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| 1 | -449 C>G polymorphism of NFKB1 gene,coding nuclear factor-kappa-B,is associated with the susceptibility to ulcerative colitis显示文摘AIM:To clarify the association between a polymorphism-449 C>G(rs72696119) in 5'-UTR of NFKB1 with ulcerative colitis(UC).METHODS:The studied population comprised 639 subjects,including patients with UC(UC cases,n = 174) and subjects without UC(controls,n = 465).We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene polymorphism.RESULTS:The rs72696119 G allele frequencies in controls and UC cases were 33.4% and 38.5%,respectively(P = 0.10).Genotype frequency of the GG homozygote in UC cases was significantly higher than that in controls(P = 0.017),and the GG homozygote was significantly associated with susceptibility to UC [odds ratio(OR),1.88;95%CI,1.13-3.14].In male subjects,the GG homozygote was associated with an increased risk for UC(OR,3.10;95%CI,1.47-6.54;P = 0.0053),whereas this association was not found in female subjects.In addition,the GG homozygote was significantly associated with the risk of non-continuous disease(OR,2.06;95%CI,1.12-3.79;P = 0.029),not having total colitis(OR,2.40;95%CI,1.09-3.80,P = 0.040),disease which developed before 20 years of age(OR,2.80;95%CI,1.07-7.32,P = 0.041),no hospitalization(OR,2.28;95%CI,1.29-4.05;P = 0.0090) and with a maximum of 8 or less on the UCDAI score(OR,2.45;95%CI,1.23-4.93;P = 0.022).CONCLUSION:Our results provide evidence that NFKB1 polymorphism rs72696119 was significantly associated with the development of UC.This polymorphism influences the susceptibility to and pathophysiological features of UC. | Ranji Hayashi Tomomitsu Tahara Tsukasa Yamaaki Takashi Saito Kazuhiro Matsunaga Nobuhiko Hayashi Atsushi Fukumura Kazuaki Ozaki Masakatsu Nakamura Hisakazu Shiroeda Mikihiro Tsutsumi Tomoyuki Shibata Tomiyasu Arisawa | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 2 | Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3′-UTR, influence susceptibility to gastric cancer显示文摘 | Tomiyasu Arisawa Tomomitsu Tahara Hisakazu Shiroeda Yasuhito Matsue Takahiro Minato Tomoe Nomura Hideto Yamada Ranji Hayashi Takashi Saito Kazuhiro Matsunaga Tomoki Fukuyama Nobuhiko Hayashi Toshimi Otsuka Atsushi Fukumura Masakatsu Nakamura Tomoyuki Shib | 2012 | Human Immunology2012，，7： | 1 |
| 3 | The usefulness of magnifying endoscopy with narrow-band imaging to distinguish carcinoma in flat elevated lesions in the stomach diagnosed as adenoma by using biopsy samples显示文摘 | Masakatsu Nakamura Tomoyuki Shibata Tomomitsu Tahara Daisuke Yoshioka Masaaki Okubo Yoshikazu Mizoguchi Makoto Kuroda Tomiyasu Arisawa Ichiro Hirata | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 4 | Homozygous 825T Allele of the GNB3 Protein Influences the Susceptibility of Japanese to Dyspepsia显示文摘 | Tomomitsu Tahara Tomiyasu Arisawa Tomoyuki Shibata Fangyu Wang Masakatsu Nakamura Mikijyu Sakata Ichiro Hirata Hiroshi Nakano | 2008 | Digestive Diseases and Sciences2008，，3： | 1 |
| 5 | Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects显示文摘 | Tomiyasu Arisawa Tomomitsu Tahara Hisakazu Shiroeda Takahiro Minato Yasuhiro Matsue Takashi Saito Tomoki Fukuyama Toshimi Otsuka Atsushi Fukumura Masakatsu Nakamura Tomoyuki Shibata | 2013 | Journal of Gastroenterology2013，，1： | 1 |
| 6 | Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis显示文摘 | Tomoyuki Shibata Tomomitsu Tahara Ichiro Hirata Tomiyasu Arisawa | 2009 | Human Immunology2009，，7： | 1 |
| 7 | Homozygous TRPV1 315C Influences the Susceptibility to Functional Dyspepsia显示文摘 | Tomomitsu Tahara Tomoyuki Shibata Masakatsu Nakamura Hiromi Yamashita Daisuke Yoshioka Ichiro Hirata Tomiyasu Arisawa | 2010 | Journal of Clinical Gastroenterology2010，，1： | 1 |
| 8 | Toll-like Receptor 2 (TLR) ?196 to 174del Polymorphism in Gastro-duodenal Diseases in Japanese Population显示文摘 | Tomomitsu Tahara Tomiyasu Arisawa Fangyu Wang Tomoyuki Shibata Masakatsu Nakamura Mikijyu Sakata Ichiro Hirata Hiroshi Nakano | 2008 | Digestive Diseases and Sciences2008，，4： | 1 |
| 9 | Association between functional promoter polymorphisms of macrophage migration inhibitory factor (MIF) gene and ulcerative colitis in Japan显示文摘 | Hisakazu Shiroeda Tomomitsu Tahara Masakatsu Nakamura Tomoyuki Shibata Tomoe Nomura Hideto Yamada Ranji Hayashi Takashi Saito Masayoshi Yamada Tomoki Fukuyama Toshimi Otsuka Hirokazu Yano Kazuaki Ozaki Mutsumi Tsuchishima Mikihiro Tsutsumi Tomiyasu Arisaw | 2010 | Cytokine2010，，2： | 1 |
| 10 | Homozygous 825T Allele of the GNB3 Protein Influences the Susceptibility of Japanese to Dyspepsia显示文摘 | Tomomitsu Tahara Tomiyasu Arisawa Tomoyuki Shibata Fangyu Wang Masakatsu Nakamura Mikijyu Sakata Ichiro Hirata Hiroshi Nakano | 2008 | Digestive Diseases and Sciences2008，，3： | 1 |
| 11 | A Polymorphism of microRNA 27a Genome Region Is Associated With the Development of Gastric Mucosal Atrophy in Japanese Male Subjects显示文摘 | Tomiyasu Arisawa Tomomitsu Tahara Tomoyuki Shibata Mitsuo Nagasaka Masakatsu Nakamura Yoshio Kamiya Hiroshi Fujita Shin Hasegawa Tamaki Takagi Fang-Yu Wang Ichiro Hirata Hiroshi Nakano | 2007 | Digestive Diseases and Sciences2007，，7： | 1 |
| 12 | Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan显示文摘AIM To investigate whether single nucleotide polymorphisms in maf protein K(MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. METHODS This case control study examined the associations between MAFK single nucleotide polymorphisms(rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis(UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia(controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings(IBM controls).RESULTS The genotype frequency of rs4268033 AA and allelic frequency of the rs4268033 A allele were significantly higher in the UC cases than in both controls(P = 0.0005 and < 0.0001, P = 0.015 and 0.0027 vs controls and IBM controls, respectively). Logistic regression analysis after adjustment for age and gender showed that the rs4268033 AA and rs3735656 CC genotypes were significantly associated with susceptibility to UC development(OR = 2.63, 95%CI: 1.61-4.30, P = 0.0001 and OR = 1.81; 95%CI: 1.12-2.94, P = 0.015, respectively). Similar findings were observed by the comparison with IBM controls. In addition, the rs4268033 AA genotype was significantly associated with all phenotypes of UC except early onset. There was no significant association between rs10226620 and ulcerative colitis. CONCLUSION Our results provide the first evidence that MAFK genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC. | Tomiyasu Arisawa Masakatsu Nakamura Toshimi Otsuka Wu Jing Naoko Sakurai Hikaru Takano Tasuku Hayashi Masafumi Ota Tomoe Nomura Ranji Hayashi Takeo Shimasaki Tomomitsu Tahara Tomoyuki Shibata | 2017 | World Journal of Gastroenterology2017，23，29： | 1 |
| 13 | CD14 Promoter-159 Polymorphism Is Associated with Reduced Risk of Intestinal-Type Gastric Cancer in a Japanese Population显示文摘 | Tomomitsu Tahara Tomoyuki Shibata Ichiro Hirata Hiroshi Nakano Tomiyasu Arisawa | 2009 | Digestive Diseases and Sciences2009，，： | 1 |
| 14 | Influence of Peroxisome Proliferator-activated Receptor (PPAR)γ Plo12Ala Polymorphism as a Shared Risk Marker for Both Gastric Cancer and Impaired Fasting Glucose (IFG) in Japanese显示文摘 | Tomomitsu Tahara Tomiyasu Arisawa Tomoyuki Shibata Masakatsu Nakamura Fangyu Wang Naoko Maruyama Yoshio Kamiya Masahiko Nakamura Hiroshi Fujita Mitsuo Nagasaka Masami Iwata Kazuya Takahama Makoto Watanabe Ichiro Hirata Hiroshi Nakano | 2008 | Digestive Diseases and Sciences2008，，3： | 1 |
| 15 | Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis显示文摘 | Tomoyuki Shibata Tomomitsu Tahara Ichiro Hirata Tomiyasu Arisawa | 2009 | Human Immunology2009，，7： | 1 |
| 16 | The Influence of Polymorphisms of Interleukin-17A and Interleukin-17F Genes on the Susceptibility to Ulcerative Colitis显示文摘 | Tomiyasu Arisawa Tomomitsu Tahara Tomoyuki Shibata Mitsuo Nagasaka Masakatsu Nakamura Yoshio Kamiya Hiroshi Fujita Masahiko Nakamura Daisuke Yoshioka Yuko Arima Masaaki Okubo Ichiro Hirata Hiroshi Nakano | 2008 | Journal of Clinical Immunology2008，，1： | 1 |
| 17 | Gastric mucosal pattern by using magnifying narrow-band imaging endoscopy clearly distinguishes histological and serological severity of chronic gastritis显示文摘 | Tomomitsu Tahara Tomoyuki Shibata Masakatsu Nakamura Daisuke Yoshioka Masaaki Okubo Tomiyasu Arisawa Ichiro Hirata | 2009 | Gastrointestinal Endoscopy2009，，2： | 1 |
| 18 | Association between IL-17A, -17F and MIF polymorphisms predispose toCpG island hyper-methylation in gastric cancer显示文摘 | Tomomitsu Tahara Tomoyuki Shibata Masakatsu Nakamura Hiromi Yamashita Daisuke Yoshioka Masaaki Okubo Joh Yonemura Yoshiteru Maeda Naoko Maruyama Toshiaki Kamano Yoshio Kamiya Hiroshi Fujita Yoshihito Nakagawa Mitsuo Nagasaka Masami Iwata Ichiro Hirata Tom | 2010 | International Journal of Molecular Medicine2010，，3： | 1 |
| 19 | Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors显示文摘 | Akemi Kamatani Yoshihito Nakagawa Yukihiro Akao Naoko Maruyama Mitsuo Nagasaka Tomoyuki Shibata Tomomitsu Tahara Ichiro Hirata | 2013 | Medical Molecular Morphology2013，，3： | 1 |
| 20 | Colorectal Carcinomas with CpG Island Methylator Phenotype 1 Frequently Contain Mutations in Chromatin Regulators显示文摘 | Tomomitsu Tahara Eiichiro Yamamoto Priyanka Madireddi Hiromu Suzuki Reo Maruyama Woonbok Chung Judith Garriga Jaroslav Jelinek Hiro-o Yamano Tamotsu Sugai Yutaka Kondo Minoru Toyota Jean-Pierre J. Issa Marcos R.H. Estécio | 2013 | Gastroenterology2013，，： | 1 |
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