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| 1 | Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation显示文摘Splenomegaly is a well-known phenomenon typically associated with inflammation.However,the underlying cause of this phenotype has not been well characterized.Furthermore,the splenomegaly phenotype seen in lymphotoxin(LT)signaling-deficient mice is characterized by increased numbers of splenocytes and splenic neutrophils.Splenomegaly,as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues,is thought to result from the absence of secondary lymphoid tissues in LT-deficient mice.We now present evidence that mice deficient in LTα1β2 or LTβR develop splenomegaly and increased numbers of lymphocytes in non-lymphoid tissues in a microbiota-dependent manner.Antibiotic administration to LTα1β2-or LTβR-deficient mice reduces splenomegaly.Furthermore,re-derived germ-free Ltbr−/−mice do not exhibit splenomegaly or increased inflammation in non-lymphoid tissues compared to specific pathogen-free Ltbr−/−mice.By using various LTβ-and LTβR-conditional knockout mice,we demonstrate that retinoic acid-related orphan receptorγT-positive type 3 innate lymphoid cells provide the required active LT signaling to prevent the development of splenomegaly.Thus,this study demonstrates the importance of LT-mediated immune responses for the prevention of splenomegaly and systemic inflammation induced by microbiota. | Yuan Zhang Tae-Jin Kim Joanna A Wroblewska Vera Tesic Vaibhav Upadhyay Ralph R Weichselbaum Alexei V Tumanov Hong Tang Xiaohuan Guo Haidong Tang Yang-Xin Fu | 2018 | Cellular & Molecular Immunology2018，15，7： | 3 |
| 2 | Viscosity Measure-Ments of Ferrofluid:Comparison with Various Hydrodynamic Equations 显示文摘 | Rajesh Patel R V Upadhyay R V Mehta | 2003 | Journal of Colloid and Interface Science2003，26，3： | 1 |
| 3 | Concentrations of heavy metals and aquatic macrophytes of Govind Ballabh Pant Sagar an anthropogenic lake affected by coal mining effluent显示文摘 | MISHRA V K UPADHYAY A R PANDEY S K | 2008 | Environmental Monitoring and Assessment2008，141，： | 1 |
| 4 | Removal of toluene vapour using agro-waste as biofiher media 显示文摘 | Singh R S Agnihotri S S Upadhyay S N | 2006 | Bioresouree Technology2006，97，18： | 1 |
| 5 | Role of graphene/metal oxide composites as photocatalysts , adsorbents and disinfectants in water treatment: a review显示文摘 | Upadhyay R K Soin N Roy S S | 2014 | RSC Adv2014，4，： | 1 |
| 6 | Inflammation in stroke and focal cerebral ischemia显示文摘 | Huang J Upadhyay U M Tamargo R | 2006 | Surg Neurol2006，66，3： | 1 |
| 7 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 8 | Association of commonpolymorphisms in TNFA,NFkBl and NFKBIA with risk and prog-nosis of esophageal squamous cell carcinoma显示文摘 | Umar M Upadhyay R Kumar S | 2013 | Plos One2013，8，81： | 1 |
| 9 | Opti- mization of nutrients for gellan gum production by Sphin- gomonas paucimobilis ATCC 31461 in molasses based medium using response surface methodology 显示文摘 | BANIK R M SANTHIAGU A UPADHYAY S N | 2007 | Biore- sour Technol2007，98，4： | 1 |
| 10 | Analgesic effect of expressed breast milk in procedural pain in term neonates:A randomized,placebo-controlled,double-blind trial显示文摘 | Upadhyay A Aggarwal R Narayan S | 2004 | Acta Paediatr2004，93，4： | 1 |
| 11 | Role of Xenobiotic-metaboliz- ing enzyme gene polymorphisms and interactions with environmental factors in susceptibility to gastric cancer in kashmir valley显示文摘 | Malik MA Upadhyay R | 2009 | Journal of Gastrointestinal Canc er2009，40，1： | 1 |
| 12 | Dynamics of a three spe- cies food chain model with Crowley-Martin type functional response 显示文摘 | UPADHYAY R K NAJI R K | 2009 | Chaos Solitons and Fractals2009，42，： | 1 |
| 13 | Exopolysaccharidc of thegellanfamily: prospectsandpotential显示文摘 | BAN1K R M KANARI B UPADHYAY S N | 2000 | WorldJMicrobiol Biotechnol2000，16，： | 1 |
| 14 | Spatiotemporal pattern induced by self and cross-diffusion in a spatial HoUing-Tanner model显示文摘 | UPADHYAY R K THAKUR N K | 2012 | Computational Ecology and Software2012，2，1： | 1 |
| 15 | A screen for conserved sequences with biased base composition identifies noncoding RNAs in the A-T rich genome of Plasmodiumfalciparum显示文摘 | Upadhyay R Bawankar P Malhotra D | 2005 | Mol Biochem Parasitol2005，144，2： | 1 |
| 16 | Biological control of Pythium aphanidermatum causing damping-off of mustard by mutants of Trichoderma viride 1433显示文摘 | KHARE A SINGH B K UPADHYAY R S | 2010 | Journal of Agricultural Technology2010，6，2： | 1 |
| 17 | Characterization of bread dough: Rheological properties and microstrueture 显示文摘 | UPADHYAY R GHOSAL D MEHRA A | 2012 | Journal of Food Engineering2012，109，1： | 1 |
| 18 | Functional polymor- phisms of cyclooxygenase-2 (COX 2) gene and risk for esopha- geal squamouscell carcinoma显示文摘 | Upadhyay R Jain M Kumar S | 2009 | Mutat Res2009，663，： | 1 |
| 19 | Exopolysaccharide of the gellan family:prospects and potential 显示文摘 | Banik R M Kanari B Upadhyay S N | 2000 | World Journal of Microjbiology and B iotechnology2000，16，5： | 1 |
| 20 | Microwave-assisted extraction of chlorogenic acids from green coffee beans显示文摘 | Upadhyay R Ramalakshmi K Rao L.Jagan Mohan | | 0，，01： | 1 |
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