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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Current practices and future prospects for the management of gallbladder polyps: A topical review显示文摘A gallbladder polyp is an elevation of the gallbladder mucosa that protrudes into the gallbladder lumen. Gallbladder polyps have an estimated prevalence in adults of between 0.3%-12.3%. However, only 5% of polyps are considered to be 'true' gallbladder polyps, meaning that they are malignant or have malignant potential. The main radiological modality used for diagnosing and surveilling gallbladder polyps is transabdominal ultrasonography. However, evidence shows that other modalities such as endoscopic ultrasound may improve diagnostic accuracy. These are discussed in turn during the course of this review. Current guidelines recommend cholecystectomy for gallbladder polyps sized 10 mm and greater, although this threshold is lowered when other risk factors are identified. The evidence behind this practice is relatively low quality. This review identifies current gaps in the available evidence and highlights the necessity for further research to enable better decision making regarding which patients should undergo cholecystectomy, and/or radiological follow-up. | R Stephen McCain Anna Diamond Claire Jones Helen G Coleman | 2018 | World Journal of Gastroenterology2018，24，26： | 25 |
| 3 | Citrulline as a Biomarker in the Non-human Primate Total- and Partial-body Irradiation Models: Correlation of Circulating Citrulline to Acute and Prolonged Gastrointestinal Injury显示文摘 | Jace W. Jones Alexander Bennett Claire L. Carter Gregory Tudor Kim G. Hankey Ann M. Farese Catherine Booth Thomas J. MacVittie Maureen A. Kane | 2015 | Health Physics2015，，5： | 1 |
| 4 | Temporal Analysis of Early Immune Responses in Patients With Acute Hepatitis B Virus Infection显示文摘 | Claire Dunn Dimitra Peppa Pooja Khanna Gaia Nebbia Meleri Jones Nathan Brendish R. Monica Lascar David Brown Richard J. Gilson Richard J. Tedder Geoffrey M. Dusheiko Michael Jacobs Paul Klenerman Mala K. Maini | 2009 | Gastroenterology2009，，4： | 1 |
| 5 | The immunobiology of avian systemic salmonellosis显示文摘 | Lucy Chappell Peter Kaiser Paul Barrow Michael A. Jones Claire Johnston Paul Wigley | 2008 | Veterinary Immunology and Immunopathology2008，，1： | 1 |
| 6 | Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis显示文摘 | Kieren G. Hollingsworth Julia L. Newton Roy Taylor Claire McDonald Jeremy M. Palmer Andrew M. Blamire David E.J. Jones | 2008 | Clinical Gastroenterology and Hepatology2008，，9： | 1 |
| 7 | The use of antiendotoxin peptides in obstructive jaundice endotoxemia显示文摘 | Claire Jones Stephen A. Badger James M. Black Neil V. McFerran Margaret Hoper Tom Diamond Rowan W. Parks Mark A. Taylor | 2012 | European Journal of Gastroenterology & Hepatology2012，，3： | 1 |
| 8 | QTL analysis of quantitative resistance to Phytophthora infestans ( late blight) in tomato and comparisons with potato 显示文摘 | BROUWER DJ JONES ES CLAIR DAS 2004 | 2004 | Genome2004，47，3： | 1 |
| 9 | Development of diagnostic markers for use in breeding potatoes resistant to Globodera pallida pathotype Pa2/3 using germplasm derived from Solanum tuberosum ssp. andigena CPC 2802显示文摘 | Claire Moloney Denis Griffin Peter W. Jones Glenn J. Bryan Karen McLean John E. Bradshaw Dan Milbourne | | 0，，： | 1 |
| 10 | FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin‐Dependent Kinase Inhibitors p21Waf1 and p27Kip1显示文摘 | Christian Dombrowski Torben Helledie Ling Ling Martin Grünert Claire A. Canning C. Michael Jones James H. Hui Victor Nurcombe Andre J. van Wijnen Simon M. Cool | 2013 | Stem Cells2013，，： | 1 |
| 11 | Local leadership for rural tourism development: A case study of Adventa, Monmouthshire, UK显示文摘 | Claire Haven‐Tang Eleri Jones | 2012 | Tourism Management Perspectives2012，，： | 1 |
| 12 | Sexual dimorphism of male face shape, partnership status and the temporal context of relationship sought modulate women's preferences for direct gaze显示文摘 | Claire A Conway Benedict C Jones Lisa M DeBruine | 2010 | British Journal of Psychology2010，101，1： | 1 |
| 13 | Critical Success Factors for Business Tourism Destinations: Exploiting Cardiff's National Capital City Status and Shaping Its Business Tourism Offer 显示文摘 | CLAIRE HAVEN-TANG ELERI JONES | 2007 | Journal of Travel & Tourism Marketing2007，22，3： | 1 |
| 14 | PKC inhibition increases gap junction intercellular communication and cell adhesion in human neuroblastoma显示文摘 | Melissa Morley Claire Jones Mandeep Sidhu Vishal Gupta Suzanne M. Bernier Walter J. Rushlow Daniel J. Belliveau | 2010 | Cell and Tissue Research2010，，2： | 1 |
| 15 | Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial显示文摘 | Paul D Griffiths Anna Stanton Erin McCarrell Colette Smith Mohamed Osman Mark Harber Andrew Davenport Gareth Jones David C Wheeler James O’Beirne Douglas Thorburn David Patch Claire E Atkinson Sylvie Pichon Paul Sweny Marisa Lanzman Elizabeth Woodford Emi | 2011 | The Lancet2011，，9773： | 1 |
| 16 | Effects of cryopreservation and density-gradient washing on phospholipase C zeta concentrations in human spermatozoa显示文摘 | Junaid Kashir Ariane Heynen Celine Jones Claire Durrans Jo Craig Joaquín Gadea Karen Turner John Parrington Kevin Coward | 2011 | Reproductive BioMedicine Online2011，，2： | 1 |
| 17 | 品牌总裁爱发帖李维斯陷入文化冲突显示文摘2020年3月,新冠疫情初起,詹妮弗·赛伊(JenniferSey)发现自己跟丈夫和四个孩子被困在了家里,只能在由餐桌改成的临时办公室工作。她不知道这场疫情会如何发展,也不知道它何时能结束。于是她开始在社交媒体上发帖子,而且一发不可收拾。当时她住在旧金山,那是美国最早一批颁布居家令的城市之一。 | CLAIRE SUDDATH JANELLE JONES(摄影) | 2022 | 商业周刊(中文版)2022，，11： | 0 |
| 18 | Impacts of timing,length,and intensity of behavioral interventions to COVID-19 dynamics:North Carolina countylevel examples显示文摘We sought to examine how the impact of revocable behavioral interventions,e.g.,shelterin-place,varies throughout an epidemic,as well as the role that the proportion of susceptible individuals had on an intervention's impact.We estimated the theoretical impacts of start day,length,and intensity of interventions on disease transmission and illustrated them on COVID-19 dynamics inWake County,North Carolina,to inform how interventions can be most effective.We used a Susceptible,Exposed,Infectious,and Recovered(SEIR)model to estimate epidemic curves with modifications to the disease transmission parameter(β).We designed modifications to simulate events likely to increase transmission(e.g.,long weekends,holiday seasons)or behavioral interventions likely to decrease it(e.g.,shelter-in-place,masking).We compared the resultant curves'shape,timing,and cumulative case count to baseline and across other modified curves.Interventions led to changes in COVID-19 dynamics,including moving the peak's location,height,and width.The proportion susceptible,at the start day,strongly influenced their impact.Early interventions shifted the curve,while interventions near the peak modified shape and case count.For some scenarios,in which the transmission parameter was decreased,the final cumulative count increased over baseline.We showed that the timing of revocable interventions has a strong impact on their effect.The same intervention applied at different time points,corresponding to different proportions of susceptibility,resulted in qualitatively differential effects.Accurate estimation of the proportion susceptible is critical for understanding an intervention's impact.The findings presented here provide evidence of the importance of estimating the proportion of the population that is susceptible when predicting the impact of behavioral infection control interventions.Greater emphasis should be placed on the estimation of this epidemic component in intervention design and decision-making.Our results are generic and are applicable to other infectious disease epidemics,as well as to future waves of the current COVID-19 epidemic.Developed into a publicly available tool that allows users to modify the parameters to estimate impacts of different interventions,these models could aid in evaluating behavioral intervention options prior to their use and in predicting case increases from specific events. | Claire Quiner Kasey Jones Georgiy Bobashev | 2022 | Infectious Disease Modelling2022，7，3： | 0 |
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