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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Compensatory growth of three herbaceous perennial species:the effect of clipping and nutrient a- vailability显示文摘 | Hicks S Turkington R | 2000 | Conidia Journal of Botany2000，78，6： | 1 |
| 3 | The effect of initial seed density on the structure of a desert annual plant community 显示文摘 | Lortie C J Turkington R | 2002 | Journal of Ecology2002，90，： | 1 |
| 4 | Sandstone weathering:a century of research and innovation显示文摘 | TURKINGTON A V PARADISE T R | 2005 | Geomorphology2005，67，12： | 1 |
| 5 | Acceptance, effectiveness and safety of continuous positive airwaypressure in acute stroke: a pilot study显示文摘 | SCALA R TURKINGTON P M WANKLYN P | 2009 | Respir Med2009，103，1： | 1 |
| 6 | Sandstone weathering:a century of research and innovation显示文摘 | TURKINGTON A V PARADISE T R | 2005 | Geomorphology2005，，67： | 1 |
| 7 | Sandstone weathering : a century of research and innovation 显示文摘 | Turkington A V Paradise T R | 2005 | Geomorphology2005，67，12： | 1 |
| 8 | Competitive relationamong species from pastures of different ages显示文摘 | AARSSEN I W TURKINGTON R | 1985 | Canadian Journal of botany1985，63，： | 1 |
| 9 | Competitive relation among species from pastures of different ages 显示文摘 | Aarssen L W Turkington R | 1985 | Canadian Journal of botany1985，63，： | 1 |
| 10 | The Growth,Distribution and Neighbor Relationships of Trifolium repens in a Permanent Pasture:Ⅳ:Fine Scale Biotic Differentiation显示文摘 | Turkington R Harper J L | 1979 | Journal of Ecology1979，67，： | 1 |
| 11 | Integration among ramets of Trifolium repens显示文摘 | Turkington R Klein E | 1991 | Canadian Journal of Botany1991，69，： | 1 |
| 12 | The effects of NPK fertilization for nine years on boreal forest vegetation in northwestern Canada 显示文摘 | Turkington R John E Krebs CJ Dale MRT Nams VO Boonstra R Boutin S Martin K Sinclair ARE Smith JNM | 1998 | J Veg Sci1998，9，： | 1 |
| 13 | Effects of density on timing of emergence and its consequences for survival and growth in two communities of annual plants 显示文摘 | TURKINGTON R GOLDBERG D E OESVIG-WHITTAKER L | 2005 | Journal of Arid Environments2005，61，： | 1 |
| 14 | The effect of initial seed density on the structure of a desert annual plant community 显示文摘 | Lortie C J Turkington R | 2002 | Journal of Ecology2002，90，： | 1 |
| 15 | Nonequivalent statistical equilibrium ensembles and refined stability theorems for most probable flows显示文摘 | Ellis R S Haven K Turkington B | 2002 | Nonlinearity2002，15，： | 1 |
| 16 | Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer显示文摘 | Stevenson L Allen W L Turkington R | 2012 | Clin Cancer Res2012，18，19： | 1 |
| 17 | Sample sizes in relation to forecasting sclerotinia stem rot of canola显示文摘 | TURKINGTON T K MORRAL R A A BAKER R J | 1988 | Canadian Journal of Plant Pathology1988，，10： | 1 |
| 18 | The effect of initial seed density on the structure of a desert annual plant community 显示文摘 | Lortie C J Turkington R | 2002 | Journal of Ecology2002，90，： | 1 |
| 19 | Sandstone weathering: A century of research and innovation 显示文摘 | Turkington Alice V Paradise Thomas R | 2005 | Geomorphology2005，67，： | 1 |
| 20 | Acceptance, effective- ness and safety of continuous positive airway pressure in acute stroke : a pilot study 显示文摘 | Scala R Turkington PM Wanklyn P | 2009 | Respir Med2009，103，1： | 1 |
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