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| 1 | Enhanced allelopathy and competitive ability of invasive plant Solidago canadensis in its introduced range显示文摘Aims Why invasive plants are more competitive in their introduced range than native range is still an unanswered question in plant invasion ecology.Here,we used the model invasive plant Solidago canaden-sis to test a hypothesis that enhanced production of allelopathic compounds results in greater competitive ability of invasive plants in the invaded range rather than in the native range.We also exam-ined the degree to which the allelopathy contributes increased com-petitive ability of S.canadensis in the invaded range.Methods We compared allelochemical production by S.canadensis growing in its native area(the USA)and invaded area(China)and also by populations that were collected from the two countries and grown together in a'common garden'greenhouse experiment.We also tested the allelopathic effects of S.canadensis collected from either the USA or China on the germination of Kummerowia striata(a native plant in China).Finally,we conducted a common garden,greenhouse experiment in which K.striata was grown in monocul-ture or with S.canadensis from the USA or China to test the effects of allopathy on plant-plant competition with suitable controls such as adding activated carbon to the soil to absorb the allelochemicals and thereby eliminating any corresponding allopathic effects.Important findings Allelochemical contents(total phenolics,total flavones and total saponins)and allelopathic effects were greater in S.canadensis sampled from China than those from the USA as demonstrated in a field survey and a common garden experiment.Inhibition of K.stri-ata germination using S.canadensis extracts or previously grown in soil was greater using samples from China than from the USA.The competitive ability of S.canadensis against K.striata was also greater for plants originating from China than those from the USA.Allelopathy could explain about 46%of the difference.These find-ings demonstrated that S.canadensis has evolved to be more allelo-pathic and competitive in the introduced range and that allelopathy significantly contributes to increased competitiveness for this inva-sive species. | Yongge Yuan Bing Wang Shanshan Zhang Jianjun Tang Cong Tu Shuijin Hu Jean W.H.Yong Xin Chen | 2013 | Journal of Plant Ecology2013，6，3： | 15 |
| 2 | Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction显示文摘 | Mei Hua Jiang Bing Cai Ying Tuo Jiancheng Wang Zhi Jun Zang Xiang'an Tu Yong Gao Zhijian Su Weiqiang Li Guilan Li Min Zhang Jianwei Jiao Zi Wan Chunhua Deng Bruce T Lahn Andy Peng Xiang | 2014 | Cell Research2014，24，12： | 14 |
| 3 | Spaceborne GPS receiver antenna phase center offset and variation estimation for the Shiyan 3 satellite显示文摘In determining the orbits of low Earth orbit(LEO) satellites using spaceborne GPS, the errors caused by receiver antenna phase center offset(PCO) and phase center variations(PCVs) are gradually becoming a major limiting factor for continued improvements to accuracy. Shiyan 3, a small satellite mission for space technology experimentation and climate exploration, was developed by China and launched on November 5, 2008. The dual-frequency GPS receiver payload delivers1 Hz data and provides the basis for precise orbit determination within the range of a few centimeters. The antenna PCO and PCV error characteristics and the principles influencing orbit determination are analyzed. The feasibility of PCO and PCV estimation and compensation in different directions is demonstrated through simulation and in-flight tests. The values of receiver antenna PCO and PCVs for Gravity Recovery and Climate Experiment(GRACE) and Shiyan 3 satellites are estimated from one month of data. A large and stable antenna PCO error, reaching up to10.34 cm in the z-direction, is found with the Shiyan 3 satellite. The PCVs on the Shiyan 3 satellite are estimated and reach up to 3.0 cm, which is slightly larger than that of GRACE satellites. Orbit validation clearly improved with independent k-band ranging(KBR) and satellite laser ranging(SLR) measurements. For GRACE satellites, the average root mean square(RMS) of KBR residuals improved from 1.01 cm to 0.88 cm. For the Shiyan 3 satellite, the average RMS of SLR residuals improved from 4.95 cm to 4.06 cm. | Gu Defeng Lai Yuwang Liu Junhong Ju Bing Tu Jia | 2016 | Chinese Journal of Aeronautics2016，29，5： | 11 |
| 4 | Tumorigenesis and spontaneous metastasis by luciferase-labeled human xenograft osteosarcoma cells in nude mice显示文摘 | DU Lin XU Wen-ting FAN Qi-ming TU Bing SHEN Yang YAN Wei TANG Ting-ting WANG You | 2012 | Chinese Medical Journal2012，，22： | 9 |
| 5 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 6 | Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions显示文摘Objective:The aim of this study was to investigate the effects of plumbagin(PL),a naphthoquinone derived from the medicinal plant plumbago zeylanica,on the invasion and migration of human breast cancer cells.Methods:Human breast cancer MDA-MB-231SArfp cells were treated with different concentrations of plumbagin for 24 h.The effects of plumbagin on the migration and invasion were observed by a transwell method.The expressions of IL-1α,IL-1β,IL-6,IL-8,TGF-β,TNFα,MMP-2 and MMP-9 mRNA in MDA-MB-231SArfp cells were detected using Real-Time PCR.MDA-MB-231SArfp cells were treated with plumbagin at different concentrations for 45 minutes.The activation of STAT3 was detected by western blot.Following this analysis,STAT3 in MDA-MB-231SArfp cells was knocked out using specific siRNA.mRNA levels of IL-1α,TGF-β,MMP-2 and MMP-9 were then detected.Consequently,MDA-MB-231SArfp cells were injected intracardially into BALB/c nude mice to construct a breast cancer bone metastatic model.The mice were injected intraperitoneally with plumbagin.Non-invasive in vivo monitoring,X-ray imaging and histological staining were performed to investigate the effects of plumbagin on the invasion and migration of breast cancer cells in vivo.Results:The in vitro results showed that plumbagin could suppress the migration and invasion of breast cancer cells and down-regulate mRNA expressions of IL-1α,TGF-β,MMP-2 and MMP-9.Western blotting demonstrated that plumbagin inhibited the activation of STAT3 signaling in MDA-MB-231SArfp cells.The inactivation of STAT3 was found to have an inhibitory effect on the expressions of IL-1α,TGF-β,MMP-2 and MMP-9.In vivo studies showed that plumbagin inhibited the metastasis of breast cancer cells and decreased osteolytic bone metastases,as well as the secretion of MMP-2 and MMP-9 by tumor cells at metastatic lesions.Conclusions:Plumbagin can suppress the invasion and migration of breast cancer cells via the inhibition of STAT3 signaling and by downregulation of IL-1α,TGF-β,MMP-2 and MMP-9. | Wei Yan Bing Tu Yun-yun Liu Ting-yu Wang Han Qiao Zan-jing Zhai Hao-wei Li Ting-ting Tang | 2013 | Bone Research2013，1，4： | 5 |
| 7 | Quantum computation on gate-defined semiconductor quantum dots显示文摘During the past few years, researchers have made significant progress on quantum information processing in gate controlled semiconductor quantum dots. We review the global research efforts, including works by our group, which provides pathways towards applications in quantum computation. | LI HaiOu YAO Bing TU Tao GUO GuoPing | 2012 | Chinese Science Bulletin2012，57，16： | 5 |
| 8 | Prevention of common bile duct injury during laparoscopic cholecystectomy显示文摘BACKGROUND:Since the widespread adoption of laparoscopic cholecystectomy(LC)in the late 1980s,a rise in common bile duct(CBD)injury has been reported.We analyzed the factors contributing to a record of zero CBD injuries in 10 000 consecutive LCs. METHODS:The retrospective investigation included 10 000 patients who underwent LC from July 1992 to June 2007. LC was performed by 4 teams of surgeons.The chief main surgeon of each team has had over 10 years of experience in hepatobiliary surgery.Calot's triangle was carefully dissected,and the relationship of the cystic duct to the CBD and common hepatic duct was clearly identified.A clip was applied to the cystic duct at the neck of the gallbladder and the duct was incised with scissors proximal to the clip.The cystic artery was dissected by the same method. Then,the gallbladder was dissected from its liver bed.A drain was routinely left at the gallbladder bed for 1-2 days postoperatively. RESULTS:No CBD injuries occurred in 10 000 consecutive LCs,and there were 16 duct leaks(0.16%).Among these, there were 10 Luschka duct leaks(0.1%)and 6 cystic duct leaks(0.06%).Four hundred thirty cases were converted to open cholecystectomy(OC),giving a conversion rate of 4.3%.After a mean follow-up of 17.5 months(range 6-24 months),no postoperative death due to LC occurred,and good results were observed in 95%of the patients. CONCLUSIONS:In our 10 000 LCs with zero CBD injuries, the techniques used and practices at our department have been successful.Surgeon's expertise in biliary surgery,preoperative imaging,precise operative procedures,and conversion from LC to OC when needed are important measures to prevent CBD injuries. | Ou, Zhi-Bing Li, Sheng-Wei Liu, Chang-An Tu, Bing Wu, Chuan-Xin Ding, Xiong Liu, Zuo-Jin Sun, Ke Feng, Hu-Yi Gong, Jian-Ping | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，4： | 5 |
| 9 | New Discovery and Zircon Hf Isotopic Composition of the Early Yanshannian Monzogranite in the Yingyangguan Group of Eastern Guangxi, China显示文摘Objective The Yingyangguan Group is widely exposed in the southwestern segment of boundary belt between Yangtze and Cathaysian blocks and is mainly composed of a suit of lower-grade metamorphic marine volcanoclasticsedimentary rocks(Zhou Hanwen et al.,2002).Its forming age and petrogenesis are critical for better understanding the orogenic process and relationship of the Yangtze | LI Xiang TU Bing WANG Lingzhan TIAN Yang XIE Guogang ZHANG Jianyu | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 2 |
| 10 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 11 | Preparation of Spherical Microfine Silicon Powder显示文摘Under certain conditions of proper temperature and pH value, sodium silicate was hydrolyzed in liquid ammonia chloride, and spherical microfine SiO2 powder in micrometer-size was prepared. In this experiment, the relationship between needed time and proper pH value, temperature, density of the solution, and its current capacity were found .The optimum conditions are pH 8.5, 70 ℃, and the concentration of sodium silicate is 0.6 mol/L for the density of the solution. The structure of spherical microfi ne silicon was charactetized by SEM and XRD. | SHENG Yong ZOU Jun LI Bing TU Mingjing | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 2 |
| 12 | Pancreatic tumor:DSA diagnosis and treatment显示文摘Pancreatictumor:DSAdiagnosisandtreatmentXUHongBing1,ZHANGYiJun2,WEIWenJiang3,LIWeiMin1andTUXiangQun1Subjectheadingspanc... | XU HongBing1, ZHANG YiJun2, WEI WenJiang3, LI WeiMin1 and TU XiangQun1 | 1998 | World Journal of Gastroenterology1998，4，1： | 2 |
| 13 | Multi-residual analysis of 16 β-agonists in pig liver, kidney and muscle by ultra performance liquid chromatography tandem mass spectrometry显示文摘 | Bing Shao Xiaofei Jia Jing Zhang Juan Meng Yongning Wu Hejun Duan Xiaoming Tu | 2008 | Food Chemistry2008，，3： | 1 |
| 14 | Laparoscopic liver resection for hepatocellular carcinoma complicated with significant portal hypertension:A propensity score-matched survival analysis显示文摘Background: Significant portal hypertension(SPH) is a relative contraindication for patients with resectable hepatocellular carcinoma(HCC). However, increasing evidence indicates that liver resection is feasible for HCC patients with SPH. Methods: HCC patients with cirrhosis who underwent laparoscopic liver resection(LLR) in two centers from January 2013 to April 2018 were included. Surgical and survival outcomes were analyzed to explore potential prognostic factors. Propensity score matching(PSM) analysis was performed to minimize bias. Results: A total of 165 patients were divided into two groups based on the presence(SPH, n = 76) or absence(non-SPH, n = 89) of SPH. Patients in the SPH group had longer operative time, more blood loss, and more advanced TNM stage than patients in the non-SPH group( P < 0.05). However, there were no significant differences in the postoperative 90-day mortality rate( n = 0), overall postoperative complications(47.4% vs. 41.6%, P = 0.455), Clavien-Dindo classification( P = 0.347), conversion to open surgery(9.2% vs. 6.7%, P = 0.557), or length of hospitalization(16 vs. 15 days, P = 0.203) between the SPH and non-SPH groups before PSM. Similar results were obtained after PSM. The 1-, 3-, and 5-year overall survival(OS) and recurrence-free survival rates in the SPH group were not significantly different from those in the non-SPH group both before and after PSM(log-rank P > 0.05). After PSM, alpha-fetoprotein(AFP) ≥ 400 μg/L [hazard ratio(HR) = 4.71, 95% confidence interval(CI): 2.69-8.25], ascites(HR = 2.18, 95% CI: 1.30-3.66), American Society of Anesthesiologists(ASA) classification(Ⅲ vs. Ⅱ)(HR = 2.13, 95% CI: 1.11-4.07) and tumor diameter > 5 cm(HR = 3.91, 95% CI: 2.02-7.56) independently predicted worse OS. Conclusions: LLR for patients with HCC complicated with SPH appears feasible at the price of increasing operative time and blood loss. AFP, ascites, ASA classification and tumor diameter may predict the prognosis of HCC complicated with SPH after LLR. | Zhang-You Guo Yuan Hong Bing Tu Yao Cheng Xiao-Mei Wang | 2023 | Hepatobiliary & Pancreatic Diseases International2023，22，4： | 1 |
| 15 | Construction of adenovirus vectors encoding the lumican gene by gateway recombinant cloning technology显示文摘AIM:To construct adenovirus vectors of lumican gene by gateway recombinant cloning technology to further understand the role of lumican gene in myopia.METHODS:Gateway recombinant cloning technology was used to construct adenovirus vectors.The wild-type(wt) and mutant(mut) forms of the lumican gene were synthesized and amplified by polymerase chain reaction(PCR).The lumican cDNA fragments were purified and ligated into the adenovirus shuttle vector pDownmultiple cloning site(MCS)-/internal ribozyme entry site(IRES)/enhanced green fluorescent protein(EGFP).Then the desired DNA fragments were integrated into the destination vector pAV.Des1 d yielding the final expression constructs pAV.Ex1d-CMV>wt-lumican/IRES/EGFP and pAV.Ex1d-cytomegalovirus(CMV)>mutlumican/IRES/EGFP,respectively.RESULTS:The adenovirus plasmids pAV.Ex1d-CMV>wt-lumican/IRES/EGFP and pAV.Ex1d-CMV>mutlumican/IRES/EGFP were successfully constructed by gateway recombinant cloning technology.Positive clones identified by PCR and sequencing were selected and packaged into recombinant adenovirus in HEK293 cells.CONCLUSION:We construct adenovirus vectors containing the lumican gene by gateway recombinant cloning technology,which provides a basis for investigating the role of lumican gene in the pathogenesis of high myopia. | Gui-Fang Wang Bing Qi Lei-Lei Tu Lian Liu Guo-Cheng Yu Jing-Xiang Zhong | 2016 | International Journal of Ophthalmology(English edition)2016，9，9： | 1 |
| 16 | Analysis of free amino acids in Chinese teas and flower of tea plant by high performance liquid chromatography combined with solid-phase extraction显示文摘 | Lin Wang Renjie Xu Bing Hu Wei Li Yi Sun Youying Tu Xiaoxiong Zeng | 2010 | Food Chemistry2010，，4： | 1 |
| 17 | STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma显示文摘 | Bing Tu Lin Du Qi-Ming Fan Ze Tang Ting-Ting Tang | 2012 | Cancer Letters2012，，1： | 1 |
| 18 | Data release of the LAMOST pilot survey显示文摘This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects. | A-Li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-Ping Li Yao-Quan Chu Jian-Rong Shi Gang Wang Jian-Nan Zhang Zhong-Rui Bai Xiao-Yan Chen Feng-Fei Wang Yan-Xin Guo Jian-Jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi Li Yi-Han Song Yue Wu Yan-Xia Zhang Xin-Lin Zhou Fang Zuo Peng Du Lin He Wen Hou Yi-Qiao Dong Jian Li Guang-Wei Li Shuang Li Jing Song Yuan Tian Meng-Xin Wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Qi Li Yin-Dun Mao Zheng-Hong Tang Qing-Sheng Tao Liang-Ping Tu Da-Qing Wang Dan Wang Jian-Ping Wang Lei Wang Shou-Guan Wang Shu-Qing Wang Ya-Nan Wang You Wang Yue-Fei Wang Ming-Zhi Wei Xiang-Xiang Xue Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu De-Hua Yang Shi-Hai Yang Zheng-Qiu Yao Yong Yu Hui Yuan Chao Zhai En-Peng Zhang Jing Zhang Li-Ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang Ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou | 2012 | Research in Astronomy and Astrophysics2012，12，9： | 1 |
| 19 | Effects of Raloxifene on Caveolin-1 mRNA and Protein Expressions in Vascular Smooth Muscle Cells显示文摘Caveolin-1 被雌激素在脉管的光滑的肌肉房间调整。Raloxifene,没有癌症的增加的风险或雌激素的另外的副作用,可能有 cardioprotective 性质的一个选择雌激素受体调节的人,可以与冠的动脉疾病的风险在女人被使用。然而,在 raloxifene 和 caveolin-1 之间的关系仍然是未知的。因此,这研究被设计看 raloxifene 是否调整 caveolin-1 表示并且如果那么,如此的规定是否被雌激素调停受体。老鼠大动脉的光滑的肌肉房间在 raloxifene 的缺席或存在是有教养的(10 (8-) 到 10 (6-) M ) 为 12 或 24 h。mRNA 和 caveolin-1 的蛋白质层次与 raloxifene 在 24 h 治疗以后显著地被增加。这些增加被雌激素受体对手帝国化学工业公司 182780 禁止(10 (5-) M ) 。这研究的结果建议 raloxifene 通过雌激素受体刺激 caveolin-1 抄写和翻译调停的机制。 | Fa-Lin YAN Hong HE Xian-Xi LIU Bing TU Xian-Wei ZENG Ji-Xin SU Xin WANG Qin HU | 2006 | Acta Biochimica et Biophysica Sinica2006，38，11： | 1 |
| 20 | Multi-residual analysis of 16 β-agonists in pig liver, kidney and muscle by ultra performance liquid chromatography tandem mass spectrometry显示文摘 | Bing Shao Xiaofei Jia Jing Zhang Juan Meng Yongning Wu Hejun Duan Xiaoming Tu | 2008 | Food Chemistry2008，，3： | 1 |
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