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| 1 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 2 | Nonlinear optical absorption of few-layer molybdenum diselenide (MoSe2) for passively mode-locked soliton fiber laser [Invited]显示文摘In this paper,both nonlinear saturable absorption and two-photon absorption(TPA) of few-layer molybdenum diselenide(MoSe2) were observed at 1.56 μm wavelength and further applied to mode-locked ultrafast fiber laser for the first time to our knowledge.Few-layer MoSe2 nanosheets were prepared by liquid-phase exfoliation method and characterized by x ray diffractometer,Raman spectroscopy,and atomic force microscopy.The obtained fewlayer MoSe2 dispersion is further composited with a polymer material for convenient fabrication of MoSe2 thin films.Then,we investigated the nonlinear optical(NLO) absorption property of the few-layer MoSe2 film using a balanced twin-detector measurement technique.Both the saturable absorption and TPA effects of the few-layer MoSe2 film were found by increasing the input optical intensity.The saturable absorption shows a modulation depth of 0.63% and a low nonsaturable loss of 3.5%,corresponding to the relative modulation depth of 18%.The TPA effect occurred when the input optical intensity exceeds 260 MW∕cm2.Furthermore,we experimentally exploit the saturable absorption of few-layer MoSe2 film to mode lock an all-fiber erbium-doped fiber laser.Stable soliton mode locking at 1558 nm center wavelength is achieved with pulse duration of 1.45 ps.It was also observed that the TPA process suppresses the mode-locking operation in the case of higher optical intensity.Our results indicate that layered MoSe2,as another two-dimensional nanomaterial,can provide excellent NLO properties(e.g.,saturable absorption and TPA) for potential applications in ultrashort pulse generation and optical limiting. | Zhengqian Luo Yingyue Li Min Zhong Yizhong Huang Xiaojiao Wan Jian Peng Jian Weng | 2015 | Photonics Research2015，3，3： | 8 |
| 3 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 4 | A Truncated F-Box Protein Confers the Dwarfism in Cucumber显示文摘Dwarfism is an important plant architecture trait in crop breeding(Peng et al.,1999;Sasaki el al.,2002).In cucurbits.the compact plant type was proposed to develop new varieties for the once-over mechanical harvest for concentrated fruit set and higher densities(Li et al.,2011;Mondal et al.,2011).Several recessive genes in cucurbits have been reported to confer the phenotype of short internodes or bushy plant habits,such as compact,cp-2,and dw in cucumber(Cucumis | Tao Lin Shenhao Wang Yang Zhong Dongli Gao Qingzhi Cui Huiming Chen Zhonghua Zhang Huolin Shen Yiqun Weng Sanwen Huang | 2016 | Journal of Genetics and Genomics2016，43，4： | 5 |
| 5 | Different expression patterns of duplicated PHANTASTICA-like genes in Lotus japonicus suggest their divergent functions during compound leaf development显示文摘Recent studies on leaf development demonstrate that the mechanism on the adaxial-abaxial polarity pattern formation could be well conserved among the far-related species, in which PHANTASTICA (PAHN)-like genes play important roles. In this study, we explored the conservation and diversity on functions of PHAN-like genes during the compound leaf development in Lotus japonicus, a papilionoid legume. Two PHAN-like genes in L. japonicus, LjPHANa and LjPHANb, were found to originate from a gene duplication event and displayed different expression patterns during compound leaf development. Two mutants, reduced leaflets1 (rel1) and reduced leaflets3 (rel3), which exhibited decreased adaxial identity of leaflets and reduced leaflet initiation, were identified and investigated. The expression patterns of both LjPHANs in rel mutants were altered and correlated with abnormalities of compound leaves. Our data suggest that LjPHANa and LjPHANb play important but divergent roles in regulating adaxial-abaxial polarity of compound leaves in L. japonicus. | Jiang Hong LUO Jun YAN Lin WENG Jun YANG Zhong ZHAO Jiang Hua CHEN Xiao He HU Da LUO | 2005 | Cell Research2005，15，8： | 5 |
| 6 | Computer Controlled Polishing of the Off-axis Aspheric Mirrors显示文摘In this paper, the manufacturing and testing procedures to make large off-axis aspherical mirrors are presented. The difficulties in polishing and testing for both circular aperture and rectangular aperture mirrors are previewed, and a possible solution is given. The two mirrors have been polished by means of CCOS, and the final accuracy is 25nm rms for 770mm×210mm rectangular mirror and 20nm rms for φ600mm circular mirror. These results just meet the optical tolerances specified by the designer, and the manufacturing and testing procedures presented here show good ability to make the large off-axis aspherical mirrors. | ZHANG Xue jun,WENG Zhi cheng,ZHANG Zhong yu, WANG Quan dou,ZHANG Feng (Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130022, China) | 2001 | 光学精密工程2001，9，5： | 4 |
| 7 | Therapeutic siRNA:state of the art显示文摘RNA interference(RNAi)is an ancient biological mechanism used to defend against external invasion.It theoretically can silence any disease-related genes in a sequence-specific manner,making small interfering RNA(siRNA)a promising therapeutic modality.After a two-decade journey from its discovery,two approvals of siRNA therapeutics,ONPATTRO®(patisiran)and GIVLAARI™(givosiran),have been achieved by Alnylam Pharmaceuticals.Reviewing the long-term pharmaceutical history of human beings,siRNA therapy currently has set up an extraordinary milestone,as it has already changed and will continue to change the treatment and management of human diseases.It can be administered quarterly,even twice-yearly,to achieve therapeutic effects,which is not the case for small molecules and antibodies.The drug development process was extremely hard,aiming to surmount complex obstacles,such as how to efficiently and safely deliver siRNAs to desired tissues and cells and how to enhance the performance of siRNAs with respect to their activity,stability,specificity and potential off-target effects.In this review,the evolution of siRNA chemical modifications and their biomedical performance are comprehensively reviewed.All clinically explored and commercialized siRNA delivery platforms,including the GalNAc(N-acetylgalactosamine)–siRNA conjugate,and their fundamental design principles are thoroughly discussed.The latest progress in siRNA therapeutic development is also summarized.This review provides a comprehensive view and roadmap for general readers working in the field. | Bo Hu Liping Zhong Yuhua Weng Ling Peng Yuanyu Huang Yongxiang Zhao Xing-Jie Liang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 8 | Engineering electrochemical actuators with large bending strain based on 3D-structure titanium carbide MXene composites显示文摘Electrically responsive electrochemical actuators that contain a polymer electrolyte membrane laminated between two electrodes have attracted great attention due to their potential applications in smart electronics,wearable devices,and soft robotics.However,some challenges such as the achievement of large bending strain under low applied voltage and fast ion diffusion and accumulation still exist to be resolved.The key to the solution lies in the choice of electrode materials and the design of electrode structures.In this study,an engineering electrochemical actuator that presents large bending strain under low applied voltage based on MXene/polystyrene-MXene hybrid electrodes is developed.The developed electrochemical actuator based on the MXene/polystyrene-MXene 3D-structure is found to exhibit large bending strain(ca.1.18%),broad frequency bandwidth,good durability(90%retention after 10,000 cycles)and considerable Young’s modulus(ca.246 MPa).The high-performance actuation mainly stems from the excellent properties of MXene and 3D-structure of the electrode.The MXene provides excellent mechanical strength and high electrical conductivity which facilitate strong interaction and rapid electron transfer in electrodes.The 3D architectures formed by polystyrene microspheres generate unimpeded ion pathways for ionic short diffusion and fast injection.This study reveals that the 3D-structure hybrid electrodes play a crucial role in promoting the performance of such electrochemical actuators. | Tong Wang Tianjiao Wang Chuanxin Weng Luqi Liu Jun Zhao Zhong Zhang | 2021 | Nano Research2021，14，7： | 4 |
| 9 | A new member of the topological semimetals family显示文摘In topological semimetals(TSMs),the quasi-particle excitations of electrons can be described by the Dirac or Weyl equation,mimicking the elusive massless Dirac or Weyl fermions in the low-frequency regime as emergent phenomena.The realization of elementary excitations,with and even | Hongming Weng Chen Fang Zhong Fang Xi Dai | 2017 | National Science Review2017，4，6： | 3 |
| 10 | Topological nodal line semimetals predicted from first-principles calculations显示文摘拓扑的半金属是量物质的最新发现的状态,它从绝缘体扩大了拓扑的状态的概念到金属并且在最近的年里吸引了大研究兴趣。一般来说,有三种拓扑的半金属,也就是迪拉克半金属, Weyl 半金属,和节的线半金属。节的线半金属能为另外的拓扑的状态被看作先锋状态。例如,从如此的节的线开始说,节的线结构可能演变为 Weyl 点,把点变换成迪拉克,或由介绍联合的纺纱轨道(SOC ) 或集体术语成为拓扑的绝缘体。在这篇评论论文,我们介绍显示出节的线半金属状态的理论材料,包括所有碳 Mackay-Terrones 水晶( MTC ), anti-perovskite Cu 3 PdN ,压的黑磷,和材料的帽子3家庭,并且我们在场为获得物质的如此的新奇状态的设计原则。 | Rui Yu Zhong Fang Xi Dai Hongming Weng | 2017 | Frontiers of physics2017，12，3： | 3 |
| 11 | Peptide-specific,allogeneic T cell response in vitro induced by a self-peptide binding to HLA-A2显示文摘The role of the bound peptide in alloreactive T-cell recognition is controversial, ranging from pep-tide-independent to peptide-specific recognition of alloreactive T-cells. The aim of this study is to find the evidence that there exist peptide/MHC complex (pMHC)-specific CTLs among alloreactive T cells generated with long-term mixed lymphocytes culture (LTMLC). A single pMHC was manipulated by loading the TAP-defective, HLA-A2 expressing T2 cells with a viral peptide (LMP2A426-434) or a self-peptide (Tyr369-377). The PBLs samples from 4 HLA-A2 positive (HLA-A2+ve) and 4 HLA-A2 negative (HLA-A2-ve) donors were included in this study. The HLA-A2+ve PBL co-cultured with the LMP2A426-434 pulsed T2 (T2/LMP) stands for the nominal T-cell response to a viral antigen, and the HLA-A2-ve PBLs co-cultured with the Tyr369-377 pulsed T2 (T2/Tyr) for alloreactive T-cell response to an allogeneic antigen. The specificity of the expanded CTLs after the LTMLC was detected by their specific cytotoxicity and binding ability to specific pMHC-tetramer. An HLA-A2 restricted, HIV peptide (Gag77-85)was included for control. The cultural bulk of HLA-A2+ve PBLs with the T2/LMP showed an elevated specific cytotoxicity against the T2/LMP compared to that against the T2/HIV (26.52%±3.72% vs 7.01%±0.87%, P<0.001), and an increased frequency of binding to LMP-tetramer compared to that binding to HIV-tetramer (0.98%±0.33% vs 0.05%±0.01%, P=0.0014). The cultural bulk of HLA-A2-ve PBLs with the T2/Tyr showed a more active cytotoxicity against the T2/Tyr than that against T2/HIV (28.07%±2.58% vs 6.87%±0.01 %, P<0.001), and a higher frequency of binding to the Tyr-tetramer than that binding to the HIV-tetramer (0.88%±0.3% vs 0.06%±0.03%, P=0.0018). Our results indicate that the LTMLC is able to expand the viral antigen-specific CTLs as well as allogeneic antigen-specific CTLs. A relatively large proportion of alloreactive CTLs should be pMHC-specific, i.e., the specificity of the alloreactive lines depends on both the bound peptide and the allotype of MHC. Our observations support the hypothesis that the cumulative effect of T cells specific to each peptide epitope could account for the strength and diversity of the alloresponse. The method using manipulated pMHC and the LTMLC to generate pMHC-specific, alloreactive CTLs is of potential importance for adoptive T-cell immunotherapy. | WENG XiuFang, LIANG ZhiHui, LU XiaoLing, ZHONG MaoHua, LU ShengJun, ZHANG CaiE, DENG Jing, WU XiongWen & GONG FeiLi Department of Immunology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China | 2007 | Science China(Life Sciences)2007，50，2： | 2 |
| 12 | Sustainable routes for quantitative green selenocyanation of activated alkynes显示文摘Most organic reactions require the usage of volatile organic compounds in the synthesis, work-up and purification processes, thus resulting in major environmental pollution and high manufacturing cost. By using cheap biomass lactic acid as the reaction media and catalyst, a sustainable protocol for the synthesis of Z-3-selenocyanatoacrylates and analogues through green selenocyanation of activated alkynes has been achieved. A principal advantage of this protocol is that the usage of organic volatile compounds can be avoided entirely, as the conversion of substrate is almost quantitative or quantitative with a minimal amount of lactic acid employed as reaction media, and the pure products can be conveniently collected through water precipitation. | Ling-Hui Lu Zheng Wang Weng Xia Ping Cheng Bo Zhang Zhong Cao Wei-Min He | 2019 | Chinese Chemical Letters2019，30，6： | 2 |
| 13 | Soil Organic Carbon Stocks of Citrus Orchards in Yongchun County Fujian Province China显示文摘Studies related to the quantitation and distribution of soil organic carbon(C) under different land use types can help to fill the knowledge gaps regarding estimation of the amount of C stored in soils at a global scale. Orchards are an important land use type in southern China; the total area(1.15 × 10~7 ha) of orchards in China comprises approximately 20.5% of the area of all orchards worldwide. We assessed soil organic C stocks(SOCS) in citrus orchards in Yongchun County(consisting of 22 towns), Fujian Province,China in 1982 and 2010. The southeastern part of the county, an area featuring extensive citrus farming with a gently sloping landscape and low rates of water erosion, had the highest SOCS. In contrast, the lowest SCOS was observed in the northern part of the county,where steep hills with severe erosion problems are common and citrus orchards are sparsely distributed. From 1982 to 2010, the mean SOCS in citrus orchards increased from 22.1 to 41.7 Mg ha^(-1), which indicated that current management practices such as fertilization,irrigation, and cultivation enhanced soil C stocks. Further in-depth studies on the effects of these practices on C sequestration would be worthwhile and surveys of SOCS throughout Fujian Province are needed, to support efforts to mitigate global C emission. | WANG Yixiang WENG Boqi TIAN Na ZHONG Zhenmei WANG Mingkuang | 2017 | Pedosphere2017，27，5： | 1 |
| 14 | Dilating Gabor transform for the fringe analysis of 3-D shape measurement 显示文摘 | Zhong J Weng J | 2004 | Optical Engi- neering2004，43，4： | 1 |
| 15 | Identification of forensically important blow fly species (Diptera: Calliphoridae) in China by mitochondrial cytochrome oxidase I gene differentiation显示文摘不含糊、快速的 sarcosaphagous 昆虫种类鉴定是为法庭的调查的一个必要要求。尽管某昆虫种类是困难的词法上分类,他们能有效地被识别在本地数据库与丰富的证实的引用 DNA 序列基于类似使用分子的方法。然而,因为大陆地区域,本地数据库在中国仍然是相对不完全的。在这研究, 75 个法庭地重要的打击苍蝇在 16 个中国省,和细胞色素 oxidase 子单元的一个 278-bp 片断从 23 个地点被收集我所有标本的基因成功地被定序。定序的片断的种系发生的分析证明所有 Calliphorid 标本适当地与相对强壮的支持的价值被分配进九种,因此显示一个区域是的 278-bp 细胞色素 oxidase 子单元对 Calliphorid 的鉴定合适种类。intraspecific 阀值和种间的分叉之间的清楚的差别为 Calliphorid 种类鉴定证实了这个区域的潜力,特别为在词法上类似的种类之间区分。Intraspecific 地理变化在 Lucilia sericata 被观察(Meigen, 1826 ) 并且 Lucilia caesar (Linnaeus, 1758 ) 。 | Qin-Lai Liu Ji-Feng Cai Yun-Feng Chang Yan Gu Ya-Dong Guo Xing-Hua Wang Ji-Fang Weng Ming Zhong Xiang Wang Li Yang Kun-Lu Wu Ling-Mei Lan Jiang-Feng Wang Yao-Qing Chen | 2011 | Insect Science2011，18，5： | 1 |
| 16 | Catalytic performance, structure, surface properties and active oxygen species of the fluoride-containing rare earth (alkaline earth)-based catalysts for the oxidative coupling of methane and oxidative dehydrogenation of light alkanes显示文摘 | Hui Lin Wan Xiao Ping Zhou Wei Zheng Weng Rui Qiang Long Zi Sheng Chao Wei De Zhang Ming Shu Chen Ji Zhong Luo Shui Qin Zhou | 1999 | Catalysis Today1999，，1： | 1 |
| 17 | Changes on the disease pattern of primary colorectal cancers in Southern China: a retrospective study of 20?years显示文摘 | Shenghong Zhang Yi Cui Zijin Weng Xiaorong Gong Minhu Chen Bihui Zhong | 2009 | International Journal of Colorectal Disease2009，，8： | 1 |
| 18 | Phase retrieval of optical fringe pat- terns from the ridge of a wavelet transform 显示文摘 | Zhong J Weng J | 2005 | Optics Letters2005，30，19： | 1 |
| 19 | Generalized Fourier analysis for phase retrieval of fringe pattern 显示文摘 | Zhong J Weng J | 2010 | Optics Express2010，18，26： | 1 |
| 20 | Topological electronic states in HfRuP family superconductors显示文摘Based on the first-principles calculations and experimental measurements,we report that the hexagonal phase of ternary transition metal pnictides TT’X(T=Zr,Hf;T’=Ru;X=P,As),which are well-known noncentrosymmetric superconductors with relatively high transition temperatures,host nontrivial bulk topology.Before the superconducting phase transition,we find that HfRuP belongs to a Weyl semimetal phase with 12 pairs of type-II Weyl points,while ZrRuAs,ZrRuP and HfRuAs belong to a topological crystalline insulating phase with trivial Fu-Kane Z_(2) indices but nontrivial mirror Chern numbers.High-quality single crystal samples of the noncentrosymmetric superconductors with these two different topological states have been obtained and the superconductivity is verified experimentally.The wide-range band structures of ZrRuAs have been identified by ARPES and reproduced by theoretical calculations.Combined with intrinsic superconductivity,the nontrivial topology of the normal state may generate unconventional superconductivity in both bulk and surfaces.Our findings could largely inspire the experimental searching for possible topological superconductivity in these compounds. | Yuting Qian Simin Nie Changjiang Yi Lingyuan Kong Chen Fang Tian Qian Hong Ding Youguo Shi Zhijun Wang Hongming Weng Zhong Fang | 2019 | npj Computational Materials2019，，1： | 1 |
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