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| 1 | Oxidation kinetics regularity in spontaneous combustion of gas coal显示文摘In order to investigate the oxidation kinetics of gas coal at low temperatures, we derived a rate equation of oxygen con-sumption during low-temperature oxidation of gas coal and deduced an E-c equation, expressing the relation between active energy E and oxygen concentration c. The reaction order n and active energy E were calculated with this equation based on experiments of static oxygen consumption tests. In addition, we proved the rationality of the E-c equation using a kinetic compensation effect and obtained the isokinetic temperature Tc. The results show that: 1) the gas coal oxidizes easily with increasing temperature and the oxidation tends to be spontaneous at higher temperatures; 2) the oxygen concentration c affects oxygen consumption very much at lower temperatures but has only a small effect at higher temperatures; 3) the isokinetic temperature Tc was 127 °C which has been experimentally validated as the key turning point during low-temperature spontaneous combustion of gas coal. | WANG Lanyun JIANG Shuguang WU Zhengyan SHAO Hao ZHANG Weiqing CHEN Yueqin ZOU Lili | 2010 | Mining Science and Technology2010，20，1： | 13 |
| 2 | Destruction mechanism of gas explosion to ventilation facilities and automatic recovery technology显示文摘In order to overcome the heavy casualties caused by gas explosion, we verified the propagation law of shock wave in pipeline and the overpressure distribution of gas explosion by similar experiments according to the analyses of reasons for casualty and ventilation system model destroyed by gas explosion in the mining face. We summarized the gas composition after the explosion and its danger, analyzed the effects of the gas explosion shock wave to ventilation system and facilities and the laws of toxic gas spread and diffusion in the ventilation network after the explosion. We presented a technical proposal to control the smoke and recover the ventilation system after a gas explosion and developed a reserve air door and control system that were embed in the lane, and could close automatically in conditions of no pressure and electricity. The results showed that the reserve air door normally opened and could close automatically controlling the smoke flow and resuming the ventilation system when the gas explosion shock wave destroyed the original shutting air door which resulted in the air short circuit. | Wang Kai | 2012 | International Journal of Mining Science and Technology2012，22，3： | 8 |
| 3 | Simultaneous pyridine biodegradation and nitrogen removal in an aerobic granular system显示文摘Simultaneous pyridine biodegradation and nitrogen removal were successfully achieved in a sequencing batch reactor(SBR) based on aerobic granules. In a typical SBR cycle, nitritation occurred obviously after the majority of pyridine was removed, while denitrification occurred at early stage of the cycle when oxygen consumption was aggravated. The effect of several key operation parameters, i.e., air flow rate, influent NH_4^+-N concentration,influent p H and pyridine concentration, on nitritation, pyridine degradation and total nitrogen(TN) removal, was systematically investigated. The results indicated that high air flow rate had a positive effect on both pyridine degradation and nitritation but a negative impact of overhigh air flow rate. With the increase of NH_4^+ dosage, both nitritation and TN removal could be severely inhibited. Slightly alkaline condition, i.e., pH 7.0–8.0, was beneficial for both pyridine degradation and nitritation. High pyridine dosage often resulted in the delay of both pyridine degradation and nitritation. Besides, extracellular polymeric substances production was affected by air flow rate, NH_4^+ dosage, pyridine dosage and p H.In addition, high-throughput sequencing analysis demonstrated that Bdellovibrio and Paracoccus were the dominant species in the aerobic granulation system. Coexistence of pyridine degrader, nitrification related species, denitrification related species, polymeric substances producer and self-aggregation related species was also confirmed by highthroughput sequencing. | Xiaodong Liu Shijing Wu Dejin Zhang Jinyou Shen Weiqing Han Xiuyun Sun Jiansheng Li Lianjun Wang | 2018 | Journal of Environmental Sciences2018，30，5： | 7 |
| 4 | Signal processing in underwater acoustic communication system for manned deep submersible 'Jiaolong'显示文摘For the first time in the world,underwater acoustic transmission of images,human voice,data and texts between vehicle under 7000 m depth and surface ship was accomplished by underwater acoustic communication system of manned deep submersible 'Jiaolong'.In this paper,signal processing in underwater acoustic communication system for manned deep submersible 'Jiaolong' is introduced.(1) Four communication methods are integrated to meet different needs:1) coherent underwater acoustic communication,with a variable transmission rate from 5 kbps to 15 kbps,to transmit images.2) Non-coherent underwater acoustic communication, with a transmission rate 300 bps,to transmit texts,instructions,and sensor data. 3) Spread spectrum underwater acoustic communication,with a transmission rate 16 bps,to transmit instructions.4) Underwater voice communication,using single sideband modulation to transmit human voice.(2) Signal processing method in coherent communication mainly consists of concatenation of decision feedback equalizer and Turbo decoder,and wavelet based image compression with fixed length coding.In the equalizer,Doppler compensation,multichannel combining and equalizer coefficients updating are all using fast self-optimized adaptive algorithm.(3) A linear hydrophone array is lowered from the mother ship to certain depth, and spatial diversity combining technology is adopted.(4) Diving trials of 'Jiaolong' were carried out in Pacific Ocean.The communication range can cover nearly all ocean depth.One optical/acoustic image can be transmitted in 7 or 14 seconds. | ZHU Weiqing ZHU Min WU Yanbo YANG Bo XU Lijun FU Xiang PAN Feng | 2013 | Chinese Journal of Acoustics2013，32，1： | 7 |
| 5 | Highly effective and reproducible surface-enhanced Raman scattering substrates based on Ag pyramidal arrays显示文摘 | Yandong Wang Nan Lu Wentao Wang Lingxiao Liu Lei Feng Zhoufang Zeng Haibo Li Weiqing Xu Zijian Wu Wei Hu Yanqing Lu Lifeng Chi | 2013 | Nano Research2013，6，3： | 6 |
| 6 | MiR-147b inhibits cell viability and promotes apoptosis of rat H9c2 cardiomyocytes via down-regulating KLF13 expression显示文摘最近, microRNAs (miRNAs ) 被显示了在心失败的过程包含。这研究试图在老鼠 H9c2 cardiomyocytes 调查 miR-147b 的功能的角色并且探索内在的分子的机制。H9c2 房间的房间生存能力被 MTT 试金检测。房间 apoptosis 被流动 cytometry 检测。miR-147b 和 KLF13 mRNA 的表示被量的即时 PCR 检测。在 miR-147b 和 KLF13 之间的关系被双酶的记者试金验证。蛋白质层次被西方的污点分析检测。它被发现那 H 2 O 2 禁止了房间生存能力并且以一种集中依赖者方式支持了 H9c2 房间的房间 apoptosis。MiR-147b overexpression miR-147b 压制了房间生存能力并且在 H9c2 房间增加了 apoptosis,当击倒时在 H 2 O 2-treated H9c2 房间。酶记者试金并且在功能的试金显示出的 vitro,那 KLF13 是 miR-147b,和 KLF13 的一个下游的目标在 H9c2 房间的击倒的压制的房间生存能力和导致的 apoptosis。KLF13 的强制表示在 H9c2 房间在房间生存能力和 apoptosis 上恢复了 miR-147b overexpression 的效果。MiR-147b 在 apoptosis 相关的蛋白质上调制了 miR-147b overexpression 的 apoptosis 相关的蛋白质,和效果的表示层次层次被 KLF13 的强制表示在 H9c2 房间阻止。在里面 vivo 实验证明 miR-147b 是起来调整的,并且 KLF13 在从有长期的心失败的老鼠的心肌的纸巾是下面调整的。一起, miR-147b 禁止生存能力并且由在 H9c2 房间指向 KLF13 支持房间 apoptosis,它可以与心失败的致病被联系。 | Mingxia Gu Jing Wang Yi Wang Yanjuan Xu Yingqiang Zhang Weiqing Wu Shuping Liao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 6 |
| 7 | An experimental study of the effect of ionic liquids on the low temperature oxidation of coal显示文摘Fourier transform infrared spectroscopy(FTIR) and constant heating rate experiments were performed to study the low temperature oxidation of coal treated by an ionic liquid,1-allyl-3-methylimidazolium chloride.The inerting effect of the ionic liquid toward the low temperature oxidation process is discussed.The results show that:(1) The hydroxyl content associated with hydrogen bonds,the aliphatic methyl content,the methylene group content,and the ether oxygen bond content are reduced in the treated coal.At the same time the content of aromatic C@C bonds is constant but these chemical bonds weaken and some substituted aromatic hydrocarbon content increases while other types decrease.This demonstrates that(AMIm)Cl dissolves and destroys the coal surface microstructure;(2) The oxygen consumption of the treated coal is less than what is seen in raw coal.The CO,CO 2,C 2 H 4,and C 2 H 6 content from the treated coal is reduced compared to the untreated coal;(3) The apparent activation energy for the oxidizing reaction is different in the treated and raw coals.Micro-structural changes and macroscopic gas production allow us to conclude that(AMIm)Cl can effectively inhibit low temperature oxidation of coal. | Zhang Weiqing | 2012 | International Journal of Mining Science and Technology2012，22，5： | 5 |
| 8 | Prevalence, risk factors, and survival associated with pulmonary hypertension and heart failure among patients with underlying coronary artery disease: a national prospective, multicenter registry study in China显示文摘Background: Coronary artery disease (CAD) is the commonest cause of heart failure (HF), whereas pulmonary hypertension (PH) has not been established or reported in this patient population. Therefore, we assessed the prevalence, risk factors, and survival in CAD-associated HF (CAD-HF) complicated with PH.Methods: Symptomatic CAD-HF patients were continuously enrolled in this prospective, multicenter registry study. Echocardiography, coronary arteriography, left and right heart catheterization (RHC), and other baseline clinical data were recorded. Patients were followed up and their survival was recorded.Results: One hundred and eighty-two CAD-HF patients were enrolled, including 142 with HF with a preserved ejection fraction (heart failure with preserved ejection fraction [HFpEF];left ventricular ejection fraction [LVEF] ≥50%) and 40 with a reduced ejection fraction (heart failure with reduced ejection fraction [HFrEF];LVEF < 50%). PH was diagnosed with RHC in 77.5% of patients. Patients with PH showed worse hemodynamic parameters and higher mortality. HFrEF-PH patients had worse survival than HFpEF-PH patients. CAD-HF patients with an enlarged left ventricular end-diastolic diameter and reduced hemoglobin were at higher risk of PH. Nitrate treatment reduced the risk of PH. Elevated creatinine and mean pulmonary arterial pressure (mPAP), diastolic pressure gradient (DPG) ≥7 mmHg, and previous myocardial infarction (MI) entailed a higher risk of mortality in CAD-HF patients with PH.Conclusions: PH is common in CAD-HF and worsens the hemodynamics and survival in these patients. Left ventricle enlargement and anemia increase the risk of PH in CAD-HF. Patients may benefit from nitrate medications. Renal impairment, elevated mPAP, DPG ≥7 mmHg, and previous MI are strong predictors of mortality in CAD-HF-PH patients.Trial Registration: ClinicalTrials.gov, NCT02164526. | Li Huang Lingpin Pang Qing Gu Tao Yang Wen Li Ruilin Quan Weiqing Su Weifeng Wu Fangming Tang Xiulong Zhu Jieyan Shen Jingzhi Sun Guangliang Shan Changming Xiong Shian Huang Jianguo He | 2022 | Chinese Medical Journal2022，，15： | 4 |
| 9 | Signal processing for noncoherent underwater acoustic communication approaching channel capacity显示文摘Noncoherent underwater acoustic communication channel in adverse conditions is modeled as a phase-random Rayleigh fading channel,and its capacity curve is derived.To approach the channel capacity curve,the concatenated code of the nonbinary LDPC code and the constant weight code is proposed for noncoherent communication which can late be iteratively decoded in the probability domain.Without information of channel amplitude or phase in the receiver,statistic parameters of the respective signal and noise bins were estimated based on the moment estimation method,the posterior probabilities of the constant weight code words were further calculated,and the nonbinary LDPC code was decoded with the nonbinary factor graph algorithm.It is verified by simulations that by utilizing the proposed concatenated code and its processing algorithm,gap to channel capacity curve is reduced by 3 dB when compared to the existing method.Underwater communication experiments were carried out in both deep ocean(vertical communication,5 km)and shallow lake(horizontal communication,near 3 km,delay spread larger than 50 ms),in which the signal frequency band was 6 kHz to10 kHz,and the data transmission rate Was 357 bps.The proposed scheme can work properly in both experiments with a signal-to-noise ratio threshold of 2 dB.The performance of the proposed algorithm Was well verified by the experiments. | WU Yanbo ZHU Min ZHU Weiqing XING Zeping | 2014 | Chinese Journal of Acoustics2014，33，4： | 4 |
| 10 | Tuning Atomically Dispersed Fe Sites in Metal–Organic Frameworks Boosts Peroxidase‑Like Activity for Sensitive Biosensing显示文摘Although nanozymes have been widely developed,accurate design of highly active sites at the atomic level to mimic the electronic and geometrical structure of enzymes and the exploration of underlying mechanisms still face significant challenges.Herein,two functional groups with opposite electron modulation abilities(nitro and amino)were introduced into the metal–organic frameworks(MIL-101(Fe))to tune the atomically dispersed metal sites and thus regulate the enzymelike activity.Notably,the functionalization of nitro can enhance the peroxidase(POD)-like activity of MIL-101(Fe),while the amino is poles apart.Theoretical calculations demonstrate that the introduction of nitro can not only regulate the geometry of adsorbed intermediates but also improve the electronic structure of metal active sites.Benefiting from both geometric and electronic effects,the nitro-functionalized MIL-101(Fe)with a low reaction energy barrier for the HO*formation exhibits a superior POD-like activity.As a concept of the application,a nitro-functionalized MIL-101(Fe)-based biosensor was elaborately applied for the sensitive detection of acetylcholinesterase activity in the range of 0.2–50 mU mL−1 with a limit of detection of 0.14 mU mL−1.Moreover,the detection of organophosphorus pesticides was also achieved.This work not only opens up new prospects for the rational design of highly active nanozymes at the atomic scale but also enhances the performance of nanozyme-based biosensors. | Weiqing Xu Yikun Kang Lei Jiao Yu Wu Hongye Yan Jinli Li Wenling Gu Weiyu Song Chengzhou Zhu | 2020 | Nano-Micro Letters2020，12，12： | 4 |
| 11 | Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study显示文摘The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown.This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,China.Oral glucose tole3rance test was conducted during baseline and follow-up visits.Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 years.Fasting plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in women.Accordingly,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women. | Di Cheng Chunyan Hu Rui Du Hongyan Qi Lin Lin Xueyan Wu Lina Ma Kui Peng Mian Li Min Xu Yu Xu Yufang Bi Weiqing Wang Yuhong Chen Jieli Lu | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 12 | Meta-analysis of Shenqi Fuzheng Injection Combined with Chemotherapy in Treatment of Colorectal Cancer显示文摘[Objectives] To make a systematic evaluation of the clinical efficacy and safety of Shenqi Fuzheng Injection in the treatment of colorectal cancer. [Methods] Databases,such as China National Knowledge Infrastructure( CNKI),Wanfang,China biomedical literature service system( CBM),CQVIP,Medline,and Cochrane,were searched for the time before April 2017. The randomized controlled trial( RCT) that met the inclusion criteria was screened. Then,quality evaluation was made based on the modified Jadad scale. Data were extracted and meta-analysis was made with the aid of Review Manager 5. 3. [Results] Finally,21 papers met the inclusion criteria,including 2 high quality papers. The average Jadad score was 2. 5 points,1 589 patients were included. Meta-analysis results showed that the intervention of the experimental group could improve the quality of life[OR = 3. 32,95% CI( 2. 33,4. 74),P < 0. 000 01]; improve the short-term efficacy[OR =1. 68,95% CI( 1. 26,2. 24),P =0. 000 4]; reduce the incidence of adverse chemotherapy reactions such as reducing the gastrointestinal reactions[OR = 0. 33,95% CI( 0. 25,0. 43),P < 0. 000 01],reducing myelosuppressive reactions[OR = 0. 33,95% CI( 0. 24,0. 46),P < 0. 000 01]; improve the immune functions,such as increasing CD4/CD8 cell ratio[WMD = 1. 19,95% CI( 0. 24,0. 41),( P <0. 000 01) ],and increasing the number of NK cells[WMD =1. 72,95% CI( 5. 62,14. 30),( P <0. 000 01) ]. [Conclusions]The clinical effect of Shenqi Fuzheng Injection in the treatment of colorectal cancer is better than that of chemotherapy alone,but it needs more highquality RCTs to improve the level of research. | Weiqing ZHANG Jinhuan ZHANG Zhulin WU Lisheng PENG | 2018 | Medicinal Plant2018，9，5： | 2 |
| 13 | Voltage Security Operation Region Calculation Based on Improved Particle Swarm Optimization and Recursive Least Square Hybrid Algorithm显示文摘Large-scale voltage collapse incidences, which result in power outages over large regions and extensive economic losses, are presently common occurrences worldwide. To avoid voltage collapse and operate more safely and reliably, it is necessary to analyze the voltage security operation region(VSOR) of power systems, which has become a topic of increasing interest lately. In this paper, a novel improved particle swarm optimization and recursive least square(IPSO-RLS) hybrid algorithm is proposed to determine the VSOR of a power system. Also, stability analysis on the proposed algorithm is carried out by analyzing the errors and convergence accuracy of the obtained results. Firstly, the voltage stability and VSOR-surface of a power system are analyzed in this paper. Secondly, the two algorithms,namely IPSO and RLS algorithms, are studied individually.Based on this understanding, a novel IPSO-RLS hybrid algorithm is proposed to optimize the active and reactive power,and the voltage allowed to identify the VSOR-surface accurately. Finally, the proposed algorithm is validated by using a simulation case study on three wind farm regions of actual Hami Power Grid of China in DIg SILENT/Power Factory software.The error and accuracy of the obtained simulation results are analyzed and compared with those of the particle swarm optimization(PSO), IPSO and IPSO-RLS hybrid algorithms. | Saniye Maihemuti Weiqing Wang Haiyun Wang Jiahui Wu | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，1： | 2 |
| 14 | Atomically dispersed N-coordinated Fe-Fe dual-sites with enhanced enzyme-like activities显示文摘Replacement of enzymes with nanomaterials such as atomically dispersed metal catalysts is one of the most crucial steps in addressing the challenges in biocataiysis.Despite the breakthroughs of single-atom catalysts in enzyme-mimicking,a fundamental investigation on the development of an instructional strategy is still required for mimicking biatomic/multiatomic active sites in natural enzymes and constructing synergistically enhanced metal atom active sites.Herein,Fe_(2)NC catalysts with atomically dispersed Fe-Fe dual-sites supported by the metal-organic frameworks-derived nitrogen-doped carbon are employed as biomimetic catalysts to perform proof-of-concept investigation.The effect of Fe atom number toward typical oxidase(cytochrome C oxidase,NADH oxidase,and ascorbic acid oxidase)and peroxidase(NADH peroxidase and ascorbic acid peroxidase)activities is systematically evaluated by experimental and theoretical investigations.A peroxo-like O_(2) adsorption in Fe_(2)NC nanozymes could accelerate the O-O activation and thus achieve the enhanced enzyme-like activities.This work achieves the vivid simulation of the enzyme active sites and provides the theoretical basis for the design of high-performance nanozymes.As a concept application,a colorimetric biosensor for the detection of S^(2-) in tap water is established based on the inhibition of enzyme-like activity of Fe_(2)NC nanozymes. | Lei Jiao Wei Ye Yikun Kang Yu Zhang Weiqing Xu Yu Wu Wenling Gu Weiyu Song Yujie Xiong Chengzhou Zhu | 2022 | Nano Research2022，15，2： | 1 |
| 15 | 肿瘤坏死因子α致肝细胞凋亡效应及其机制的研究(英文)显示文摘Objective: To investigate the apoptosis effect of TNF-α on HepG2 cells and its mechanism in vitro. Methods: HepG2 cells were treated with TNF-α (400 U/mL). HepG2 cells treated with TNF-α for 24 h and apoptosis was proved by DNA fragments on gel electrophoresis. Fluorescent quantitative real-time PCR was used to detect Fas and FasL expression. HepG2 cells treated by TNF-α were co-cultivated with normal HepG2 cells. Apoptosis of HepG2 cells was determined by the method of FACS. Results: After 24 h TNF-α treatment, DNA was collapsed into fragments to form DNA ladder in gel elec- trophoresis; FasL expression increases and induces HepG2 cells apoptosis. By FACS, 98.4% of the co-cultivated cells were apoptosis, but 16.5% cells in control group were apoptosis. Conclusion: TNF-α can induce apoptosis of HepG2 cells in vitro. FasL expression on TNF-α pre-treated HepG2 cells increased and these cells can lead normal HepG2 cells to apoptosis. This may attribute to the cure of virus hepatitis and hepatoma. | Weiqing Song Weihong Lu Huabo Chen Huahui Li Jianmin Wu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，2： | 1 |
| 16 | Theoretical and numerical simulation of critical gas supply of refuge chamber显示文摘The personnel in refuge chamber absorb O_2 and exhale CO_2 all the time. Supplying O_2 and removing CO_2 are the basic function of refuge chamber. After disaster occurs, the supply of the compressed air or oxygen for personnel in refuge chamber is limited. Thus, how to effectively use the compressed air and oxygen and try to improve the time of supply has a great significance. Supplying more oxygen will result in waste, while supplying less oxygen will cause its concentration to be lower, and harm life safety. This research uses the theoretical calculation and numerical simulation, finds critical gas supply for refuge chamber, and illuminates the change law of gas concentration with critical gas supply in refuge chamber,which provides theoretical guidance for effective use of compressed air and oxygen in refuge chamber. | Shao Hao Jiang Shuguang Tao Weiyong Wu Zhengyan Zhang Weiqing Wang Kai | 2016 | International Journal of Mining Science and Technology2016，26，3： | 1 |
| 17 | Defect-rich and ultrathin nitrogen-doped carbon nanosheets with enhanced peroxidase-like activity for the detection of urease activity and fluoride ion显示文摘Although carbon nanozymes have attracted great interest due to their good biocompatibility, low cost,and high stability, designing high-active carbon nanozymes still faces great challenges. Herein, ultrathin nitrogen-doped carbon nanosheets with rich defects(d-NC) were prepared through a high-temperature annealing process, using potassium chloride and ammonium chloride as templates. Owing to the large specific surface area, rich defects and the high exposure of active sites, the proposed d-NC nanozymes exhibited excellent peroxidase-like activity. The d-NC nanozymes possess maximal reaction velocity and their specific activity is 9.4-fold higher than that of nitrogen-doped carbon nanozymes, indicating that the induced defects can boost the catalytic performance. Benefited from the good peroxidase-like activities of d-NC nanozymes, the colorimetric sensing platforms were constructed for the detection of urease activity and fluoride ion, exhibiting satisfactory stability and selectivity. This study not only offers a way to synthesize carbon nanozymes with improved enzyme-like activities but also broadens their applications in colorimetric biosensing. | Yu Zhang Lei Jiao Weiqing Xu Yifeng Chen Yu Wu Hongye Yan Wenling Gu Chengzhou Zhu | 2022 | Chinese Chemical Letters2022，33，3： | 1 |
| 18 | Effects of Crocin on Nox2 Expression and ROS Level of Hypoxia/Reoxygenation-induced Injury of Cardiomyocytes显示文摘[Objectives]To explore the protection mechanism of crocin against ischemia-reperfusion injury of myocardial cells.[Methods]Newborn male SD rats were selected,left ventricular cardiomyocytes(CMs)were isolated,and a hypoxia/reoxygenation model of CMs was established to simulate the process of ischemia/reperfusion injury.The cells were randomly divided into four groups:normal cell group(control group),crocin group),hypoxia/reoxygenation group(H/R group),hypoxia/reoxygenation+crocin group(H/R+crocin group).H/R+crocin group selected the concentration of crocin 1,10,and 100μmol/L,and determined the optimal concentration of crocin by detecting the cell proliferation ability.After the cells were pretreated using the optimal concentration of crocin,the levels of superoxide anion,cell proliferation,apoptosis and Nox2 levels in each group of cells were detected.[Results]Compared with the control group,the proliferation ability of CMs after hypoxia-reoxygenation injury was reduced(P<0.05),while cell apoptosis and intracellular superoxide anion levels were significantly increased(P<0.01);the CMs pretreated with crocin can reduce the level of Nox2(P<0.01),increase the cell proliferation ability of CMs,reduce cell apoptosis,and accordingly reduce the level of superoxide anion in the cell(P<0.05).[Conclusions]Crocin protects CMs from hypoxia/reoxygenation injury through down-regulating the level of Nox2 and reducing oxidative stress injury. | Chao ZENG Yongji XING Lizhi BAO Yuanyuan WANG Weiqing HU Jun WU Xiaohong LIU Nengwu WEN Jiping FAN | 2020 | Medicinal Plant2020，11，5： | 1 |
| 19 | Growth Defects of Lead Germanate Single Crystals Grown by the Vertical Bridgman Method显示文摘 | Wu Xianjun Xu Jiayue Jin Weiqing | 2005 | Materials Characterization2005，55，2： | 1 |
| 20 | Optimal order-replacement policy for a phase-type geometric process model with extreme shocks显示文摘 | YU Miamiao TANG Yinghui WU Weiqing ZHOU Jie | 2014 | Applied Mathematical Modeling2014，38，1718： | 1 |
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