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| 1 | Nitrate Transport, Sensing, and Responses in Plants显示文摘氮(N) 是影响植物生长和开发的必要 macronutrient。N 是叶绿素,氨基酸, nucleic 酸,和第二等的代谢物的一个重要部件。硝酸盐是在土壤的最丰富的 N 来源之一。因为硝酸盐和其它 N 营养素经常正在限制,植物开发了复杂机制在可变环境保证营养素的足够的供应。硝酸盐全神贯注于根并且由硝酸盐 transporters 动员了到另外的机关。硝酸盐察觉到激活局部地并且在整个植物水平在分子、新陈代谢、生理、发展的回答之上侵犯的发信号的小径。与 genomics 技术和基因工具的来临,在我们硝酸盐和另外的 N 滋养的回答的理解的重要进展在过去的十年被完成了。而且,从单个种利用在分叉的个人在场的自然多型性的技术在揭开是必要的新部件。然而,仍然在我们硝酸盐发信号怎么在植物影响生物过程的理解有差距。而且,我们仍然缺乏识别的所有规章的因素怎么交往的一个综合看法或串音安排植物典型地展出的无数 N 回答。在这评论,我们提供由哪个硝酸盐全部被察觉到并且搬运植物的机制的更新的概述。我们讨论发信号的部件并且怎么在植物局部地并且全球性为发展回答与神经质的小径察觉到串音的硝酸盐。理解硝酸盐怎么在植物影响植物新陈代谢,生理学,和生长和开发对为持续农业改进庄稼关键。 | Jose A. O'Brien Andrea Vega Eleonore Bouguyon Gabriel Krouk Alain Gojon Gloria Coruzzi Rodrigo A. Gutierrez | 2016 | Molecular Plant2016，9，6： | 32 |
| 2 | Helicobacter pylori and oral pathology:Relationship with the gastric infection显示文摘Helicobacter pylori(H.pylori)has been found in the oral cavity and stomach,and its infection is one of the most frequent worldwide.We reviewed the literature and conducted a Topic Highlight,which identified studies reporting an association between H.pylori-infection in the oral cavity and H.pylori-positive stomach bacterium.This work was designed to determine whether H.pylori is the etiologic agent in periodontal disease,recurrent aphthous stomatitis(RAS),squamous cell carcinoma,burning and halitosis.Record selection focused on the highest quality studies and meta-analyses.We selected 48 articles reporting on the association between saliva and plaque and H.pylori-infection.In order to assess periodontal disease data,we included 12 clinical trials and 1 meta-analysis.We evaluated 13 published articles that addressed the potential association with RAS,and 6 with squamous cell carcinoma.Fourteen publications focused on our questions on burning and halitosis.There is a close relation between H.pylori infection in the oral cavity and the stomach.The mouth is the first extra-gastric reservoir.Regarding the role of H.pylori in the etiology of squamous cell carcinoma,no evidence is still available. | Isabel Adler Andrea Muio Silvia Aguas Laura Harada Mariana Diaz Adriana Lence Mario Labbrozzi Juan Manuel Muio Boris Elsner Alejandra Avagnina Valeria Denninghoff | 2014 | World Journal of Gastroenterology2014，20，29： | 21 |
| 3 | Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells显示文摘Enzymes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and-4(PFKFB-3 and PFKFB-4)play a significant role in the regulation of glycolysis in cancer cells as well as its proliferation and survival.The expression of these mRNAs is increased in malignant tumors and strongly induced in different cancer cell lines by hypoxia inducible factor(HIF)through active HIF binding sites in promoter region of PFKFB-4 and PFKFB-3 genes.Moreover,the expression and hypoxia responsibility of PFKFB-4 and PFKFB-3 was also shown for pancreatic(Panc1,PSN-1,and MIA PaCa-2)as well as gastric(MKN45 and NUGC3)cancer cells.At the same time,their basal expression level and hypoxia responsiveness vary in the different cells studied:the highest level of PFKFB-4 protein expression was found in NUGC3 gastric cancer cell line and lowest in Panc1 cells,with a stronger response to hypoxia in the pancreatic cancer cell line.Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is correlated with enhanced expression of vascular endothelial growth factor(VEGF)and Glut1 mRNA as well as with increased level of HIF-1αprotein.Increased expression of different PFKFB genes was also demonstrated in gastric,lung,breast,and colon cancers as compared to corresponding nonmalignant tissue counterparts from the same patients,being more robust in the breast and lung tumors.Moreover,induction of PFKFB-4 mRNA expression in the breast and lung cancers is stronger than PFKFB-3mRNA.The levels of both PFKFB-4 and PFKFB-3 proteins in non-malignant gastric and colon tissues were more pronounced than in the non-malignant breast and lung tissues.It is interesting to note that Panc1and PSN-1 cells transfected with dominant/negative PFKFB-3(dnPFKFB-3)showed a lower level of endogenous PFKFB-3,PFKFB-4,and VEGF mRNA expressions as well as a decreased proliferation rate of these cells.Moreover,a similar effect had dnPFKFB-4.In conclusion,there is strong evidence that PFKFB-4 and PFKFB-3 isoenzymes are induced under hypoxia in pancreatic and other cancer cell lines,are overexpressed in gastric,colon,lung,and breast malignant tumors and undergo changes in their metabolism that contribute to the proliferation and survival of cancer cells.Thus,targeting these PFKFB may therefore present new therapeutic opportunities. | Oleksandr H Minchenko Katsuya Tsuchihara Dmytro O Minchenko Andreas Bikfalvi Hiroyasu Esumi | 2014 | World Journal of Gastroenterology2014，20，38： | 17 |
| 4 | A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma显示文摘 | Gregory L. Beatty Drew A. Torigian E. Gabriela Chiorean Babak Saboury Alex Brothers Abass Alavi Andrea B. Troxel Weijing Sun Ursina R. Teitelbaum Robert H. Vonderheide Peter J. O’Dwyer | 2013 | Clinical Cancer Research2013，，22： | 6 |
| 5 | Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)显示文摘 | René Adam Vincent Karam Valérie Delvart John O’Grady Darius Mirza Jurgen Klempnauer Denis Castaing Peter Neuhaus Neville Jamieson Mauro Salizzoni Stephen Pollard Jan Lerut Andreas Paul Juan Carlos Garcia-Valdecasas Fernando San Juan Rodríguez Andrew Burro | 2012 | Journal of Hepatology2012，，3： | 6 |
| 6 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial显示文摘 | Gunnar Folprecht Thomas Gruenberger Wolf O Bechstein Hans-Rudolf Raab Florian Lordick J?rg T Hartmann Hauke Lang Andrea Frilling Jan Stoehlmacher Jürgen Weitz Ralf Konopke Christian Stroszczynski Torsten Liersch Detlev Ockert Thomas Herrmann Eray Goekkurt | 2010 | Lancet Oncology2010，，1： | 3 |
| 7 | Photonic implementation of boson sampling:a review显示文摘Boson sampling is a computational problem that has recently been proposed as a candidate to obtain an unequivocal quantum computational advantage.The problem consists in sampling from the output distribution of indistinguishable bosons in a linear interferometer.There is strong evidence that such an experiment is hard to classically simulate,but it is naturally solved by dedicated photonic quantum hardware,comprising single photons,linear evolution,and photodetection.This prospect has stimulated much effort resulting in the experimental implementation of progressively larger devices.We review recent advances in photonic boson sampling,describing both the technological improvements achieved and the future challenges.We also discuss recent proposals and implementations of variants of the original problem,theoretical issues occurring when imperfections are considered,and advances in the development of suitable techniques for validation of boson sampling experiments.We conclude by discussing the future application of photonic boson sampling devices beyond the original theoretical scope. | Daniel J.Brod Ernesto F.Galvão Andrea Crespi Roberto Osellame NicolòSpagnolo Fabio Sciarrino | 2019 | Advanced Photonics2019，1，3： | 3 |
| 8 | Developing a donation after cardiac death risk index for adult and pediatric liver transplantation显示文摘AIM To identify objective predictive factors for donor after cardiac death(DCD) graft loss and using those factors, develop a donor recipient stratification risk predictive model that could be used to calculate a DCD risk index(DCD-RI) to help in prospective decision making on organ use.METHODS The model included objective data from a single institute DCD database(2005-2013, n = 261). Univariate survival analysis was followed by adjusted Cox-regressional hazard model. Covariates selected via univariate regression were added to the model via forward selection, significance level P = 0.3. The warm ischemic threshold was clinically set at 30 min. Points were given to each predictor in proportion to their hazard ratio. Using this model, the DCD-RI was calculated. The cohort was stratified to predict graft loss risk and respective graft survival calculated.RESULTS DCD graft survival predictors were primary indication for transplant(P = 0.066), retransplantation(P = 0.176), MELD > 25(P = 0.05), cold ischemia > 10 h(P = 0.292) and donor hepatectomy time > 60 min(P = 0.028).According to the calculated DCD-RI score three risk classes could be defined of low(DCD-RI < 1), standard(DCD-RI 2-4) and high risk(DCD-RI > 5) with a 5 years graft survival of 86%, 78% and 34%, respectively.CONCLUSION The DCD-RI score independently predicted graft loss(P < 0.001) and the DCD-RI class predicted graft survival(P < 0.001). | Shirin Elizabeth Khorsandi Emmanouil Giorgakis Hector Vilca-Melendez John O'Grady Michael Heneghan Varuna Aluvihare Abid Suddle Kosh Agarwal Krishna Menon Andreas Prachalias Parthi Srinivasan Mohamed Rela Wayel Jassem Nigel Heaton | 2017 | World Journal of Transplantation2017，7，3： | 3 |
| 9 | C-Terminal Provasopressin (Copeptin) as a Novel and Prognostic Marker in Acute Myocardial Infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study显示文摘 | Sohail Q. Khan Onkar S. Dhillon Russell J. O’Brien Joachim Struck Paulene A. Quinn Nils G. Morgenthaler Iain B. Squire Joan E. Davies Andreas Bergmann Leong L. Ng | 2007 | Circulation2007，，16： | 2 |
| 10 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 11 | Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients显示文摘 | Giuseppe Cardillo Francesco Facciolo Andrea O Cavazzana Girolamo Capece Roberto Gasparri Massimo Martelli | 2000 | The Annals of Thoracic Surgery2000，，6： | 2 |
| 12 | Emission of trace gases and aerosols from biomass burning 显示文摘 | Andreae M O Merlet P | 2001 | Global Biogeochemical Cycles2001，15，4： | 1 |
| 13 | Dimethyl Sulfide in the Surface Ocean and the Marine Atmosphere:A Global View显示文摘 | Andreae M O Hans Raemdonck | 1983 | Science1983，221，： | 1 |
| 14 | Oceanic phyto- plankton, atmospheric suifur, cloud albedo and climate 显示文摘 | Charlson R J Lovelock J E Andreae M O | 1987 | Na- ture1987，326，： | 1 |
| 15 | Oceanic phytoplankton, atmospheric sulphur, cloud albedo and climate 显示文摘 | Charlson R J Lovelock J E Andreae M O | 1987 | Nature1987，326，6114： | 1 |
| 16 | Distribution and speciation of arsenic in natural waters and some marine algae显示文摘 | Andreae M O | 2005 | Deep Sea Res2005，25，： | 1 |
| 17 | Nitrous oxide cycling in the Arabian Sea显示文摘 | Bange H W Rapsomanikis S Andreae M O | 2001 | Journal of Geophysical Research2001，106，1： | 1 |
| 18 | Blomass burning aerosol emissions from vegetation fires:Particle number and mass emission factors and size distnibutions显示文摘 | Janh 11 S Andreae M O P schl U | | 0，，03： | 1 |
| 19 | Contact endoscopy during microlaryngeal surgery: a new technique for endoscopic examination of the lar-ynx显示文摘 | Andrea M Dias O Santos A | 1995 | Ann Otol Rhinol Laryngol1995，104，5： | 1 |
| 20 | Stent-based antirestenotic coatings显示文摘 | Martin O Christian H Andreas B et al | 2002 | Cath and Cadiovas Interv2002，55，： | 1 |
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