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| 1 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 2 | An update: Epstein-Barr virus and immune evasion via microRNA regulation显示文摘Epstein-Barr virus(EBV) is an oncogenic virus that ubiquitously establishes life-long persistence in humans. To ensure its survival and maintain its B cell transformation function, EBV has developed powerful strategies to evade host immune responses. Emerging evidence has shown that micro RNAs(mi RNAs) are powerful regulators of the maintenance of cellular homeostasis. In this review, we summarize current progress on how EBV utilizes mi RNAs for immune evasion. EBV encodes mi RNAs targeting both viral and host genes involved in the immune response. The mi RNAs are found in two gene clusters, and recent studies have demonstrated that lack of these clusters increases the CD4^+ and CD8^+ T cell response of infected cells. These reports strongly indicate that EBV mi RNAs are critical for immune evasion. In addition, EBV is able to dysregulate the expression of a variety of host mi RNAs, which influence multiple immune-related molecules and signaling pathways. The transport via exosomes of EBV-regulated mi RNAs and viral proteins contributes to the construction and modification of the inflammatory tumor microenvironment.During EBV immune evasion, viral proteins, immune cells, chemokines, pro-inflammatory cytokines, and pro-apoptosis molecules are involved. Our increasing knowledge of the role of mi RNAs in immune evasion will improve the understanding of EBV persistence and help to develop new treatments for EBV-associated cancers and other diseases. | Lielian Zuo Wenxin Yue Shujuan Du Shuyu Xin Jing Zhang Lingzhi Liu Guiyuan Li Jianhong Lu | 2017 | Virologica Sinica2017，32，3： | 9 |
| 3 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 4 | Herbal formula of Bushen Jianpi(补肾健脾方)combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle显示文摘OBJECTIVE:To investigate the efficacy of an herbal formula of Bushen Jianpi(补肾健脾方,BSJP)combined with sorafenib on hepatocellular carcinoma(HCC)in vitro and in vivo,and to study the underlying mechanisms of action.METHODS:BSJP,a mixture of 12 raw herbs,was extracted in 70%alcohol/30%water and freeze-dried into a powder.The in vitro effects of BSJP alone,sorafenib alone,and their combination on cell survival,apoptosis,and cell cycle distribution were evaluated in HCC cell lines HCCLM3,HepG2,and SMMC-7721.The expression of B-cell lymphoma-2(Bcl-2),caspase-3,and caspase-9 in HCCLM3 cells was measured using Western blots after drug administration.The in vivo effects of BSJP and sorafenib were evaluated in a tumor surgical resection model using 4-week old male athymic BALB/c nude mice injected with HCCLM3 cells.Immunohistochemical analysis of tumor tissues was performed to evaluate the effects of BSJP alone,sorafenib alone,and their combination on the expression of caspase-3,caspase-9,and Bcl-2.RESULTS:BSJP decreased the survival rate of HCC cell lines,and the combination of BSJP and sorafenib further decreased the survival rate.BSJP significantly promoted cell apoptosis and blocked cell-cycle progression in HCCLM3,HepG2,and SMMC-7721 cells in a dose-dependent manner.Furthermore,the administration of BSJP and sorafenib inhibited the growth of HCCLM3 cell xenografts in nude mice,with no reduction in body weight.In vivo and in vitro experiments showed that BSJP combined with sorafenib could significantly decrease the expression of Bcl-2.CONCLUSION:Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent. | ZHOU Zhangjie LIU Xinhua WU Tingting QUE Zujue WU Zhonghua WU Weizhong FU Shujuan ZHANG Shiqiang YANG Yun JIANG Haiyan XIA Xiaoting LV Junqiang DU Boqian LI Yun LU Tao ZHANG Zhihui ZHONG Yi | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 3 |
| 5 | A preliminary analy- sis of main factors affecting stress-strain behaviors of frozen soil with high water content 显示文摘 | Zhang Shujuan Sun Zhizhong Du Haimin | 2012 | Applied Mechanics and Materials2012，204，： | 1 |
| 6 | Correction to:MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘CORRECTION TO:PROTEIN CELL(2014)5(11):851-861 http://gffzzd3cc09b8251d45dfoqcn9ocxf5vfq60cv.ffgz.tsg.suse.edu.cn/10.1007/S13238-014-0093-5 In the original publication the display of Fig.1 is in correct.The correct Fig.1 is available in this correction. | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaiing Hu Qifeng Wang Shujuan Ni Bojian Fei Weiii Wang Xiang Du Dong Hua Zhaohui Huang | 2021 | Protein & Cell2021，12，8： | 1 |
| 7 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 8 | Luminescent gold nanocluster-based sensing platform for accurate H_(2)S detection in vitro and in vivo with improved anti-interference显示文摘Gold nanoclusters(Au NCs)are promising luminescent nanomaterials due to their outstanding optical properties.However,their relatively low quantum yields and environment-dependent photoluminescence properties have limited their biological applications.To address these problems,we developed a novel strategy to prepare chitosan oligosaccharide lactate(Chi)-functionalized Au NCs(Au NCs@Chi),which exhibited emission with enhanced quantum yield and elongated emission lifetime as compared to the Au NCs,as well as exhibited environment-independent photoluminescence properties.In addition,utilizing the free amino groups of Chi onto Au NCs@Chi,we designed a FRET-based sensing platform for the detection of hydrogen sulfide(H_(2)S).The Au NCs and the specific H_(2)S-sensitive merocyanine compound were respectively employed as an energy donor and acceptor in the platform.The addition of H_(2)S induced changes in the emission profile and luminescence lifetime of the platform with high sensitivity and selectivity.Utilization of the platform was demonstrated to detect exogenous and endogenous H_(2)S in vitro and in vivo through wavelength-ratiometric and time-resolved luminescence imaging(TLI).Compared to previously reported luminescent molecules,the platform was less affected by experimental conditions and showed minimized autofluorescence interference and improved accuracy of detection. | Qi Yu Pengli Gao Kenneth Yin Zhang Xiao Tong Huiran Yang Shujuan Liu Jing Du Qiang Zhao Wei Huang | 2017 | Light(Science & Applications)2017，6，1： | 1 |
| 9 | Bifunctional resin- ZVI composites for effective removal of arsenite through simultaneous adsorption and oxidation 显示文摘 | DU Qiong ZHANG Shujuan PAN Bingcai | 2013 | Water Research2013，47，16： | 1 |
| 10 | Analysis and discussion of different methods of artificial ice-high specimen preparation显示文摘Because ice-high foundation soil is widely distributed in permafrost regions,the correct preparation of ice-high specimens is of critical interest in engineering design for foundation stability.Past research has shown that the uniaxial compression strength of ice-high frozen soils changes as the ice or total water content increases; the differences of different methods of specimen preparation are analyzed here and the advantages and disadvantages of them are presented.It is confirmed that the role of crushed ice is significantly different from that of naturally frozen ice in frozen soils,and the size and amount of crushed ice will influence the strength and deformation mechanism of frozen soils.Therefore,it is strongly recommended that when a ice-high specimen is artificially prepared,the ice should be frozen through natural means and not be replaced with crushed ice. | ShuJuan Zhang Wei Ma ZhiZhong Sun HaiMin Du | 2014 | Research in Cold and Arid Regions2014，6，5： | 1 |
| 11 | Surface plasmon enhanced solar-blind photoresponse of Ga2O3 film with Ga nanospheres显示文摘Semiconductor solar-blind(220-280 nm)photodetectors(PDs),which have important applications both in civil and military aspects,are mainly based on diamond[1],Al Ga N[2],Mg Zn O[3],and Ga_2O_3[4-11].Among these materials,Ga_2O_3has a direct band gap(~4.9 e V)just falling in solarblind spectral range,which makes Ga_2O_3a desirable candidate for solar-blind photodetection.Up to now,many kinds of Ga_2O_3PDs have been demonstrated including bulk[4,5],film[6-8]and nanostructures[9-11],as summarized in Table 1.From the summary,we can see although bulk | Shujuan Cui Zengxia Mei Yaonan Hou Muhua Sun Quansheng Chen Huili Liang Yonghui Zhang Xuedong Bai Xiaolong Du | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，10： | 0 |
| 12 | Tectonic activity and earthquake risk in the Chengnanhe fault zone in Weihai city,Shandong province,China,obtained by using an integrated prospecting technique in geophysics and geology显示文摘For city planning and reducing potential earthquake risk,it’s necessary to detect the information of the buried faults in an urban area especially,including the location and activities.An integrated technique with geophysical and geological methods,including the shallow seismic reflection profile,electrical resistivity measurement,geologic borehole section,and exploration trench,was used to detect the Chengnanhe fault,which is one of the two main faults passing through the Weihai urban area in Shandong province,China.The results show that it is a normal fault striking with E-W direction,and it is relatively inactive and stable.By using the thermoluminescence(TL)dating,we found that the Chengnanhe fault initiated in mid-Pleistocene and there was no offset after late Pleistocene.Such an integrated technique with multiple geological and geophysical methods provides a significant assessment of earthquake risk for city planning in urban areas. | Gui-Lin Du Lian-Feng Zhao Xiaobo Tian Shujuan Su Xiangchun Chang Hualin Wang Zhuqing Huo Tao Zhu Yonghua Li | 2021 | Earthquake Science2021，34，2： | 0 |
| 13 | CORRECTION:Author Correction:Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘In the initial published version of this article,there were errors in the 5th and 6th affiliations.The correct 5th affiliation is“State Key Laboratory of Molecular Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Beijing,China”. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，6： | 0 |
| 14 | (GdxDy1-x)12Co7 Magneto-thermal Effect显示文摘Because of its own advantages such as energy saving and environmental protection,the greenhouse magnetic refrigeration technology is attracting more and more attention.Magnetic refrigeration materials as one of the key technology,its development has a very important role.This paper begins with a brief overview of the basic principles of magnetic refrigeration and the development of magnetic refrigeration materials.In this paper,the phase structure and Magnetocaloric eff ect of(GdxDy1-x)12Co7(x=0.3,0.5,0.7,0.8)series alloys were investigated by X-ray diff raction and magnetic properties measurements.The results show that all samples are monoclinic crystals,with the Gd composition increases,the Curie temperature of the alloy from 92K to 142K linear increase.In the case of an external magnetic fi eld of 2Td,the maximum magnetic entropy of the(GdxDy1-x)12Co7(x=0.3,0.5,0.7,0.8)series alloy becomes 6.93 J/kg·K.By analyzing the XRD patterns of the alloys and the graphs of the M-H and Arrott graphs,it is shown that the alloy is transformed from a secondary phase transition to a primary phase transition. | Yunyue Du Shujuan Bi Shaoyong Cai | 2018 | Insight-Physics2018，1，1： | 0 |
| 15 | Genome resources for the elite bread wheat cultivar Aikang 58 and mining of elite homeologous haplotypes for accelerating wheat improvement显示文摘Despite recent progress in crop genomics studies,the genomic changes brought about by modern breeding selection are still poorly understood,thus hampering genomics-assisted breeding,especially in polyploid crops with compound genomes such as common wheat(Triticum aestivum).In this work,we constructed genome resources for the modern elite common wheat variety Aikang 58(AK58).Comparative genomics between AK58 and the landrace cultivar Chinese Spring(CS)shed light on genomic changes that occurred through recent varietal improvement.We also explored subgenome diploidization and divergence in common wheat and developed a homoeologous locus-based genome-wide association study(HGWAS)approach,which was more effective than single homoeolog-based GWAS in unraveling agronomic trait-associated loci.A total of 123 major HGWAs loci were detected using a genetic population derived from AK58 and cs.Elite homoeologous haplotypes(HHs),formed by combinations of subgenomic homoeologs of the associated loci,were found in both parents and progeny,and many could substantially improve wheat yield and related traits.We built a website where users can download genome assembly sequence and annotation data for AK58,perform blast analysis,and run JBrowse.Our work enriches genome resources for wheat,provides new insights into genomic changes during modern wheat improve-.ment,and suggests that efficientmining of elite HHs can make a substantial contribuutionto genomics-assisted breeding in common wheat and other polyploid crops. | Jizeng Jia Guangyao Zhao Danping Li Kai Wang Chuizheng Kong Pingchuan Deng Xueqing Yan Xueyong Zhang Zefu Lu Shujuan Xu Yuannian Jiao Kang Chong Xu Liu Dangqun Cui Guangwei Li Yijing Zhang Chunguang Du Liang Wu Tianbao Li Dong Yan Kehui Zhan Feng Chen Zhiyong Wang Lichao Zhang Xiuying Kong Zhengang Ru Daowen Wang Lifeng Gao | 2023 | Molecular Plant2023，16，12： | 0 |
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