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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma 显示文摘 | Fregonese L Swan F J van Schadewijk A | 2005 | J Allergy Clin Immunol2005，115，6： | 1 |
| 3 | Consumer Perceptions of Interpersonal Equity and Satisfaction in Transactions : A Field Survey Approach 显示文摘 | OLIVER R L SWAN J E | 1989 | Jour- nal of Marketing1989，，4： | 1 |
| 4 | Consumer perceptions of interpersonal equity and satisfaction in transactions : A field survey ap- proach显示文摘 | OLIVER R L SWAN J E | 1989 | Journal of Marketing1989，，8： | 1 |
| 5 | Surface soil moisture and stubble management practice effects on the progress of infection of wheat by Fusarium pseudograminearum 显示文摘 | Swan L J Backhouse D Burgess L W | 2000 | Australian Journal of Experimental Agriculture2000，40，： | 1 |
| 6 | Equity and disconfirmationperceptions as influences on merchant and productsatisfaction 显示文摘 | Oliver R L Swan J E | 1989 | Joural of Consumer Research1989，16，12： | 1 |
| 7 | Consumer perceptions of interpersonal equity and satisfaction in transactions: a field survey approach 显示文摘 | OLIVER R L SWAN J E | 1989 | Jour- nal of Marketing1989，53，2： | 1 |
| 8 | Consumer perceptions of interpersonal equity and satisfaction in transactions : A field survey ap- proach显示文摘 | OLIVER R L SWAN J E | 1989 | J Mark1989，53，2： | 1 |
| 9 | Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular out- comes in sleep apnea syndrome 显示文摘 | Doherty L S Kiely J L Swan V | 2005 | Chest2005，127，6： | 1 |
| 10 | Product performance and consumersatisfaction : A new concept 显示文摘 | Swan J E Combs L J | 1976 | Journal of Marketing1976，40，2： | 1 |
| 11 | Consumer perceptions of interpersonal equity and satisfaction in transactions: A field survey approach显示文摘 | Oliver R L Swan J E | 1989 | Journal of Marketing1989，，： | 1 |
| 12 | User-centred design and evaluation of virtual environments显示文摘 | Hix D Swan J E | 1999 | IEEE Computer Graphics and Applications1999，19，6： | 1 |
| 13 | Single-cell RT-PCR gene expression profiling of acutely dissociated and immunocytochemically identified central neurons显示文摘 | Volgin D V Swan J Kubin L | 2004 | J Neurosci Methods2004，136，： | 1 |
| 14 | Consumer Perceptions of Interpersonal Equity and Satisfaction in Transaction: A Field Survey Approach显示文摘 | OLIVER R L SWAN J E | 1989 | Journal of Marketing1989，53，4： | 1 |
| 15 | Consumer perceptions of interpersonal equity and satisfaction in transaclions: A field survey approach 显示文摘 | Oliver R L Swan J E | 1989 | Journal of Marketing1989，53，2： | 1 |
| 16 | Effects of erosion on soil chemical properties in the north central region of the United States显示文摘 | Cihacek L J Swan J B | 1994 | J Soil Water Conserv1994，49，： | 1 |
| 17 | Comparison of anticoagulant effects and safety of argatroban and heparin in healthy subjects 显示文摘 | Swan S K St Peter J V Lambrecht L J | 2000 | Pharmacotherapy2000，20，7： | 1 |
| 18 | Consumer perceptions of interpersonal equity and satisfaction in transactions:a field survey approach显示文摘 | Oliver R L Swan J E | 1989 | Journal of Marketing1989，，53： | 1 |
| 19 | Product performance and consumer sat- isfaction 显示文摘 | Swan J Combs L | 1976 | Journal of Marketing Research1976，40，： | 1 |
| 20 | Postpurchase communications by consumers 显示文摘 | Swan J E Oliver R L | 1989 | Journal of Retailing1989，，： | 1 |
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