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| 1 | Anesthetic Sevoflurane Causes Neurotoxicity Differently in Neonatal Na?ve and Alzheimer Disease Transgenic Mice显示文摘 | Yan Lu Xu Wu Yuanlin Dong Zhipeng Xu Yiying Zhang Zhongcong Xie | 2010 | Anesthesiology2010，，6： | 2 |
| 2 | The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β显示文摘 | Xu Wu Yan Lu Yuanlin Dong Guohua Zhang Yiying Zhang Zhipeng Xu Deborah J. Culley Gregory Crosby Edward R. Marcantonio Rudolph E. Tanzi Zhongcong Xie | 2012 | Neurobiology of Aging2012，，7： | 1 |
| 3 | The Common Inhalation Anesthetic Isoflurane Induces Apoptosis and Increases Amyloid β Protein Levels显示文摘 | Zhongcong Xie Yuanlin Dong Uta Maeda Paul Alfille Deborah J. Culley Gregory Crosby Rudolph E. Tanzi | 2006 | Anesthesiology2006，，5： | 1 |
| 4 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 5 | Glucose May Attenuate Isoflurane-Induced Caspase-3 Activation in H4 Human Neuroglioma Cells显示文摘 | Yongxing Sun Yiying Zhang Baiqi Cheng Yuanlin Dong Chuxiong Pan Tianzuo Li Zhongcong Xie | 2014 | Anesthesia & Analgesia2014，，6： | 1 |
| 6 | Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice显示文摘Alzheimer’s disease(AD)is the most common form of dementia.At the present time,however,AD still lacks effective treatments.Our recent studies showed that chronic treatment with anesthetic propofol attenuated brain caspase-3 activation and improved cognitive function in aged mice.Accumulation ofβ-amyloid protein(Aβ)is a major component of the neuropathogenesis of AD dementia and cognitive impairment.We therefore set out to determine the effects of chronic treatment with propofol on Aβlevels in brain tissues of aged mice.Propofol(50 mg/kg)was administrated to aged(18 month-old)wild-type mice once a week for 8 weeks.The brain tissues of mice were harvested one day after the final propofol treatment.The harvested brain tissues were then subjected to enzyme-linked immunosorbent assay(ELISA)and Western blot analysis.Here we report that the propofol treatment reduced Aβ(Aβ40 and Aβ42)levels in the brain tissues of the aged mice.Moreover,the propofol treatment decreased the levels ofβ-site amyloid precursor protein cleaving enzyme(the enzyme for Aβgeneration),and increased the levels of neprilysin(the enzyme for Aβdegradation)in the brain tissues of the aged mice.These results suggested that the chronic treatment with propofol might reduce brain Aβlevels potentially via decreasing brain levels ofβ-site amyloid precursor protein cleaving enzyme,thus decreasing Aβgeneration;and via increasing brain neprilysin levels,thus increasing Aβdegradation.These preliminary findings from our pilot studies have established a system and postulated a new hypothesis for future research. | Yiying Zhang Haijun Shao Yuanlin Dong Celeste A Swain Buwei Yu Weiming Xia Zhongcong Xie | 2014 | Translational Neurodegeneration2014，3，1： | 1 |
| 7 | A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection显示文摘Dear Editor,Identifying the host factors that are utilized for virus infection and mapping their cell-type expression profile can help to understand the viral tissue/organ tropism and pathogenesis.Much effort has been devoted to the identification of SARS-CoV-2 infection-dependent host factors.CRISPR-based activation(Konermann et al.,2015). | Fei Feng Yunkai Zhu Yanlong Ma Yuyan Wang Yin Yu Xinran Sun Yuanlin Song Zhugui Shao Xinxin Huang Ying Liao Jingyun Ma Yuping He Mingyuan Wang Longhai Tang Yaowei Huang Jincun Zhao Qiang Ding Youhua Xie Qiliang Cai Hui Xiao Chun Li Zhenghong Yuan Rong Zhang | 2023 | Protein & Cell2023，14，1： | 0 |
| 8 | RNAi-mediated knock-down of Dab and Numb attenuate Ab levels via g-secretase mediated APP processing显示文摘Amyloid-b-protein(Ab),the key component of senile plaques in Alzheimer’s disease(AD)brain,is produced from amyloid precursor protein(APP)by cleavage of b-secretase and then g-secretase.APP adaptor proteins with phosphotyrosine-binding(PTB)domains,including Dab(gene:DAB)and Numb(gene:NUMB),can bind to and interact with the conserved YENPTY-motif in the APP C-terminus.Here we describe,for the first time,the effects of RNAi knock-down of Dab and Numb expression on APP processing and Ab production.RNAi knock-down of Dab and Numb in H4 human neuroglioma cells stably transfected to express either FL-APP(H4-FL-APP cells)or APP-C99(H4-APP-C99 cells)increased levels of APP-C-terminal fragments(APP-CTFs)and lowered Ab levels in both cell lines by inhibiting g-secretase cleavage of APP.Finally,RNAi knock-down of APP also reduced levels of Numb in H4-APP cells.These findings suggest that pharmacologically blocking interaction of APP with Dab and Numb may provide novel therapeutic strategies of AD.The notion of attenuating g-secretase cleavage of APP via the APP adaptor proteins,Dab and Numb,is particularly attractive with regard to therapeutic potential,given that side effects of gsecretase inhibition owing to impaired proteolysis of other g-secretase substrates,e.g.Notch,might be avoided. | Zhongcong Xie Yuanlin Dong Uta Maeda Weiming Xia Rudolph E Tanzi | 2012 | Translational Neurodegeneration2012，1，1： | 0 |
| 9 | STUDY OF THE PROPERTIES OF INFRARED INTERSUBBAND TRANSITION IN DOPED GaAs/A1_(x)Ga_(1-x)As MULTIPLE QUANTUM WELLS显示文摘The properties of intersubband transition of GaAs/A1_(x)Ga_(1-x)As multiple quantum wells with various well widths and doped-well concentrations have been studied.Both theoretical and experimental results are in good agreement.For the appropriate well width and higher doping concentration,we directly observed two intersubband absorption peaks from E_(1)→E_(2) and E_(2)→E_(3) transitions in well.The experimental results and theoretical analysis are given. | CHEN Zhenghao CUI Dafu ZHOU Junming PAN Shaohua HUANG Qi ZHOU Yueliang LÜHuibin XIE Yuanlin FENG Simin YANG Guozhen | 1990 | Chinese Physics Letters1990，7，7： | 0 |
| 10 | 常用吸入麻醉剂异氟烷诱导凋亡和增加淀粉样β蛋白的水平显示文摘背景:β淀粉样蛋白(Aβ)的过度蓄积是阿尔茨海默病的发病机制之一。异氟烷是一种常用的吸入麻醉药,曾经有异氟烷可增加嗜铬细胞瘤细胞内Aβ的寡聚化反应和细胞毒性的报道。为了探讨异氟烷在AD发病机制和术后认知障碍(POCD)中的可能作用,我们研究了异氟烷在临床应用浓度(2%)下是否能诱导过度表达人APP的人H4神经胶质瘤细胞凋亡、改变APP加工处理过程和增加Aβ的生成。 | Zhongcong Xie Yuanlin Dong Uta Maeda Paui Alfille Deborah J.Culley Gregory Crosby Rudolph E.Tanzi | 2007 | 麻醉与监护论坛2007，14，4： | 0 |
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