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| 1 | A novel animal model for in vivo study of liver cancer metastasis显示文摘AIM:To establish an animal model with human hepatocyte-repopulated liver for the study of liver cancer metastasis.METHODS:Cell transplantation into mouse livers was conducted using alpha-fetoprotein(AFP)-producing hu-man gastric cancer cells(h-GCCs) and h-hepatocytes as donor cells in a transgenic mouse line expressing urokinase-type plasminogen activator(uPA) driven by the albumin enhancer/promoter crossed with a severe combined immunodeficient(SCID) mouse line(uPA/SCID mice).Host mice were divided into two groups(A and B).Group A mice were transplanted with h-GCCs alone,and group B mice were transplanted with h-GCCs and h-hepatocytes together.The replacement index(RI),which is the ratio of transplanted h-GCCs and h-hepatocytes that occupy the examined area of a histological section,was estimated by measuring h-AFP and h-albumin concentrations in sera,respectively,as well as by immunohistochemical analyses of h-AFP and human cytokeratin 18 in histological sections.RESULTS:The h-GCCs successfully engrafted,repopulated,and colonized the livers of mice in group A(RI = 22.0% ± 2.6%).These mice had moderately differentiated adenocarcinomatous lesions with disrupted glandular structures,which is a characteristics feature of gastric cancers.The serum h-AFP level reached 211.0 ± 142.2 g/mL(range,7.1-324.2 g/mL).In group B mice,the h-GCCs and h-hepatocytes independently engrafted,repopulated the host liver,and developed colonies(RI = 12.0% ± 6.8% and 66.0% ± 12.3%,respectively).h-GCC colonies also showed typical adenocarcinomatous glandular structures around the h-hepatocyte-colonies.These mice survived for the full 56 day-study and did not exhibit any metastasis of h-GCCs in the extrahepatic regions during the observational period.The mice with an h-hepatocyte-repopulated liver possessed metastasized h-GCCs and therefore could be a useful humanized liver animal model for studying liver cancer metastasis in vivo.CONCLUSION:A novel animal model of human liver cancer metastasis was established using the uPA/SCID mouse line.This model could be useful for in vivo testing of anti-cancer drugs and for studying the mechanisms of human liver cancer metastasis. | Shinsuke Fujiwara Hikaru Fujioka Chise Tateno Ken Taniguchi Masahiro Ito Hiroshi Ohishi Rie Utoh Hiromi Ishibashi Takashi Kanematsu Katsutoshi Yoshizato | 2012 | World Journal of Gastroenterology2012，18，29： | 6 |
| 2 | Immunological milieu in the peritoneal cavity at laparotomy for gastric cancer显示文摘AIM:To investigate the immunological repertoire in the peritoneal cavity of gastric cancer patients.METHODS:The peritoneal cavity is a compartment in which immunological host-tumor interactions can occur.However,the role of lymphocytes in the peritoneal cavity of gastric cancer patients is unclear.We observed 64 patients who underwent gastrectomy for gastric cancer and 11 patients who underwent laparoscopic cholecystectomy for gallstones and acted as controls.Lymphocytes isolated from both peripheral blood and peritoneal lavage were analyzed for surface markers of lymphocytes and their cytokine production by flow cytometry.CD4+CD25high T cells isolated from the patient's peripheral blood were co-cultivated for 4 d with the intra-peritoneal lymphocytes,and a cytokine assay was performed.RESULTS:At gastrectomy,CCR7 -CD45RA-CD8+ef-fector memory T cells were observed in the peritoneal cavity.The frequency of CD4+CD25 high T cells in both the peripheral blood and peritoneal cavity was elevated in patients at advanced stage[control vs stage Ⅳin the peripheral blood:6.89(3.39-10.4)vs 15.34(11.37-19.31),P<0.05,control vs stageⅣin the peritoneal cavity:8.65(5.28-12.0)vs 19.56(14.81-24.32),P<0.05].On the other hand,the suppression was restored with CD4+CD25high T cells from their own peripheral blood.This study is the first to analyze lymphocyte and cytokine production in the peritoneal cavity in patients with gastric cancer.Immune regulation at advanced stage is reversible at the point of gastrectomy.CONCLUSION:The immunological milieu in the peritoneal cavity of patients with advanced gastric cancer elicited a Th2 response even at gastrectomy,but this response was reversible. | Akira Yoneda Shinichiro Ito Seiya Susumu Mitsutoshi Matsuo Ken Taniguchi Yoshitsugu Tajima Susumu Eguchi Takashi Kanematsu Yasuhiro Nagata | 2012 | World Journal of Gastroenterology2012，18，13： | 5 |
| 3 | Networking retinomorphic sensor with memristive crossbar for brain-inspired visual perception显示文摘Compared to human vision,conventional machine vision composed of an image sensor and processor suffers from high latency and large power consumption due to physically separated image sensing and processing.A neuromorphic vision system with brain-inspired visual perception provides a promising solution to the problem.Here we propose and demonstrate a prototype neuromorphic vision system by networking a retinomorphic sensor with a memristive crossbar.We fabricate the retinomorphic sensor by using WSe_(2)/h-BN/Al_(2)O_(3)van der Waals heterostructures with gate-tunable photoresponses,to closely mimic the human retinal capabilities in simultaneously sensing and processing images.We then network the sensor with a large-scale Pt/Ta/Hf O_(2)/Ta one-transistor-one-resistor(1 T1 R)memristive crossbar,which plays a similar role to the visual cortex in the human brain.The realized neuromorphic vision system allows for fast letter recognition and object tracking,indicating the capabilities of image sensing,processing and recognition in the full analog regime.Our work suggests that such a neuromorphic vision system may open up unprecedented opportunities in future visual perception applications. | Shuang Wang Chen-Yu Wang Pengfei Wang Cong Wang Zhu-An Li Chen Pan Yitong Dai Anyuan Gao Chuan Liu Jian Liu Huafeng Yang Xiaowei Liu Bin Cheng Kunji Chen Zhenlin Wang Kenji Watanabe Takashi Taniguchi Shi-Jun Liang Feng Miao | 2021 | National Science Review2021，8，2： | 5 |
| 4 | Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood flow after living-donor liver transplantation in adult recipients with liver cirrhosis显示文摘AIM: To investigate the correlation between systemic hemodynamics and splanchnic circulation in recipients with cirrhosis undergoing living-donor liver transplantation (LDLT), and to clarify how systemic hemodynamics impact on local graft circulation after LDLT. METHODS: Systemic hemodynamics, indocyanine green (ICG) elimination rate (KICG) and splanchnic circulation were simultaneously and non-invasively investigated by pulse dye densitometry (PDD) and ultrasound. Accurate estimators of optimal systemic hyperdynamics after LDLT [i.e., balance of cardiac output (CO) to blood volume (BV) and mean transit time (MTT), defined as the timerequired for half the administered ICG to pass through an attached PDD sensor in the first circulation] were also measured. Thirty recipients with cirrhosis were divided into two groups based on clinical outcomes corresponding to postoperative graft function. RESULTS: Cirrhotic systemic hyperdynamics characterized by high CO, expanded BV and low total peripheral resistance (TPR) were observed before LDLT. TPR reflecting cirrhotic vascular alterations was slowly restored after LDLT in both groups. Although no significant temporal differences in TPR were detected between the two groups, CO/BV and MTT differed significantly. Recipients with good outcomes showed persistent cirrhotic systemic hyperdynamics after LDLT, whereas recipients with poor outcomes presented with unstable cirrhotic systemic hyperdynamics and severely decreased KICG. Systemic hyperdynamic disorders after LDLT impacted on portal venous flow but not hepatic arterial flow. CONCLUSION: We conclude that subtle systemic hyperdynamics disorders impact on splanchnic circulation, and that an imbalance between CO and BV decreases portal venous flow, which results in critical outcomes. | Tomohide Hori Shintaro Yagi Taku Iida Kentaro Taniguchi Kentaro Yamagiwa Chiduru Yamamoto Takashi Hasegawa Koichiro Yamakado Takuma Kato Kanako Saito Linan Wang Mie Torii Yukinobu Hori Kan Takeda Kazuo Maruyama Shinji Uemoto | 2007 | World Journal of Gastroenterology2007，13，44： | 5 |
| 5 | Xyloglucan for Generating Tensile Stress to Bend Tree Stem显示文摘响应环境变化,被子植物树由形成紧张木头把他们的茎弄弯,它由充满纤维素的 G 组成(凝胶状) 在纤维房间的墙中的层并且在第二等的木部产生反常张力的应力。我们生产了转基因的白杨植物 overexpressing 在房间墙中减少每特定的多糖,,的几 endoglycanases 第二等的木部由主要、第二等的墙层组成。当水平地放了时,转基因的白杨 overexpressing xyloglucanase 的茎的基础区域不能独自在木部的紧张方面由于低紧张向上弯曲。在野类型的植物, xyloglucan 在多重 layering 期间在 G 层的内部表面被发现。在 situ xyloglucan endotransglucosylase ( XET ),活动证明整个 xyloglucan 的加入,潜在地因为墙紧缩,在内部表面层 S1 和 S2 开始了并且在整个G层开发被保留,当为墙松开的 xyloglucan heptasaccharide ( XXXG )的加入发生在膨胀地区的主要的墙中时。我们建议 xyloglucan 网络被 XET 增强形成在墙界限之间的一个进一步的连接并且分泌了 xyloglucans 以便承受在纤维素 G 层 microfibrils 以内创造的张力的压力。 | Kei'ichi Baba Yong Woo Park Tomomi Kaku Rumi Kaida Miyuki Takeuchi Masato Yoshida Yoshihiro Hosoo Yasuhisa Ojio Takashi Okuyama Toru Taniguchi Yasunori Ohmiya Teiji Kondo Ziv Shani Oded Shoseyov Tatsuya Awano Satoshi Serada Naoko Norioka Shigemi Norioka Takahisa Hayashi | 2009 | Molecular Plant2009，2，5： | 4 |
| 6 | Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation显示文摘Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT. | Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa Shoko Mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 7 | Ultra-long-working-distance spectroscopy of single nanostructures with aspherical solid immersion microlenses显示文摘In light science and applications,equally important roles are played by efficient light emitters/detectors and by the optical elements responsible for light extraction and delivery.The latter should be simple,cost effective,broadband,versatile and compatible with other components of widely desired micro-optical systems.Ideally,they should also operate without high-numerical-aperture optics.Here,we demonstrate that all these requirements can be met with elliptical microlenses 3D printed on top of light emitters.Importantly,the microlenses we propose readily form the collected light into an ultra-low divergence beam(half-angle divergence below 1°)perfectly suited for ultra-longworking-distance optical measurements(600mm with a 1-inch collection lens),which are not accessible to date with other spectroscopic techniques.Our microlenses can be fabricated on a wide variety of samples,including semiconductor quantum dots and fragile van der Waals heterostructures made of novel two-dimensional materials,such as monolayer and few-layer transition metal dichalcogenides. | Aleksander Bogucki Lukasz Zinkiewicz Magdalena Grzeszczyk Wojciech Pacuski Karol Nogajewski Tomasz Kazimierczuk Aleksander Rodek Jan Suffczynski Kenji Watanabe Takashi Taniguchi Piotr Wasylczyk Marek Potemski Piotr Kossacki | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 8 | Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma显示文摘 | Etsuro Bando Yutaka Yonemura Keizo Taniguchi Toshiaki Yasui Sachio Fushida Takashi Fujimura Gen-ichi Nishimura Koichi Miwa | 1999 | The American Journal of Surgery1999，，3： | 2 |
| 9 | Assessment of cardiac output in liver transplantation recipients显示文摘BACKGROUND:Liver cirrhosis causes peculiar systemic hemodynamics,and accurate evaluation of systemic hemodynamic state is important for cirrhotic recipients who underwent living donor liver transplantation(LDLT). We investigated the clinical advantages of a novel non- invasive method for measuring systemic hemodynamic parameters using indocyanine green(ICG). METHODS:Twenty-eight LDLT recipients were evaluated. Simultaneous measurements of cardiac output(CO)using Swan-Ganz catheters and pulse dye densitometry(PDD) were performed every 12 hours after LDLT.A total of 155 sets of simultaneous CO measurements were obtained. RESULTS:The CO values obtained by PDD correlated well with those obtained by the invasive catheter technique.In addition,none of the recipients developed any side-effects, and we verified the safety of repeated ICG injections.ICG is safe,even for repeated use over time in the same recipient. Moreover,PDD can measure the blood volume(BV).CONCLUSIONS:Since the cirrhotic systemic hemody- namics characterized by high CO and large BV remains, even after LDLT,the ability to measure CO and BV in a non-invasive,simple and real-time manner using PDD has advantages for cirrhotic LDLT recipients. | Tomohide Hori Chiduru Yamamoto Shintaro Yagi Taku Iida Kentaro Taniguchi Takashi Hasegawa Koichiro Yamakado Yukinobu Hori Kan Takeda Kazuo Maruyama Shinji Uemoto | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 10 | Multi-institutional study of risk factors of liver metastasis from colorectal cancer: correlation with CD10 expression显示文摘 | Shin Fujita Hirokazu Taniguchi Takashi Yao Tadakazu Shimoda Hideki Ueno Takashi Hirai Masayuki Ohue | 2010 | International Journal of Colorectal Disease2010，，6： | 1 |
| 11 | Three novel NY-ESO-1 epitopes bound to DRB1*0803, DQB1*0401 and DRB1*0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients显示文摘 | Yu Mizote Taku Taniguchi Kei Tanaka Midori Isobe Hisashi Wada Takashi Saika Shoichi Kita Yukari Koide Akiko Uenaka Eiichi Nakayama | 2010 | Vaccine2010，，32： | 1 |
| 12 | Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma显示文摘 | Etsuro Bando Yutaka Yonemura Keizo Taniguchi Toshiaki Yasui Sachio Fushida Takashi Fujimura Gen-ichi Nishimura Koichi Miwa | 1999 | The American Journal of Surgery1999，，3： | 1 |
| 13 | Production of glucosyl-xylose using Cellvibrio gilvus cells and its properties显示文摘 | Motomitsu Kitaoka Hajime Taniguchi Takashi Sasaki | 1990 | Applied Microbiology and Biotechnology1990，，2： | 1 |
| 14 | Electrically Tunable Energy Bandgap in Dual-Gated Ultra-Thin Black Phosphorus Field Effect Transistors显示文摘The energy bandgap is an intrinsic character of semiconductors, which largely determines their properties. The ability to continuously and reversibly tune the bandgap of a single device during real time operation is of great importance not only to device physics but also to technological applications. Here we demonstrate a widely tunable bandgap of few-layer black phosphorus(BP) by the application of vertical electric field in dual-gated BP field-effect transistors. A total bandgap reduction of 124 meV is observed when the electrical displacement field is increased from 0.10 V/nm to 0.83 V/nm. Our results suggest appealing potential for few-layer BP as a tunable bandgap material in infrared optoelectronics, thermoelectric power generation and thermal imaging. | 颜世莉 谢志坚 陈剑豪 Takashi Taniguchi Kenji Watanabe | 2017 | Chinese Physics Letters2017，34，4： | 1 |
| 15 | Potentiation of antitumor effect of NKT cell ligand, α-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells1显示文摘 | Minoru Nakui Akio Ohta Masashi Sekimoto Marimo Sato Kenji Iwakabe Takashi Yahata Hidemitsu Kitamura Toshiaki Koda Tetsu Kawano Hiroyasu Makuuchi Masaru Taniguchi Takashi Nishimura | 2000 | Clinical and Experimental Metastasis2000，，2： | 1 |
| 16 | A monolithically sculpted van der Waals nano-opto-electro-mechanical coupler显示文摘The nano-opto-electro-mechanical systems(NOEMS)are a class of hybrid solid devices that hold promises in both classical and quantum manipulations of the interplay between one or more degrees of freedom in optical,electrical and mechanical modes.To date,studies of NOEMS using van der Waals(vdW)heterostructures are very limited,although vdW materials are known for emerging phenomena such as spin,valley,and topological physics.Here,we devise a universal method to easily and robustly fabricate vdW heterostructures into an architecture that hosts opto-electro-mechanical couplings in one single device.We demonstrated several functionalities,including nano-mechanical resonator,vacuum channel diodes,and ultrafast thermo-radiator,using monolithically sculpted graphene NOEMS as a platform.Optical readout of electric and magnetic field tuning of mechanical resonance in a CrOCl/graphene vdW NOEMS is further demonstrated.Our results suggest that the introduction of the vdW heterostructure into the NOEMS family will be of particular potential for the development of novel lab-on-a-chip systems. | Tongyao Zhang Hanwen Wang Xiuxin Xia Ning Yan Xuanzhe Sha Jinqiang Huang Kenji Watanabe Takashi Taniguchi Mengjian Zhu Lei Wang Jiantou Gao Xilong Liang Chengbing Qin Liantuan Xiao Dongming Sun Jing Zhang Zheng Han Xiaoxi Li | 2022 | Light(Science & Applications)2022，11，3： | 1 |
| 17 | Chronic Probucol Treatment Decreases the Slow Component of the Delayed-Rectifier Potassium Current in CHO Cells Transfected With KCNQ1 and KCNE1: A Novel Mechanism of QT Prolongation显示文摘 | Tomohiko Taniguchi Mai Uesugi Toru Arai Takashi Yoshinaga Norimasa Miyamoto Kohei Sawada | 2012 | Journal of Cardiovascular Pharmacology2012，，4： | 1 |
| 18 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Differentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells显示文摘Hormone replacement therapy is necessary for patients with adrenal and gonadal failure.Steroid hormone treatment is also employed in aging people for sex hormone deficiency.These patients undergo such therapies,which have associated risks,for their entire life.Stem cells represent an innovative tool for tissue regeneration and the possibility of solving these problems.Among various stem cell types,mesenchymal stem cells have the potential to differentiate into steroidogenic cells both in vivo and in vitro.In particular,they can effectively be differentiated into steroidogenic cells by expressing nuclear receptor 5A subfamily proteins(steroidogenic factor-1 and liver receptor homolog-1)with the aid of cAMP.This approach will provide a source of cells for future regenerative medicine for the treatment of diseases caused by steroidogenesis deficiencies.It can also represent a useful tool for studying the molecular mechanisms of steroidogenesis and its related diseases. | Takashi Yazawa Yoshitaka Imamichi Kaoru Miyamoto Akihiro Umezawa Takanobu Taniguchi | 2014 | World Journal of Stem Cells2014，6，2： | 1 |
| 19 | 显示文摘 | Masataka Sugimoto Hirokazu Hida Takashi Taniguchi | 2007 | Rheol Acta2007，46，7： | 1 |
| 20 | Outcome of ratio of lymph node metastasis in gastric carcinoma显示文摘 | Etsuro Bando MD Yutaka Yonemura MD Keizo Taniguchi MD Sachio Fushida MD Takashi Fujimura MD Koichi Miwa MD | 2002 | Annals of Surgical Oncology2002，，8： | 1 |
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