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| 1 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 23 |
| 2 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 3 | Effects of Dietary β-Glucan and Glycyrrhizin on Non-Specific Immunity and Disease Resistance of the Sea Cucumber (Apostichopus japonicus Selenka) Challenged with Vibrio splendidus显示文摘Sea cucumbers, Apostichopus japonicus Selenka, were fed diets containing non-immunostimulant (basal diet), 0.2% β-glucan and 0.02% glycyrrhizin in a recirculatory water system for 45 days, and subsequently challenged with Vibrio splendidus by injection at 1.0×108 cfu/sea cucumber for 15 days.Phagocytic capacity (PC), intracellular superoxide anion production (ISAP), ly-sozyme (LSZ) activity and superoxide dismutase (SOD) activity in the coelomic fluid were analyzed on the 0th, 5th, 10th and 15th days after injection.Results showed that after the 45-day feeding period, PC, ISAP, LSZ activity and SOD activity in sea cucumbers fed with dietary β-glucan or glycyrrhizin were significantly higher than in those fed with the basal diet.On the 5th day after infection, all the immune parameters examined in the sea cucumbers injected with V.splendidus decreased in value significantly.On the 15th day, PC, ISAP and LSZ activity returned to levels similar to those on the 0th day.For the sea cucumbers injected with saline, there were no significant differences in all the immune parameters examined and in the cumulative morbidity during the 15-day challenging trial.After injecting with V.splendidus, the cumulative morbidity of sea cucumbers fed with the basal diet was significantly higher than those fed with dietary β-glucan or glycyrrhizin when challenged with V.splendidus challenged sea cucumber fed with the basal diet was significantly higher than those fed with dietary β-glucan or glycyrrhizin.There was no significant difference in cumulative morbidity between the dietary β-glucan and glycyrrhizin treatments over time. | CHANG Jie ZHANG Wenbing MAI Kangsen MA Hongming XU Wei | 2010 | Journal of Ocean University of China2010，9，4： | 12 |
| 4 | Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens显示文摘Naturally,resistant crop germplasms are important resources for managing the issues of agricultural product safety and environment deterioration.We found a spontaneous mutant of‘Newhall’navel orange(Citrus sinensis Osbeck)(MT)with broad-spectrum protections against fungal pathogens in the orchard,postharvest-storage,and artificial inoculation conditions.To understand the defense mechanism of MT fruit,we constructed a genome-scale metabolic network that integrated metabolome and transcriptome datasets.The coordinated transcriptomic and metabolic data were enriched in two sub-networks,showing the decrease in very long chain fatty acid(by 41.53%)and cuticular wax synthesis(by 81.34%),and increase in the synthesis of jasmonic acid(JA)(by 95.23%)and JA-induced metabolites such as 5-dimethylnobietin(by 28.37%)in MT.Furthermore,cytological and biochemical analyses confirmed that the response to fungal infection in MT was independent of wax deficiency and was correlated with the levels of jasmonates,and the expression of plant defensin gene PDF1.2.Results of exogenous application of MeJA and JA inhibitors such as propyl gallate proved that JA-mediated defense contributes to the strong tolerance against pathogens in MT.Our results indicated that jasmonate biosynthesis and signaling are stimulated by the fatty acid redirection of MT,and participate in the tolerance of pathogenic fungi. | Yizhong He Jingwen Han Runsheng Liu Yuduan Ding Jinqiu Wang Li Sun Xiaoming Yang Yunliu Zeng Weiwei Wen Juan Xu Hongming Zhang Xiang Yan Zhaoxing Chen Zuliang Gu Hong Chen Huanqing Tang Xiuxin Deng Yunjiang Cheng | 2018 | Horticulture Research2018，5，1： | 8 |
| 5 | Recent Progress in Automotive Gasoline Direct Injection Engine Technology显示文摘Gasoline direct injection(GDI)engines are currently the dominant powertrains for passenger cars.With the implementation of increasingly stringent fuel consumption and emission regulationsworldwide,GDI engines are facing challenges owing to high particulate matter emissions and a tendency to knock,leading to a change in the research and design(R&D)issues compared with those in the twentieth century.This paper reviews the progress in research regarding GDI engine technologies over the past 20 years,focusing on combustion system configurations,and also highlights common issues in GDI R&D,including pre-ignition and deto-knock,soot formation and PM emissions,injector deposits and gasoline compression ignition(GCI).First,an overview of recent developments in the field as driven by regulations is provided,following which progress in injection and combustion systems is examined.Third,the review addresses the occurrence and mechanism of deto-knock and considers means of suppressing this phenomenon.The fourth section discusses soot formation mechanisms and particulate matter emission characteristics of GDI engines and describes the application of gasoline particulate filter(GPF)after-treatment.The subsequent section summarizes studies regarding injector deposit formation,as well as pioneering research into GCI combustion modes.Finally,a summary and future prospects for GDI engine technologies are provided. | Shijin Shuai Xiao Ma Yanfei Li Yunliang Qi Hongming Xu | 2018 | Automotive Innovation2018，1，2： | 8 |
| 6 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 7 | 汽油和柴油混合燃料均质压燃(HCCI)的试验研究显示文摘汽油和柴油这两种不同特性的燃料被用作HCCI发动机的燃料。汽油具有高挥发性、易雾化和易于形成混合气的特性,被用来形成均质混合气;柴油具有良好的着火性和可燃性,被用来控制自燃和限制爆震燃烧。期望这两种特性不同而又相互补充的燃料混合后能够达到一个折衷的HCCI的燃烧性能。试验在一个专用于HCCI研究的单缸发动机上实施,采用两种中等的压缩比(10.4和15)和两种HCCI模式(进气加热和负气门叠开),试验结果证实了这种期望。结果是:随着混合燃料中柴油比例的增加,对于进气加热模式,HC- CI能稳定工作所需要的进气温度有所降低,对于负气门叠开模式,缸内平均指示压力和过量空气系数的范围有所扩展,并且两种方式下HC和NOx的排放均有所减少。 | 钟绍华 张永红 金国栋 Miroslaw Lech Wyszynski Xu Hongming | 2007 | 内燃机学报2007，25，1： | 7 |
| 8 | V_2O_5-WO_3-MoO_3/TiO_2催化剂在柴油机NH_3-SCR系统中的性能显示文摘针对柴油机运行工况特点及柴油机尾气成分特点,以工业纯锐钛型二氧化钛、偏钒酸铵、偏钨酸铵、钼酸铵为主要原料制备了颗粒状V2O5-WO3-MoO3/TiO2催化剂,以Lister Petter TR1重型直喷式单缸柴油机为依托搭建试验台,研究了在真实柴油机尾气环境下催化剂的脱硝性能。结果表明,柴油机负载增大,催化剂脱硝活性呈现下降趋势。1800r·min-1时,脱硝活性最大值87.1%在负载25%、反应温度380℃、空速20000h-1、氨氮比1.0处取得。柴油机负载不同,导致催化剂活性温度窗口(脱硝活性>70%)发生较大变化,与负载25%相比,负载50%活性温度窗口减小约60℃。增大柴油机负载可以提高NH3/N2O反应起始温度,但是同时会导致高温区间(>400℃)N2O生成量增大。 | 高岩 栾涛 彭吉伟 XU Hongming | 2013 | 化工学报2013，64，9： | 7 |
| 9 | Healthcare data analytics:using a metadata annotation approach for integrating electronic hospital records显示文摘The data in electronic medical records(EMR)are complex in structure.They are independent,yet related to each other.In order to improve information access through the use of EMR,annotating work on these data is necessary.The annotation on metadata,the resource data which contain a meta-model of the database,is the basis of the annotating work if a semi-automated or an automated annotating approach which aims at making the database more accessible is expected.In this study,a method has been proposed to transform the terms which cannot be matched directly by changing them literally but maintaining their semantics,and then annotating them indirectly.After the transforming work,a refinement method which is reducible to phrase sense disambiguation(PSD)is employed to ensure accuracy.A pilot study on a hospital database has been conducted to test the accuracy and effectiveness of the proposed method. | Boyi Xu Ke Xu LiuLiu Fu Ling Li Weiwei Xin Hongming Cai | 2016 | Journal of Management Analytics2016，3，2： | 6 |
| 10 | Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial显示文摘 | Ann-Lii Cheng Zhongzhen Guan Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Tsai-Sheng Yang Won Young Tak Hongming Pan Shiying Yu Jianming Xu Fang Fang Jessie Zou Giuseppe Lentini Dimitris Voliotis Yoon-Koo Kang | 2011 | European Journal of Cancer2011，，10： | 4 |
| 11 | Comparing the adsorption behaviors of Cd, Cu and Pb from water onto Fe-Mn binary oxide, MnO2 and FeOOH显示文摘FMBO 的吸附潜力, FeOOH , MnO <潜水艇class=“ a-plus-plus ”>为 Cd 的移动的 2 <啜class=“ a-plus-plus ”>2+, Cu <啜class=“ a-plus-plus ”>2+和 Pb <啜class=“ a-plus-plus ”>在水的系统的2+在这研究被调查。比作 FMBO 和 FeOOH, MnO < 潜水艇 class= “ a-plus-plus ” > 2 向三个金属离子为高得多的移动提供了能力。 MnO 的最大的吸附能力<潜水艇class=“ a-plus-plus ”>为 Cd 的 2 <啜class=“ a-plus-plus ”>2+, Cu <啜class=“ a-plus-plus ”>2+和 Pb <啜class=“ a-plus-plus ”>2+是 1.23 , 2.25 和 2.60 mmol ???????剕偅??????????????????????￡?? 蓈 ?? | Wei XU Huachun LAN Hongjie WANG Hongming LIU Jiuhui QU | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 4 |
| 12 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 3 |
| 13 | Spray,atomization and combustion characteristics of oxygenated fuels in a constant volume bomb:A review显示文摘Biofuels have extensive available resources and have an immense potential as promising alternative fuels for automobile.The application advantages of biofuels are mainly reflected as particulate matter(PM)reduction,carbon neutral,greenhouse gases reduction,waste utilization,energy and economic security,and fuel pluralism.Based on the understanding of molecular structure effects of biofuels on soot formation and particles morphology,the effects of alcohols,ethers,esters and biodiesel on spray and combustion process in constant volume bomb in recent years are retrospectively analyzed in this paper.For the mixture,macromolecular ester fuels and polyoxymethylene dimethyl ether(PODE)are conducive to the improvement of liquid spray,while biodiesel,small molecules,dimethyl ether(DME)and alcohols are reversed.Alcohols are advantageous to the extension of mixing time and the increasing of vapor-phase mixture.Through the influence integrated assessment,alcohols show the best performance on the spray,atomization and combustion,while biodiesels show the worst.But in terms of combustion,PODE is the best choice without considering spray and atomization.For binary alternative-diesel fuel blends,methanol or butanol is the best additive based on synthetically considerations on spray,atomization and combustion.To meet the requirements of the fuel application of diesel engine,ternary fuel or even quaternary fuel have been proposed and explored.This review can help to form a systematic understanding on fuel recombining and obtain the guide of clean and efficient fuel formulation for diesel engine. | Peng Zhang Xin Su Chengshan Yi Hao Chen Hongming Xu Limin Geng | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，3： | 2 |
| 14 | 均质压燃(HCCI)单区和多区燃烧模型的比较显示文摘利用耦合化学动力学软件包CHEMKIN建立了汽油HCCI发动机的单区和多区燃烧模型。与试验数据的对比表明:虽然单区模型在参数化研究中能较准确地预测混合气的自燃定时,但其准确性在很大程度上取决于缸内的均匀性;包含缝隙区、淬熄区、质量交换区和绝热核心区的九区燃烧模型通过设置特定的功能分区能更好地模拟HCCI的燃烧过程,它在对自燃定时的预测和对热量释放过程和排放物的形成机理的模拟等方面都有很好的性能。 | 钟绍华 孔斌 Miroslaw Lech Wyszynski Xu Hongming | 2007 | 内燃机工程2007，28，3： | 2 |
| 15 | Effect of spark timing and load on a DISI engine fuelled with 2,5-dimethylfuran显示文摘 | Ritchie Daniel Guohong Tian Hongming Xu Miroslaw L. Wyszynski Xuesong Wu Zuohua Huang | 2010 | Fuel2010，，2： | 1 |
| 16 | Combustion characteristics and emissions of 2-methylfuran compared to 2,5-dimethylfuran, gasoline and ethanol in a DISI engine显示文摘 | Chongming Wang Hongming Xu Ritchie Daniel Akbar Ghafourian Jose Martin Herreros Shijin Shuai Xiao Ma | 2013 | Fuel2013，，： | 1 |
| 17 | Ultra-High Speed Imaging and OH-LIF Study of DMF and MF Combustion in a DISI Optical Engine显示文摘 | Xiao Ma Hongming Xu Changzhao Jiang Shijin Shuai | 2014 | Applied Energy2014，，： | 1 |
| 18 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 1 |
| 19 | Active autophagy in the tumor microenvironment: A novel mechanism forcancer metastasis (Review)显示文摘 | Yinghua Xu Xiaoping Xia Hongming Pan | 2013 | Oncology Letters2013，，2： | 1 |
| 20 | New premixed compression ignition concept for direct injection IC engines fueled with straight-run naphtha显示文摘 | Hongqiang Yang Shijin Shuai Zhi Wang Jianxin Wang Hongming Xu | 2013 | Energy Conversion and Management2013，，： | 1 |
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