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| 1 | Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved. | Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. | 2011 | 南京医科大学学报(自然科学版)2011，31，7： | 123 |
| 2 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 3 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 4 | Seafloor hydrothermal activity and polymetallic sulfide exploration on the southwest Indian ridge显示文摘Polymetallic sulfides have attracted more attentions,which are regarded as one of the potential seabed mineral resources for their high grade of precious metal elements such as Cu,Zn,Pb,Au,and Ag.Since2007,there are four China dayang cruises(CDCs)with eight legs totally,which have been carried out to investigate polymetallic sulfides on the southwest Indian ridge(SWIR),and eight hydrothermal vents have been found.In2011,the China Ocean Mineral Resources Research and Development Association(COMRA)and International Seabed Authority(ISA)signed a 15-year contract for exploration for polymetallic sulfides located on the SWIR between 46°S and 53°S.The area allocated to the COMRA is approximately 10,000 km2.In this paper,we review the recent research advances about hydrothermal activity of the SWIR by the CDCs.As for the sulfides exploration in the future,some aspects should be emphasized,such as the controlling factors of sulfide mineralization on the SWIR,prospecting methods of inactive and buried sulfide deposits,sulfides resources assessment method,and the nearbottom sulfides exploration technology systems. | Chunhui Tao Huaiming Li Xiaobing Jin Jianping Zhou Tao Wu Yonghua He Xianming Deng Chunhua Gu Guoyin Zhang Weiyong Liu | 2014 | Chinese Science Bulletin2014，59，19： | 25 |
| 5 | Vanadium recovery from clay vanadium mineral using an acid leaching method显示文摘包括直接酸的沥滤的一种技术,钒降水与碱,钠氢氧化物重新沥滤,杂质由由烤步调整 pH 价值,有铵氯化物的降水钒,和钒 pentoxide 搬迁根据 Xichuan 的特征被建议泥土钒矿物质。影响象温度和硫磺的酸的集中那样的沥滤的钒的因素被调查并且优化。试验性的结果显示 V2O5 的摘录比率能分别地在 3% 的钠氯酸盐比率和 3% 的锰二氧化物比率到达 94% 和 92% 。一个完全化学的降水方法被采用清除并且在酸的沥滤溶液充实钒。X 光检查衍射(XRD ) 模式和钒 pentoxide 的纯净分析显示最后的钒 pentoxide 的纯净能到达 99% 并且遇见标准说明。全部的恢复能到达大约 75% 。这种技术作为与传统的咸烤方法相比有简洁,更少的投资,和更多的环境安全的特征。 | LI Haoran FENG Yali LIANG Jianglong LUO Xiaobing DU Zhuwei | 2008 | Rare Metals2008，27，2： | 23 |
| 6 | Developing land use scenario dynamics model by the integration of system dynamics model and cellular automata model显示文摘Modeling land use scenario changes and its potential impacts on the structure and function of the ecosystem in the typical regions are helpful to understanding the interactive mechanism between land use system and ecological system. A Land Use Scenario Dynamics (LUSD) model by the integration of System Dynamics (SD) model and Cellular Automata (CA) model is developed with land use scenario changes in northern China in the next 20 years simulated in this paper. The basic idea of LUSD model is to simulate the land use scenario de-mands by using SD model at first, then allocate the land use scenario patterns at the local scale with the considerations of land use suitability, inheritance ability and neighborhood effect by using CA model to satisfy the balance between land use scenario demands and supply. The application of LUSD model in northern China suggests that the model has the ability to reflect the complex behavior of land use system at different scales to some extent and is a useful tool for assessing the potential impacts of land use system on ecological system. In addition, the simulated results also indicate that obvious land use changes will take place in the farming-pastoral zone of northern China in the next 20 years with cultivated land and urban land being the most active land use types. | HE Chunyang, SHI Peijun, CHEN Jin, Li Xiaobing, PAN Yaozhong, LI Jing, LI Yuechen & LI Jinggang Key Laboratory of Environmental Change and Natural Disaster, Ministry of Education of China, Beijing Normal University College of Resources Science & Technology, Beijing Normal University, Beijing 100875, China | 2005 | Science China Earth Sciences2005，48，11： | 21 |
| 7 | Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment显示文摘Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, wesummarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent. | Xu Wu Wei Hu Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao Lin Zhang Hanyu Zhang Xiaobing Li Wanping Li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 20 |
| 8 | Estimation of carbon sinks in chemical weathering in a humid subtropical mountainous basin显示文摘The fluvial geochemistry of the mainstream and tributaries of the Zengjiang River was investigated,and the mass balance approach and deduction methods were used to estimate the uptake of atmospheric CO2 through rock chemical weathering.The results showed that the chemical runoff mainly consisted of HCO3-,Ca2+,Na+,and dissolved Si,and that silicate mineral weathering was significant,but carbonate mineral weathering was a minor source of dissolved loads in the Zengjiang River basin because of the low amount of interlayered carbonate rock strata in the catchment.The ion composition indicated that atmospheric CO2 was the primary erosive agent for rock chemical weathering in the Zengjiang River basin.The CO2 consumption fluxes caused by rock chemical weathering were(3.50-3.81) × 105 mol km-2 a-1,which is just lower than that in tropical and subtropical basalt and carbonate regions,and is much higher than that in temperate and cold-temperate regions,indicating that surficial chemical weathering processes in the humid and hot monsoon current influencing the low-middle latitude zone of the Northern Hemisphere constitutes a significant carbon sink in the global biogeochemical cycle. | TAO Zhen GAO QuanZhou WANG ZhenGang ZHANG ShengHua XIE ChenJi LIN PeiSong RUAN XiaoBing LI ShuHong MAO HaiRuo | 2011 | Chinese Science Bulletin2011，56，35： | 15 |
| 9 | The Interactions among DWARF10,Auxin and Cytokinin Underlie Lateral Bud Outgrowth in Rice显示文摘Previous studies have shown that DWARF10(D10) is a rice ortholog of MAX4/RMS1/DAD1,encoding a carotenoid cleavage dioxygenase and functioning in strigolactones/strigolactone-derivatives(SL) biosynthesis.Here we use D10-RNA interference(RNAi) transgenic plants similar to d10 mutant in phenotypes to investigate the interactions among D10,auxin and cytokinin in regulating rice shoot branching.Auxin levels in node 1 of both decapitated D10-RNAi and wild type plants decreased significantly,showing that decapitation does reduce endogenous auxin concentration,but decapitation has no clear effects on auxin levels in node 2 of the same plants.This implies that node 1 may be the location where a possible interaction between auxin and D10 gene would be detected.D10 expression in node 1 is inhibited by decapitation,and this inhibition can be restored by exogenous auxin application,indicating that D10 may play an important role in auxin regulation of SL.The decreased expression of most OsPINs in shoot nodes of D10-RNAi plants may cause a reduced auxin transport capacity.Furthermore,effects of auxin treatment of decapitated plants on the expression of cytokinin biosynthetic genes suggest that D10 promotes cytokinin biosynthesis by reducing auxin levels.Besides,in D10-RNAi plants,decreased storage cytokinin levels in the shoot node may partly account for the increased active cytokinin contents,resulting in more tillering phenotypes. | Shuying Zhang Gang Li Jun Fang Weiqi Chen Haipai Jiang Junhuang Zou Xue Liu Xianfeng Zhao Xiaobing Li Chengcai Chu Qi Xie Xiangning Jiang Lihuang Zhu | 2010 | Journal of Integrative Plant Biology2010，52，7： | 14 |
| 10 | Paleo-Tethyan Oceanic Crust Subduction in the Eastern Section of the East Kunlun Orogenic Belt:Geochronology and Petrogenesis of the Qushi'ang Granodiorite显示文摘The Qushi'ang granodiorite(QSG) is located at the central east of the ophiolitic melange belt in the East Kunlun Orogenic Belt(EKOB) in the northern margin of the Qinghai-Tibetan Plateau. LA-MC-ICP-MS zircon U–Pb dating suggests that the granodiorite and mafic microgranular enclaves(MMEs) crystallized 246.61±0.62 and 245.45±0.9 Ma ago, respectively. Granodiorite, porphyritic diorite, and MMEs are metaluminous and medium-K calk-alkaline series, with island-arc magma features, such as LILE enrichment and HFSE depletion. The porphyritic diorite has high Cr(13.50 ppm to 59.01 ppm), Ni(228.53 ppm to 261.29 ppm), and Mg~#(46–54). Granodiorite and porphyritic diorite have similar mineral compositions and evolved major and trace elements contents, particularly Cr and Ni, both of which are significantly higher than that in granites of the same period. The crystallization age of MMEs is close to that of granodiorite, and their major and trace elements contents are in-between porphyritic diorite and granodiorite. The results suggest that the original mafic magma, which was the product of mantle melting by subduction process, intruded into the lower crust(Kuhai Rock Group), resulting in the formation of granodiorite. Countinous intrusion of mafic magma into the unconsolidated granodiorite formed MMEs and porphyritic diorite. The granodiorite reformed by late-stage strike-slip faulting tectonic event indicates that the strike-slip fault of Middle Kunlun and the collision of the Bayanhar block with East Kunlun were later than 246 Ma. Therefore, the formation of the QSG not only indicates the critical period of evolution of East Kunlun but also represents the tectonic transition from oceanic crust subduction to slab breaking. | CHEN Guochao PEI Xianzhi LI Ruibao LI Zuochen LIU Chengjun CHEN Youxin PEI Lei WANG Meng LI Xiaobing | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 14 |
| 11 | Effects of Topography and Land Use Change on Gully Development in Typical Mollisol Region of Northeast China显示文摘Due to high intensity agricultural exploitation since the middle of the 20 th century, farmland gullies have become a pervasive form of water erosion in Northeast China. Yet few researches are concentrated on how topography and land use affect long-term gully development in this region. In this study, gully distribution in a village with an area of 24.2 km^2 in the central Mollisols area of Northeast China in different times were compared by Aerial photography(1968), Quickbird image(2009) and field survey, and factors affecting gully development including land use and topography were analyzed. The results showed that the total gully number decreased from 104 to 69, while occupying area rose from 34.8 ha to 78.4 ha from 1968 to 2009. Fundamental gully distribution had been formed by 1968 as most of 2009′s gullies were evolved from 1968′s gullies′ merge and width expansion process, and new gullies those initiated after 1968 occupied only 7% of total gully area in 2009. Gully area increasing ratio in grassland was the highest and that in forestland was the lowest. The threshold catchment area between simple and complex gully development was around 15 ha to 25 ha. This threshold value sets apart catchment areas that will develop simple or complex gullies in areas with similar environmental conditions. Gully control measurements were urgent because if appropriate gully control implements would not be applied, present gully erosion crisis could be doubled within 50 years. | LI Hao Richard M CRUSE LIU Xiaobing ZHANG Xingyi | 2016 | Chinese Geographical Science2016，26，6： | 11 |
| 12 | Characteristic Rainfall for Warning of Debris Flows显示文摘A characteristic rainfall is introduced to overcome the difficulties encountered in determining a critical rainfall value for triggering debris flow.The characteristic value is defined as the rainfall at which debris-flow occurrence probability shows a rapid increase,and can be used as a warning rainfall threshold for debris flows.Investigation of recorded debris flows and 24-hour rainfall data at Jiangjia basin,Yunnan Province,in southwestern China,demonstrates the existence of such a characteristic rainfall.It was found that the characteristic rainfall corresponds to the daily rainfall of 90% cumulative probability by analyzing the basin's daily rainfall histogram.The result provides a simple and useful method for estimating a debris-flow warning rainfall threshold from the daily rainfall distribution.It was applied to estimate the debris-flow warning rainfall threshold for the Subaohe basin,a watershed in the 2008 Wenchuan earthquake zone with many physical characteristics similar to those of the Jiangjia basin. | HU Kaiheng Cui Peng Wang Chuanchang Li Yong Lu Xiaobing | 2010 | Journal of Mountain Science2010，7，3： | 11 |
| 13 | Distribution, features, and influence factors of the submarine topographic boundaries of the Okinawa Trough显示文摘Based on multiple types of data, the topographical features of the Okinawa Trough(OT) have been characterized and a computation method has been proposed to determine the break point of continental shelf(BOS), foot point of the continental slope(FOS), the central axial point, and the maximum depth point. A total of 48 topographical profiles that crosscut the continental slope have been used to determine the trends of the BOS and FOS(the BOS and FOS lines) in the East China Sea(ECS). The trend of central axial points in the OT has been similarly determined by analyzing 39 topographical profiles across the axis of the trough. The BOS line forms the boundary between the continental shelf and slope. In the ECS, the BOS line roughly follows the 200 m isobath, continuously in the northern and middle parts of the OT, but jumping about somewhat in the south. The FOS line is the boundary between the continental slope and the bottom of the trough. The depth of the FOS increases gradually from north to south in the OT. Intense incisions by canyons into the slope in the southern part of the trough have led to the complex distribution of FOS. Topographical profiles crosscutting the northern, middle, and southern parts of the OT exhibit features that include: a single W-shape, a composite W-shape, and a U-shape, respectively, which suggests that in the middle and northern parts of the trough the central axial points are always located on seamount peaks or ridges associated with linear seamounts, whereas in the south they are found in the center of en echelon depressions. The line formed by the central axial points is the east-west dividing line of the OT, which indicates that the trough is a natural gap that prevents the extension of ECS continental shelf to the east. The distributions of the BOS and FOS lines are influenced by fluctuation of sea levels and submarine canyons, whereas the distribution of axis lines is controlled by tectonics and deposition. | WU ZiYin LI JiaBiao JIN XiangLong SHANG JiHong LI ShouJun JIN XiaoBing | 2014 | Science China Earth Sciences2014，57，8： | 11 |
| 14 | TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA显示文摘An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further elucidated.Here,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency factor.We elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation potential.Exposure of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m RNA.Reduced expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland cells.Our finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional level.Moreover,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine. | Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 15 | Effects of Boron on the Microstructure,Ductility-dip-cracking,and Tensile Properties for NiCrFe-7 Weld Metal显示文摘The distribution of boron and the microstructure of grain boundary(GB) precipitates(M_(23)(C,B)_6 and M_2B)have been analyzed with their effects on the susceptibility of ductility-dip-cracking(DDC) and tensile properties for NiCrFe-7 weld metal,using optical microscopy(OM),secondary ion mass spectroscopy(SIMS),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).The results show that boron segregates at GBs in NiCrFe-7 weld metal during the welding process.The segregation of boron at GBs promotes the formation of continuous M_(23)(C,B)_6 carbide chains and M_2B borides along GBs.The addition of boron aggravates GB embrittlement and causes more DDC in the weld metal,by its segregation at GBs presenting as an impurity,and promoting the formation of larger and continuous M_(23)(C,B)_6 carbides,and M_2B borides along GBs.DDC in the weld metal deteriorates the ductility and tensile strength of the weld metal simultaneously. | Wenlin Mo Xiaobing Hu Shanping Lu Dianzhong Li Yiyi Li | 2015 | Journal of Materials Science & Technology2015，31，12： | 9 |
| 16 | Experimental investigation and modeling of flotation column for treatment of oily wastewater显示文摘A unique cyclonic static microbubble flotation column was developed for oily wastewater separation.The separation effciency was found to be highly dependent on gas holdup and bubble size distribution.By changing the circulation pressure,gas flow rate,frother concentration,the effect of operation parameters on gas holdup and oil removal effciency were attained.A mathematical modeling between the kinetic constant and the gas holdup was established for oily water separation process.The results show that higher gas holdup and smaller microbubble sizes are benefcial to improve oil removal effciency. | Ran Jincai Liu Jiongtian Zhang Chunjuan Wang Dengyue Li Xiaobing | 2013 | International Journal of Mining Science and Technology2013，23，5： | 9 |
| 17 | YEATS2 是一个选择 histone crotonylation 读者显示文摘 | Dan Zhao Haipeng Guan Shuai Zhao Wenyi Mi Hong Wen Yuanyuan Li Yingming Zhao C David Allis Xiaobing Shi Haitao Li | 2016 | Cell Research2016，26，5： | 9 |
| 18 | Effects of long-term fertilizer applications on peanut yield and quality and plant and soil heavy metal accumulation显示文摘The status of essential and potentially toxic trace elements in soils and crops can be affected by long-term fertilization practices. This study aimed to investigate changes in peanut (Arachis hypogaea L.) yield and kernel quality, and changes in copper (Cu), zinc (Zn), lead (Pb), and cadmium (Cd)concentrations in soil and peanut kernels after 16 years of continuous cropping with different fertilization treatments. Five fertilization treatments were applied at a red soil site in Southeast China:chemical fertilizer (F) containing nitrogen, phosphorus, and potassium, F+trace elements (FT), pig manure (M), M+effective microorganisms (MB), and MB+trace elements (MBT). Properties of soil and pig manure, heavy metal contents in soil and peanut kernels, and the compositions of amino and fatty acids in kernels were determined. Application of pig manure significantly increased peanut biomass, kernel yield, and crude protein and total amino acid contents in kernels, but led to higher amounts of Cu, Zn, and Cd in soil and higher amounts of Zn and Cd in peanut kernels compared with that of chemical fertilizer. There should be greater concern about potential kernel Cd and Zn contaminations resulting from long-term application of pig manure contaminated with potentially toxic metals as an organic fertilizer. | Xiaobing WANG Wuxing LIU Zhengao LI Ying TENG Peter CHRISTIE Yongming LUO | 2020 | Pedosphere2020，30，4： | 9 |
| 19 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 20 | Ultrasound-triggered release of sinoporphyrin sodium from liposome-microbubble complexes and its enhanced sonodynamic toxicity in breast cancer显示文摘把超声(美国) 用于药交货和疾病治疗是重要工作。Sonodynamic 治疗(SDT ) 用在许多肿瘤的美国和一项 sonosensitizerexhibits antineoplastic 活动的全面治疗。在这研究,我们调查了使用新 sonosensitizer 的可行性(sinoporphyrin 钠, DVDMS ) 作为一个可能的候选人装进 liposome-microbubble 建筑群(DLMB ) 对乳癌提高 SDT。DLMB 经由 biotin 卵白素连接被综合并且证实了有好美国反应。导致美国的成穴起了一个关键作用从 DLMB 触发一个增加的收费载重版本并且改进细胞的举起和 DVDMS 的 intratumoral 散开认识到更好的 SDT 效果。DLMB 和美国治疗的联合在 vitro 导致了房间形态学,线粒体损坏,和房间 apoptosis 的重要变化。在 vivo,联合治疗显著地禁止了肿瘤生长,它看起来源于增加的 apoptosis 并且减少了增长活动。DLMB 正美国的 antitumor 效果的重要增加作为一条新途径建议他们的潜在的使用对乳癌支持 SDT 的杀死的活动。 | Yixiang Li Huanxiao An Xiaobing Wang Pan Wang Fei Qu Yan Jiao Kun Zhang Quanhong Liu | 2018 | Nano Research2018，11，2： | 8 |
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