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| 1 | Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells显示文摘There is currently a pressing need for alternative the-rapies to liver transplantation. The number of patients waiting for a liver transplant is substantially higher than the number of transplantable donor livers, resulting in a long waiting time and a high waiting list mortality. An extracorporeal liver support system is one possible approach to overcome this problem. However, the ideal cell source for developing bioartificial liver(BAL) support systems has yet to be determined. Recent advancements in stem cell technology allow researchers to generate highly functional hepatocyte-like cells from human pluripotent stem cells(h PSCs). In this mini-review, we summarize previous clinical trials with different BAL systems, and discuss advantages of and potential obstacles to utilizing h PSC-derived hepatic cells in clinical-scale BAL systems. | Ryoichi Sakiyama Brandon J Blau Toshio Miki | 2017 | World Journal of Gastroenterology2017，23，11： | 13 |
| 2 | Amnion-derived pluripotent/multipotent stem cells显示文摘 | Toshio Miki Stephen C. Strom | 2006 | Stem Cell Reviews2006，，2： | 3 |
| 3 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 2 |
| 4 | Association of Th1 and Th2 cytokines with transient inflammatory reaction during lenalidomide plus dexamethasone therapy in multiple myeloma显示文摘 | Takeshi Harada Shuji Ozaki Asuka Oda Shiro Fujii Shingen Nakamura Hirokazu Miki Kumiko Kagawa Kyoko Takeuchi Toshio Matsumoto Masahiro Abe | 2013 | International Journal of Hematology2013，，： | 1 |
| 5 | Biosynthesis of poly-γ-glutamic acid in plants: Transient expression of poly-γ-glutamate synthetase complex in tobacco leaves显示文摘 | Yutaka Tarui Hanako Iida Eiichiro Ono Wataru Miki Eiji Hirasawa Ken-ichi Fujita Toshio Tanaka Makoto Taniguchi | 2005 | Journal of Bioscience and Bioengineering2005，，4： | 1 |
| 6 | Mechanism of growth inhibitory effect of Blumea balsamifera extract in hepatocellular carcinoma显示文摘 | TOSHIO NORIKURA AKIKO KOJIMA-YUASA MIKI SHIMIZU | 2008 | Biosci Biotechnol Biochem2008，72，5： | 1 |
| 7 | Quantitative comparison of stem cell marker-positive cells in fetal and term human amnion显示文摘 | Masanori Izumi Benjamin J. Pazin Crescenzio F. Minervini J?rg Gerlach Mark A. Ross Donna B. Stolz Morris E. Turner Robert L. Thompson Toshio Miki | 2009 | Journal of Reproductive Immunology2009，，1： | 1 |
| 8 | Oxidation of thymines by peroxosulfate ions in water显示文摘 | Toshio Itahara Yukiko Fujii Miki Tada | 1988 | Journal of Organic Chemistry1988，，53： | 1 |
| 9 | Induction of lysophosphatidic acid receptor-3 by 12-O-tetradecanoylphorbol-13-acetate stimulates cell migration of rat liver cells显示文摘 | Kyoko Okabe Kohei Kato Miki Teranishi Mai Okumura Rie Fukui Toshio Mori Nobuyuki Fukushima Toshifumi Tsujiuchi | 2011 | Cancer Letters2011，，2： | 1 |
| 10 | New tumor necrosis factor-α-inducing protein released from Helicobacter pylori for gastric cancer progression显示文摘 | Masami Suganuma Miki Kurusu Kaori Suzuki Akira Nishizono Kazunori Murakami Toshio Fujioka Hirota Fujiki | 2005 | Journal of Cancer Research and Clinical Oncology2005，，5： | 1 |
| 11 | Oxidation of thymines by peroxosulfate ions in water 显示文摘 | Toshio I Yukiko F Miki T | 1988 | TOrg Chem1988，53，： | 1 |
| 12 | Polymorphism of the Apolipoprotein E and Angiotensin-Converting Enzyme Genes in Japanese Subjects With Silent Myocardial Ischemia显示文摘 | Yukiko Nakata Tomohiro Katsuya Hiromi Rakugi Seiju Takami Mitsuru Ohishi Kouzin Kamino Jitsuo Higaki Yoshikatsu Tabuchi Yuichi Kumahara Tetsuro Miki Toshio Ogihara | 1996 | Hypertension1996，，6： | 1 |
| 13 | New tumor necrosis factor-α-inducing protein released from Helicobacter pylori for gastric cancer progression显示文摘 | Masami Suganuma Miki Kurusu Kaori Suzuki Akira Nishizono Kazunori Murakami Toshio Fujioka Hirota Fujiki | 2005 | Journal of Cancer Research and Clinical Oncology2005，，5： | 1 |
| 14 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 1 |
| 15 | Amnion-derived pluripotent/multipotent stem cells显示文摘 | Toshio Miki Stephen C. Strom | 2006 | Stem Cell Reviews2006，，2： | 1 |
| 16 | Surgical Management of Adult Sigmoid Colon Intussusception Caused by a Malignant Tumor: Report of a Case显示文摘 | Keiji Matsuda Kazufumi Suda Kazuo Tamura Tomoaki Deguchi Eriko Yamazaki Hiroshi Yago Tsuyoshi Inaba Toshio Takeshima Miki Adachi Kota Okinaga | 2003 | Surgery Today2003，，10： | 1 |
| 17 | New tumor necrosis factor-α-inducing protein released from Helicobacter pylori for gastric cancer progression显示文摘 | Masami Suganuma Miki Kurusu Kaori Suzuki Akira Nishizono Kazunori Murakami Toshio Fujioka Hirota Fujiki | 2005 | Journal of Cancer Research and Clinical Oncology2005，，5： | 1 |
| 18 | Stem cell characteristics of amniotic epithelial cells显示文摘 | Toshio Miki Thomas Lehmann Hongbo Cai | 2005 | Stem Cells2005，23，10： | 1 |
| 19 | Cortical transcriptome analysis after spinal cord injury reveals the regenerative mechanism of central nervous system in CRMP2 knock-in mice显示文摘Recent studies have shown that mutation at Ser522 causes inhibition of collapsin response mediator protein 2(CRMP2) phosphorylation and induces axon elongation and partial recovery of the lost sensorimotor function after spinal cord injury(SCI).We aimed to reveal the intracellular mechanism in axotomized neurons in the CRMP2 knock-in(CRMP2KI) mouse model by performing transcriptome analysis in mouse sensorimotor cortex using micro-dissection punching system.Prior to that, we analyzed the structural pathophysiology in axotomized or neighboring neurons after SCI and found that somatic atrophy and dendritic spine reduction in sensorimotor cortex were suppressed in CRMP2KI mice.Further analysis of the transcriptome has aided in the identification of four hemoglobin genes Hba-a1, Hba-a2, Hbb-bs, and Hbb-bt that are significantly upregulated in wild-type mice with concomitant upregulation of genes involved in the oxidative phosphorylation and ribosomal pathways after SCI.However, we observed substantial upregulation in channel activity genes and downregulation of genes regulating vesicles, synaptic function, glial cell differentiation in CRMP2KI mice.Moreover, the transcriptome profile of CRMP2KI mice has been discussed wherein energy metabolism and neuronal pathways were found to be differentially regulated.Our results showed that CRMP2KI mice displayed improved SCI pathophysiology not only via microtubule stabilization in neurons, but also possibly via the whole metabolic system in the central nervous system, response changes in glial cells, and synapses.Taken together, we reveal new insights on SCI pathophysiology and the regenerative mechanism of central nervous system by the inhibition of CRMP2 phosphorylation at Ser522.All these experiments were performed in accordance with the guidelines of the Institutional Animal Care and Use Committee at Waseda University, Japan(2017-A027 approved on March 21, 2017;2018-A003 approved on March 25, 2018;2019-A026 approved on March 25, 2019). | Ayaka Sugeno Wenhui Piao Miki Yamazaki Kiyofumi Takahashi Koji Arikawa Hiroko Matsunaga Masahito Hosokawa Daisuke Tominaga Yoshio Goshima Haruko Takeyama Toshio Ohshima | 2021 | Neural Regeneration Research2021，16，7： | 0 |
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