|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 4 | Effect of particulate materials and osmoprotectants on very-high-gravity ethanolic fermentation by Saccharomyces cerevisiae显示文摘 | Thomas K C Hynes S H Ingledew W M | 1994 | Applied and EnvironmentalMicrobiology1994，60，5： | 1 |
| 5 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 6 | Glutamine synthetase and glutamate dehydrogenase isoforms in maize leaves:Localization,relative proportion and their role in ammonium assimilation or nitrogen transport显示文摘 | Thomas W B Elisa C Bertrand H | 2000 | Planta2000，211，： | 1 |
| 7 | Measurement of frost characteristics on heat exchangers fins part 1: test facility and instrumentation 显示文摘 | THOMAS L CHEN H BESANT R W | 1999 | ASHRAE Trans1999，105，： | 1 |
| 8 | Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and src activation 显示文摘 | Thomas H Manuel A Mark W | 2004 | J Biol Chem2004，22，23： | 1 |
| 9 | Relationships between flow, self-concept, psychological skills, and performance 显示文摘 | JACKSON S A THOMAS P R MARSH H W | 2001 | Journal of Aoolied Soort Psvcholow2001，13，2： | 1 |
| 10 | Effects of phosphate con- centration on cell division rates and yield of a tropical oceanic diatom 显示文摘 | Thomas W H Dodson A N | 1968 | The Biological Bulletin1968，134，1： | 1 |
| 11 | Gaussian random number generators显示文摘 | Thomas D B Luk W Leong P H W etal | 2007 | ACM Computing Surveys2007，39，4： | 1 |
| 12 | Electrospinning and dtabilization of gfully hydrolrzed poly(viny alcohol)fibers显示文摘 | YAO LI THOMAS W H ANTHONY G E | 2003 | Chem Mater2003，15，： | 1 |
| 13 | Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage 显示文摘 | Vicki W Thomas H | 2005 | Trends Pharmacol Sci2005，26，9： | 1 |
| 14 | ebooks and eflfciencies in acquisitions expenditures and workflows 显示文摘 | Thomas W Racine H Shouse D | 2013 | Against the Grain2013，25，2： | 1 |
| 15 | De novo sequencing of pep- tides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina)显示文摘 | WIELSCH N W THOMAS H SUREN- DRANATH V | 2006 | Journal of Pro- teome Research2006，57，2： | 1 |
| 16 | The Determination of the Plate Count for Large Molecules under Reversed-Phase Gradient Conditions显示文摘 | Uwe D N Hillary B H Thomas E W | 2010 | Journal of Chromatography A2010，1217，14： | 1 |
| 17 | Leaf reflectance vs leaf chlorophyll and carotenoid concentrations for eight crops 显示文摘 | Thomas J R Gausman H W | 1977 | Agronomy Journal-Abstract1977，69，5： | 1 |
| 18 | Connell integrate the effects of climate change across entire systems that predicting ecosystem shifts requires new approaches显示文摘 | Bayden D R Christopher D G H Thomas W | | 0，，10： | 1 |
| 19 | Design of school bus routes bycomputer显示文摘 | Newton R M Thomas W H | 1969 | Socio-Economic Planning Sciences1969，3，1： | 1 |
| 20 | UK evidence on the market valuation of research and development ex- penditures 显示文摘 | Green J P Stark A W Thomas H M | 1996 | Journal of Business Finance and Accounting1996，23，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员