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| 1 | Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese显示文摘AIM: To examine an association between the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene that plays a role in downregulation of T-cell activation and inflammatory bowel disease consisting of ulcerative colitis (UC) and Crohn's disease (CD) in the Japanese.METHODS: We studied 108 patients with UC, 79 patients with CD, and 200 sex-matched healthy controls, with respect to three single nucleotide polymorphisms (SNPs)in CTLA4, such as C-318T in the promoter region, A+49G in exon 1 and G+6230A in the 3' untranslated region (3'-UTR) by a PCR-restriction fragment length polymorphism method, and to an (AT)n repeat polymorphism in 3'-UTR by fragment analysis with fluorescence-labeling on denaturing sequence gels. Frequency of alleles and genotypes and their distribution were compared statistically between patients and controls and among subgroups of patients, using χ2 and Fisher exact tests.RESULTS: The frequency of 'A/A' genotype at the G+6230A SNP site was statistically lower in UC patients than in controls (3.7% vs 11.0%, P= 0.047, odds ratio (OR) = 0.311). Moreover, the frequency of'G/G' genotype at the A+49G SNP site was significantly higher in CD patients with fistula (48.6%) than those without it (26.2%)(P = 0.0388, OR=2.67).CONCLUSION: The results suggest that CTLA4 located at 2q33 is a determinant of UC and responsible for fistula formation in CD in the Japanese. | Haruhisa Machida Kazuhiro Tsukamoto Chun-Yang Wen Yukiko Narumi Saburou Shikuwa Hajime Isomoto Fuminao Takeshima Yohei Mizuta Norio Niikawa Ikuo Murata Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，27： | 4 |
| 2 | BRAF inhibitor:a novel therapy for ameloblastoma in mandible显示文摘Ameloblastoma is a benign but locally aggressive odontogenie neoplasm that accounts for 10% of all tumors arising in the mandible and maxilla (1).Eighty percent of ameloblastomas arise in the mandible,and they are usually found in young adults.It frequently recurs if not adequately resected.Therefore,the standard therapy for this tumor is complete bone resection with an adequate margin of safety: marginal or segmental osteotomy.However,aesthetic deformities,functional impairments and psychological impairments after radical surgery for large ameloblastoma, have been serious issues (1). | Masanobu Abe Liang Zong Takahiro Abe Hideyuki Takeshima Jiafu Ji Toshikazu Ushijima Kazuto Hoshi | 2018 | Chinese Journal of Cancer Research2018，30，6： | 3 |
| 3 | Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene显示文摘AIM: To investigate the frequency and distribution of N-acetyltransferase 2 (NAT2) and uridine 5′-diphosphate (UDP)-glucuronosyltransferase 1A7 (UGT1A7) genes in patients with ulcerative colitis (UC) and Crohn's disease (CD).METHODS: Frequencies and distributions of NAT2 and UGT1A7SNPs as well as their haplotypes were investigated in 95 patients with UC, 60 patients with CD, and 200gender-matched, unrelated, healthy, control volunteers by PCR-restriction fragment length polymorphism (RFLP),PCR-denaturing high-performance liquid chromatography (DHPLC), and direct DNA sequencing.RESULTS: Multiple logistic regression analysis revealed that the frequency of haplotype, NAT2*7B, significantly increased in CD patients, compared to that in controls (P= 0.0130, OR = 2.802, 95%CI = 1.243-6.316). However,there was no association between NAT2 haplotypes and UC, or between any UGT1A7haplotypes and inflammatory bowel disease (IBD).CONCLUSION: It is likely that the NAT2 gene is one of the determinants for CD in Japanese. Alternatively, a new CD determinant may exist in the 8p22 region, whereNAT2is located. | Haruhisa Machida Kazuhiro Tsukamoto Chun-Yang Wen Saburou Shikuwa Hajime Isomoto Yohei Mizuta Fuminao Takeshima Kunihiko Murase Naomichi Matsumoto Ikuo Murata Shigeru Kohno Chen-Yang Wen | 2005 | World Journal of Gastroenterology2005，11，31： | 3 |
| 4 | Ryanodine受体的功能结构和调节因子显示文摘Ryanodine受体(ryanodine receptor,Ry R)是位于细胞内内质网/肌浆网膜上的钙离子释放通道蛋白。Ry R是由四个足状结构的亚单位组成的同源四聚体,每个亚单位大于550 k Da,四聚体的总分子量超过2 MDa,是迄今发现的内质网/肌浆网膜上最大的离子通道。哺乳动物有三种类型的Ry R,其中Ry R1主要分布在骨骼肌中,Ry R2首先发现于心肌,Ry R3主要在脑中有较多分布。Ry R钙离子释放通道在肌肉收缩、突触传递、激素分泌、蛋白折叠和程控性凋亡以及坏死等一系列以细胞功能为基础的生理过程中起着极其重要的作用,因而近些年在医学生物学和药学应用上都有极大的进展。该文就Ry R在机体中的分布、功能结构和调节因子等进行了介绍,其蛋白调节因子二氢吡啶受体(dihydropyridine receptor,DHPR)、钙调蛋白(Calmodulin)、隐钙素(calsequestrin)、FKBP(FK506-binding protein)家族蛋白和小分子调节因子咖啡因、离子等都是Ry R复合体行使细胞生理功能必不可少的因素。 | 范娟 杨瑾 周鑫 董治龙 王李阳 MengMeng Xu 牟玉莲 Miyuki Nishi Williams Issacs 安书成 Hiroshi Takeshima Jianjie Ma 徐学红 | 2015 | 中国细胞生物学学报2015，37，1： | 2 |
| 5 | Clinical characteristics of hepatocellular carcinoma in elderly patients显示文摘 | Takuya Honda Hisamitsu Miyaaki Tatsuki Ichikawa Naota Taura Satoshi Miuma Hidetaka Shibata Hajime Isomoto Fuminao Takeshima Kazuhiko Nakao | 2011 | Oncology Letters2011，，5： | 2 |
| 6 | Novel serine/threonine kinase 11 gene mutations in PeutzJeghers syndrome patients and endoscopic management显示文摘AIM:To explore mutations in serine/threonine kinase 11(STK11) gene in Peutz-Jeghers syndrome(PJS) with gastrointestinal(GI) hamartomatous polyps.METHODS:Six Japanese PJS patients in 3 families were enrolled in this study.Each of the cases had hamartomatous polyposis in the gastrointestinal tract,including the small intestine,along with mucocutaneous hyperpigmentation.Narrow-band imaging(NBI)-magnification endoscopy was employed to detect microvascular and microsurface irregularities in the GI lesions.NBI magnification findings could be classified into three groups(type A,type B,or type C).Endoscopic polypectomy was performed using double-balloon enteroscopy or colonoscopy.Genomic DNA was extracted from a whole blood sample from each subject.All of the coding exons of STK11 gene,its boundary regions,and the promoter region containing the polymorphic regions were amplified by polymerase chain reaction,and direct sequencing was performed to assess the germline mutations.RESULTS:NBI-magnification endoscopic observation could detect the abnormalities in microvessels and microsurface structures of GI polyps.Overall,we found 5 cases of type A and one case without the examination for the gastric polyps,while there were 4 cases of type B and 2 case of type A for the colorectal polyps.Seventy-nine small-bowel and 115 colorectal polyps over 27 sessions for each were resected endoscopically without significant complications.The only delayed complication included the occurrence of bleeding in a case,and this was successfully managed with hemoclips.Resected polyps contained no malignant components.Based on mutation analysis,all 3 cases in Family I exhibited the +658C>T nonsense mutation in exon 5,which resulted in the production of a truncated protein(Q220X).In Family II,a case had-252C>A and-193C>A in the promoter region.In Family III,a case was found to have the +1062C>G(F342L) mutation in exon 8.CONCLUSION:We found two novel mutations of STK11 in association with PJS.Endoscopic polypectomy of GI polyps in PJS patients appears to be useful to prevent emergency laparotomies and reduce the cancer risk. | Hiroyuki Yajima Hajime Isomoto Hiroaki Nishioka Naoyuki Yamaguchi Ken Ohnita Tatsuki Ichikawa Fuminao Takeshima Saburo Shikuwa Masahiro Ito Kazuhiko Nakao Kazuhiro Tsukamoto Shigeru Kohno | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 7 | Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA显示文摘 | Takeshima H Suetake I Shimahara H | 2006 | J Biol Chem2006，139，3： | 1 |
| 8 | Isolation and Characterization of a Gene for a Ryanodine Receptor/Calcium Release Channel in Drosophila Melanogaster 显示文摘 | TAKESHIMA H NISHI M IWABE N | 1994 | FEBS Lett1994，337，1： | 1 |
| 9 | Effects of genome ar-chitecture and epigenetic factors on susceptibility of promoter CpGislands to aberrant DNA methylation induction 显示文摘 | Takeshima H Yamashita S Shimazu T | 2011 | Genomics2011，98，3： | 1 |
| 10 | A randomized study of primary bleomycin , vincristine, mitomycin and cisplatin ( BOMP )chemotherapy followed by radiotherapy versus radiotherapy alone in stage Ⅲ B and Ⅳ A squamous cell carcinoma of the cervix 显示文摘 | Takeshima N Nishida H | 2003 | Anticancer Res2003，23，3： | 1 |
| 11 | Treament failure in va- ginal cancer 显示文摘 | Tabata T Takeshima N Nishida H | 2002 | Gynecol Oncol2002，84，： | 1 |
| 12 | Mesencephalic type 1 astrocytes rescue dopaminergie neurons from death induced by serum deprivation显示文摘 | Takeshima T Johnston JM Commissiong JW | 1994 | J Neurosci1994，14，8： | 1 |
| 13 | CA125 regression during neoadjuvant chemotherapy as an independent prognostic factor for survival in patients with advanced ovarian serous adenocarcinoma显示文摘 | Tate S Hirai Y Takeshima N | 2005 | Gynecol Oncol2005，96，1： | 1 |
| 14 | A randomized study of primary bleomycin, vincristine, mitomycin and cisplatin (BOMP) chemotherapy followed by radiotherapy versus radiotherapy alone in stage Ⅲb and Ⅳa squamous cell carcinoma of the cervix 显示文摘 | Tabata T Takeshima N Nishida H | 2003 | Anticancer Res2003，23，3： | 1 |
| 15 | Mutation spectrumof the dystrophin gene in 442 Duchenne/Becker musculardystrophy cases from one Japanese referral center 显示文摘 | Takeshima Y Yagi M Okizuka Y | 2010 | JHum Genet2010，55，： | 1 |
| 16 | Evaluation of human epididymis protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA) as diagnostic tools of type I and type II epithelial ovariancancer in Japanese women 显示文摘 | Fujiwara H Suzuki M Takeshima N | 2015 | Tumour Biol2015，36，2： | 1 |
| 17 | A Unique fibrous tumor of the ovary:fibrosarcoma or mitotically active cellular fibrema显示文摘 | KaKu S Takeshima N Akiyama F | 2007 | An- ticancer Res2007，27，6： | 1 |
| 18 | Cardioprotective effect of apelin-13 on cardiac performance and remodeling in end-stage heart failure显示文摘 | KOGUCHI W KOBAYASHI N TAKESHIMA H | 2012 | Circ J2012，76，1： | 1 |
| 19 | Fabrication of high-efficiency diffraction gratings in glass显示文摘 | TAKESHIMA N NARITA Y TANAKA S | 2005 | Opt Lett2005，30，4： | 1 |
| 20 | Major patterns of higher teleostean phylogenies:a new perspective based on 100 complete mitochondrial DNA sequences显示文摘 | Miya M Takeshima H Endo H | 2003 | Mol Phyl Evol2003，26，1： | 1 |
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