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| 1 | Uptake pathway and continuous removal of nitric oxide from flue gas using microalgae显示文摘 | Hiroyasu Nagase Ken-ichi Yoshihara Kaoru Eguchi Yasunobu Okamoto Sachi Murasaki Risako Yamashita Kazumasa Hirata Kazuhisa Miyamoto | 2001 | Biochemical Engineering Journal2001，，3： | 1 |
| 2 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Differentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells显示文摘Hormone replacement therapy is necessary for patients with adrenal and gonadal failure.Steroid hormone treatment is also employed in aging people for sex hormone deficiency.These patients undergo such therapies,which have associated risks,for their entire life.Stem cells represent an innovative tool for tissue regeneration and the possibility of solving these problems.Among various stem cell types,mesenchymal stem cells have the potential to differentiate into steroidogenic cells both in vivo and in vitro.In particular,they can effectively be differentiated into steroidogenic cells by expressing nuclear receptor 5A subfamily proteins(steroidogenic factor-1 and liver receptor homolog-1)with the aid of cAMP.This approach will provide a source of cells for future regenerative medicine for the treatment of diseases caused by steroidogenesis deficiencies.It can also represent a useful tool for studying the molecular mechanisms of steroidogenesis and its related diseases. | Takashi Yazawa Yoshitaka Imamichi Kaoru Miyamoto Akihiro Umezawa Takanobu Taniguchi | 2014 | World Journal of Stem Cells2014，6，2： | 1 |
| 3 | Amplification and detection of a single molecule of human immunodeficiency virus RNA显示文摘 | Satoru Nakamura Dr. Shigeru Katamine Taro Yamamoto Steven K. H. Foung Takeshi Kurata Yoshihiro Hirabayashi Kaoru Shimada Shigeo Hino Tsutomu Miyamoto | 1993 | Virus Genes1993，，4： | 1 |
| 4 | Radiologic Variations in Gastrorenal Shunts and Collateral Veins from Gastric Varices in Images Obtained Before Balloon-Occluded Retrograde Transvenous Obliteration显示文摘 | Hiroaki Maeda Shozo Hirota Satoshi Yamamoto Kaoru Kobayashi Keisuke Arai Yoshiya Miyamoto Tetsuya Fukuda Koji Sugimoto Norio Nakao | 2007 | CardioVascular and Interventional Radiology2007，，3： | 1 |
| 5 | Transcriptional regulation of human ferredoxin reductase through an intronic enhancer in steroidogenic cells显示文摘 | Yoshitaka Imamichi Tetsuya Mizutani Yunfeng Ju Takehiro Matsumura Shinya Kawabe Masafumi Kanno Takashi Yazawa Kaoru Miyamoto | | BBA - Gene Regulatory Mechanisms0，，1： | 1 |
| 6 | Transcriptional regulation of human ferredoxin 1 in ovarian granulosa cells显示文摘 | Yoshitaka Imamichi Tetsuya Mizutani Yunfeng Ju Takehiro Matsumura Shinya Kawabe Masafumi Kanno Takashi Yazawa Kaoru Miyamoto | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
| 7 | Transcriptional regulation of human ferredoxin 1 in ovarian granulosa cells显示文摘 | Yoshitaka Imamichi Tetsuya Mizutani Yunfeng Ju Takehiro Matsumura Shinya Kawabe Masafumi Kanno Takashi Yazawa Kaoru Miyamoto | 2013 | Molecular and Cellular Endocrinology . 2013 (1-2)2013，，1： | 1 |
| 8 | Androgen/androgen receptor pathway regulates expression of the genes for cyclooxygenase-2 and amphiregulin in periovulatory granulosa cells显示文摘 | Takashi Yazawa Shinya Kawabe Masafumi Kanno Tetsuya Mizutani Yoshitaka Imamichi Yunfeng Ju Takehiro Matsumura Yukiko Yamazaki Yoko Usami Mayu Kuribayashi Masayuki Shimada Takeshi Kitano Akihiro Umezawa Kaoru Miyamoto | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
| 9 | Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis显示文摘 | Takehiro Matsumura Yoshitaka Imamichi Tetsuya Mizutani Yunfeng Ju Takashi Yazawa Shinya Kawabe Masafumi Kanno Tadayuki Ayabe Noriyuki Katsumata Maki Fukami Masaru Inatani Yoshio Akagi Akihiro Umezawa Tsutomu Ogata Kaoru Miyamoto | 2013 | The FASEB Journal2013，，8： | 1 |
| 10 | Proximal Promoter of the Cytochrome P450 Oxidoreductase Gene: Identification of Microdeletions Involving the Untranslated Exon 1 and Critical Function of the SP1 Binding Sites显示文摘 | Shun Soneda Takashi Yazawa Maki Fukami Masanori Adachi Michiyo Mizota Kenji Fujieda Kaoru Miyamoto Tsutomu Ogata | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，11： | 1 |
| 11 | Stem cell differentiation into steroidogenic cell lineages by NR5A family显示文摘 | Kaoru Miyamoto Takashi Yazawa Tetsuya Mizutani Yoshitaka Imamichi Shin-ya Kawabe Masafumi Kanno Takahiro Matsumura Yunfeng Ju Akihiko Umezawa | 2010 | Molecular and Cellular Endocrinology2010，，1： | 1 |
| 12 | Differentiation of mesenchymal stem cells and embryonic stem cells into steroidogenic cells using steroidogenic factor-1 and liver receptor homolog-1显示文摘 | Takashi Yazawa Shinya Kawabe Yoshihiko Inaoka Reiko Okada Tetsuya Mizutani Yoshitaka Imamichi Yunfeng Ju Yukiko Yamazaki Yoko Usami Mayu Kuribayashi Akihiro Umezawa Kaoru Miyamoto | 2010 | Molecular and Cellular Endocrinology2010，，1： | 1 |
| 13 | PI-3 kinase pathway can mediate the effect of TGF-β1 in inducing the expression of SHARP-2 in LLC-PK1 cells显示文摘We aim to investigate the effect of transforming growth factor (TGF)-β1 on the expression of enhancer of split- and hairy-related protein-2 (SHARP-2) messenger RNA (mRNA) and its signaling pathway. In this study, several cell lines including LLC-PK1 (a porcine kidney tubular epithelial cell line), MDCK (Madin-Darby canine kidney) and CTLL-2 (cytotoxic T-lymphocyte line) were treated with recombinant human TGF-β1, and a series of experiments were carried out, involving Northern blot analysis of total RNA from these cells. Further, several specific chemical inhibitors were applied before TGF-β1 treatment to probe the signaling pathway. The results showed that TGF-β1 can significantly up-regulate SHARP-2 mRNA expression in the LLC-PK1 cell line. The peak level of induction was found 2 h after TGF-β1 stimulation. While one phospho-inositide 3-kinases (PI-3) kinase inhibitor, LY294002, completely blocked the effect of TGF-β1 on SHARP-2 mRNA expression in LLC-PK1 cells at a low concentration, other inhibitors, including PD98059, staurosporine, AG490, wortmannin, okadaic acid and rapamycin, had no effect. The effect of LY294002 was dose-dependent. We conclude that, in LLC-PK1 cells at least, TGF-β1 can effectively induce the SHARP-2 mRNA expression and that the PI-3 kinase pathway can mediate this effect. | Zhang-fei SHOU Qin ZHOU Jie-ru CAI Jiang-hua CHEN Kazuya YAMADA Kaoru MIYAMOTO | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，9： | 0 |
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