|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors显示文摘AIM:To clarify differences in mucin phenotype, prolif-erative activity and oncogenetic alteration among subtypes of colorectal laterally spreading tumor (LST). METHODS:LSTs, defined as superficial elevated lesions greater than 10 mm in diameter with a low vertical axis, were macroscopically classified into two subtypes:(1) a granular type (Gr-LST) composed of superficially spreading aggregates of nodules forming a flat-based lesion with a granulonodular and uneven surface; and (2) a non-granular type (NGr-LST) with a flat smooth surface and an absence of granulonodular formation. A total of 69 LSTs, comprising 36 Gr-LSTs and 33 NGr-LSTs, were immunohistochemically stained with MUC2, MUC5AC,MUC6, CD10 (markers of gastrointestinal cell lineage), p53, β-catenin and Ki-67 antibodies, and examined for alteration in exon 1 of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and exon 15 of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) by poly-merase chain reaction followed by direct sequencing. RESULTS:Histologically, 15 Gr-LST samples were adenomas with low-grade dysplasia (LGD), 12 were high-grade dysplasia (HGD) and 9 were adenocarcinomas invading the submucosa (INV), while 12 NGr-LSTs demonstrated LGD, 14 HGD and 7 INV. In the proximal colon, MUC5AC expression was significantly higher in the Gr-type than the NGr-type. MUC6 was expressed only in NGr-LST. MUC2 or CD10 did not differ. P53 expression demonstrated a significant stepwise increment in progression through LGD-HGD-INV with both types of LST. Nuclear β-catenin expression was significantly higher in the NGr-type. Ki-67 expression was signifi-cantly higher in the Gr-type in the lower one third zone of the tumor. In proximal, but not distal colon tumors, the incidence of KRAS provided mutation was signifi-cantly higher in the Gr-type harboring a specific mutational pattern (G12V). BRAF mutations (V600E) were detected only in two Gr-LSTs. CONCLUSION:The two subtypes of LST, especially in the proximal colon, have differing phenotypes of gastrointestinal cell lineage, proliferation and activation of Wnt/β-catenin or RAS/RAF/extracellular signal-regulated kinase signaling. | Kosaburo Nakae Hiroyuki Mitomi Tsuyoshi Saito Michiko Takahashi Takashi Morimoto Yasuhiro Hidaka Naoto Sakamoto Takashi Yao Sumio Watanabe | 2012 | World Journal of Gastroenterology2012，18，39： | 8 |
| 2 | Peeling a giant ileal lipoma with endoscopic unroofing and submucosal dissection显示文摘Lipoma is relatively common in the colon but is less often in the small intestine. Most lipomas are incidentally detected at endoscopy and are usually small and asymptomatic. However, some of them can present with obstruction and/or intussusceptions. Surgical resection is commonly recommended to remove such significant lipomas with a limited pedicle and larger than 2 cm in size, as endoscopic resection may result in unfavorable complications such as intestinal perforations. We report a case of 62-year-old man presenting with hematochezia. Colonoscopy showed a submucosal tumor, about 50 mm in size, in the terminal ileum. A clinical diagnosis of lipoma was established based on the findings of colonoscopy and abdominal computed tomography (CT). As the patient complained of hematochezia and mild iron deficiency anemia associated with repeated tumor prolapse, we decided to remove his lipoma. Consequently, the lesion was completely removed en bloc . Although abdominal CT immediately after removal of the lesion showed a small amount of free air, conservative treatment was successfully carried out for the perforation. Histologically, the removed lesion was a lipoma. | Takashi Morimoto Kuang-I Fu Hironori Konuma Yuko Izumi Syujirou Matsuyama Kanako Ogura Akihisa Miyazaki Sumio Watanabe | 2010 | World Journal of Gastroenterology2010，16，13： | 4 |
| 3 | Endoscopic retrieval of a gastric trichobezoar显示文摘A 9-year-old girl presented with a chief complaint of abdominal pain. Esophagogastroduodenal endoscopy (EGD) identifi ed a long and large gastric trichobezoar extending into the duodenum. We attempted endoscopic retrieval after informed consent was obtained from the patient's mother. Initially, a gasper with 5-prolongs, com monly used for retrieval of endoscopically excised poly ps, failed to remove the whole trichobezoar. When a net was used instead, it proved impossible to remove the trichobezoar completely. Therefore, we withdrew the scope from the mouth, leaving the net grasping the tri co bezoar firmly in the stomach. Subsequently, we were able to retrieve about 70% of the trichobezoar manually by grasping the snare part of the net directly. A second pass found no deep laceration or perforation endoscopically. The remaining trichobezoar was completely retrieved with the net. The procedure was completed within 15 min. The retrieved specimens were34 cm in length and 100 g in weight. The patient was discharged uneventfully 5 d thereafter. She was advised to visit a psychiatrist to avoid suffering from a relapse. Follow-up EGD showed no trichobezoar, and the patient' s frontal hair grew back. | Hironori Konuma Kuangi Fu Takashi Morimoto Takayoshi Shimizu Yuko Izumi Satoko Shiyanagi Masahiko Urao Akihisa Miyazaki Sumio Watanabe | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，1： | 4 |
| 4 | C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells显示文摘 | Ko-ichi Kawahara Kamal Krishna Biswas Masako Unoshima Takashi Ito Kiyoshi Kikuchi Yoko Morimoto Masahiro Iwata Salunya Tancharoen Yoko Oyama Kazunori Takenouchi Yuko Nawa Noboru Arimura Meng Xiao Jie Binita Shrestha Naoki Miura Toshiaki Shimizu Kentaro Me | 2008 | Cardiovascular Pathology2008，，3： | 3 |
| 5 | MOBILE PHONE DEPENDENCE OF FEMALE STUDENTS AND PERCEIVED PARENTAL REARING ATTITUDES显示文摘 | Toda Masahiro Ezoe Satoko Nishi Asaya Mukai Takashi Goto Mika Morimoto Kanehisa | 2008 | Social Behavior and Personality2008，，6： | 2 |
| 6 | Antiplatelet Therapy and Stent Thrombosis After Sirolimus-Eluting Stent Implantation显示文摘 | Takeshi Kimura Takeshi Morimoto Yoshihisa Nakagawa Toshihiro Tamura Kazushige Kadota Hitoshi Yasumoto Hideo Nishikawa Yoshikazu Hiasa Toshiya Muramatsu Taiichiro Meguro Naoto Inoue Hidehiko Honda Yasuhiko Hayashi Shunichi Miyazaki Shigeru Oshima Takashi H | 2009 | Circulation2009，，7： | 1 |
| 7 | The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection显示文摘 | Kozo Yoshikawa Mitsuo Shimada Masanori Nishioka Nobuhiro Kurita Takashi Iwata Shinya Morimoto Tomohiko Miyatani Masato Komatsu Hideya Kashihara Chie Mikami | 2012 | Surgery Today2012，，7： | 1 |
| 8 | Practical reduction of carbonyl compounds with NaBH4 and silica gel in an aprotic solvent显示文摘 | Shigetaka Yakabe Masao Hirano Takashi Morimoto | 1999 | Synthetic Communications1999，29，2： | 1 |
| 9 | Practical reduction of carbonyl compounds with NaBH4 and silica gel in an aprotic solvent 显示文摘 | Shigetaka Yakabe Masao Hirano Takashi Morimoto | 1999 | Synthet Communications1999，29，2： | 1 |
| 10 | Survival After Curative Resection for Mucinous Adenocarcinoma of the Colorectum显示文摘 | Yukihide Kanemitsu M.D. Tomoyuki Kato M.D. Takashi Hirai M.D. Kenzo Yasui M.D. Takeshi Morimoto M.D. Yasuhiro Shimizu M.D. Yasuhiro Kodera M.D. Yoshitaka Yamamura M.D | 2003 | Diseases of the Colon & Rectum2003，，2： | 1 |
| 11 | Role of Sonazoid-enhanced three-dimensional ultrasonography in the evaluation of percutaneous radiofrequency ablation of hepatocellular carcinoma显示文摘 | Wen Luo Kazushi Numata Manabu Morimoto Takashi Oshima Michio Ueda Masahiro Okada Shigeo Takebayashi Xiaodong Zhou Katsuaki Tanaka | 2009 | European Journal of Radiology2009，，1： | 1 |
| 12 | Automaticevaluation of mixed-mode stress intensity factors utilizingdigital image correla-tion显示文摘 | YONEYAMA S MORIMOTO Y TAKASHI M | 2006 | Strain2006，42，： | 1 |
| 13 | Abdominal compartment syndrome and intrahepatic portal venous gas: a possible complication of endoscopy显示文摘 | Mineji Hayakawa Satoshi Gando Takashi Kameue Yuji Morimoto Osamu Kemmotsu | 2002 | Intensive Care Medicine2002，，11： | 1 |
| 14 | Guidelines for donor selection and an overview of the donor operation in living related liver transplantation显示文摘 | Taisuke Morimoto Masato Ichimiya Akira Tanaka Iwao Ikai Yuzo Yanamoto Yoshiaki Nakamura Yasugu Takada Yukihiro Inomata Kazuo Honda Takashi Inamoto Koichi Tanaka Yoshio Yamaoka | 1996 | Transplant International1996，，3： | 1 |
| 15 | microRNA expression is able to predict response to chemoradiotherapyin rectal cancer显示文摘 | Masanori Hotchi Mitsuo Shimada Nobuhiro Kurita Takashi Iwata Hirohiko Sato Shinya Morimoto Kozo Yoshikawa Jun Higashijima Tomohiko Miyatani | 2013 | Molecular and Clinical Oncology2013，，： | 1 |
| 16 | Reduction of Pneumonia Risk by an Angiotensin I–Converting Enzyme Inhibitor in Elderly Japanese Inpatients According to Insertion/Deletion Polymorphism of the Angiotensin I–Converting Enzyme Gene显示文摘 | Takashi Takahashi Shigeto Morimoto Kohya Okaishi Tsugiyasu Kanda Takeshi Nakahashi Masashi Okuro Hiroshi Murai Yukiharu Nishimura Kunimitsu Iwai Masayuki Matsumoto | 2005 | American Journal of Hypertension2005，，10： | 1 |
| 17 | Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolicacid in Prunus mume Sieb. et Zucc.显示文摘 | Ko-ichi Kawahara Teruto Hashiguchi Kazuo Masuda Abbi Saniabadi Kiyoshi Kikuchi Salunya Tancharoen Takashi Ito Naoki Miura Yoko Morimoto Kamal Biswas Yuko Nawa Xiaojie Meng Yoko Oyama Kazunori Takenouchi Binita Shrestha Hisayo Sameshima Toshiaki Shimizu Ta | 2009 | International Journal of Molecular Medicine2009，，5： | 1 |
| 18 | MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells显示文摘 | Yoko Morimoto Kiyoshi Kikuchi Takashi Ito Masayuki Tokuda Takashi Matsuyama Satoshi Noma Teruto Hashiguchi Mitsuo Torii Ikuro Maruyama Ko-ichi Kawahara | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
| 19 | Effect of Transcorneal Electrical Stimulation in Patients with Nonarteritic Ischemic Optic Neuropathy or Traumatic Optic Neuropathy显示文摘 | Takashi Fujikado Takeshi Morimoto Kenji Matsushita Hiroshi Shimojo Yoshitaka Okawa Yasuo Tano | 2006 | Japanese Journal of Ophthalmology2006，，3： | 1 |
| 20 | Automatic evaluation of mixed-mode stress intensity factors utilizing digital image correlation 显示文摘 | Yoneyama S Morimoto Y Takashi M | 2006 | Strain2006，42，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员