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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Effectiveness of the flipped classroom on the development of self-directed learning in nursing education:a meta-analysis显示文摘Objectives: To examine the best practice evidence of the effectiveness of the flipped classroom(FC) as a burgeoning teaching model on the development of self-directed learning in nursing education.Data sources: The relevant randomized controlled trial(RCT) and non-RCT comparative studies were searched from multiple electronic databases including PubMed, Embase, Web of Science, Cumulative Index to Nursing and Allied Health Literature(CINAHL), Cochrane Central Register of Controlled Trials(CENTRAL), Wanfang Data, China National Knowledge Infrastructure(CNKI), and Chinese Science and Technology Periodical Database(VIP) from inception to June 2017.Review methods: The data were independently assessed and extracted for eligibility by two reviewers. The quality of included studies was assessed by another two reviewers using a standardized form and evaluated by using the Cochrane Collaboration's risk of bias tool. The self-directed learning scores(continuous outcomes) were analyzed by using the 95% confidence intervals(Cls) with the standard deviation average(SMD) or weighted mean difference(WMD). The heterogeneity was assessed using Cochran's I^2 statistic.Results: A total of 12 studies, which encompassed 1440 nursing students(intervention group = 685, control group = 755), were eligible for inclusion in this review. Of 12 included studies, the quality level of one included study was A and of the others was B. The pooled effect size showed that compared with traditional teaching models, the FC could improve nursing students' selfdirected learning skill, as measured by the Self-Directed Learning Readiness Scale(SDLRS), Self-Directed Learning Readiness Scale for Nursing Education(SDLRSNE), Self-Regulated Learning Scale(SRL), Autonomous Learning Competencies scale(ALC), and Competencies of Autonomous Learning of Nursing Students(CALNS). Overall scores and subgroup analyses with the SRL were all in favor of the FC.Conclusions: The result of this meta-analysis indicated that FCs could improve the effect of self-directed learning in nursing education.Future studies with more RCTs using the same measurement tools are needed to draw more authoritative conclusions. | Ya-Qian Liu Yu-Feng Li Meng-Jie Lei Peng-Xi Liu Julie Theobald Li-Na Meng Ting-Ting Liu Chun-Mei Zhang Chang-De Jin | 2018 | Frontiers of Nursing2018，5，4： | 3 |
| 3 | Stereospecificity of phenylalanine plasma kinetics and hydroxylation in nmn following oral application of a stable isotope-labelled pseudo-racemic mixture of L-and D-phenylalanine 显示文摘 | Lehmmm WD Theobald N Fischer R | 1993 | Clin Chim Acta1993，128，2： | 1 |
| 4 | Indirect comparison oflixisenatide versus neutral protamine Hagedom insulin as add-on tometformin and sulphonylurea in patients with type 2 diabetes mellitus显示文摘 | Fournier M Germe M Theobald K | 2014 | GerMed Sci2014，12，： | 1 |
| 5 | High pR implosions for fast-ignition fuel assembly显示文摘 | Zhou C D Theobald W Betti R | 2007 | Phys Rev Lett2007，98，02： | 1 |
| 6 | Compari son of ASE and SPE with Soxhlet, sonication, and methanolic saponification extractions for the determination of organic micropollutants in marine particulate matter显示文摘 | Heemken O P Theobald N Wenclawiak B W | 1997 | Anal Chem1997，69，11： | 1 |
| 7 | The fimctional anatomy of Kager's fat pad in relation to retrocalcaneal problems and other hindfoot disorders显示文摘 | Theobald P Bydder G Dent C | 2006 | J Anat2006，208，1： | 1 |
| 8 | Alternation of wet and dry sides during partial rootzone drying irrigation alters root-to-shoot signalling of abscisic acid显示文摘 | Dodd I C Theobald J C Bacon M A | 2006 | Functional Plant Biology2006，33，12： | 1 |
| 9 | Temporal Variability of Organic Micropollutants in Suspended Particulate Matter of the River Elbe at Hamburg and the River Mulde at Dessau, Germany显示文摘 | O. P. Heemken B. Stachel N. Theobald B. W. Wenclawiak | 2000 | Archives of Environmental Contamination and Toxicology2000，，1： | 1 |
| 10 | EML: A modeling environment for exploring landscape dynamic显示文摘 | Theobald D Gross M | 1994 | Computers Environment and Urban Systems1994，18，3： | 1 |
| 11 | Nucleus accumbens D2/3receptors predict traitimpulsivity and cocaine reinforcement显示文摘 | Dalley JW Fryer TD Brichard L Robinson ES Theobald DE Lne K | 2007 | Science2007，315，5816： | 1 |
| 12 | Frequency shifts in cesium beam clocks induced by microwave leakages显示文摘 | Bertrand Boussert Genevieve Theobald Pierre Cerez | 1998 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control1998，45，3： | 1 |
| 13 | Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia显示文摘 | Lowenberg B van Putten W Theobald M | 2003 | N Engl J Med2003，349，8： | 1 |
| 14 | Alternation of wet and dry sides during partial rootzone drying irri- gation alters root-to-shoot signalling of abscisic acid显示文摘 | Dodd I C Theobald J C Bacon M A | 2006 | Functional Plant Biology2006，33，12： | 1 |
| 15 | Tissue-specific remodeling of the mitochondri- al proteome in type 1 diabetic akita mice显示文摘 | BUGGER H CHEN D RIEHLE C SOTO J THEOBALD HA HU XX | 2009 | Diabetes2009，58，9： | 1 |
| 16 | Landscape dynamics of Amazonian deforestation between 1984 and 2002 in central Rondonia, Brazil: assessment and future scenarios显示文摘 | Ferraz S F B Vettorazzi C A Theobald D M | 2005 | Forest Ecology and Management2005，204，： | 1 |
| 17 | Low- dose docosahexaenoic acid lowers diastolic bloodpressure in middle-aged men and women显示文摘 | Theobald HE Goodall AH Sattar N | 2007 | J Nutr2007，137，4： | 1 |
| 18 | Operation of a single-photon-counting X-ray charge-coupled device camera spectrometer in a petawatt environment显示文摘 | Stoeckl C Theobald W Sangster T C | 2004 | Review of Scientific Instruments2004，75，10： | 1 |
| 19 | Anti-inflammatory dose doxycycline (40 mg controlled-release) confers maximum antiinflammatory efficacy in rosacea显示文摘 | Theobald K Bradshaw M Leyden J | 2007 | Skinmed2007，6，5： | 1 |
| 20 | Optical calibration for both out-of-plane and inplane displacement sensitivity of acoustic emission sensors显示文摘 | Theobald P D | 2009 | Ultrasonics2009，49，8： | 1 |
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