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| 1 | The directional migration and differentiation of mesenchymal stem cells toward vascular endothelial cells stimulated by biphasic calcium phosphate ceramic显示文摘Osteoinductivity of porous calcium phosphate(CaP)ceramics has been widely investigated and confirmed,and it might be attributed to the rapid formation of the vascular networks after in vivo implantation of the ceramics.In this study,to explore the vascularization mechanism within the CaP ceramics,the migration and differentiation of bone marrow-derived mesenchymal stem cells(BMSCs)under the stimulation of porous biphasic calcium phosphate(BCP)ceramic with excellent osteoinductivity were systematically investigated.The results indicated that the directional migration of BMSCs toward BCP ceramic occurred when evaluated by using a transwell model,and the BMSCs migration was enhanced by the seeded macrophages on the ceramic in advance.Besides,by directly culturing BMSCs on BCP ceramic discs under both in vitro and in vivo physiological environment,it was found that the differentiation of BMSCs toward vascular endothelial cells(VECs)happened under the stimulation of BCP ceramic,as was confirmed by the up-regulated gene expressions and protein secretions of VECs-related characteristic factors,including kinase insert domain receptor,von willebrand factor,vascular cell adhesion molecule-1 and cadherin 5 in the BMSCs.This study offered a possibility for explaining the origin of VECs during the rapid vascularization process after in vivo implantation of porous CaP ceramics and could give some useful guidance to reveal the vascularization mechanism of the ceramics. | Ying Chen Jing Wang Xiangdong Zhu Xuening Chen Xiao Yang Kai Zhang Yujiang Fan Xingdong Zhang | 2018 | Regenerative Biomaterials2018，5，3： | 8 |
| 2 | An improved OFDM chirp waveform used for MIMO SAR system显示文摘Special attention has been devoted to multi-input multi-output(MIMO)synthetic aperture radar(SAR)systems in recent years.The applications of MIMO SAR systems which involve 3D imaging,highresolution wide-swath remote sensing,and multi-baseline interferometry are seriously limited to the orthogonal waveforms.Although orthogonal frequency division multiplexing(OFDM)chirp waveforms can be used for MIMO SAR systems to avoid intra-pulse interferences,there is a small frequency shift between the transmitted OFDM pulses.This vulnerable shift,which can not only affect the waveform orthogonality,but also introduce residual phase error,renders the OFDM waveforms impractical.In this paper,an improved OFDM chirp waveform which works without the mentioned shift is presented,along with the novel modulation and efficient demodulation procedures.Comparison between the improved and the conventional OFDM chirp waveforms is detailed.The influence of random noise,quantization error,and Doppler shift on the orthogonality of OFDM waveform is also investigated in this paper.Theoretical analysis and simulation results illustrate the feasibility of this waveform scheme. | WANG Jie LIANG XingDong DING ChiBiao CHEN LongYong ZHOU LiangJiang DONG YongWei | 2014 | Science China(Information Sciences)2014，57，6： | 6 |
| 3 | The optimized preparation of HA/L-TiO2/D-TiO2 composite coating on porous titanium and its effect on the behavior osteoblasts显示文摘Various surface bioactivation technology has been confirmed to improve the osteogenic ability of porous titanium(pTi)implants effectively.In this study,a three-layered composite coating,i.e.outer layer of hydroxyapatite(HA),middle layer of loose titanium dioxide(L-TiO2)and inner layer of dense TiO2(D-TiO2),was fabricated on pTi by a combined processing procedure of pickling,alkali heat(AH),anodic oxidation(AO),electrochemical deposition(ED)and hydrothermal treatment(HT).After soaking in simulated body fluid for 48 h,the surface of the AHAOEDHT-treated pTi was completely covered by a homogeneous apatite layer.Using MC3T3-E1 pro-osteoblasts as cell model,the cell culture revealed that both the pTi without surface treatment and the AHAOEDHT sample could support the attachment,growth and proliferation of the cells.Compared to the pTi sample,the AHAOEDHT one induced higher expressions of osteogenesis-related genes in the cells,including alkaline phosphatase,Type I collagen,osteopontin,osteoclast inhibitor,osteocalcin and zinc finger structure transcription factor.As thus,besides the good corrosion resistance,the HA/L-TiO2/D-TiO2-coated pTi had good osteogenic activity,showing good potential in practical application for bone defect repair. | Xi Fu Xingyu Zhou Pin Liu Hewei Chen Zhanwen Xiao Bo Yuan Xiao Yang Xiangdong Zhu Kai Zhang Xingdong Zhang | 2020 | Regenerative Biomaterials2020，7，5： | 5 |
| 4 | Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes显示文摘As an excitatory transmitter system,the glutamatergic transmitter system controls excitability and conductivity of neurons.Since both cardiomyocytes and neurons are excitable cells,we hypothesized that cardiomyocytes may also be regulated by a similar system. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qiang Ji Qicheng Zou Lingling Wang Yi Liu Dandan Liang Jinfeng Xue Luxin Wang Xueting Gao Xingdong Gu Hongyu Liu r Xiaoyu He Li Li Jian Yang Youming Lu Luying Peng Yi-Han Chen | 2021 | Cell Research2021，31，9： | 5 |
| 5 | Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys显示文摘The rapid degradation of magnesium(Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the degradation rate of Mg-based materials. In the present study, three Mg alloys, including Mg-0.8Ca(denoted as ZQ), Mg-0.8Ca-5Zn-1.5Ag(denoted as ZQ71) and Mg-0.8Ca-5Zn-2.5Ag(denoted as ZQ63), were fabricated by alloying with calcium(Ca), zinc(Zn) and silver(Ag). The results obtained from electrochemical corrosion tests and in vitro degradation evaluation demonstrated that the three Mg alloys exhibited distinct corrosion resistance, and ZQ71 exhibited the lowest degradation rate in vitro among them. After addition of Zn and Ag, the antibacterial potential of Mg alloys was also enhanced. The in vitro cell experiments showed that all the three Mg alloys had good biocompatibility. After implantation in a rat femoral defect, ZQ71 showed significantly higher osteogenic activity and bone substitution rate than ZQ63 and ZQ, due to its higher corrosion resistance as well as the stimulatory effects of the released metallic ions. In addition, the average daily degradation rate of each Mg alloy in vivo was significantly higher than that in vitro, as could be due to the implantation site located in the highly vascularized trabecular region. Importantly, the correlations between the in vitro and in vivo degradation parameters of the Mg alloys were systematically analyzed to find out the potential predictors of the in vivo degradation performance of the materials. The current work not only evaluated the clinical potential of the three biodegradable Mg alloys as bone grafts but also provided a feasible approach for predicting the in vivo degradation behavior of biodegradable materials. | Hewei Chen Bo Yuan Rui Zhao Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Xiangdong Zhu Antoniac Vasile Iulian Xingdong Zhang | 2022 | Journal of Magnesium and Alloys2022，10，12： | 3 |
| 6 | Dynamic mechanical loading facilitated chondrogenic differentiation of rabbit BMSCs in collagen scaffolds显示文摘Mechanical signals have been played close attention to regulate chondrogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).In this study,dynamic mechanical loading simulation with natural frequencies and intensities were applied to the 3D cultured BMSCs–collagen scaffold constructs.We investigated the effects of dynamic mechanical loading on cell adhesion,uniform distribution,proliferation,secretion of extracellular matrix(ECM)and chondrogenic differentiation of BMSCs–collagen scaffold constructs.The results indicated that dynamic mechanical loading facilitated the BMSCs adhesion,uniform distribution,proliferation and secretion of ECM with a slight contraction,which significantly improved the mechanical strength of the BMSCs–collagen scaffold constructs for better mimicking the structure and function of a native cartilage.Gene expression results indicated that dynamic mechanical loading contributed to the chondrogenic differentiation of BMSCs with higher levels of AGG,COL2A1 and SOX9 genes,and prevented of hypertrophic process with lower levels of COL10A1,and reduced the possibility of fibrocartilage formation due to down-regulated COL1A2.In conclusion,this study emphasized the important role of dynamic mechanical loading on promoting BMSCs chondrogenic differentiation and maintaining the cartilage phenotype for in vitro reconstruction of tissue-engineered cartilage,which provided an attractive prospect and a feasibility strategy for cartilage repair. | Wanxu Cao Weimin Lin Hanxu Cai Yafang Chen Yi Man Jie Liang Qiguang Wang Yong Sun Yujiang Fan Xingdong Zhang | 2019 | Regenerative Biomaterials2019，6，2： | 3 |
| 7 | Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants显示文摘So far,how to achieve the optimal regenerative repair of large load-bearing bone defects using artificial bone grafts is a huge challenge in clinic.In this study,a strategy of combining osteoinductive biphasic calcium phosphate(BCP)bioceramic scaffolds with intramedullary nail fixation for creating stable osteogenic microenvironment was applied to repair large segmental bone defects(3.0 cm in length)in goat femur model.The material characterization results showed that the BCP scaffold had the initial compressive strength of over 2.0 MPa,and total porosity of 84%.The cell culture experiments demonstrated that the scaffold had the excellent ability to promote the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells(BMSCs).The in vivo results showed that the intramedullary nail fixation maintained the initial stability and structural integrity of the implants at early stage,promoting the osteogenic process both guided and induced by the BCP scaffolds.At 9 months postoperatively,good integration between the implants and host bone was observed,and a large amount of newborn bones formed,accompanying with the degradation of the material.At 18 months postoperatively,almost the complete new bone substitution in the defect area was achieved.The maximum bending strength of the repaired bone defects reached to the 100% of normal femur at 18 months post-surgery.Our results demonstrated the good potential of osteoinductive BCP bioceramics in the regenerative repair of large load-bearing bone defects.The current study could provide an effective method to treat the clinical large segmental bone defects. | Wei Zhi Xiaohua Wang Dong Sun Taijun Chen Bo Yuan Xiangfeng Li Xuening Chen Jianxin Wang Zhao Xie Xiangdong Zhu Kai Zhang Xingdong Zhang | 2022 | Bioactive Materials2022，7，5： | 3 |
| 8 | Through-space charge transfer blue polymers containing acridan donor and oxygen-bridged triphenylboron acceptor for highly efficient solution-processed organic light-emitting diodes显示文摘Three kinds of through-space charge transfer(TSCT)blue polymers containing non-conjugated polystyrene backbone together with spatially-separated acridan donor and oxygen-bridged triphenylboron acceptors having different substituents of tert-butyl,hydrogen and fluorine are designed and synthesized.The designed TSCT blue polymers possess photoluminescence quantum yields up to 70%in solid-state film,single-triplet energy splitting below 0.1 eV,and typical thermally activated delayed fluorescence(TADF)effect.Meanwhile,the resulting polymers exhibit aggregation-induced emission(AIE)effect with emission intensity increased by up to^27 folds from solution to aggregation state.By changing the substituent of acceptors to tune the charge transfer strength,blue emission with peaks from 444 to 480 nm can be realized for the resulting polymers.Solution-processed organic light-emitting diodes based on the polymers exhibit excellent device performance with Commission Internationale de L’Eclairage(CIE)coordinates of(0.16,0.27),together with the maximum luminous efficiency of 30.7 cd A-1 and maximum external quantum efficiency of 15.0%,which is the best device efficiency for blue TADF polymers. | Fan Chen Jun Hu Xingdong Wang Shiyang Shao Lixiang Wang Xiabin Jing Fosong Wang | 2020 | Science China Chemistry2020，63，8： | 2 |
| 9 | Fabrication and biological evaluation of 3D-printed calcium phosphate ceramic scaffolds with distinct macroporous geometries through digital light processing technology显示文摘Digital light processing(DLP)-based 3D printing technique holds promise in fabricating scaffolds with high precision.Here raw calcium phosphate(CaP)powders were modified by 5.5%monoalcohol ethoxylate phosphate(MAEP)to ensure high solid loading and low viscosity.The rheological tests found that photocurable slurries composed of 50wt%modified CaP powders and 2wt%toners were suitable for DLP printing.Based on geometric models designed by computer-aided design(CAD)system,three printed CaP ceramics with distinct macroporous structures were prepared,including simple cube,octet-truss and inverse face-centered cube(fcc),which presented the similar phase composition and microstructure,but the different macropore geometries.Inverse fcc group showed the highest porosity and compressive strength.The in vitro and in vivo biological evaluations were performed to compare the bioactivity of three printed CaP ceramics,and the traditional foamed ceramic was used as control.It suggested that all CaP ceramics exhibited good biocompatibility,as evidence by an even bone-like apatite layer formation on the surface,and the good cell proliferation and spreading.A mouse intramuscular implantation model found that all of CaP ceramics could induce ectopic bone formation,and foam group had the strongest osteoinduction,followed by inverse fcc,while cube and octet-truss had the weakest one.It indicated that macropore geometry was of great importance to affect the osteoinductivity of scaffolds,and spherical,concave macropores facilitated osteogenesis.These findings provide a strategy to design and fabricate high-performance orthopedic grafts with proper pore geometry and desired biological performance via DLP-based 3D printing technique. | Jing Wang Yitao Tang Quanle Cao Yonghao Wu Yitian Wang Bo Yuan Xiangfeng Li Yong Zhou Xuening Chen Xiangdong Zhu Chongqi Tu Xingdong Zhang | 2022 | Regenerative Biomaterials2022，9，1： | 2 |
| 10 | The HuaBiao project:whole-exome sequencing of 5000 Han Chinese individuals显示文摘Next-generation sequencing technologies have significantly accelerated the identification of disease-causing mutations and facilitated the emergence of personalized medicine(Genomes Project Consortium et al.,2015;Goodwin et al.,2016;Sirugo et al.,2019).In comparison with whole-genome sequencing,whole-exome sequencing(WES),which covers the coding regions of the genome,offers a cost-efficacy balance.WES provides deeper sequencing depth(>100)and allows the more accurate detection of rare variants that are tailored for clinical applications(Lek et al.,2016). | Meng Hao Weilin Pu Yi Li Shaoqing Wen Chang Sun Yanyun Ma Hongxiang Zheng Xingdong Chen Jingze Tan Guoqing Zhang Menghan Zhang Shuhua Xu Yi Wang Hui Li Jiucun Wang Li Jin | 2021 | Journal of Genetics and Genomics2021，48，11： | 2 |
| 11 | Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg-Ca-Zn-Ag alloy to inhibit bacterial infection and promote bone regeneration显示文摘The improved corrosion resistance, osteogenic activity, and antibacterial ability are the key factors for promoting the large-scale clinical application of magnesium (Mg)-based implants. In the present study, a novel nanocomposite coating composed of inner magnesium hydroxide, middle graphene oxide, and outer hydroxyapatite (Mg(OH)_(2)/GO/HA) is constructed on the surface of Mg-0.8Ca-5Zn-1.5Ag by a combined strategy of hydrothermal treatment, electrophoretic deposition, and electrochemical deposition. The results of material characterization and electrochemical corrosion test showed that all the three coatings have high bonding strength, hydrophilicity and corrosion resistance. In vitro studies show that Mg(OH)2 indeed improves the antibacterial activity of the substrate. The next GO and GO/HA coating procedures both promote the osteogenic differentiation of MC3T3-E1 cells and show no harm to the antibacterial activity of Mg(OH)2 coating, but the latter exhibits the best promoting effect. In vivo studies demonstrate that the Mg alloy with the composite coating not only ameliorates osteolysis induced by bacterial invasion but also promotes bone regeneration under both normal and infected conditions. The current study provides a promising surface modification strategy for developing multifunctional Mg-based implants with good corrosion resistance, antibacterial ability and osteogenic activity to enlarge their biomedical applications. | Bo Yuan Hewei Chen Rui Zhao Xuangeng Deng Guo Chen Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Kai Zhang Xiangdong Zhu Antoniac Vasile Iulian Shen Hai Xingdong Zhang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 12 | Highly efficient perovskite solar cells based on symmetric hole transport material constructed with indaceno[1,2-b:5,6-b’]dithiophene core building block显示文摘Two novel hole transport materials (HTMs) with indaceno[1,2-b:5,6-b’]dithiophene (IDT) as core building blocks,termed IDT1 and IDT2,were designed and synthesized.The side alkyl chains were introduced to regulate and control the morphology and stacking behavior of HTMs,and the peripheral triarylamine arms were introduced to adjust the energy levels and to facilitate efficient hole transport.Applied in mesoporous structured perovskite solar cells (PSCs),HTM IDT1 achieved higher power conversion efficiency (PCE,19.55%) and better stability than Spiro-OMeTAD (19.25%) and IDT2 (15.77%) based PSC.These results suggest the potential of IDTl as a promising HTM for PSCs. | Cheng Wu Cheng Chen Li Tao Xingdong Ding Mengmeng Zheng Hongping Li Gongqiang Li Hongfei Lu Ming Cheng | 2020 | Journal of Energy Chemistry2020，29，4： | 2 |
| 13 | Controlling blown sand along the highway crossing the Taklimakan Desert显示文摘 | Dong Zhibao Chen Guangting He Xingdong | 2004 | Journal of Arid Environments2004，57，： | 1 |
| 14 | High temperature characteristics of synthetic hydroxyapatite显示文摘 | Zhang Xingdong Chen Jiyong | 1993 | Journal of Materials Science: Materials in Medicine1993，4，1： | 1 |
| 15 | Controlling blown sand along the highway crossing the Taklimakan desert 显示文摘 | Dong Zhibao Chen Guangting He Xingdong | 2004 | Journal of Arid Environments2004，57，3： | 1 |
| 16 | Synthesis of photo-reactive poly(vinyl alcohol)and construction of scaffold-free cartilage like pellets in vitro显示文摘Photo-reactive poly(vinyl alcohol)(PRPVA)was synthesized by introduction of phenyl azido groups into poly(vinyl alcohol)(PVA)and applied for surface modification.PRPVA was grafted onto cell culture plate surface homogeneously or in a micropattern.Human mesenchymal stem cells(hMSCs)cultured on cell culture plate surface and PVA-modified surface showed different behaviors.Cells adhered and spread well on cell culture plate surface,while they did not adhere on PVA-grafted surface at all.When hMSCs were cultured on PVA-micropatterned surface,they formed a cell micropattern.Cells formed pellets after cultured on PVA homogeneously modified surface in chondrogenic induction medium for 2 weeks.The pellets were positively stained by hematoxylin/eosin,safranin-O/fast green and toluidin blue,and they were also stained brown by Type II collagen and proteoglycan immunohistological staining.Real-time PCR analysis was conducted to investigate the expression of colI,colII,colX,aggrecan and sox9 mRNA.Results of gene expression were in agreement with those of histological and immunohistological observations.These results indicated that hMSCs cultured on PVA-modified surface performed chondrogenic differentiation,and it was possible to construct scaffold-free cartilage like pellets with PVA-modified surface in vitro. | Bao Li Yongli Gao Likun Guo Yujiang Fan Naoki Kawazoe Hongsong Fan Xingdong Zhang Guoping Chen | 2018 | Regenerative Biomaterials2018，5，3： | 1 |
| 17 | A HIGH RESOLUTION WIDE SWATH SAR METHOD BASED ON INTRA-PULSE NULL STEERING AND MIMO显示文摘High Resolution Wide Swath (HRWS) Synthetic Aperture Radar (SAR) often suffers from low Signal-to-Noise Ratio (SNR) due to small transmitting antenna, especially in phased array antenna systems. Digital Beam Forming (DBF) based on Single Input and Multiple Output (SIMO) achieves receiving array gain at the cost of increasing data rate. This letter proposes a new HRWS SAR method, which employs intra-pulse null steering to get receiving gain in elevation and decrease the data rate, and Multiple Input and Multiple Output (MIMO) using Space-Time Block Coding (STBC) in azimuth to get transmitting gain and receiving array gain simultaneously. The feasibility is verified by deduction and simulations. | Chen Longyong Liang Xingdong Ding Chibiao | 2008 | Journal of Electronics(China)2008，25，6： | 1 |
| 18 | Existence, uniqueness and stability of positive periodic solution for a nonlinear prey-competition model with delays显示文摘 | Chen Fengde Xie Xingdong Shi Jinlin | 2006 | Journal of Computational and Applied Mathematics2006，194，2： | 1 |
| 19 | Synthesis algorithm based on overcomplete wavelet expansion for line scratch restoration in old films显示文摘 | Xu Jin SUN 3un WANG Xingdong CHEN Li | 2008 | Optical Engineering2008，47，6： | 1 |
| 20 | Non-conjugated Polynorbornene Hosts with High Triplet Energy Levels for Solution-processed Narrowband Blue OLEDs显示文摘Three polymer hosts(namely PNB-tBuCz,PNB-Ac,PNB-TAc)containing non-conjugated polynorbornene(PNB)backbone and hole-transporting arylamine segments(carbazole,acridan and dendritic teracridan)in side chains are developed for solution-processed narrowband blue organic light-emitting diodes(OLEDs).It is found that the non-conjugated polynorbornenes can keep high triplet energy(ET)levels in range of 3.12-3.20 eV by interrupting the conjugation of repeating units,making them capable as host materials for blue emitters.Meanwhile,by increasing the electron-donating capability of side chain arylamine from carbazole to acridan and dendritic teracridan,the highest occupied molecular orbital(HOMO)levels for the polymer hosts are elevated from-5.50 eV to-5.11 eV,beneficial for reducing the hole injection barrier from anode to emissive layer.As a result,solution-processed OLEDs employing polynorbornenes with dendritic teracridan side chain(PNB-TAc)as host and boron,selenium,nitrogen-containing multiple resonance thermally activated delayed fluorescence emitter as dopant reveal efficient narrowband blue electroluminescence with emission peak at 474 nm,full-width at half maximum of 30 nm,together with maximum external quantum efficiency of 20.2%,representing the state-of-the-art device efficiency for solution-processed OLEDs with narrowband blue emission. | LI Qiang CHEN Liang WANG Xingdong WANG Shumeng SHAO Shiyang WANG Lixiang | 2023 | Chemical Research in Chinese Universities2023，39，5： | 1 |
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