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| 1 | AMPK activation by peri-sciatic nerve administration of ozone attenuates CCl-induced neuropathic pain in rats显示文摘 | Lijuan Lu Cailong Pan Lu Chen Liang Hu Chaoyu Wang Yuan Han Yanjing Yang Zhixiang Cheng Wen-Tao Liu | 2017 | Journal of Molecular Cell Biology2017，9，2： | 14 |
| 2 | Experimental comparison between aircraft fuel tank inerting processes using NEA and MIG显示文摘Fuel tank inerting technologies are able to reduce the fire risk by injection of inert gas into the ullage or fuel, the former called ullage washing and the latter fuel scrubbing. The Green On-Board Inert Gas Generation System(GOBIGGS) is a novel technology based on flameless catalytic combustion, and owning to its simple structure and high inerting efficiency, it has received a lot of attentions. The inert gas in the GOBIGGS is mainly comprised of CO_2, N_2, and O_2(hereinafter, Mixed Inert Gas(MIG)), while that in the On-Board Inert Gas Generation System(OBIGGS), which is one of the most widely used fuel tank inerting technologies, is NitrogenEnriched Air(NEA). The solubility of CO_2 is nearly 20 times higher than that of N_2 in jet fuels,so the inerting capability and performance are definitely disparate if the inert gas is selected as NEA or MIG. An inerting test bench was constructed to compare the inerting capabilities between NEA and MIG. Experimental results reveal that, if ullage washing is adopted, the variations of oxygen concentrations on the ullage and in the fuel are nearly identical no matter the inert gas is NEA or MIG. However, the ullage and dissolved oxygen concentrations of MIG scrubbing are always higher than those of NEA scrubbing. | Lei SHAO Weihua LIU Chaoyue LI Shiyu FENG Chenchen WANG Jun PAN | 2018 | Chinese Journal of Aeronautics2018，31，7： | 11 |
| 3 | Oxidative stress, nutritional antioxidants and beyond显示文摘Free radical-induced oxidative stress contributes to the development of metabolic syndromes(Mets), including overweight,hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain;under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress status.Natural antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and antiinflammatory effect of polyphenols as potential nutritional therapy. | Qiuping Guo Fengna Li Yehui Duan Chaoyue Wen Wenlong Wang Lingyu Zhang Ruilin Huang Yulong Yin | 2020 | Science China(Life Sciences)2020，63，6： | 10 |
| 4 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 5 | Effect of static bed height in the upper fluidized bed on flow behavior in the lower riser section of a coupled reactor显示文摘To study olefin reduction by using an auxiliary reactor for FCC naphtha upgrading, a large-scale cold model of a riser-bed coupled to an upper fluidized bed was established. The effect of static bed height in the upper fluidized bed on particle flow behavior in the lower riser was investigated experimentally. A restriction index of solids holdup was used to evaluate quantitatively the restrictive effect of the upper fluidized bed. Experimental results show that, under the restrictive effect of the upper fluidized bed, the riser could be divided into three regions in the longitudinal direction: accelerating, fully developed and restriction. The axial distribution of solids holdup in the riser is characterized by large solids holdup in the top and bottom sections and small solids holdup in the middle section. Overall solids holdup increased with increasing static bed height in the upper fluidized bed, while particle velocity decreased. Such restrictive effect of the upper fluidized bed could extend from the middle and top sections to the whole riser volume when riser outlet resistance is increased, which increases with increasing static bed height in the upper fluidized bed. The upper bed exerts the strongest restriction on the area close to the riser outlet. | Dewu Wang Chunxi Lu Chaoyu Yan | 2009 | Particuology2009，7，1： | 9 |
| 6 | A general alternate loading technique and its applications in the inverse designs of centrifugal and mixed-flow pump impellers显示文摘For the inverse designs of centrifugal and mixed-flow pump impellers,clarifying the generation process of secondary flows and putting forward corresponding suppression measures is an important approach to improve the impeller performance.In this paper,to provide a better qualitative insight into the generation mechanism of secondary flows in the impeller,a simple kinematic equation is derived based on the ideal assumptions,which indicates that the potential rothalpy gradient(PRG)is the most important dynamic source that actively induces secondary vortical flows.Induced by the natural adverse PRG on the S1 and S2 stream surfaces,two typical secondary flows,H-S and P-S secondary flows,are clearly presented.To specially suppress these typical secondary flows,a general alternate loading technique(GALT)is proposed,aiming to adjust the real blade loadingδp to control the PRG features.At the blade fore part,theδp on the hub streamline should be slowly increased to avoid breakneck growth of the potential rothalpy to reduce adverse streamwise PRG on the S2 streamsurface.At the blade middle part,theδp should be moderately decreased to reduce adverse streamwise PRG on the S1 streamsurface.At the blade aft part,the difference in theδp between the shroud and hub streamlines should be decreased faster to control the exit uniformity.By applying the GALT to the impeller designs of three typical pump types in hydraulic engineering,the organizational effect of the PRG on fundamental flow structures is proven.The GALT can effectively control the PRG distributions and suppress the secondary flows,thereby widening the pump’s high-efficiency zone,improving flow uniformity and suppressing pressure fluctuations.Compared with the current Z-G method and the ALT,the GALT can meet the requirements of'de-experience'better,thereby enabling the designers to obtain good products explicitly and quickly. | WANG ChaoYue WANG FuJun AN DongSen YAO ZhiFeng XIAO RuoFu LU Li HE ChengLian ZOU ZhiChao | 2021 | Science China(Technological Sciences)2021，64，4： | 7 |
| 7 | Simulation and Field Testing of Multiple Vehicles Collision Avoidance Algorithms显示文摘A global planning algorithm for intelligent vehicles is designed based on the A* algorithm, which provides intelligent vehicles with a global path towards their destinations. A distributed real-time multiple vehicle collision avoidance(MVCA)algorithm is proposed by extending the reciprocal n-body collision avoidance method. MVCA enables the intelligent vehicles to choose their destinations and control inputs independently,without needing to negotiate with each other or with the coordinator. Compared to the centralized trajectory-planning algorithm, MVCA reduces computation costs and greatly improves the robustness of the system. Because the destination of each intelligent vehicle can be regarded as private, which can be protected by MVCA, at the same time MVCA can provide a real-time trajectory planning for intelligent vehicles. Therefore,MVCA can better improve the safety of intelligent vehicles. The simulation was conducted in MATLAB, including crossroads scene simulation and circular exchange position simulation. The results show that MVCA behaves safely and reliably. The effects of latency and packet loss on MVCA are also statistically investigated through theoretically formulating broadcasting process based on one-dimensional Markov chain. The results uncover that the tolerant delay should not exceed the half of deciding cycle of trajectory planning, and shortening the sending interval could alleviate the negative effects caused by the packet loss to an extent. The cases of short delay(< 100100 ms) and low packet loss(< 5%) can bring little influence to those trajectory planning algorithms that only depend on V2 V to sense the context, but the unpredictable collision may occur if the delay and packet loss are further worsened. The MVCA was also tested by a real intelligent vehicle, the test results prove the operability of MVCA. | Chaoyue Zu Chao Yang Jian Wang Wenbin Gao Dongpu Cao Fei-Yue Wang | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，4： | 6 |
| 8 | Advances in dielectric elastomer actuation technology显示文摘Dielectric elastomer actuators(DEAs) have attracted much interest over the past decades due to the inherent flexibility, large strain, high efficiency, high energy density, and fast response of the material, which are known as one of the most promising candidates for artificial muscle. In this paper, we first introduce the actuation principle and electromechanical modeling approaches of dielectric elastomers(DEs). Then, the performance of different DEs material and existing compliant electrodes that are widely utilized for DEAs are presented. We also highlight the compatibility of DEs, which is suitable for a variety of actuator designs and applications. Lastly, we summarize the challenges and future development in terms of electromechanical modeling, improvement of materials including compliant electrodes and dielectric elastomer, designs and applications of novel dielectric elastomer actuators. | WANG NianFeng CUI ChaoYu GUO Hao CHEN BiCheng ZHANG XianMin | 2018 | Science China(Technological Sciences)2018，61，10： | 6 |
| 9 | Effect of substrate cooling on the epitaxial growth of Ni-based single-crystal superalloy fabricated by direct energy deposition显示文摘The columnar-to-equiaxed transition(CET)or the formation of stray grains in the laser melting deposition is the least desirable for the repair of single-crystal blades.In this work,the forced water-cooling was conducted on a single-crystal Rene N5 substrate during the direct energy deposition(DED).The single track remelting,one-layer,two-layer,and eight-layer depositions were investigated to explore the grain growth mechanism.The solidification conditions of the DED process,including temperature field,temperature gradient,and solidification speed,were numerically analyzed by a finite element model.The single-track remelting results showed that the fraction of columnar crystal regions increases from55.81%in the air-cooled sample to 77.14%in the water-cooled one.The single-track deposits of one-and two-layer have the same trend,where the proportion of columnar crystal height was higher under the forced water-cooled condition.The electron backscattered diffraction(EBSD)grain-structure maps of an eight-layer deposit show that the epitaxial growth height increases from 1 mm in the air-cooling sample to 1.5 mm in the water-cooling one.The numerical results showed that the tempe rature gradient in[0011 direction was significantly increased by using forced water-cooling.In conclusion,the in-situ substrate cooling can become a potential method to promote epitaxial growth during DED via the influence on CET occurrence. | Jianwen Nie Chaoyue Chen Longtao Liu Xiaodong Wang Ruixin Zhao Sansan Shuai Jiang Wang Zhongming Ren | 2021 | Journal of Materials Science & Technology2021，，3： | 6 |
| 10 | Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets显示文摘Background: Oxidative stress is a key factor that influences piglets' health. Taurine plays an imperative role in keeping the biological system from damage. This study was conducted to investigate the protective effect of taurine against muscle injury due to the secondary effect of diquat toxicity.Results: Our study found that taurine effectively and dose-dependently alleviated the diquat toxicity induced rise of feed/gain, with a concurrent improvement of carcass lean percentage. The plasma content of taurine was considerably increased in a dose-dependent manner. Consequently, dietary taurine efficiently improved the activity of plasma antioxidant enzymes. Furthermore, taurine attenuated muscle damage by restoring mitochondrial micromorphology, suppressing protein degradation and reducing the percentage of apoptotic cells in the skeletal muscle. Taurine supplementation also suppressed the genes expression levels of the antioxidant-, mitochondrial biogenesis-, and muscle atrophy-related genes in the skeletal muscle of piglets with oxidative stress.Conclusions: These results showed that the dose of 0.60% taurine supplementation in the diet could attenuate skeletal muscle injury induced by diquat toxicity. It is suggested that taurine could be a potential nutritional intervention strategy to improve growth performance. | Chaoyue Wen Fengna Li Qiuping Guo Lingyu Zhang Yehui Duan Wenlong Wang Jianzhong Li Shanping He Wen Chen Yulong Yin | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 5 |
| 11 | Strain hardening of as-extruded Mg-xZn(x=1, 2, 3 and 4 wt%) alloys显示文摘The influence of Zn on the strain hardening of as-extruded Mg-x Zn(x = 1, 2, 3 and 4 wt%) magnesium alloys was investigated using uniaxial tensile tests at 10^(-3)s^(-1) at room temperature. The strain hardening rate,the strain hardening exponent and the hardening capacity were obtained from true plastic stress-strain curves. There were almost no second phases in the as-extruded Mg-Zn magnesium alloys. Average grain sizes of the four as-extruded alloys were about 17.8 μm. With increasing Zn content from 1 to 4 wt%, the strain hardening rate increased from 2850 MPa to 6810 MPa at(б-б_(0.2)) = 60 MPa, the strain hardening exponent n increased from 0.160 to 0.203, and the hardening capacity, Hc increased from 1.17 to 2.34.The difference in strain hardening response of these Mg-Zn alloys might be mainly caused by weaker basal texture and more solute atoms in the α-Mg matrix with higher Zn content. | Chaoyue Zhao Xianhua Chen Fusheng Pan Jingfeng Wang Shangyu Gao Teng Tu Chunquan Liu Jiahao Yao Andrej Atrens | 2019 | Journal of Materials Science & Technology2019，35，1： | 4 |
| 12 | Cold spray additive manufacturing of Invar 36 alloy:microstructure,thermal expansion and mechanical properties显示文摘In this work,the Invar 36 alloys were manufactured using cold spray(CS)additive manufacturing technique.The systematic investigations were made on the microstructural evolution,thermal expansion and mechanical properties under as-sprayed(AS)and heat-treated(HT)conditions.XRD(X-ray diffraction)and ICP-AES(inductively coupled plasma atomic emission spectroscopy)analyses show that no phase transformation,oxidation,nor element content change have occurred.The X-ray computed tomography(XCT)exhibited a near fully dense structure with a porosity of 0.025%in the helium-produced sample under as-sprayed condition,whereas the nitrogen-produced samples produced at 5 MPa and 800℃show more irregular pore defects.He-AS sample shows a more prominent grain refinement than that of nitrogen samples due to the more extensive plastic deformation.The post heat-treatment exhibited a promoted grain growth,inter-particle diffusion,as well as the formation of annealing twins.Between25℃and 200℃,the nitrogen samples possessed lower CTE(coefficient of thermal expansion)values(1.53×10^(-6)/℃)compared with those produced by casting and laser additive manufacturing.The He-AS samples exhibited a noticeable negative CTE value between 25℃and 200℃,which may due to the significant compressive residual stress(-272 MPa)compensating its displacement with temperature increase during CTE test.The N2-HT and He-HT Invar 36 samples present a notable balance between strength and ductility.In conclusion,the CS technique can be considered as a potential method to produce the Invar36 component with high thermal and mechanical performance. | Chaoyue Chen Yingchun Xie Longtao Liu Ruixin Zhao Xiaoli Jin Shanqing Li Renzhong Huang Jiang Wang Hanlin Liao Zhongming Ren | 2021 | Journal of Materials Science & Technology2021，，13： | 4 |
| 13 | Governing the Inclination Angle of Graphite Flakes in the Graphite Flake/Al Composites by Controlling the Al Particle Size via Flake Powder Metallurgy显示文摘The inclination angle of the flake particle has a significant impact on the in-plane thermal conductivity of composites.The graphite flake/Al composites(50 vol%)with different inclination angles were fabricated via flake powder metallurgy,and the results show that with increasing the size of Al particle from 25.6 to 50.7μm,the inclination angle of graphite flake decreases from 7.3°to 4.4°,while the in-plane thermal conductivity of composites increases from 473 to 555 Wm-1 K-1.Based on the rules of mixture,an effective model was established to qualify and quantify the relation between the inclination angle and the in-plane thermal conductivity of the corresponding composites.This model can also be applied to other flake particle-reinforced composites. | Dong Li Chaoyu Wang Yishi Su Di Zhang Qiubao Ouyang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 3 |
| 14 | Microbiota-gut-brain axis and nutritional strategy under heat stress显示文摘Heat stress is a very universal stress event in recent years.Various lines of evidence in the past literatures indicate that gut microbiota composition is susceptible to variable temperature.A varied microbiota is necessary for optimal regulation of host signaling pathways and disrupting microbiota-host homeostasis that induces disease pathology.The microbiota-gut-brain axis involves an interactive mode of communication between the microbes colonizing the gut and brain function.This review summarizes the effects of heat stress on intestinal function and microbiota-gut-brain axis.Heat stress negatively affects intestinal immunity and barrier functions.Microbiota-gut-brain axis is involved in the homeostasis of the gut microbiota,at the same time,heat stress affects the metabolites of microbiota which could alter the function of microbiota-gut-brain axis.We aim to bridge the evidence that the microbiota is adapted to survive and thrive in an extreme environment.Additionally,nutritional strategies for alleviating intestinal heat stress are introduced. | Chaoyue Wen Siyu Wei Xin Zong Yizhen Wang Mingliang Jin | 2021 | Animal Nutrition2021，，4： | 2 |
| 15 | Tensile properties analysis of CFRP-titanium plate multi-bolt hybrid joints显示文摘Hybrid joints have better tensile properties than pure bonded and bolted bolts,and are increasingly used in the aerospace field.Tensile tests are carried out for the Hybrid Bonded/Bolted(HBB)joints of Carbon Fiber Reinforced Polymer(CFRP)laminate and titanium alloy plate under different bolt numbers,and the corresponding load–displacement curves are obtained.At the same time,based on Continuum Damage Mechanics(CDM)theory,which is derived from 3D Hashin failure criteria,and a Cohesive Zone Model(CZM),the tensile strength prediction model of the composite laminate-titanium alloy plate multi-bolted HBB joint was established,and the numerical simulation results were in good agreement with the experimental height,which validate the feasibility of the model.The difference in the bearing capacity of HBB joints under different numbers of bolts is compared and analyzed.On this basis,the influence of inter-bolt distance on the tensile properties of the HBB joints is explored.The results show that the double-nail HBB joints can effectively improve the end warpage and low bearing capacity of the single-nail HBB joints.The tensile failure load of the double-nail HBB joints under the standard lap width(30 mm)is 82.6%higher than that of the single nail,the tensile failure load of the three-bolt HBB joints is 34.1%higher than that of the double nail.For the three-bolt HBB joint,the joint strength is controlled by the adhesive and the external bolt,while the internal bolt is redundant,the hybrid joint can be simplified by reducing the middle bolt.The inter-bolt distance has a great influence on the failure load of the hybrid joint.Increasing the inter-bolt distance can effectively improve the bearing capacity of the structure. | Yanping ZHENG Chaoyu ZHANG Ying TIE Xu WANG Mingkun LI | 2022 | Chinese Journal of Aeronautics2022，35，3： | 2 |
| 16 | Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis显示文摘METRNL is a recently identified secreted protein with emerging functions.This study is to find major cellular source of circulating METRNL and to determine METRNL novel function.Here,we show METRNL is abundant in human and mouse vascular endothelium and released by endothelial cells using endoplasmic reticulum-Golgi apparatus pathway.By creating endothelial cell-specific Metrnl knockout mice,combined with bone marrow transplantation to produce bone marrow-specific deletion of Metrnl,we demonstrate that most of circulating METRNL(approximately 75%)originates from the endothelial cells.Both endothelial and circulating METRNL decrease in atherosclerosis mice and patients.By generating endothelial cell-specific Metrnl knockout in apolipoprotein E-deficient mice,combined with bone marrow-specific deletion of Metrnl in apolipoprotein E-deficient mice,we further demonstrate that endothelial METRNL deficiency accelerates atherosclerosis.Mechanically,endothelial METRNL deficiency causes vascular endothelial dysfunction including vasodilation impairment via reducing eNOS phosphorylation at Ser1177 and inflammation activation via enhancing NFκB pathway,which promotes the susceptibility of atherosclerosis.Exogenous METRNL rescues METRNL deficiency induced endothelial dysfunction.These findings reveal that METRNL is a new endothelial substance not only determining the circulating METRNL level but also regulating endothelial function for vascular health and disease.METRNL is a therapeutic target against endothelial dysfunction and atherosclerosis. | Sili Zheng Zhiyong Li Jie Song Pin Wang Jian Xu Wenjun Hu Yi Shi Qi Qi Zhuwei Miao Yunfeng Guan Chaoyu Miao | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 2 |
| 17 | Postconflict behavior among Rhinopithecus roxellana leader males in the Qinling Mountains, China显示文摘 | Haitao ZHAO Xiaowei WANG Jiaxuan Li Jian ZHANG Chengliang WANG Xiaoguang QI Songtao Guo Rongtao WANG Ke SHI Xiaoyan WANG Chaoyu YUE Baoguo LI | 2016 | Current Zoology2016，62，1： | 2 |
| 18 | Energy Model for UAV Communications:Experimental Validation and Model Generalization显示文摘Wireless communication involving unmanned aerial vehicles(UAVs)is expected to play an important role in future wireless networks.However,different from conventional terrestrial communication systems,UAVs typically have rather limited onboard energy on one hand,and require additional flying energy consumption on the other hand.This renders energy-efficient UAV communication with smart energy expenditure of paramount importance.In this paper,via extensive flight experiments,we aim to firstly validate the recently derived theoretical energy model for rotary-wing UAVs,and then develop a general model for those complicated flight scenarios where rigorous theoretical model derivation is quite challenging,if not impossible.Specifically,we first investigate how UAV power consumption varies with its flying speed for the simplest straight-and-level flight.With about 12,000 valid power-speed data points collected,we first apply the model-based curve fitting to obtain the modelling parameters based on the theoretical closed-form energy model in the existing literature.In addition,in order to exclude the potential bias caused by the theoretical energy model,the obtained measurement data is also trained using a model-free deep neural network.It is found that the obtained curve from both methods can match quite well with the theoretical energy model.Next,we further extend the study to arbitrary 2-dimensional(2-D)flight,where,to our best knowledge,no rigorous theoretical derivation is available for the closed-form energy model as a function of its flying speed,direction,and acceleration.To fill the gap,we first propose a heuristic energy model for these more complicated cases,and then provide experimental validation based on the measurement results for circular level flight. | Ning Gao Yong Zeng Jian Wang Di Wu Chaoyue Zhang Qingheng Song Jachen Qian Shi Jin | 2021 | China Communications2021，18，7： | 2 |
| 19 | Effects of Y and Zn additions on electrical conductivity and electromagnetic shielding effectiveness of Mg-Y-Zn alloys显示文摘Microstructure, electrical conductivity, and electromagnetic interference(EMI) shielding effectiveness(SE) of cast Mg-x Zn-y Y(x = 2–5, y = 1–10) alloys were systematically investigated to understand the effects of Zn and Y additions on electrical conductivity and electromagnetic shielding effectiveness of the alloys.Experimental results indicate that the electrical conductivity and SE of the Mg-x Zn-y Y alloys decrease with Y/Zn ratio. Electrical conductivity is the main factor that affects the electromagnetic shielding properties and the variation tendency of electromagnetic shielding properties of the Mg-x Zn-y Y alloys is consistent with conductivity. Valence of Y and Zn atoms, configuration of extranuclear electron and volumetric difference are main reasons for the variations in the electrical conductivity. A high density of second phase and the formation of semi-continuous network structure can also improve the SE value at high frequencies. | Lizi Liu Xianhua Chen Jingfeng Wang Liying Qiao Shangyu Gao Kai Song Chaoyue Zhao Xiaofang Liu Di Zhao Fusheng Pan | 2019 | Journal of Materials Science & Technology2019，35，6： | 2 |
| 20 | Microfluidic 3D printing polyhydroxyalkanoates-based bionic skin for wound healing显示文摘Biomimetic scaffolds with extracellular matrix(ECM)-mimicking structure have been widely investigated in wound healing applications,while insufficient mechanical strength and limited biological activity remain major challenges.Here,we present a microfluidic 3D printing biomimetic polyhydroxyalkanoates-based scaffold with excellent mechanical properties and hierarchical porous structures for enhanced wound healing.This scaffold is composed of poly(3-hydroxybutyrate-4-hydroxybutyrate)and polycaprolactone,endowing it with excellent tensile strength(2.99 MPa)and degradability(80%of weight loss within 7 d).The ECM-mimicking hierarchical porous structure allows bone marrow mesenchymal stem cells(BMSCs)and human umbilical vein endothelial cells(HUVECs)to proliferate and adhere on the scaffolds.Besides,anisotropic composite scaffolds loaded with BMSCs and HUVECs can significantly promote re-epithelization,collagen deposition and capillary formation in rat wound defects,indicating their satisfactory in vivo tissue regenerative activity.These results indicate the feasibility of polyhydroxyalkanoates-based biomimetic scaffolds for skin repair and regeneration,which also provide a promising therapeutic strategy in diverse tissue engineering applications. | Wentai Guo Xiaocheng Wang Chaoyu Yang Rongkang Huang Hui Wang Yuanjin Zhao | 2022 | Materials Futures2022，1，1： | 1 |
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