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| 1 | Increased leptin by hypoxic-preconditioning promotes autophagy of mesenchymal stem cells and protects them from apoptosis显示文摘Autophagy is the basic catabolic progress involved in cell degradation of unnecessary or dysfunctional cellular components.It has been proven that autophagy could be utilized for cell survival under stresses.Hypoxic-preconditioning(HPC)could reduce apoptosis induced by ischemia and hypoxia/serum deprivation(H/SD)in bone marrow-derived mesenchymal stem cells(BMSCs).Previous studies have shown that both leptin signaling and autophagy activation were involved in the protection against apoptosis induced by various stress,including ischemia-reperfusion.However,it has never been fully understood how leptin was involved in the protective effects conferred by autophagy.In the present study,we demonstrated that HPC can induce autophagy in BMSCs by increased LC3-II/LC3-I ratio and autophagosome formation.Interestingly,similar effects were also observed when BMSCs were pretreated with rapamycin.The beneficial effects offered by HPC were absent when BMSCs were incubated with autophagy inhibitor,3-methyladenine(3-MA).In addition,down-regulated leptin expression by leptin-shRNA also attenuated HPC-induced autophagy in BMSCs,which in turn was associated with increased apoptosis after exposed to sustained H/SD.Furthermore,increased AMP-activated protein kinase phosphorylation and decreased mammalian target of rapamycin phosphorylation that were observed in HPC-treated BMSCs can also be attenuated by down-regulation of leptin expression.Our data suggests that leptin has impact on HPC-induced autophagy in BMSCs which confers protection against apoptosis under H/SD,possibly through modulating both AMPK and mTOR pathway. | WANG LiHan HU XinYang ZHU Wei JIANG Zhi ZHOU Yu CHEN PanPan WANG JianAn | 2014 | Science China(Life Sciences)2014，57，2： | 8 |
| 2 | The Glutamatergic Postrhinal Cortex–Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval显示文摘A deficit in spatial memory has been taken as an early predictor of Alzheimer’s disease(AD) or mild cognitive impairment(MCI). The uncinate fasciculus(UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex(OFC)in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. The pathway arising from the postrhinal cortex(POR) and projecting to the ventrolateral orbitofrontal cortex(vlOFC)performs most of the functions of the UF in rodents.Although the literature suggests an association between spatial memory and the regions connected by the POR–vlOFC pathway, the function of the pathway in spatialmemory is relatively unknown. To further illuminate the function of the UF in spatial memory, we dissected the POR–vlOFC pathway in mice. We determined that the POR–vlOFC pathway is a glutamatergic structure, and that glutamatergic neurons in the POR regulate spatial memory retrieval. We also demonstrated that the POR–vlOFC pathway specifically transmits spatial information to participate in memory retrieval. These findings provide a deeper understanding of UF function and dysfunction related to disorders of memory, as in MCI and AD. | Xinyang Qi Zhanhong Jeff Du Lin Zhu Xuemei Liu Hua Xu Zheng Zhou Cheng Zhong Shijiang Li Liping Wang Zhijun Zhang | 2019 | Neuroscience Bulletin2019，35，3： | 7 |
| 3 | Effect of butanol on flotation separation of quartz from hematite with N-dodecyl ethylenediamine显示文摘In order to investigate the effect of butanol on quartz flotation when N-dodecyl ethylenediamine(ND)was used as collector, single mineral flotation and artificial mixed mineral(hematite and quartz were mixed at a mass ratio of 3:2) separation were conducted in the laboratory. Experimental results indicated that addition of butanol could improve the collecting performance of ND on quartz and enhance the floatability of quartz. Best flotation recovery of quartz was obtained when butanol was mixed with ND at a mass ratio of 1:1. Moreover, the molecular structure of alcohols had a significant effect on mineral recovery. Best separation efficiency could be obtained when tert-butanol was added as it had the largest cross-sectional area. Zeta potential measurements indicated that alcohols could strengthen electrostatic adsorption between quartz and collector. Molecular dynamic simulations revealed that co-adsorption of alcohols along with ND had taken place on the quartz surface, and ND/tert-butyl combinations were more easily absorbed on the quartz surface. | Liu Wengang Liu Wenbao Wang Xinyang Wei Dezhou Zhang Hao Liu Wei | 2016 | International Journal of Mining Science and Technology2016，26，6： | 7 |
| 4 | Microstructure Evolution and Pore Formation Mechanism of Porous TiAl3 Intermetallics via Reactive Sintering显示文摘Porous TiAl_3 intermetallics were fabricated through vacuum reactive sintering from Ti–75 Al at.% elemental powder mixture. The phase compositions, expansion behaviors, pore characteristics and microstructure evolution of TiAl_3 intermetallics were investigated, and the pore formation mechanism was also proposed. It was found that the actual temperature of compacts showed an acute climb from 668 to 1244 °C in 166 s, while the furnace temperature maintained the linear growth of 5 °C/min, which indicated that an obvious thermal explosion(TE) reaction occurred during sintering,and only single-phase TiAl_3 intermetallic was synthesized in TE products. The open porosity increased from 22.2(green compact) to 32.8% after reactive diffusion sintering at 600 °C and rised to 58.7% after TE, then decreased to 51.2% after high-temperature homogenization at 1100 °C. Therefore, TE reaction is the dominated pore formation mechanism of porous TiAl_3 intermetallics. The pore evolution in porous TiAl_3 intermetallics occurred by the following mechanisms:certain intergranular pores remained among powder particles of green compact, then low-temperature sintering resulted in a further increase in porosity due to the Kirkendall effect. Moreover, TE reaction gave rise to a dramatic volume expansion because of the rapid increase in temperature, and high-temperature sintering caused densification and a slight shrinkage. | Xinyang Jiao Xiaohong Wang Peizhong Feng Yanan Liu Laiqi Zhang Farid Akhtar | 2018 | Acta Metallurgica Sinica(English Letters)2018，31，4： | 3 |
| 5 | Genetic polymorphism of the phospholipase C epsilon 1 gene and risk of gastric cancer显示文摘 | Liu Xinyang Zhang Xiaowei Wang Zhichao Chang Jinjia Wu Zheng Zhang Zhe Wang Shanshan Li Jin | 2014 | Chinese Medical Journal2014，，13： | 3 |
| 6 | Electro-Fenton treatment of concentrates generated in nanofiltration of biologically pretreated landfill leachate显示文摘 | Yujue Wang Xinyang Li Limin Zhen Heqing Zhang Ying Zhang Chengwen Wang | 2012 | Journal of Hazardous Materials2012，，： | 3 |
| 7 | 紊乱的肺部菌群通过分泌外膜囊泡调控白介素-17B的产生促进肺纤维化显示文摘文章简介粘膜微生态一直是当前免疫学领域的研究热点,它已经被证明广泛参与多种粘膜组织免疫稳态的维持以及相关疾病的发生。该团队多年来围绕粘膜微生态与白介素-17家族细胞因子做了一系列研究工作,一方面肠癌发生过程中紊乱的微生态菌群可以通过调控IL-17C的产生促进肠癌的发生,另一方面肠道中微生态菌群也可以通过调控IL-17A的分泌促进肠道损伤修复。尽管如此,目前我们对肺组织中微生态的功能尚知之甚少。 | 杨大平 Xi Chen Jingjing Wang Qi Lou Yunwei Lou Li Li Honglin Wang Jiangye Chen Meng Wu Xinyang Song 钱友存 | 2020 | 科学新闻2020，，2： | 3 |
| 8 | Amplification and expression of c-MET correlate with poor prognosis of patients with gastric cancer and upregulate the expression of PDL1显示文摘The prognostic significance of c-MET in gastric cancer(GC)remains uncertain.In the present study,we examined the amplification,expression,and the prognostic value of c-MET,human epidermal growth factor receptor 2(HER2),and programmed cell death 1 ligand 1(PDL1),together with the correlations among them in a large cohort of Chinese samples.A total of 444 patients were included.The immunohistochemistry(IHC)and the dual-color silver in situ hybridization(SISH)were performed to examine their expression and amplification.Univariate and multivariate analyses were performed by the Cox proportional hazard regression model,and survival curves were estimated by the Kaplan-Meier method.The positivity determined by IHC of c-MET was 24.8%,and the MET amplification rate was 2.3%.The positivity rates of HER2 and PDL1 were 8%and 34.7%,respectively.PDL1 expression had a significantly positive association with c-MET expression.c-MET positivity played a significant prognostic role in disease-free survival(DFS)(P=0.032).Patients with mesenchymal-epithelial transition(MET)amplification had significantly poorer prognosis on both DFS and overall survival(OS).Subgroup analysis showed that in HER2-negative patients,but not in HER2-positive patients,MET-positive patients had significantly worse DFS(P=0.000)and OS(P=0.006).c-MET regulated the expression of PDL1 through an AKT-dependent pathway.c-MET inhibitor enhanced the T-cell killing ability and increased the efficacy of PD1 antibody.c-MET was found to be an independent prognostic factor for DFS of GC patients.A combination of c-MET inhibitors and PD1 antibodies could enhance the killing capacity of T cells,providing a preliminary basis for the clinical research on the same combination in GC treatment. | Ya’nan Yang Chenchen Wang Congqi Dai Xinyang Liu Wenhua Li Mingzhu Huang Xiaoying Zhao Dongmei Ji Jin Li Weijian Guo | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 2 |
| 9 | Flotation performance of a novel Gemini collector for kaolinite at low temperature显示文摘How to sustainably produce bauxite by effective reverse froth flotation of kaolinite at low temperature is an urgent problem to be solved in the field of mineral processing.In this work,a novel amino-based Gemini surfactant butadiyl-1,4-bis(dimethyl dodecylammonium bromide)(BBDB) was prepared and first utilized as a novel collector for kaolinite flotation.Its flotation performance for kaolinite was compared with that of the common monomolecular surfactant 1-dodecylamine(DDA) by micro-flotation tests.The tests results indicated that 95% kaolinite recovery was obtained using 2.0×10^(-4) mol/L BBDB at 25℃ which was half of the dosage when DDA obtained the maximum kaolinite recovery of81%.At extremely low temperature(0℃),3.0×10^(-4) mol/L BBDB could still collect 91% kaolinite,while DDA showed a frustrating ability.The contact angle tests indicated that BBDB could still significantly improve the hydrophobicity of the kaolinite surface(contact angle 71.7°) than DDA(contact angle only25.8°) at 0℃.The Krafft point comparison tests indicated that BBDB had a much lower Krafft point(below0℃) than DDA.Fourier transform infrared spectroscopy(FTIR)-spectrum analysis and zeta potential measurements showed that BBDB was physically adsorbed on the surface of kaolinite through electrostatic interaction. | Shiyong Zhang Zhiqiang Huang Hongling Wang Rukuan Liu Chen Cheng Shuyi Shuai Yajing Hu Zhiqun Guo Xinyang Yu Guichun He Weng Fu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 10 | 王立新:《踌躇的霸权:美国崛起后的身份困惑与秩序追求(1913-1945)》显示文摘The years between 1913 and 1945 were a critical period in American diplomatic history which witnessed the transition of U.S.foreign policy from isolationism to liberal internationalism.Such a crucial transformation,expectedly,met with many obstacles and setbacks before internationalism finally carried the day.In A Hesitant Hegemony:America’s Search for National Identity and International Order after Its Emergence as a Great Power,1913-1945,Wang Lixin traces the vicissitudes of the development of liberal internationalism during this era. | Wang Xinyang | 2018 | World History Studies2018，5，2： | 2 |
| 11 | Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease显示文摘The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD. | Lin Zhu Zan Wang Zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing Ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang | 2020 | Neuroscience Bulletin2020，36，8： | 2 |
| 12 | Mechanism of the Effect of Bacillus coagulans on Production Performance of Laying Hens in Late Laying Period显示文摘[Objective]The paper was to investigate the mechanism of Bacillus coagulans preparation in improving production performance of laying hens in late period of laying.[Method]A total of 648 individuals of'Jingfen 1'laying hens(66 weeks of age)in late period of laying were randomly divided into four groups,six replicates each group,and each group had 27 individuals of laying hens.The laying hens in control group were fed with basal diet,and those in experimental groupsⅠ,Ⅱ and Ⅲ were fed with the basal diets added with 3.33×10^6,1×10^7,3.33×10^7 CFU/g B.coagulans,respectively.The pretrial lasted one week,and the formal test lasted eight weeks.[Result]Compared with the control group,the laying rate in group Ⅰ increased significantly,and the feed-gain ratio in experimental group Ⅱ decreased noticeably while the spleen index increased remarkably;the alkaline phosphatase activities and blood calcium content in experimental groups Ⅰ,Ⅱ and Ⅲ increased significantly(P<0.05),while the triglyceride content decreased remarkably(P<0.05);the urea content in experimental groups Ⅰ and Ⅱ decreased obviously(P<0.05).Adding B.coagulans significantly increased the specific activity of amylase,lipase and protease in various intestinal mucosa of small intestine(P<0.05);adding B.coagulans significantly increased the content of follicle-stimulating hormone(FSH)and estradiol(E2),and significantly increased the mRNA expression of follicle stimulating hormone receptor gene(FSHR).[Conclusion]B.coagulans preparation could significantly improve the production performance of laying hens in late period of laying;appropriately enhance the immune capacity of laying hens;improve the serum biochemical indicators;increase the activity of digestive enzymes in the small intestine;and promote the release of gonadal hormone and the mRNA expression of FSHR gene in the ovary. | Xing Guanrun Lang Xinrui Wu Ji’an Lou Hongxing Liu Wenqiang Zhang Hengshuo Dong Xinyang Pan Xiaoliang Wang Youming | 2019 | Animal Husbandry and Feed Science2019，11，5： | 2 |
| 13 | Real-time monitoring the formation and decomposition processes of methane hydrate with THz spectroscopy显示文摘Gas hydrates are crystalline clathrate compounds comprised of hydrogen-bonded water cavities,consisting of guest molecules trapped in a lattice of polyhedral water cages under elevated pressures and low temperatures[1].The structures of the gas hydrates are closely related to the types and sizes of the guest species,and three distinct structures,including cubic structure-Ⅰ(sⅠ),cubic structure-Ⅱ(sⅡ),and hexagonal structure-H(sH),are known to form[2].Being expected as a kind of future energy resource,natural | XinYang Miao ShiNing Sun YiZhang Li Wei Wang RiMa Bao Kun Zhao | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，1： | 2 |
| 14 | Principle of Interaction between Plastic Volumetric and Shear Strains and the Constitutive Model for Geotechnical Materials显示文摘Here is proposed the principle of interaction between plastic volumetric and shear strains, revealing the main origin of generating the complexity and variety of deformations for geotechnical materials. Here are also explained the manners of the interaction between plastic volumetric and shear strains and the conditions of generating shear dilatancy. It is demonstrated that dependency of the stress path exists and is a combination of effects of this interaction. According to this principle, it is theoretically proved that the space critical state line exists, and is unique and independent of the stress history. Based on this principle, the constitutive models that are able completely and accurately to characterize the basic behavior features for geotechnical materials have been constructed within the framework of thermodynamics. What is determined is a general expression of the constitutive relation as well as the inequality of the dissipative potential increment for obeying the second law of thermodynamics. | Wang Jingtao(1.Department of Architectural Engineering, Xinyang Normal University, Xinyang 464000, Henan, China 2.School of Civil Engineering and Mechanics, Huazhong University of Science and Technology, Wuhan 430074, China) | 2007 | 工程科学(英文版)2007，5，2： | 2 |
| 15 | Brain metabolite alterations and cognitive dysfunction in early Huntington’s disease显示文摘 | Paul G. Unschuld Richard A. E. Edden Aaron Carass Xinyang Liu Megan Shanahan Xin Wang Kenichi Oishi Jason Brandt Susan S. Bassett Graham W. Redgrave Russell L. Margolis Peter C. M. van Zijl Peter B. Barker Christopher A. Ross | 2012 | Mov Disord2012，，7： | 1 |
| 16 | A cost-effective approach to recycle serpentine tailings:Destruction of stable layered structure and solvent displacement crystallization显示文摘In this work,the stable layer structure of serpentine,which seriously restricts the extraction of magnesium,was broken down,and a nearly 94%leaching efficiency of Mg was obtained by adding 5%fluorite powder.Compared with the system without fluorite,the Mg leaching efficiency increased by 36.42%.This result was achieved because the complexation of fluorinion(F)with Si in serpentine promoted a distorted tetrahedral orientation,which led to a loose crystal structure of serpentine and contributed to exposing more Mg for a remarkable increase in Mg recovery.It is suggested that fluorite powder could replace expensive assisted reagents in the leaching process,which would markedly decreased the cost.Moreover,an energy-efficient‘‘solvent displacement crystallization”(SDC)method was employed to efficiently recover magnesium(99.04%)from pregnant solutions.At the same time,the reuse of fluorinecontaining solutions was explored. | Wengang Liu Xiangyu Peng Wenbao Liu Naixu Zhang Xinyang Wang | 2022 | International Journal of Mining Science and Technology2022，32，3： | 1 |
| 17 | Unsupervised content-preserving transformation for optical microscopy显示文摘The development of deep learning and open access to a substantial collection of imaging data together provide a potential solution for computational image transformation,which is gradually changing the landscape of optical imaging and biomedical research.However,current implementations of deep learning usually operate in a supervised manner,and their reliance on laborious and error-prone data annotation procedures remains a barrier to more general applicability.Here,we propose an unsupervised image transformation to facilitate the utilization of deep learning for optical microscopy,even in some cases in which supervised models cannot be applied.Through the introduction of a saliency constraint,the unsupervised model,named Unsupervised content-preserving Transformation for Optical Microscopy(UTOM);can learn the mapping between two image domains without requiring paired training data while avoiding distortions of the image content.UTOM shows promising performance in a wide range of biomedical image transformation tasks,including in silico histological staining,fluorescence image restoration,and virtual fluorescence labeling.Quantitative evaluations reveal that UTOM achieves stable and high-fidelity image transformations across different imaging conditions and modalities.We anticipate that our framework will encourage a paradigm shift in training neural networks and enable more applications of artificial intelligence in biomedical imaging. | Xinyang Li Guoxun Zhang Hui Qiao Feng Bao Yue Deng Jiamin Wu Yangfan He Jingping Yun Xing Lin Hao Xie Haoqian Wang Qionghai Dai | 2021 | Light(Science & Applications)2021，10，3： | 1 |
| 18 | Numerical simulation of the fiber fragmentation process in single-fiber composites显示文摘 | Xiaohong Wang Boming Zhang Shanyi Du Yufen Wu Xinyang Sun | 2009 | Materials and Design2009，，5： | 1 |
| 19 | ITO/Cu multilayer electrodes for high-brightness electrochromic displays显示文摘Fabry-Perot(F-P)nanocavity-type electrochromic devices with multicolor tunability have attracted significant interest in the past two years for their potential uses in a wide variety of applications,such as electronic display,military camouflage,and dynamic decoration.However,challenges such as insufficient brightness,lengthy switching times,and poor cycling stability have yet to be overcome.Herein,we demonstrate electrochromic electrodes based on ITO/Cu as both the current collector and the reflective layer,with WO_(3 )as the electrochromic material,forming a unique three-layered structure.The constituted WO_(3 )/ITO/Cu films present a high brightness value of about 84%before coloration,and a decent brightness value of 48%after coloration at−0.8V.Moreover,a fast switching time between different coloration states(tc=2.2s;tb=1s)is recorded,attributed to the extremely low sheet resistivity of the ITO/Cu current collector.The films also reveal excellent electrochemical cycling stability across 2000 cycles. | Xueqing Tang Zishou Hu Zhen Wang Jian Chen Xinyang Mu Ge Song Peiyan Sun Zhengji Wen Jiaming Hao Shan Cong Zhigang Zhao | 2022 | eScience2022，2，6： | 1 |
| 20 | Degradation of CMOS image sensors in deep-submicron technology due to γ-irradiation显示文摘 | Padmakumar R. Rao Xinyang Wang Albert J.P. Theuwissen | 2008 | Solid State Electronics2008，，9： | 1 |
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