian Orogenic Belt显示文摘The Chinese Altai in northwestern Xinjiang has numerous outcrops of granitoids which provide critical information on accretionary orogenic processes and crustal growth of the Central Asian Orogenic Belt.Zircon U-Pb ages, Hf-isotopic compositions and whole-rock geochemistry of monzogranite and granodiorites in the Qinghe County are employed to elucidate Paleozoic tectonics of the Chinese Altai. Granodiorites have crystallization ages of 424.6 ± 3.1 Ma(MSWD = 0.23) and 404.0 ± 3.4 Ma(MSWD = 0.18);monzogranite was emplaced in the early Permian with a crystallization age of 293.7 ± 4.6 Ma(MSWD = 1.06). Both granodiorites and monzogranite are I-type granites with A/CNK ratios of 0.92 -0.97 and 1.03 -1.06, respectively. They also show similar geochemical features of high HREE and Y contents, low Sr contents and Sr/Y ratios, as well as enrichment of Cs, Rb, Th and U, and depletion of Nb, Ta, P and Ti.These geochemical features indicate that the monzogranite and granodiorites were formed in an arc setting related to subduction. The gneissic monzogranites display high SiO_2 and K_2 O contents, and belong to the high-K calc-alkaline series. In the chondrite normalized REE distribution pattern, the monzogranite samples exhibit enrichment of LREE with strong negative Eu anomalies(σE u =0.44 -0.53), zircon εHf(t) values from +7.24 to +12.63 and two-stage Hf model ages of 463 -740 Ma. This suggests that the monzogranite was generated from the mixing of pelitic and mantle material. The granodiorite samples are calc-alkaline granites with lower contents of Si O_2 and Na_2 O + K_2 O, higher contents of TiO_2, Fe_2O_3~t, MgO and CaO compared to the monzogranite samples. They also show enrichment of LREE and moderate negative Eu anomalies(σE u= 0.54 =0.81), as well as slightly higher differentiation of LREE than that of HREE. The425 Ma granodiorite has zircon εHf(t) values from -0.51 to +1.98 and two-stage Hf model ages of 1133 -1240 Ma, whereas the 404 Ma granodiorite displays those of +2.52 to +7.50 and 816 -1071 Ma.Geochemistry and zircon Hf isotopic compositions indicate that granodiorites were formed by partial melting of juvenile lower crust. Together with regional geology and previous data, the geochemical and geochronological data of the monzogranite and granodiorites from this study suggest long-lived subduction and accretion along the Altai Orogen during ca. 425 -294 Ma. | Dengfeng He Yunpeng Dong Xueyi Xu Junlu Chen Xiaoming Liu Wei Li Xiangmin Li | 2018 | Geoscience Frontiers2018，9，5： | 3 |
| 5 | Profiles of and variations in aluminum species in PAC-MC used for the removal of blooming microalgae显示文摘Polyaluminum chloride modified clay(PAC-MC)is a safe and efficient red tide control agent that has been studied and applied worldwide.Although it is well known that the distribution of hydrolytic aluminum species in PAC affects its flocculation,little is known about the influence of particulars aluminum species on the microalgae removal efficiency of PAC-MC;this lack of knowledge creates a bottleneck in the development of more efficient MCs based on aluminum salts.The ferron method was used in this study to quantitatively analyze the distributions of and variations in different hydrolytic aluminum species during the process of microalgae removal by PAC-MC.The results showed that Ala,which made up 5%–20%of the total aluminum,and Alp,which made up 15%–55%of the total aluminum,significantly affected microalgae removal,with Pearson’s correlation coefficients of 0.83 and 0.89,respectively.Most of the aluminum in the PAC-MC sank rapidly into the sediments,but the rate and velocity of settlement were affected by the dose of modified clay.The optimal dose of PAC-MC for precipitating microalgae was determined based on its aluminum profile.These results provide guidance for the precise application of PAC-MC in the control of harmful algal blooms. | Xueyi Dong Xihua Cao Wenbin Jiang Xiuxian Song Zhiming Yu Shitao Yu | 2021 | Journal of Environmental Sciences2021，33，8： | 2 |
| 6 | Leaching behavior of metals from a limonitic nickel laterite using a sulfation–roasting–leaching process显示文摘 | Xueyi Guo Dong Li Kyung-Ho Park Qinghua Tian Zhan Wu | 2009 | Hydrometallurgy2009，，： | 2 |
| 7 | Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer显示文摘Objective: Hypoxia is a significant feature of solid tumors, including pancreatic ductal adenocarcinoma(PDAC). It is associated with tumor invasion, metastasis, and drug resistance. However, the spatial distribution of hypoxia-related heterogeneity in PDAC remains unclear.Methods: Spatial transcriptomics(STs), a new technique, was used to investigate the ST features of engrafted human PDAC in the ischemic hind limbs of nude mice. Transcriptomes from ST spots in the hypoxic tumor and the control were clustered using differentially-expressed genes. These data were compared to determine the spatial organization of hypoxia-induced heterogeneity in PDAC. Clinical relevance was validated using the Tumor Cancer Genome Atlas and KM-plotter databases. The CMAP website was used to identify molecules that may serve as therapeutic targets for PDAC.Results: ST showed that the tumor cell subgroups decreased to 7 subgroups in the hypoxia group, compared to 9 subgroups in the control group. Different subgroups showed positional characteristics and different gene signatures. Subgroup 6 located at the invasive front showed a higher proliferative ability under hypoxia. Subgroup 6 had active functions including cell proliferation, invasion, and response to stress. Expressions of hypoxia-related genes, LDHA, TPI1, and ENO1, induced changes. CMAP analysis indicated that ADZ-6482, a PI3 K inhibitor, was targeted by the invasive subgroup in hypoxic tumors.Conclusions: This study is the first to describe hypoxic microenvironment-induced spatial transcriptome changes in PDAC, and to identify potential treatment targets for PDAC. These data will provide the basis for further investigations of the prognoses and treatments of hypoxic tumors. | Huizhi Sun Danfang Zhang Chongbiao Huang Yuhong Guo Zhao Yang Nan Yao Xueyi Dong Runfen Cheng Nan Zhao Jie Meng Baocun Sun Jihui Hao | 2021 | Cancer Biology & Medicine2021，18，2： | 2 |
| 8 | Leaching behavior of metals from a limonitic nickel laterite using a sulfation-roasting-leaching process显示文摘 | Xueyi Guo Dong Li Kyung-Ho Park | 2009 | Hydronaetallurgy2009，99，3： | 1 |
| 9 | Impact of ablation ratio on 5-year postoperative posterior corneal stability after refractive surgery:SMILE and FS-LASIK显示文摘Background:To investigate the impact of the ablation ratio on 5-year postoperative posterior corneal stability in myopic eyes after small incision lenticule extraction(SMILE)and femtosecond laser-assisted in situ keratomileusis(FS-LASIK)surgery.Methods:A prospective,nonrandomized,cohort study:80 eyes of 43 patients underwent SMILE surgery and 63 eyes of 32 patients underwent FS-LASIK surgery at the EYE&ENT Hospital,Fudan University.Ablation ratio was defined as lenticule thickness(SMILE cases)or ablation depth(FS-LASIK cases)divided by central corneal thickness(CCT).Posterior corneal elevation changes were recorded as posterior central elevation(PCE),posterior corneal surface at thinnest point(PTE)and posterior corneal mean elevation(PME).Patients were followed up at 6-month and 5-year interval to investigate the impact of the ablation ratio on posterior corneal elevation after SMILE and FSLASIK surgery.Results:PCE dropped at the 6-month follow-up for both SMILE(decreased by−1.11±2.93μm,P<0.05)and FSLASIK groups(decreased by−0.46±3.72μm,P<0.05).PTE also dropped in SMILE(reduced by−2.04±3.02μm,P<0.05)and FS-LASIK group(reduced by−1.28±4.21μm,P<0.05)at the 6-month follow-up.Stable PCE(elevation change:SMILE−0.28±4.03μm;FS-LASIK 0.79±4.13μm,P>0.05)and PTE(elevation change:SMILE−0.08±4.28μm;FS-LASIK 1.42±3.85μm,P>0.05)for both groups were recorded at the 5-year follow-up compared to the 6-month visit.Ablation ratio was strongly correlated with 5-year postoperative PCE(β=2.68±1.05,P<0.01)and PTE(β=2.35±1.17,P<0.05).Cut-off value for 5-year postoperative raised PCE and PTE was 27.3 and 27.1%,respectively.Conclusions:Ablation ratio was strongly correlated with postoperative posterior corneal elevation in a 5-year follow-up in both SMILE and FS-LASIK groups.PCE and PTE underwent slight backward displacement 6-month postoperatively and remain stable at the 5-year follow-up.Threshold of the ablation ratio for resisting forward displacement of posterior corneal surface was 27.3 and 27.1%for SMILE and FS-LASIK groups,respectively. | Meiyan Li Danjuan Yang Yu Zhao Weiming Yang Jianmin Shang Xueyi Zhou Peijun Yao Dong Yang Xue Lin Xingtao Zhou | 2020 | Eye and Vision2020，7，1： | 1 |
| 10 | Structural design of a practical suspen-dome 显示文摘 | Zhang Zhihong Cao Qingshuai Dong Shilin Fu Xueyi | 2008 | International Journal Advanced Steel Construction2008，4，4： | 1 |
| 11 | Structural design of a spherical cable dome with stiff roof 显示文摘 | Zhang Zhihong Dong Shilin Fu Xueyi | 2008 | International Journal Space Structures2008，23，1： | 1 |
| 12 | Leaching behavior of metals from a lirnonitic nickel laterite using a sulfation-roasting-leac- hing process 显示文摘 | Xueyi Guo Dong Li Kyung-Ho Park | 2009 | Hydrometallargy2009，99，： | 1 |
| 13 | Leaching behavior of metals from a limonitic nickel laterite using a sulfation–roasting–leaching process显示文摘 | Xueyi Guo Dong Li Kyung-Ho Park Qinghua Tian Zhan Wu | 2009 | Hydrometallurgy2009，，3： | 1 |
| 14 | Structural design of a practical suspendome 显示文摘 | Zhang Zhihong Cao Qingshui Dong Shilin Fu Xueyi | 2008 | Advanced Steel Construction2008，4，4： | 1 |
| 15 | Leaching behavior of metals from limonitic laterite ore by high pressure acid leaching显示文摘 | GUO Xueyi SHI Wentang LI Dong | 2011 | Trans Nonferrous Met Soc China2011，21，： | 1 |
| 16 | Efficacy and Safety of Dexamethasone Ointment on Recurrent Aphthous Ulceration显示文摘 | Chuanxia Liu Zengtong Zhou Guanjian Liu Qintao Wang Jiangang Chen Ling Wang Yongmei Zhou Guangying Dong Xueyi Xu Yuechun Wang Yiqing Guo Mei Lin Lan Wu Gefei Du Changlei Wei Xin Zeng Xiaoyi Wang Junzheng Wu Bingqi Li Gang Zhou Hongmei Zhou | 2012 | The American Journal of Medicine2012，，3： | 1 |
| 17 | Leaching behaviorof metals from a limonitic nickel laterite using a sul-fation-roasting-leaching process显示文摘 | GUO Xueyi LI Dong KYUNG P | 2009 | Hydrometallurgy2009，99，： | 1 |
| 18 | Leaching BehaviorofMetals From a Limonitic Nickel Laterite Using a Sulfation-Roasting-Leaching Process显示文摘 | Guo Xueyi Li Dong Park Kyung-Ho | 2009 | Hydrometallurgy2009，99，： | 1 |
| 19 | HER2/neu expression correlates with vasculogenic mimicry in invasive breast carcinoma显示文摘 | Tieju Liu Baocun Sun Xiulan Zhao Qiang Gu Xueyi Dong Zhi Yao Nan Zhao Jiadong Chi Ning Liu Ran Sun Yuemei Ma | 2012 | J. Cell. Mol. Med2012，，1： | 1 |
| 20 | Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion显示文摘The technique bottleneck of repairing large bone defects with tissue engineered bone is the vascularization of tissue engineered grafts.Although some studies have shown that extracellular vesicles(EVs)derived from bone marrow mesenchymal stem cells(BMSCs)promote bone healing and repair by accelerating angiogenesis,the effector molecules and the mechanism remain unclear,which fail to provide ideas for the future research and development of cell-free interventions.Here,we found that Nidogen1-enriched EV(EV-NID1)derived from BMSCs interferes with the formation and assembly of focal adhesions(FAs)by targeting myosin-10,thereby reducing the adhesion strength of rat arterial endothelial cells(RAECs)to the extracellular matrix(ECM),and enhancing the migration and angiogenesis potential of RAECs.Moreover,by delivery with composite hydrogel,EV-NID1 is demonstrated to promote angiogenesis and bone regeneration in rat femoral defects.This study identifies the intracellular binding target of EV-NID1 and further elucidates a novel approach and mechanism,thereby providing a cell-free construction strategy with precise targets for the development of vascularized tissue engineering products. | Pengzhen Cheng Tianqing Cao Xueyi Zhao Weiguang Lu Sheng Miao Fenru Ning Dong Wang Yi Gao Long Wang Guoxian Pei Liu Yang | 2022 | Bioactive Materials2022，7，6： | 0 |
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