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| 1 | Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virusinfected liver显示文摘AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively analyzed.Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for ferroportin.As a control,normal liver tissue was obtained from 18 living donors of liver transplantation.Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.RESULTS:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in vivo.Conversely,iron administration suppresses HCV replication in vitro.Therefore,the association between HCV infection and iron metabolism remains unclear.Compared with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and hepcidin.When the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and ferroportin.Expression of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected liver.BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group.HCV infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in hepatocytes.CONCLUSION:Decreased expression of hepcidin and ferroportin in SVR patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon plus ribavirin treatment. | Motoyuki Kohjima Tsuyoshi Yoshimoto Munechika Enjoji Nobuyoshi Fukushima Kunitaka Fukuizumi Tsukasa Nakamura Miho Kurokawa Nao Fujimori Yusuke Sasaki Yasushi Shimonaka Yusuke Murata Susumu Koyama Ken Kawabe Kazuhiro Haraguchi Yorinobu Sumida Naohiko Harada Masaki Kato Kazuhiro Kotoh Makoto Nakamuta | 2015 | World Journal of Gastroenterology2015，21，11： | 4 |
| 2 | -449 C>G polymorphism of NFKB1 gene,coding nuclear factor-kappa-B,is associated with the susceptibility to ulcerative colitis显示文摘AIM:To clarify the association between a polymorphism-449 C>G(rs72696119) in 5'-UTR of NFKB1 with ulcerative colitis(UC).METHODS:The studied population comprised 639 subjects,including patients with UC(UC cases,n = 174) and subjects without UC(controls,n = 465).We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene polymorphism.RESULTS:The rs72696119 G allele frequencies in controls and UC cases were 33.4% and 38.5%,respectively(P = 0.10).Genotype frequency of the GG homozygote in UC cases was significantly higher than that in controls(P = 0.017),and the GG homozygote was significantly associated with susceptibility to UC [odds ratio(OR),1.88;95%CI,1.13-3.14].In male subjects,the GG homozygote was associated with an increased risk for UC(OR,3.10;95%CI,1.47-6.54;P = 0.0053),whereas this association was not found in female subjects.In addition,the GG homozygote was significantly associated with the risk of non-continuous disease(OR,2.06;95%CI,1.12-3.79;P = 0.029),not having total colitis(OR,2.40;95%CI,1.09-3.80,P = 0.040),disease which developed before 20 years of age(OR,2.80;95%CI,1.07-7.32,P = 0.041),no hospitalization(OR,2.28;95%CI,1.29-4.05;P = 0.0090) and with a maximum of 8 or less on the UCDAI score(OR,2.45;95%CI,1.23-4.93;P = 0.022).CONCLUSION:Our results provide evidence that NFKB1 polymorphism rs72696119 was significantly associated with the development of UC.This polymorphism influences the susceptibility to and pathophysiological features of UC. | Ranji Hayashi Tomomitsu Tahara Tsukasa Yamaaki Takashi Saito Kazuhiro Matsunaga Nobuhiko Hayashi Atsushi Fukumura Kazuaki Ozaki Masakatsu Nakamura Hisakazu Shiroeda Mikihiro Tsutsumi Tomoyuki Shibata Tomiyasu Arisawa | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 3 | Usefulness of Magnifying Endoscopy with Narrow-Band Imaging for Determining Tumor Invasion Depth in Early Gastric Cancer显示文摘 | Daisuke Kikuchi Toshiro Iizuka Shu Hoteya Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Kaoru Domon Masanori Nakamura Akira Matsui Toshifumi Mitani Osamu Ogawa Sumio Watanabe Mitsuru Kaise Guido Schumacher | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 4 | Dynamic Simulation Model of Switched Reluctance Generator 显示文摘 | Osamu Ichinokura Tsukasa Kikuchi Kenji Nakamura Tadaaki Watanabe Hai-Jiao Guo | 2003 | IEEE Transactions on Magnetics (S0018- 9464)2003，39，5： | 1 |
| 5 | Prospective Study about the Utility of Endoscopic Ultrasound for Predicting the Safety of Endoscopic Submucosal Dissection in Early Gastric Cancer (T-HOPE 0801)显示文摘 | Daisuke Kikuchi Toshiro Iizuka Shu Hoteya Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Kaoru Domon Masanori Nakamura Akira Matsui Toshifumi Mitani Osamu Ogawa Mitsuru Kaise Everson L. A. Artifon | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 6 | Heterogenous distribution of peptide-containing nerve fibres within the circular muscle layer of the human pylorus显示文摘 | Tokio Domoto Mitsuru Oki Tsukasa Kotoh Teruhisa Nakamura | 1992 | Clinical Autonomic Research1992，，6： | 1 |
| 7 | Dynamic Simulation Model of Switched Reluctance Generator显示文摘 | Osamu Iehinokura Tsukasa Kikuchi Kenji Nakamura Tadaaki Watanabe Hai-Jiao Guo | 2003 | IEEE Transactions on Magnetics (S0018-9464)2003，39，5： | 1 |
| 8 | Increased levels of soluble receptor for advanced glycation end products (sRAGE) and high mobility group box 1 (HMGB1) are associated with death in patients with acute respiratory distress syndrome显示文摘 | Tsukasa Nakamura Eiichi Sato Nobuharu Fujiwara Yasuhiro Kawagoe Sayaka Maeda Sho-ichi Yamagishi | 2010 | Clinical Biochemistry2010，，8： | 1 |
| 9 | Effect of pitavastatin on urinary liver-type fatty acid-binding protein levels in patients with early diabetic nephropathy显示文摘 | TSUKASA NAKAMURA YASUHIRO KAWAGOE TAKESHI SUGAYA | 2005 | Diabetes Care2005，28，11： | 1 |
| 10 | Host–virus specificity of morbilliviruses predicted by structural modeling of the marine mammal SLAM, a receptor显示文摘 | Kazue Ohishi Akiko Ando Rintaro Suzuki Kiyotaka Takishita Masaru Kawato Etsuko Katsumata Dai Ohtsu Kenji Okutsu Koji Tokutake Hirokazu Miyahara Hirotaka Nakamura Tsukasa Murayama Tadashi Maruyama | 2008 | Comparative Immunology Microbiology and Infectious Diseases2008，，3： | 1 |
| 11 | Formation of a fatal arterioportal fistula following needle liver biopsy in a child with a living-related liver transplant: Report of a case显示文摘 | Yoshihiro Otobe Takashi Hashimoto Yasunobu Shimizu Tsukasa Nakamura Nobuko Yamamori Syusaku Hayashi Kenji Kurono Tadao Manabe | 1995 | Surgery Today1995，，10： | 1 |
| 12 | Pancreatic cancer: Slow progression in the early stages显示文摘 | Tsukasa Nakamura Koji Masuda Shumpei Harada Kiyokazu Akioka Hirotaka Sako | 2013 | International Journal of Surgery Case Reports2013，，8： | 1 |
| 13 | Charac- terization of high-velocity impact damage in CFRP lami- nates : Part I-Experiment 显示文摘 | higeki Yashiro Keiji Ogi Tsukasa Nakamura | 2013 | Composites : Part A2013，48，： | 1 |
| 14 | Purification and properties of an allergenic protein in rice grain显示文摘 | Tsukasa Matsuda Makoto Sugiyama Ryo Nakamura | 1988 | Agrie Biol Chem1988，52，6： | 1 |
| 15 | Char- acterization of high-velocity impact damage in CFRP lami- nates: Part I-Experiment 显示文摘 | Shigeki Yashiro Keiji Ogi Tsukasa Nakamura | 2013 | Composites: Part A2013，，48： | 1 |
| 16 | Dynamic Simulation Model of Switched Reluctance Generator 显示文摘 | Osamu Ichinokura Tsukasa Kikuchi Kenji Nakamura Tadaaki Watanabe Hai-Jiao Guo | 2003 | IEEE Transactions on Magnetics (S0018- 9464)2003，39，5： | 1 |
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