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| 1 | 臂间血压差与脑卒中的关系显示文摘为了检测同时测量的双臂血压差值是否可识别踝臂血压指数〈0.90的受试者,及是否能预测未来心血管事件,Hirofumi等收集来自10个队列的日本受试者13 317人的数据(基于一般人群的队列,既往有心血管事件病史的队列及有心血管病危险因素的队列)进行荟萃分析。 | 刘青 叶鹏 Hirofumi T Toshiaki O Toshiharu N Chisa M Kazuomi K Satoshi H Yoshikuni K Toyoshi I Yasutaka M Katsuhiko K Yasuharu T Motoyuki N Takayoshi O Hirotaka W Masanori M Mitsuru O Norihisa I Michinari N Tetsuo S Charalambos V Akira Y | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 2 | Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy显示文摘IgG 的 Fc 区域的 Glycosylation 在安全和治疗学的抗体的临床的功效上有深刻影响。当复杂类型的 oligosaccharide 纳入了 Fc 的 Asn297 的 biantennary 为抗体受动器功能是必要的时,海藻糖和外部手臂的糖属于核心 heptasaccharide 产生结构的异质(glycoforms ) 展出唯一的生物活动。因此,有效、量的 glycan 分析技术为治疗学的抗体的发展和质量控制是日益重要的,并且 Fc 的 glycan 侧面作为批评优秀属性被认出。在过去的十年,我们 IgG-Fc 的结构 / 功能上的 glycosylation 的影响的理解通过 X 光检查结晶、原子的磁性的回声研究很快成长了,它为新奇抗体治疗学的设计提供可能性。而且,用基于 endoglycosidase 的 glycosynthases 的 chemoenzymatic glycoengineering 途径可以作为下一代的治疗学的抗体与理想的功能便于同类的 IgG glycoforms 的发展。因此, Fc glycans 是在精确药的时代的治疗学的 IgG 抗体的安全,功能,和功效的改进的肥沃的地面。 | Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd | 2018 | Protein & Cell2018，9，1： | 2 |
| 3 | Isolation and characterization offibrinogenase from Candida albicans NH-1 显示文摘 | TOSHIAKI N YOSHIYUKI O YOUICHI H | 1993 | Int J Biochem1993，25，12： | 1 |
| 4 | A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density显示文摘 | Nobutaka O Toshiaki N Ichirou N | 2001 | J Hum Genet2001，46，： | 1 |
| 5 | SIRS- associated coagulopa-thy and organ dysfunction in critically ill patient with thrombocytopenia显示文摘 | Hiroshi O Satoshi G Toshiaki 1 | 2007 | Shock2007，28，4： | 1 |
| 6 | Improvement of fatigue properties of fillet lap joints by applying-local heat treatment with TIG arc显示文摘 | Tsuyoshi S Toshiaki U | 1999 | 溶接学会论文集1999，17，2： | 1 |
| 7 | Maintenance of large surface area of alumina heated at elevated temperatures above 1300 ℃ by preparing silica-containing pseudoboehmite aerogel显示文摘 | Tatsuro H Toshihiko O Toyohiko S Kenzi S Toshiaki M | | 0，，： | 1 |
| 8 | Optimal application timing of simeconazole granules for control of rice kernel smut and false smut显示文摘 | Mikio T Masashi S Toshiaki O | 2006 | Journal of General Plant Pathology2006，72，： | 1 |
| 9 | Analysis of the shape of the tibial tray in total knee arthroplasty using a three-dimension finite element model 显示文摘 | Shinya M S Toshiaki T H Masahiro O H | 2002 | Clinical Biomechanics2002，17，7： | 1 |
| 10 | Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soft microatganisms显示文摘 | TOMOYASU H TOSHIAKI S SATOSHI O | 2010 | Proceedings of the Japan Academy2010，86，2： | 1 |
| 11 | Monoclonal antibodies recognising serum immunoglobulins and surface immunoglobulin-positive cells of puffer fish,torafugu (Takifugu rubripes)显示文摘 | Toshiaki M Maki O Daisuke T | | 0，，03： | 1 |
| 12 | Anti-allergic effects of enzymatically modified isoquercitrin (a-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, a-oligoglucosyl rutin, and quereetin, when administered orally to mice 显示文摘 | Toshiaki M Misaki K Shuji O | 2013 | JNat Med2013，67，4： | 1 |
| 13 | Activation of mitochondrial ATP-dependent potassium channels by nitric oxide显示文摘 | Norihito S Toshiaki S Andreas O Brian O Eduardo M Sasaaki N | 2000 | Circulation2000，101，： | 1 |
| 14 | Electrochemical properties of ceria-based oxides for use in intermediate-temperature SOFCs显示文摘 | Toshiaki M Minoru I Atsushi M Iempachi O | 2005 | Solid State Ionics2005，176，： | 1 |
| 15 | 查看详情显示文摘 | Hiroko O Sukeo Y Tetsuo K Shigeyoshi H Toshiaki M Soo Ryan K Takeyuki M Kenzo K Toshiro T | | 0，，5： | 1 |
| 16 | Tests for serum levels of Trefoil factor family proteins can improve gastric cancer screening 显示文摘 | Susumu A Yasukazu O Toshiaki G | 2011 | Gastroenterology2011，141，3： | 1 |
| 17 | Nitrogen-containing sugars II on the acetal derivatives of D-glucosamine 显示文摘 | Shichiro A Toshiaki O | 1956 | Yakugaku Zasshi1956，76，11： | 1 |
| 18 | Surface layers formed initially on copper in air containing water vapor and SO2 as determined by IR-RAS and 2D-IR 显示文摘 | JUN I TAKESH S TOSHIAKI O | 1999 | J Electroanal Chem1999，473，： | 1 |
| 19 | The Effects of Rockfall Volume on Runout Distance 显示文摘 | YOICHI O HIKARU K TOSHIAKI S | 2000 | Engineering Geology2000，58，2： | 1 |
| 20 | Reduction of molten steel temperature drop with improvent of ladle lining 显示文摘 | TOSHIAKI O KATSUTOSHI S MASAHARU H | 2001 | Shinagawa Technical Report2001，44，： | 1 |
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