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| 1 | Slow transit constipation: A functional disorder becomes an enteric neuropathy显示文摘慢运输便秘传统地被看作了并且分类机能紊乱。然而,临床、压力计的证据一直在积累那建议大多数在 STC 的活动性改变怎么可能神经病的类型被考虑。另外,进一步的调查显示出那伤寒神经系统的微妙的改变,不是对常规组织学的检查明显,可能在这些病人在场。在现在的文章,我们将讨论这些证据,并且将试着与处于这个病理学的条件记录的大肠的反常运动机能把他们放在关系。 | Gabrio Bassotti Vincenzo Villanacci | 2006 | World Journal of Gastroenterology2006，12，29： | 38 |
| 2 | Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies显示文摘The role of enteric glial cells has somewhat changed from that of mere mechanical support elements, gluing together the various components of the enteric nervous system, to that of active participants in the complex interrelationships of the gut motor and inflammatory events. Due to their multiple functions, spanning from supporting elements in the myenteric plexuses to neurotransmitters, to neuronal homeostasis, to antigen presenting cells, this cell population has probably more intriguing abilities than previously thought. Recently, some evidence has been accumulating that shows how these cells may be involved in the pathophysiological aspects of some diseases. This review will deal with the properties of the enteric glial cells more strictly related to gastrointestinal motor function and the human pathological conditions in which these cells may play a role, suggesting the possibility of enteric neuro- gliopathies. | Gabrio Bassotti Vincenzo Villanacci Simona Fisogni Elisa Rossi Paola Baronio Carlo Clerici Christoph A Maurer Gieri Cathomas Elisabetta Antonelli | 2007 | World Journal of Gastroenterology2007，13，30： | 16 |
| 3 | Gastrointestinal motility disorders in inflammatory bowel diseases显示文摘The relationship between motility and inflammatory gastrointestinal disorders is at the same time complex and intriguing since these conditions might share some genetic,environmental,immunological and microbial predisposing factors.In addition,significant symptom overlapping may occur,muddling the waters within the clinical context.Although on one hand this represents a challenge for the clinician for a potential under-or over-treatment and diagnostic delay,on the other hand it possibly represents an opportunity for the researcher to better disclose the intimate relationship between chronic(often low-grade)inflammation,motor disorders and deranged sensory function.The best example is probably represented by Crohn’s disease and ulcerative colitis.In fact,a number of gastrointestinal motor disorders have been described in association with these diseases,disorders which span from the esophagus to the anorectum,and which will be extensively covered in this review.It is conceivable that at least part of this derangement is strictly related to inflammatory cytokine trafficking and neuromuscular changes;however,given the high prevalence of functional gastrointestinal disorders in the general population,this overlap might also be serendipitous.However,it is worth noting that literature data on this topic are relatively scarce,sometimes quite outdated,and mostly focused on the interplay between irritable bowel syndrome and inflammatory bowel disease.Nevertheless,both researchers and clinicians must be aware that symptoms related to gastrointestinal motility disorders may be highly prevalent in both active and inactive inflammatory bowel disease,correlate with greater psychological comorbidity and poorer quality of life,and may negatively influence the therapeutic approaches. | Gabrio Bassotti Elisabetta Antonelli Vincenzo Villanacci Marianna Salemme Manuela Coppola Vito Annese | 2014 | World Journal of Gastroenterology2014，20，1： | 11 |
| 4 | Cellular and molecular basis of chronic constipation: Taking the functional/idiopathic label out显示文摘In recent years, the improvement of technology and the increase in knowledge have shifted several strongly held paradigms. This is particularly true in gastroenterology, and specifically in the field of the so-called 'functional' or 'idiopathic' disease, where conditions thought for decades to be based mainly on alterations of visceral perception or aberrant psychosomatic mechanisms have, in fact, be reconducted to an organic basis (or, at the very least, have shown one or more demonstrable abnormalities). This is particularly true, for instance, for irritable bowel syndrome, the prototype entity of 'functional' gastrointestinal disorders, where low-grade inflammation of both mucosa and myenteric plexus has been repeatedly demonstrated. Thus, researchers have also investigated other functional/idiopathic gastrointestinal disorders, and found that some organic ground is present, such as abnormal neurotransmission and myenteric plexitis in esophageal achalasia and mucosal immune activation and mild eosinophilia in functional dyspepsia. Here we show evidence, based on our own and other authors' work, that chronic constipation has several abnormalities reconductable to alterations in the enteric nervous system, abnormalities mainly characterized by a constant decrease of enteric glial cells and interstitial cells of Cajal (and, sometimes, of enteric neurons). Thus, we feel that (at least some forms of) chronic constipation should no more be considered as a functional/idiopathic gastrointestinal disorder, but instead as a true enteric neuropathic abnormality. | Gabrio Bassotti Vincenzo Villanacci Dragos Cretoiu Sanda Maria Cretoiu Gabriel Becheanu | 2013 | World Journal of Gastroenterology2013，19，26： | 9 |
| 5 | Neurological disorders and inflammatory bowel diseases显示文摘Extraintestinal manifestations occur in about one-third of patients living with inflammatory bowel disease(IBD) and may precede the onset of gastrointestinal symptoms by many years. Neurologic disorders associated with IBD are not frequent, being reported in 3% of patients, but they often represent an important cause of morbidity and a relevant diagnostic issue. In addition, the increasing use of immunosuppressant and biological therapies for IBD may also play a pivotal role in the development of neurological disorders of different type and pathogenesis. Hence, we provide a complete and profound review of the main features of neurological complications associated with IBD, with particular reference to those related to drugs and with a specific focus on their clinical presentation and possible pathophysiological mechanisms. | Giovanni Casella Gian Eugenio Tontini Gabrio Bassotti Luca Pastorelli Vincenzo Villanacci Luisa Spina Vittorio Baldini Maurizio Vecchi | 2014 | World Journal of Gastroenterology2014，20，27： | 7 |
| 6 | Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors显示文摘AIM:To assess linear endoscopic ultrasound (L-EUS) and magnetic resonance imaging (MRI) in biliary tract dilation and suspect small ampullary tumor.METHODS:L-EUS and MRI data were compared in 24 patients with small ampullary tumors;all with subsequent histological confirmation.Data were collected prospectively and the accuracy of detection,histological characterization and N staging were assessed retrospectivelyusing the results of surgical or endoscopic treatment as a benchmark.RESULTS:A suspicion of ampullary tumor was present in 75% of MRI and all L-EUS examinations,with 80% agreement between EUS and histological findings at endoscopy.However,L-EUS and histological TN staging at surgery showed moderate agreement (κ=0.54).CONCLUSION:L-EUS could be a useful adjunct as a diagnostic tool in the evaluation of patients with sus-pected ampullary tumors. | Raffaele Manta Rita Conigliaro Danilo Castellani Alessandro Messerotti Helga Bertani Giuseppe Sabatino Elena Vetruccio Luisa Losi Vincenzo Villanacci Gabrio Bassotti | 2010 | World Journal of Gastroenterology2010，16，44： | 6 |
| 7 | Endoscopic mucosal resection for high-grade dysplasia and intramucosal carcinoma in Barrett's esophagus: An Italian experience显示文摘AIM: To evaluate endoscopic mucosal resection (EMR)in patients with high-grade dysplasia (HGD) and/or intramucosal cancer (IMC) in Barrett's esophagus (BE).METHODS: Between June 2000 and December 2003,39 consecutive patients with HGD (35) and/or IMC (4)underwent EMR. BE >30 mm was present in 27 patients.In three patients with short segment BE (25.0%), HGDwas detected in a normal appearing BE. Lesions had a mean diameter of 14.8±10.3 mm. Mucosal resection was carried out using the cap method.RESULTS: The average size of resections was 19.7±9.4×14.6±8.2 mm. Histopathologic assessment postresection revealed 5 low-grade dysplasia (LGD) (12.8%),27 HGD (69.2%), 2 IMC (5.1%), and 5 SMC (-12.8%).EMR changed the pre-treatment diagnosis in 10 patients (25.6%). Three patients with SMC underwehtsurgery.Histology of the surgical specimen revealed 1 T0N0 and 2 T1N0 lesions. The remaining two patients were cancer free at 32.5 and 45.6 mo, respectively. A metachronous lesion was detected after 25 mo in one patient with HGD. Intra-procedural bleeding, controlled at endoscopy,occurred in four patients (10.3%). After a median followup of 34.9 mo, all patients remained in remission.CONCLUSION: In the medium term, EMR is effective and safe to treat HGD and/or IMC within BE and is a valuable staging method. It could become an alternative to surgery. | Massimo Conio Alessandro Repici Renzo Cestari Sabrina Blanchi Gabriella Lapertosa Guido Missale Domenico Della Casa Vincenzo Villanacci Pier Gigi Calandri Rosangela Filiberti | 2005 | World Journal of Gastroenterology2005，11，42： | 6 |
| 8 | Novel oral-targeted therapies for mucosal healing in ulcerative colitis显示文摘Ulcerative colitis(UC), a chronic, relapsing, remitting disease of the colon and rectum, is characterized by inflammatory ulceration of the mucosa. Current UC therapy relies on controlling acute episodes and preventing relapse. To predict modifications in the natural course of UC, mucosal healing(MH) has emerged as a major treatment goal. Endoscopic evaluation is considered the gold standard for assessing MH, which can be achieved by conventional drugs and biologics in many, but not all, patients. Consequently, interest is focusing on the development of new substances for UC therapy, and new oral agents are in the pipeline. This review will focus on the ability of newly developed oral drugs to induce and maintain MH in UC patients. | Elisabetta Antonelli Vincenzo Villanacci Gabrio Bassotti | 2018 | World Journal of Gastroenterology2018，24，47： | 4 |
| 9 | Quantitative analysis of contrast-enhanced ultrasonography of the bowel wall can predict disease activity in inflammatory bowel disease显示文摘 | Laura Romanini Matteo Passamonti Mario Navarria Francesco Lanzarotto Vincenzo Villanacci Grazioli Luigi Fabrizio Calliada Roberto Maroldi | 2014 | European Journal of Radiology2014，，： | 2 |
| 10 | Histological healing in inflammatory bowel disease:A still unfulfilled promise显示文摘Treatment of inflammatory bowel disease(IBD) is traditionally based on several drugs,including salicylates,corticosteroids,and antibiotics;in addition,the therapeutic armamentarium has considerably evolved with the advent of newer,effective therapeutic measures(such as the biological agents) that are able to improve in a considerable manner both the clinical and endoscopic variables.Thus,mucosal healing,at least considered from an endoscopic point of view,is today regarded as the ultimate endpoint for treatment of these conditions.However,it is also increasingly clear that endoscopic healing is not necessarily paralleled by histological healing;There are few doubts that the latter should be considered as a true,objective healing and the ultimate goal to reach when treating patients with IBD.Unfortunately,and surprisingly,only a few,incomplete,and somewhat conflicting data exist on this topic,especially because there is still the need to standardize both histological assessment and the severity grading of these disorders;Issues that have not been yet been resolved for clinical practice and therapeutic trials.Hopefully,with the help of an increased awareness on the clinical researchers' side,and the availability of dedicated pathologists on the other side,this matter will be effectively faced and resolved in the near future. | Vincenzo Villanacci Elisabetta Antonelli Karel Geboes Giovanni Casella Gabrio Bassotti | 2013 | World Journal of Gastroenterology2013，19，7： | 2 |
| 11 | Failed stapled rectal resection in a constipated patient with rectal aganglionosis显示文摘A rare case of a severely constipated patient with rectal aganglionosis is herein reported.The patient,who had no megacolon/megarectum,underwent a STARR,i.e.,stapled transanal rectal resection,for obstructed defecation,but her symptoms were not relieved.She started suffering from severe chronic proctalgia possibly due to peri-retained staples fibrosis.Intestinal transit times were normal and no megarectum/megacolon was found at barium enema.A diverting sigmoidostomy was then carried out,which was complicated by an early parastomal hernia,which affected stoma emptying.She also had a severe diverting proctitis,causing rectal bleeding,and still complained of both proctalgia and tenesmus.A deep rectal biopsy under anesthesia showed no ganglia in the rectum,whereas ganglia were present and normal in the sigmoid at the stoma site.As she refused a Duhamel procedure,an intersphincteric rectal resection and a refashioning of the stoma was scheduled.This case report shows that a complete assessment of the potential causes of constipation should be carried out prior to any surgical procedure. | Lorenzo C Pescatori Vincenzo Villanacci Mario Pescatori | 2014 | World Journal of Gastroenterology2014，20，15： | 2 |
| 12 | Is hyperhomocysteinemia relevant in patients with celiac disease?显示文摘AIM:To investigate whether this might be related to the presence of hyperhomocysteinemia.RESULTS:Hyperhomocysteinemia was evident in 32 patients(19.3%),although most of them had moderate levels(mean value 25 mcg/ml;range 15-30).Only one patient had a history of myocardial infarction(heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation).CONCLUSION:The systematic assessment of hyperhomocysteinemia seems,at present,unjustified in CD patients. | Giovanni Casella Gabrio Bassotti Vincenzo Villanacci Camillo Di Bella Fabio Pagni Gian Luigi Corti Giuseppe Sabatino Mara Piatti Vittorio Baldini | 2011 | World Journal of Gastroenterology2011，17，24： | 1 |
| 13 | The sharp decline of beta estrogen receptors expression in long-lasting ulcerative-associated carcinoma显示文摘 | Mariabeatrice Principi Maria Principia Scavo Domenico Piscitelli Vincenzo Villanacci Rosa Lovero Giuseppe Losurdo Bruna Girardi Enzo Ierardi Alfredo Di Leo | 2014 | Scandinavian Journal of Gastroenterology2014，，8： | 1 |
| 14 | HER‐2 overexpression/amplification in Barrett’s oesophagus predicts early transition from dysplasia to adenocarcinoma: a clinico‐pathologic study显示文摘 | Elisa Rossi Salvatore Grisanti Vincenzo Villanacci Domenico Della Casa Paolo Cengia Guido Missale Luigi Minelli Michela Buglione Renzo Cestari Gabrio Bassotti | 2008 | Journal of Cellular and Molecular Medicine2008，，9： | 1 |
| 15 | Endoscopic features of celiac disease in children显示文摘 | Alberto M. Ravelli Pamela Tobanelli Luigi Minelli Vincenzo Villanacci Renzo Cestari | 2001 | Gastrointestinal Endoscopy2001，，6： | 1 |
| 16 | Microscopic enteritis:Bucharest consensus显示文摘Microscopic enteritis(ME) is an inflammatory condition of the small bowel that leads to gastrointestinal symptoms,nutrient and micronutrient deficiency.It is characterised by microscopic or sub-microscopic abnormalities such as microvillus changes and enterocytic alterations in the absence of definite macroscopic changes using standard modern endoscopy.This work recognises a need to characterize disorders with microscopic and submicroscopic features,currently regarded as functional or non-specific entities,to obtain further understanding of their clinical relevance.The consensus working party reviewed statements about the aetiology,diagnosis and symptoms associated with ME and proposes an algorithm for its investigation and treatment.Following the 5th International Course in Digestive Pathology in Bucharest in November 2012,an international group of 21 interested pathologists and gastroenterologists formed a working party with a view to formulating a consensus statement on ME.A five-step agreement scale(from strong agreement to strong disagreement) was used to score 21 statements,independently.There was strong agreement on all statements about ME histology(95%-100%).Statements concerning diagnosis achieved 85% to 100% agreement.A statement on the management of ME elicited agreement from the lowest rate(60%) up to 100%.The remaining two categories showed general agreement between experts on clinical presentation(75%-95%) and pathogenesis(80%-90%) of ME.There was strong agreement on the histological definition of ME.Weaker agreement on management indicates a need for further investigations,better definitions and clinical trials to produce quality guidelines for management.This ME consensus is a step toward greater recognition of a significant entity affecting symptomatic patients previously labelled as non-specific or functional enteropathy. | Kamran Rostami David Aldulaimi Geoffrey Holmes Matt W Johnson Marie Robert Amitabh Srivastava Jean-Francois Fléjou David S Sanders Umberto Volta Mohammad H Derakhshan James J Going Gabriel Becheanu Carlo Catassi Mihai Danciu Luke Materacki Kamran Ghafarzadegan Sauid Ishaq Mohammad Rostami-Nejad A Salvador Pe?a Gabrio Bassotti Michael N Marsh Vincenzo Villanacci | 2015 | World Journal of Gastroenterology2015，21，9： | 1 |
| 17 | HER‐2 overexpression/amplification in Barrett’s oesophagus predicts early transition from dysplasia to adenocarcinoma: a clinico‐pathologic study显示文摘 | Elisa Rossi Salvatore Grisanti Vincenzo Villanacci Domenico Della Casa Paolo Cengia Guido Missale Luigi Minelli Michela Buglione Renzo Cestari Gabrio Bassotti | 2008 | Journal of Cellular and Molecular Medicine (b)2008，，9： | 1 |
| 18 | SpyGlass ? single-operator peroral cholangioscopy in the evaluation of indeterminate biliary lesions: a single-center, prospective, cohort study显示文摘 | Raffaele Manta Marzio Frazzoni Rita Conigliaro Livia Maccio Gianlugi Melotti Emanuele Dabizzi Helga Bertani Mauro Manno Danilo Castellani Vincenzo Villanacci Gabrio Bassotti | 2013 | Surgical Endoscopy2013，，5： | 1 |
| 19 | Clinical expression of lymphocytic duodenosis in “mild enteropathy” celiac disease and in functional gastrointestinal syndromes显示文摘 | Barbara Zanini Francesco Lanzarotto Vincenzo Villanacci Nice Carabellese Chiara Ricci Alberto Lanzini | 2014 | Scandinavian Journal of Gastroenterology2014，，7： | 1 |
| 20 | Inflammatory bowel disease in the dog:Differences and similarities with humans显示文摘Inflammatory bowel diseases (IBD) represent important chronic conditions affecting the gastrointestinal tract in man.However,similar disorders are found in several animal species and the IBD affecting dogs are particularly important.These are encompassed by an umbrella of probably several different entities with common symptoms,some of which seem to share striking similarities with human conditions.This review will focus on the actual knowledge of IBD in dogs,and attempt to identify differences and similarities with human IBD conditions. | Matteo Cerquetella Andrea Spaterna Fulvio Laus Beniamino Tesei Giacomo Rossi Elisabetta Antonelli Vincenzo Villanacci Gabrio Bassotti | 2010 | World Journal of Gastroenterology2010，16，9： | 1 |
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