|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cellular and Molecular Immunopathogenesis of Ulcerative Colitis显示文摘Ulcerative 大肠炎(UC ) 是直肠、结肠的 mucosa 的煽动性的疾病并且似乎源于在危险性基因,环境和免疫系统之间的相互作用的一个复杂系列。mucosal 免疫系统的各种各样的部件在 UC 的 immunopathogenesis 被含有。从动物模型的证据也建议对宿主的共栖的 microflora 的改变的有免疫力的回答在 UC 的发展起一个中央作用。那么在这评论,我们阐明从四个方面在疾病的 immunopathogenesis 被含有的房间和分子:在肠的抗原,树枝状的房间,在 UC 敲相似受体和 NF-B。 | Suzhen Zhang Xuhui Zhao Dechun Zhang | 2006 | Cellular & Molecular Immunology2006，3，1： | 25 |
| 2 | 2-D P-wave velocity structure of lithosphere in the North China tectonic zone: Constraints from the Yancheng-Baotou deep seismic profile显示文摘We obtained the 2-D P-wave velocity structure of the lithosphere in the eastern North China Craton, Shanxi fault subsidence zone, and Yinchuan-Hetao fault subsidence zone by ray tracking technology based on six groups of clearly identified crustal phases and one group of lithospheric interface reflection phases from seismic recording sections of 21 shots along the 1300-km-long Yancheng-Baotou deep seismic wide-angle reflection/refraction profile. The results indicate significant differences between the lithospheric structure east and west of the Taihang Mountains, which is a gravity-gradient zone as well as a zone of abrupt change in lithospheric thickness and a separation zone of different rock components. East of the Taihang Mountains, the Mesozoic and Cenozoic lithospheric structure of the North China Craton has undergone strong reformation and destruction, resulting in the lithosphere thickness decreasing to 70–80 km. The North China Basin has a very thick Cenozoic sedimentary cover and the deepest point of crystalline basement is about 7.0 km, with the crustal thickness decreasing to about 31.0 km. The crystalline basement of the Luxi uplift zone is relatively shallow with a depth of 1.0–2.0 km and crustal thickness of 33.0–35.0 km. The Subei Basin has a thicker Cenozoic sedimentary cover and the bottom of its crystalline basement is at about 5.0–6.0 km with a crustal thickness of 31.0–32.0 km. The Tanlu fault is a deep fracture which cuts the lithosphere with a significant velocity structure difference on either side of the fault. The Tanlu fault plays an important role in the lithospheric destruction in the eastern part of the North China Craton. West of the Taihang Mountains, the crustal thickness increases significantly. The crust thickness beneath the Shanxi fault depression zone is about 46 km, and there is a low-velocity structure with a velocity of less than 6.1 km s?? in the upper part of the middle crust. Combined with other geophysical study results, our data shows that the lithospheric destruction at the Shaanxi-Shanxi fault depression zone and the Yinchuan-Hetao rift surrounding the Ordos block is non-uniform. The lithosphere thickness is about 80–90 km in the Datong-Baotou area, 75–137 km at the Dingxiang-Shenmu region, and about 80–120 km in the Anyang-Yichuan area. The non-uniform lithospheric destruction may be related to the ancient tectonic zone surrounding the Ordos block. This zone experienced multi-period tectonic events in the long-term process of its tectonic evolution and was repeatedly transformed and weakened. The weakening level is related to the interactions with the Ordos block. The continental collision between the Cenozoic India and Eurasia plates and N-E thrusting by the Qinghai Tibet Plateau block is causing further reformation and reduction of the lithosphere. | DUAN YongHong LIU BaoJin ZHAO JinRen LIU BaoFeng ZHANG ChengKe PAN SuZhen LIN JiYan GUO WenBin | 2015 | Science China Earth Sciences2015，58，9： | 14 |
| 3 | Deep seismic sounding data reveal the crustal structures beneath Zoigê basin and its surrounding folded orogenic belts显示文摘Songpan-Garze massif is located at the turning position of tectonics from the nearly west-east direction to the nearly north-south direction in the northeastern margin of Tibetan Plateau,with Zoigê basin in the centre of the massif.In this paper,we build a crustal structure model of Zoigê basin and its surrounding folded orogenic belts using the deep seismic sounding data in this region.We also discuss structures and properties of the basement in Zoigê basin,tectonic relations between Zoigê upland basin and its surrounding folded orogenic belts,crustal deformation and thickening in the northeastern margin of Tibetan Plateau,and decoupling and relaxing processes in the crust.The results indicate that a special 'Mesozoic basement' is formed of Triassic rocks with high density (2.65-2.75 g/cm3) and high velocity (5.6 km/s) in Zoigê basin.Songpan-Garze tectonic massif was transformed into two types of tectonic units with different crustal structures,i.e.,relatively stable Zoigê upland basin and active folded orogenic belts around the basin,in the course of the crustal material of Tibetan Plateau flowing eastward and obstructed by surrounding stable blocks.The thickening of the crust in the northeastern margin of Tibetan Plateau mainly occurred in the mid and lower crust,and the structure characterized by low velocities and multiple reflectors obviously appears in the folded orogenic belts around Zoigê basin.It implies that the mid and lower crust underwent a strong tectonic deformation in the folded orogenic areas.The thickness of the crust is about 50 km in Zoigê basin and the folded orogenic belts at the both southern and northern sides of Zoigê basin.The 'Mountain root' cannot be identified.It is inferred that during the later orogenic period the eastwards flowing deep materials moved clockwise along the relatively relaxing southern side around the eastern tectonic knot under the obstructing of surrounding rigid massifs,and it resulted in the strong stretching action of the folded orogenic belts around Zoigê basin. | JIA ShiXu,ZHANG XianKang,ZHAO JinRen,WANG FuYun,ZHANG ChengKe,XU ZhaoFan,PAN JiShun,LIU Zhi,PAN SuZhen & SUN GuoWei Geophysical Exploration Center,China Earthquake Administration,Zhengzhou 450002,China | 2010 | Science China Earth Sciences2010，53，2： | 11 |
| 4 | North China sub-craton lithospheric structure elucidated through coal mine blasting显示文摘We present a super-range seismic observation along the >1300-km-long profile passing through the Yinchuan basin and the Ordos block from the blasting point towards the southeast triggered by a large-(dynamite) scale coal blast in the Ningxia Hui Autonomous Region's Helan Mountain (yielded a profile). The seismic wave information from the uppermost mantle reflecting different depths was obtained by the China continental seismic survey. Pn refracted waves from the uppermost mantle were effectively traced up to 500 km and beyond. The stable dynamic and kinematic characteristics of the Pn wave-group indicate that the uppermost mantle below the Ordos block is a gently changing structure with a weak positive gradient. If Pm1, Pm2 waves are considered as the wave groups from the upper mantle, there may be distinct structural strata in the upper-mantle structures with average velocities of 7.70―7.80 km/s and 8.10―8.20 km/s, respectively. Based on the travel-time curve feature of Pm1, Pm2 waves, there may be a certain layer with a reverse velocity between the M1 and M2 interfaces. The depth range indicated by them is about 110―120 km and 200―220 km. These phenomena basically reflect the structural features of the upper-mantle lithosphere in this region. The information obtained may provide meaningful references for surveying North China craton lithospheric structures, as well as under-standing the shapes and structures of different spherical layers within the upper-mantle. | ZHAO JinRen ZHANG XianKang WANG FuYun ZHANG ChengKe ZHANG JianShi LIU BaoFeng PAN SuZhen | 2009 | Chinese Science Bulletin2009，54，4： | 7 |
| 5 | Transcriptome profiles reveal that gibberellin-related genes regulate weeping traits in crape myrtle显示文摘Plant architecture includes vital traits that influence and benefit crops,and economically important trees.Different plant architectures provide natural beauty.Weeping ornamental plants are aesthetically appealing to people.The regulatory mechanism controlling the weeping trait is poorly understood in crape myrtle.To investigate the weeping trait mechanism,transcriptional profiling of different organs in weeping and upright crape myrtle was performed based on phenotype.Phenotypic and histological analyses demonstrated that endodermal cells were absent,and that new shoot phenotypes could be rescued by the GA3 treatment of weeping plants.The transcriptional analysis and coexpression network analysis(WGCNA)of differentially expressed genes indicated that GA synthesis and signal transduction pathways play a role in weeping traits.When the expression level of a negative element of GA signaling,LfiGRAS1,was reduced by virus-induced gene silencing(VIGS),new branches grew in infected plants in a negatively geotropic manner.An integrated analysis implied that GA had a strong influence on weeping crape myrtle by interacting with other factors.This study helps to elucidate the mechanism governing the weeping trait and can improve the efficiency of breeding in Lagerstroemia. | Suzhen Li Tangchun Zheng Xiaokang Zhuo Zhuojiao Li Lulu Li Ping Li Like Qiu Huitang Pan Jia Wang Tangren Cheng Qixiang Zhang | 2020 | Horticulture Research2020，7，1： | 5 |
| 6 | Reference Gene Selection for qRT-PCR Normalization in Iris germanica L.显示文摘Quantitative real-time PCR(qPCR)is an effective and widely used method to analyze expression patterns of target genes.Selection of stable reference genes is a prerequisite for accurate normalization of target gene expression by qRT-PCR.In Iris germanica L.,no studies have yet been published regarding the evaluation of potential reference genes.In this study,nine candidate reference genes were assessed at different flower developmental stages and in different tissues by four different algorithms(GeNorm,NormFinder,BestKeeper,and RefFinder).The results revealed that ACT11(Actin 11)and EF1α(Elongation factor 1 alpha)were the most stable reference genes in different tissues,whereas TUA(Tubulin alpha)and UBC9(Ubiquitin-protein ligase 9)were the most stable ones in different flower developmental stages.UBC9 and ACT11 were the most stable reference genes in all of the tested samples,while the SAMDC(S-Adenosylmethionine decarboxylase)showed the least stability.Finally,to validate the suitability of the selected reference genes,the relative expression level of IgTPS(beta-caryophyllene synthase)was assessed and highlighted the importance of suitable reference gene selection.This work constitutes the first systematic evaluation of potential reference genes in I.germanica and provides guidelines for future research on gene function and molecular mechanisms on I.germanica and related species. | Yinjie Wang Yongxia Zhang Qingquan Liu Liangqin Liu Suzhen Huang Haiyan Yuan | 2021 | Phyton-International Journal of Experimental Botany2021，90，1： | 3 |
| 7 | Mitochondrial biogenesis of astrocytes is increased under experimental septic conditions显示文摘 | Wang Yang Chen Zhijiang Zhang Yu Fang Suzhen Zeng Qiyi | 2014 | Chinese Medical Journal2014，，10： | 3 |
| 8 | The Characteristics Analysis and Cogging Torque Optimization of a Surface-Interior Permanent Magnet Synchronous Motor显示文摘This paper proposes optimal stator skewed slot analytical method for cogging torque reduction in surface-interior permanent magnet synchronous motor(SIPMSM)and analyzes the characteristics of SIPMSM.The series-parallel equivalent magnetic circuit models(EMCMs)of SIPMSM is built based on the characteristics of magnetic circuits,which is used to design the basic electromagnetic parameters of SIPMSM.Analytical expressions of cogging torque are derived from applying analytical techniques.Stator skewed slot for cogging torque minimum is adopted,and the stator skewed slot pitch is confirmed based on the analytical expressions of the resultant cogging torque.The cogging torque,torque ripple,back electromotive force(back-EMF),power-angle characteristics,efficiency and power factor of SIPMSM are analyzed by establishing 3-dimensional finite element model(3-D-FED)of SIPMSM with stator skewed slot and straight slot.It is shown that the comprehensive performance of optimized SIPMSM is improved as confirmed by finite element analysis and analytical calculation results. | Jikai Si Suzhen Zhao Lufeng Zhang Ruiwu Cao Wenping Cao | 2018 | Chinese Journal of Electrical Engineering2018，4，4： | 3 |
| 9 | The chromosome-level Stevia genome provides insights into steviol glycoside biosynthesis显示文摘Stevia(Stevia rebaudiana Bertoni)is well known for its very sweet steviol glycosides(SGs)consisting of a common tetracyclic diterpenoid steviol backbone and a variable glycone.Steviol glycosides are 150–300 times sweeter than sucrose and are used as natural zero-calorie sweeteners.However,the most promising compounds are biosynthesized in small amounts.Based on Illumina,PacBio,and Hi-C sequencing,we constructed a chromosome-level assembly of Stevia covering 1416 Mb with a contig N50 value of 616.85 kb and a scaffold N50 value of 106.55 Mb.More than four-fifths of the Stevia genome consisted of repetitive elements.We annotated 44,143 high-confidence protein-coding genes in the high-quality genome.Genome evolution analysis suggested that Stevia and sunflower diverged~29.4 million years ago(Mya),shortly after the whole-genome duplication(WGD)event(WGD-2,~32.1 Mya)that occurred in their common ancestor.Comparative genomic analysis revealed that the expanded genes in Stevia were mainly enriched for biosynthesis of specialized metabolites,especially biosynthesis of terpenoid backbones,and for further oxidation and glycosylation of these compounds.We further identified all candidate genes involved in SG biosynthesis.Collectively,our current findings on the Stevia reference genome will be very helpful for dissecting the evolutionary history of Stevia and for discovering novel genes contributing to SG biosynthesis and other important agronomic traits in future breeding programs. | Xiaoyang Xu Haiyan Yuan Xiaqing Yu Suzhen Huang Yuming Sun Ting Zhang Qingquan Liu Haiying Tong Yongxia Zhang Yinjie Wang Chunxiao Liu Lei Wu Menglan Hou Yongheng Yang | 2021 | Horticulture Research2021，8，1： | 2 |
| 10 | Hypoxia-Inducible Erythropoietin Signaling in Squamous Dysplasia and Squamous Cell Carcinoma of the Uterine Cervix and Its Potential Role in Cervical Carcinogenesis and Tumor Progression显示文摘 | Geza Acs Paul J. Zhang Cindy M. McGrath Peter Acs John McBroom Ahmed Mohyeldin Suzhen Liu Huasheng Lu Ajay Verma | 2003 | The American Journal of Pathology2003，，6： | 2 |
| 11 | Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus显示文摘Metformin may reduce food intake and body weight,but the anorexigenic effects of metformin are still poorly understood.In this study,Sprague-Dawley rats were administered a single intracerebroventricular dose of metformin and compound C,in a broader attempt to investigate the regulatory effects of metformin on food intake and to explore the possible mechanism.Results showed that central administration of metformin significantly reduced food intake and body weight gain,particularly after 4 hours.A reduction of neuropeptide Y expression and induction of AMP-activated protein kinase phosphorylation in the hypothalamus were also observed 4 hours after metformin administration,which could be reversed by compound C,a commonly-used antagonist of AMP-activated protein kinase.Furthermore,metformin also improved lipid metabolism by reducing plasma low-density lipoprotein.Our findings suggest that under normal physiologica conditions,central regulation of appetite by metformin is related to a decrease in neuropeptide Y gene expression,and that the activation of AMP-activated protein kinase may simply be a response to the anorexigenic effect of metformin. | Yale Duan Rui Zhang Min Zhang Lijuan Sun Suzhen Dong Gang Wang Jun Zhang Zheng Zhao | 2013 | Neural Regeneration Research2013，8，25： | 2 |
| 12 | Changes in Ca2+ ATPase in a guinea pig endolymphatichy drops model显示文摘 | ZHANG Suzhen YANG Weiyan SUN Jianhe | | 0，，08： | 1 |
| 13 | Research on Optimization of Random Forest Algorithm Based on Spark显示文摘As society has developed,increasing amounts of data have been generated by various industries.The random forest algorithm,as a classification algorithm,is widely used because of its superior performance.However,the random forest algorithm uses a simple random sampling feature selection method when generating feature subspaces which cannot distinguish redundant features,thereby affecting its classification accuracy,and resulting in a low data calculation efficiency in the stand-alone mode.In response to the aforementioned problems,related optimization research was conducted with Spark in the present paper.This improved random forest algorithm performs feature extraction according to the calculated feature importance to form a feature subspace.When generating a random forest model,it selects decision trees based on the similarity and classification accuracy of different decision.Experimental results reveal that compared with the original random forest algorithm,the improved algorithm proposed in the present paper exhibited a higher classification accuracy rate and could effectively classify data. | Suzhen Wang Zhanfeng Zhang Shanshan Geng Chaoyi Pang | 2022 | Computers, Materials & Continua2022，，5： | 1 |
| 14 | Effect of X-ray irradiation on threshold voltage of AlGaN/GaN HEMTs with p-GaN and MIS Gates显示文摘Commercially available AlGaN/GaN high-electron-mobility transistors(HEMTs)are beginning to enter the public scene froma range of suppliers.Based on previous studies,commercial GaN-based electronics are expected to be tolerant to different types of irradiation in space.To test this assumption,we compared the characteristic electrical curves obtained at different X-ray irradiation doses for GaN HEMT devices manufactured by Infineon and Transphorm.The p-GaN-based device was found to be more robust with a stable threshold voltage,whereas the threshold voltage of the device with ametal-insulator-semiconductor gatewas found to shift first in the negative and then the positive direction.This dynamic phenomenon is caused by the releasing and trapping effects of radiation-induced charges in the dielectric layer and at the interface of irradiated devices.As such,the p-GaNgate-based GaN HEMT provides a promising solution for use as an electric source in space. | Yongle Qi Denggui Wang Jianjun Zhou Kai Zhang Yuechan Kong Suzhen Wu Tangsheng Chen | 2020 | Nanotechnology and Precision Engineering2020，3，4： | 1 |
| 15 | Study on Crustal Structure in Haiyuan Strong Earthquake Region显示文摘The crust/upper-mantle velocity structure and deep tectonic features are obtained in Haiyuan M = 8. 5 earthquake region from data processing of Xiji-Zhongwei deep seismic sounding (DSS) profile. The result shows that there is a great difference between the velocity structures on the two sides of the epicenter. The crust consists of alternative high and low velocity layers on the southern side while on the northern side it consists of a series of layers with positive velocity gradient. There exists a deep fault cutting Moho or an anomalous deep structural zone in the epicentral region. | Li Songlin,Zhang Xiankang,Zhang Chengke,Ren Qingfang,Shi Jinhu,Zhao Jinren,Fang Shengming,Liu Baofeng,Pan Suzhen, and Zhang Jianshi Research Center of Exploration Geophysics, CSB, Zhengzhou 450002 , China | 2001 | Earthquake Research in China2001，15，3： | 1 |
| 16 | Investigation of the roles of exosomes in colorectal cancer liver metastasis显示文摘 | Xia Wang Xiaoling Ding Lijuan Nan Yiting Wang Jing Wang Zhiqiang Yan Wei Zhang Jihong Sun Wei Zhu Bing Ni Suzhen Dong Lei Yu | 2015 | Oncology Reports2015，，5： | 1 |
| 17 | Study on Shigella Detection by ATP Bioluminescence Magnetic Enzyme Immunoassay显示文摘[Objective] The research aimed to establish a rapid detection method for Shigella. [Method] Combining immunomagnetic separation technology with ATP bioluminescence technology,a new kind of fast and accurate ATP bioluminescence magnetic enzyme immunoassay technique for Shigella was established. [Result]Using ATP bioluminescence magnetic enzyme immunoassay technique to detect standard solution for Shigella ( ATCC 25931) ,result showed that correlation coefficient between relative light intensity detected by instrument and bacteria concentration detected by culture counting method was 0. 981 1. Moreover,relation curve between relative light intensity and Shigella concentration was drawn. [Conclusion] The method had a high detection speed and accuracy,and could be used for the rapid detection of pathogen in food and environment. | Suzhen Zhu Xinghai Wu Liqing Zhao Jing Tang Weixing Ma Jian Zhang | 2013 | Meteorological and Environmental Research2013，4，2： | 1 |
| 18 | Development of Therapy for Duchenne Muscular Dystrophy显示文摘 | ZHANG Suzhen XIE Huiqi ZHOU Guangqian YANG Zhiming | 2007 | 中国修复重建外科杂志2007，21，2： | 1 |
| 19 | The function of targeted host genes determines the oncogenicity of HBV integration in hepatocellular carcinoma显示文摘 | Xiaojun Li Jiangbo Zhang Ziwei Yang Jingting Kang Suzhen Jiang Ting Zhang Tingting Chen Meng Li Xiangmei Chen Malcolm A. McCrae Hui Zhuang Fengmin Lu | 2013 | Journal of Hepatology2013，，： | 1 |
| 20 | Crustal velocity structures and their tectonic implications in different tectonic block regions of the Chinese mainland显示文摘In this paper,the typical velocity structures and average velocities of the crust in six different active tectonic block regions are presented on the basis of previous studies and their tectonic implications are discussed. The results show that different tectonic units have different features of crustal velocity structures. In general,there are low velocity distributions in the crust in regions with strong tectonic activities,and the scales of low velocity distributions are related to the tectonic activities. The average velocities are relatively low in such regions. This reflects strong crustal deformation and the variations of states of matter in the crust resulting from strong tectonic movements. These regions are also seismically active zones frequented by strong earthquakes. Therefore,studying crustal velocity structures of these regions is of great importance to understanding crustal geodynamic process and seismogenic tectonic background. | Xiankang Zhang Yonghong Duan Jinren Zhao Chengke Zhang Shixu Jia Jianshi Zhang Fuyun Wang Zhuoxin Yang Suzhen Pan | 2009 | Earthquake Science2009，22，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员