|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C显示文摘AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse(ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage(β = 0.1865, P < 0.0001) and hyaluronic acid levels(β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated significantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index(BMI)(β =-0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels(β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage(β = 0.2921, P = 0.0044) and hyaluronic acid levels(β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage. | Toru Nishikawa Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Mizuno Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Naohiro Ichino Keisuke Osakabe Kentaro Yoshioka | 2014 | World Journal of Gastroenterology2014，20，5： | 7 |
| 2 | A new index for non-invasive assessment of liver fibrosis显示文摘AIM:To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver f ibrosis. METHODS:A new f ibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS,platelet count and prothrombin time. The values of the Fibro-Stiffness index differed signif icantly between neighboring f ibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F≥2 (0.90), F≥ 3 (0.90) and F= 4(0.92) in the estimation group and those for F≥ 3 (0.93) and F =4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F≥2, F≥3 and F=4 in both the estimation and validation groups. The diagnostic performance for F= 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2,3 and 4. | Naohiro Ichino Keisuke Osakabe Toru Nishikawa Hiroko Sugiyama Miho Kato Shiho Kitahara Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Arima Hiroaki Shimazaki Koji Suzuki Kentaro Yoshioka | 2010 | World Journal of Gastroenterology2010，16，38： | 7 |
| 3 | Indocyanine green fluorescence and three-dimensional imaging of right gastroepiploic artery in gastric tube cancer显示文摘A 79-year-old male was admitted to our hospital for the treatment of cancer of the gastric tube.Gastrointestinal examination revealed a T1 b Union for International Cancer Control(UICC) tumor at the pyloric region of the gastric tube.Laparotomy did not reveal infiltration intothe serosa,peritoneal dissemination,regional lymph node swelling,or distant metastasis.We performed a distal gastrectomy preserving the right gastroepiploic artery by referencing the preoperative three-dimensional computed tomoangiography.We also evaluated the blood flow of the right gastroepiploic artery and in the proximal gastric tube by using indocyanine green fluorescence imaging intra-operatively and then followed with a gastrojejunal anastomosis with Roux-en-Y reconstruction.The definitive diagnosis was moderately differentiated adenocarcinoma of the gastric tube,pT 1bN 0M0,pS tage IA(UICC).His postoperative course was uneventful.Three-dimensional computed tomographic imaging is effective for assessing the course of blood vessels and the relationship with the surrounding structures.Intraoperative evaluation of blood flow of the right gastroepiploic artery and of the gastric tube in the anastomotic portion is very valuable information and could contribute to a safe gastrointestinal reconstruction. | Toru Nakano Tadashi Sakurai Shota Maruyama Yohei Ozawa Takashi Kamei Go Miyata Noriaki Ohuchi | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 4 | Combined thoracoscopic and endoscopic surgery for a large esophageal schwannoma显示文摘A 47-year-old woman presented to our hospital with complaints of dysphagia. Esophagogastroduodenoscopy identified a submucosal tumor in the left wall of the esophagus that was diagnosed as a benign schwannoma on biopsy. Computed tomography revealed a tumor of length 60 mm in the thoracic esophagus, with its cranial edge at the level of the aortic arch. On endoscopy, a submucosal tunnel was created 40 mm proximal to the cranial edge of the tumor, and its oral end was dissected from the mucosal and muscular layers. This was followed by the resection of the entire tumor by left-sided thoracoscopy. The esophageal defect was closed in layer by continuous suture from the thoracic side. Endoscopic closure was achieved by using clips. No postoperative complications were observed. Oral diet was resumed from postoperative day 7 and the patient was discharged on postoperative day 9. This combined approach has not been described for similar tumors. Our experience demonstrated that large esophageal tumors can be safely excised with minimally invasive surgery by using a combination of thoracoscopy and endoscopy. | Yu Onodera Toru Nakano Daisuke Takeyama Shota Maruyama Yusuke Taniyama Tadashi Sakurai Takahiro Heishi Chiaki Sato Takuro Kumagai Takashi Kamei | 2017 | World Journal of Gastroenterology2017，23，46： | 2 |
| 5 | Production of intergeneric hybrid plants between Sandersonia aurantiaca and Gloriosa rothschildiana via ovule culture (Colchicaceae)显示文摘 | Toru Nakamura Sachiko Kuwayama Shigefumi Tanaka Tomo Oomiya Hiroyuki Saito Masaru Nakano | 2005 | Euphytica2005，，3： | 1 |
| 6 | Use of water jet instruments in gastrointestinal endoscopy显示文摘In recent years, water jet instruments have been used in the field of gastrointestinal endoscopy, mainly in two clinical situations: Investigation and treatment under endoscopic view. Injecting water jet into the gastrointestinal lumen is helpful for maintaining a clear endoscopic view, washing away blood or mucous in the lumen or on the surface of the tip of the endoscope. This contributes to reducing time and discomfort of examination. Water jet technology is an alternative method for dissecting soft tissue; this method does not harm the small vessels or cause mechanical or thermal damage. However, its use in clinical settings has been limited to the transmucosal injection of water into the submucosal layer that elevates the mucosa to prepare for endoscopic mucosal resection or endoscopic submucosal dissection, instead of tissue dissection, which may occur because of the continuous water jet. A preclinical study has been conducted using a pulsed water jet system as an alternative method for submucosal dissection by reducing intraoperative water consumption and maintenance of dissection capability. This review introduces recent studies pertaining to using a water jet in gastrointestinal endoscopy and discusses future prospects. | Toru Nakano Chiaki Sato Tadashi Sakurai Takashi Kamei Atsuhiro Nakagawa Noriaki Ohuchi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 1 |
| 7 | A CMOS Rotary Encoder Using Magnetic Sensor Arrays 显示文摘 | KAZUHIRO NAKANO TORU TAKAHASHI SHOJI KAWAHITO | 2006 | IEEE2006，5，5： | 1 |
| 8 | Bacteriological Evaluation of the Cardiac Surgery Environment Accompanying Hospital Relocation显示文摘 | Toru Ishida Kiyoharu Nakano Hayao Nakatani Akihiko Gomi | 2006 | Surgery Today2006，，6： | 1 |
| 9 | CREB-binding proteins (CBP) as a transcriptional coactivator of GATA-2显示文摘The GATA family consists of six members, GATA 1-6. In this study, we focused on GATA-2, which is expressed predominantly in hematopoietic progenitor cells and plays the key role in keeping these cells in the undifferentiated status. CREB-binding proteins (CBP) are essential transcriptional coacti- vators for a large number of regulated DNA-binding transcription factors, including GATA-1. But there have been no reports on whether CBP is still a co-activator of GATA-2. Here, we used the immunopre- cipitation and pull-down experiments to show that the GATA-2 and CBP were physically binding to- gether, and clarified the binding sites CH1, CH3 , CH452 and CT1430 in CBP and N-finger, C-finger and N-C-finger in GATA-2. Luciferase assay results in our experiment indicated that CBP could increase GATA-2 transcriptional activity in the dose-dependent manner. GATA-1 is mainly expressed in differen- tiated hematopoietic cells, but still has overlap expression with GATA-2. CBP is a coactivator of GATA-2 and GATA-1. The investigation on the mechanism that could decide whether CBP binds to GATA-2 to keep hematopoietic cells in the progenitor status or to GATA-1 to start differentiation will be a very in- teresting and very meaningful project in the near future. | TOMOMI Takahashi TORU Nakano | 2008 | Science China(Life Sciences)2008，51，3： | 1 |
| 10 | Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson’s disease显示文摘 | Kazuhiro Nakaso Yuko Yoshimoto Toshiya Nakano Takao Takeshima Yoko Fukuhara Kenichi Yasui Shigeru Araga Toru Yanagawa Tetsuro Ishii Kenji Nakashima | 2004 | Brain Research2004，，1： | 1 |
| 11 | Hemorrhagic gastric and duodenal ulcers after the Great East Japan Earthquake Disaster显示文摘AIM:To elucidate the characteristics of hemorrhagic gastric/duodenal ulcers in a post-earthquake period within one medical district.METHODS:Hemorrhagic gastric/duodenal ulcers in the Iwate Prefectural Kamaishi Hospital during the 6-mo period after the Great East Japan Earthquake Disaster were reviewed retrospectively.The subjects were 27patients who visited our hospital with a chief complaint of hematemesis or hemorrhagic stool and were diagnosed as having hemorrhagic gastric/duodenal ulcers by upper gastrointestinal endoscopy during a 6-mo period starting on March 11,2011.This period was divided into two phases:the acute stress phase,comprising the first month after the earthquake disaster,and the chronic stress phase,from the second through the sixth month.The following items were analyzed according to these phases:age,sex,sites and number of ulcers,peptic ulcer history,status of Helicobacter pylori(H.pylori)infection,intake of non-steroidal anti-inflammatory drugs,and degree of impact of the earthquake disaster.RESULTS:In the acute stress phase from 10 d to 1mo after the disaster,the number of patients increased rapidly,with a nearly equal male-to-female ratio,and the rate of multiple ulcers was significantly higher than in the previous year(88.9%vs 25%,P<0.005).In the chronic stress phase starting 1 mo after the earthquake disaster,the number of patients decreased to a level similar to that of the previous year.There were more male patients during this period,and many patients tended to have a solitary ulcer.All patients with duodenal ulcers found in the acute stress phase were negative for serum H.pylori antibodies,and this was significantly different from the previous year’s positive rate of 75%(P<0.05).CONCLUSION:Severe stress caused by an earthquake disaster may have affected the characteristics of hemorrhagic gastric/duodenal ulcers. | Kenichi Yamanaka Hiroyuki Miyatani Yukio Yoshida Shinichi Asabe Toru Yoshida Misaki Nakano Shin Obara Hidehiko Endo | 2013 | World Journal of Gastroenterology2013，19，42： | 1 |
| 12 | Characterization of a high-affinity and specific binding site for Gas 6显示文摘 | Toru Nakano Junji Kisshino Hitoshi Arita | 1996 | FEBS1996，387，1： | 1 |
| 13 | Three-dimensional imaging of a thoracic duct cyst before thoracoscopic surgery显示文摘 | Toru Nakano Hiroshi Okamoto Shota Maruyama Noriaki Ohuchi | 2014 | European Journal of Cardio-Thoracic Surgery2014，，3： | 1 |
| 14 | Bacteriological Evaluation of the Cardiac Surgery Environment Accompanying Hospital Relocation显示文摘 | Toru Ishida Kiyoharu Nakano Hayao Nakatani Akihiko Gomi | 2006 | Surgery Today2006，，6： | 1 |
| 15 | Induction of DNA Methylation by Artificial piRNA Production in Male Germ Cells显示文摘 | Daisuke Itou Yusuke Shiromoto Yukiho Shin-ya Chika Ishii Toru Nishimura Narumi Ogonuki Atsuo Ogura Hidetoshi Hasuwa Yoshitaka Fujihara Satomi Kuramochi-Miyagawa Toru Nakano | 2015 | Current Biology2015，，7： | 1 |
| 16 | Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat显示文摘 | Chizuka Ide Yoshiyasu Nakai Norihiko Nakano Tae-Beom Seo Yoshihiro Yamada Katsuaki Endo Toru Noda Fukuki Saito Yoshihisa Suzuki Masanori Fukushima Toshio Nakatani | 2010 | Brain Research2010，，： | 1 |
| 17 | Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C显示文摘AIM: To evaluate the changes of shear-wave velocity(Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C.METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon(IFN) plus ribavirin(RBV). Vs value(m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment(EOT), 1 year after EOT, and 2 years after EOT.RESULTS: In patients with a sustained virological response(SVR)(n = 41), Vs significantly decreased at EOT [1.19(1.07-1.37), P = 0.0004], 1 year after EOT [1.10(1.00-1.22), P = 0.0001], and 2 years after EOT [1.05(0.95-1.16), P < 0.0001] compared with baseline [1.27(1.11-1.49)]. In patients with a relapse(n = 26), Vs did not significantly decrease at EOT [1.23(1.12-1.55)], 1 year after EOT [1.20(1.12-1.80)], and 2 years after EOT [1.41(1.08-2.01)] compared with baseline [1.39(1.15-1.57)]. In patients with a nonvirological response(n = 20), Vs did not significantly decrease at EOT [1.64(1.43-2.06)], 1 year after EOT [1.66(1.30-1.95)], and 2 years after EOT [1.61(1.36-2.37)] compared with baseline [1.80(1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28(1.04-1.40)] than in non-SVR patients [1.56(1.20-1.83)](P = 0.0142).CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse. | Keisuke Osakabe Naohiro Ichino Toru Nishikawa Hiroko Sugiyama Miho Kato Ai Shibata Wakana Asada Naoto Kawabe Senju Hashimoto Michihito Murao Takuji Nakano Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Takamitsu Kurashita Tomoki Takamura Kentaro Yoshioka | 2015 | World Journal of Gastroenterology2015，21，35： | 0 |
| 18 | Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors显示文摘Background:Antiangiogenic tyrosine kinase inhibitors(TKIs)provide one of the few therapeutic options for effective treatment of hepatocellular carcinoma(HCC).However,patients with HCC often develop resistance toward antiangiogenic TKIs,and the underlying mechanisms are not understood.The aim of this study was to determine the mechanisms underlying antiangiogenic TKI resistance in HCC.Methods:We used an unbiased proteomic approach to define proteins that were responsible for the resistance to antiangiogenic TKIs in HCC patients.We evaluated the prognosis,therapeutic response,and serum insulin-like growth factor-binding protein-1(IGFBP-1)levels of 31 lenvatinib-treated HCC patients.Based on the array of results,a retrospective clinical study and preclinical experiments using mouse and human hepatoma cells were conducted.Additionally,in vivo genetic and pharmacological gain-and loss-of-function experiments were performed.Results:In the patient cohort,IGFBP-1 was identified as the signaling molecule with the highest expression that was inversely associated with overall survival.Mechanistically,antiangiogenic TKI treatment markedly elevated tumor IGFBP-1 levels via the hypoxia-hypoxia inducible factor signaling.IGFBP-1 stimulated angiogenesis through activation of the integrinα5β1-focal adhesion kinase pathway.Consequently,loss of IGFBP-1 and integrinα5β1 by genetic and pharmacological approaches re-sensitized HCC to lenvatinib treatment.Conclusions:Together,our data shed light onmechanisms underlying acquired resistance of HCC to antiangiogenic TKIs.Antiangiogenic TKIs induced an increase of tumor IGFBP-1,which promoted angiogenesis through activating the IGFBP-1-integrinα5β1 pathway.These data bolster the application of a new therapeutic concept by combining antiangiogenic TKIs with IGFBP-1 inhibitors. | Hiroyuki Suzuki Hideki Iwamoto Takahiro Seki Toru Nakamura Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Yasuko Imamura Takashi Niizeki Masahito Nakano Shigeo Shimose Tomotake Shirono Yu Noda Naoki Kamachi Miwa Sakai Kazutoyo Morita Masamichi Nakayama Tomoharu Yoshizumi Ryoko Kuromatsu Hirohisa Yano Yihai Cao Hironori Koga Takuji Torimura | 2023 | Cancer Communications2023，43，4： | 0 |
| 19 | biquitin meets PIWI protein显示文摘 | Ippei Nagamori Toru Nakano | 2013 | Asian Journal of Andrology2013，15，3： | 0 |
| 20 | CBP蛋白是转录因子GATA-2的辅激活因子显示文摘转录因子GATA家族含有6个成员,分别为GATA 1-6,本实验主要针对GATA-2与CREB结合蛋白(CBP)的关系进行了研究,GATA-2主要在造血祖细胞中表达,对维持这类细胞的非分化状态有重要作用,CBP是多种可调控的与DNA结合的转录因子的辅激活因子,其中包括转录因子GATA-1,目前尚未有报道表明CBP蛋白也是GATA-2的辅激活因子,本研究利用免疫沉淀技术和洗脱技术证明了小鼠的GATA-2能够与CBP结合,而且发生结合的位点分别位于CBP蛋白的CHI,CH3和CT4523个区域,以及GATA-2蛋白的N-finger,N-C-finger和C-finger3个区域,荧光素酶活性测定结果表明,CBP能够以剂量依赖的方式提高GATA-2转录激活的活性,有研究表明,虽然GATA-1主要在已分化的造血细胞中表达,但与GATA-2的表达在时间上仍有重叠,那么是何种机制决定着CBP蛋白与GATA-2选择性结合时维持造血细胞的非分化状态,而与GATA-1结合时诱导造血细胞的分化是一个值得探讨的问题,本文对此进行了讨论, | 姜惠杰 刘林德 杨树德 Tomomi Takahashi Toru Nakano | 2008 | 中国科学(C辑)2008，38，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员