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| 1 | Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation显示文摘化疗经常被知道导致严重的胃肠的道毒性,但是内在的机制仍然保持不清楚。这研究作为一个代表性的代理人认为广泛地应用的细胞毒素的代理人是 irinotecan (CPT-11 ) 并且证明治疗从说明混合物的限制剂量的肠的毒性的肠导致双海滨 DNA 的巨大的版本。明确地,通过 exosome 分泌物释放的 self-DNA 进入天生的有免疫力的房间的 cytosol 并且激活 AIM2 (在黑瘤 2 不在) inflammasome。这导致成熟 IL-1 和 IL-18 分泌物并且导致肠的 mucositis 和迟了发作的腹泻。有趣地,在 AIM2 缺乏的老鼠或由象镇静药那样的一个药理学禁止者,没有影响 CPT-11 的 anticancer 功效, AIM2 发信号的废除显著地减少导致药的腹泻的发生。这些调查结果提供化疗怎么触发引起肠的毒性的天生的有免疫力的回答的机械学的卓见,并且揭示维持反瘤效果,但是围绕联系不利煽动性的反应的新化疗政体。 | Lian, Qiaoshi Xu, Jun Yan, Shanshan Huang, Min Ding, Honghua Sun, Xiaoyu Bi, Aiwei Ding, Jian Sun, Bing Geng, Meiyu | 2017 | Cell Research2017，27，6： | 18 |
| 2 | Identification of mecciRNAs and their roles in the mitochondrial entry of proteins显示文摘Mammalian mitochondria have small genomes encoding very limited numbers of proteins.Over one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the mitochondria.Here,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial genome.We provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported proteins.Known components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein entry.The expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein importation.mecciRNAs and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus. | Xu Liu Xiaolin Wang Jingxin Li Shanshan Hu Yuqi Deng Hao Yin Xichen Bao Qiangfeng Cliff Zhang Geng Wang Baolong Wang Qinghua Shi Ge Shan | 2020 | Science China(Life Sciences)2020，63，10： | 15 |
| 3 | OsRFPH2-10, a RING-H2 Finger E3 Ubiquitin Ligase, Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection显示文摘 | Lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li Qingqing Qin Rui Wang Shaoyi Ji Shanshan Zhao Qi Xie Chunhong Wei Can Xie Biao Ding Yi Li | 2014 | Molecular Plant2014，7，6： | 11 |
| 4 | Research on FBG-Based CFRP Structural Damage Identification Using BP Neural Network显示文摘增强的塑料(CFRP ) 组织的碳纤维的一个损坏鉴定系统用纤维布拉格被调查栅栏(FBG ) 传感器和背繁殖(BP ) 神经网络。FBG 传感器被使用构造察觉到的网络检测活跃使活动产生的结构的动态反应信号。损坏鉴定模型基于 BP 神经网络被造。Fourier 变换提取的动态信号特征是输入,并且损坏状态是模型的产量。而且,损坏被把 lumped 群众交给不同重量而不是导致真实损坏模仿,它被证实由有限元素分析(FEA ) 可行。最后,损坏鉴定系统与 300 公里在一个 CFRP 盘子上被验证 ?????????? 偍 ?????????? 瀠? 偍 ??? ‰ ?慐 吗?? | Xiangyi GENG Shizeng LU Mingshun JIANG Qingmei SUI Shanshan LV Hang XIAO Yuxi JIA Lei JIA | 2018 | Photonic Sensors2018，8，2： | 9 |
| 5 | Effects of surfactants on graphene oxide nanoparticles transport in saturated porous media显示文摘Transport behaviors of graphene oxide nanoparticles(GONPs) in saturated porous media were examined as a function of the presence and concentration of anionic surfactant(SDBS)and non-ionic surfactant(Triton X-100) under different ionic strength(IS). The results showed that the GONPs were retained obviously in the sand columns at both IS of 50 and200 mmol/L, and they were more mobile at lower IS. The presence and concentration of surfactants could enhance the GONP transport, particularly as observed at higher IS. It was interesting to see that the GONP transport was surfactant type dependent, and SDBS was more effective to facilitate GONP transport than Triton X-100 in our experimental conditions. The advection–dispersion–retention numerical modeling followed this trend and depicted the difference quantitatively. Derjaguin–Landau–Verwey–Overbeek(DLVO)interaction calculations also were performed to interpret these effects, indicating that secondary minimum deposition was critical in this study. | Wei Fan Xuehui Jiang Ying Lu Mingxin Huo Shanshan Lin Zhi Geng | 2015 | Journal of Environmental Sciences2015，27，9： | 6 |
| 6 | Expression Profiles of Six Circulating MicroRNAs Critical to Atherosclerosis in Patients With Subclinical Hypothyroidism: A Clinical Study显示文摘 | Xinhuan Zhang Shanshan Shao Houfa Geng Yong Yu Chenggang Wang Zhanfeng Liu Chunxiao Yu Xiuyun Jiang Yangxin Deng Ling Gao Jiajun Zhao | 2014 | The Journal of Clinical Endocrinology & Metabolism2014，，： | 1 |
| 7 | Research on Optimization of Random Forest Algorithm Based on Spark显示文摘As society has developed,increasing amounts of data have been generated by various industries.The random forest algorithm,as a classification algorithm,is widely used because of its superior performance.However,the random forest algorithm uses a simple random sampling feature selection method when generating feature subspaces which cannot distinguish redundant features,thereby affecting its classification accuracy,and resulting in a low data calculation efficiency in the stand-alone mode.In response to the aforementioned problems,related optimization research was conducted with Spark in the present paper.This improved random forest algorithm performs feature extraction according to the calculated feature importance to form a feature subspace.When generating a random forest model,it selects decision trees based on the similarity and classification accuracy of different decision.Experimental results reveal that compared with the original random forest algorithm,the improved algorithm proposed in the present paper exhibited a higher classification accuracy rate and could effectively classify data. | Suzhen Wang Zhanfeng Zhang Shanshan Geng Chaoyi Pang | 2022 | Computers, Materials & Continua2022，，5： | 1 |
| 8 | Ataxin-10 is involved in Golgi membrane dynamics显示文摘Cytokinesis is the final stage of cell division that generates two daughter cells(Fededa and Gerlich,2012).The textbook version di-vides the plant and animal cell cytokinesis into two categories.Plant cells form a mid-zone phragmoplast via vesicle delivering and fusion,and cell wall materials are thus deposited.Animal cells form actomyosin contractile rings,which are the sole force that drives abscission.However,recent evidence has been mounting and pinpointing a pivotal role of membrane transport and subse- | Jie Tian Yingxin Shi Shanshan Nai Qizhi Geng Leiliang Zhang Gong-Hong Wei Xingzhi Xu Jing Li | 2017 | Journal of Genetics and Genomics2017，44，11： | 0 |
| 9 | A dual-modal probe for NIR fluorogenic and ratiometric photoacoustic imaging of Cys/Hcy in vivo显示文摘Biothiols, such as cysteine(Cys) and homocysteine(Hcy), play vital roles in biological homeostasis and are closely related to various pathological and physiological processes in the living systems. Therefore, the in vivo detection of biothiols is of great importance for early diagnosis of diseases and assessment of disease progression. In this work, we developed a near-infrared(NIR) fluorescence and photoacoustic dual-modal molecular probe(NIR-S) that can be specifically activated by Cys or Hcy. The aryl-thioether substituted cyanine probe can undergo nucleophilic substitution and Smiles rearrangement reaction, resulting in specific turn-on NIR fluorescence and ratiometric photoacoustic responses for Hcy/Cys. Thus, NIR-S not only realizes the specific NIR fluorescence and photoacoustic dual mode imaging to detect Hcy/Cys in solution, but also can be applied to living cells and mice to detect Hcy/Cys. This work provided a practical tool to detect Hcy/Cys levels in vivo, which would be beneficial for the early diagnosis and progress of diseases. | Hongbao Fang Yuncong Chen Yanjun Wang Shanshan Geng Shankun Yao Dongfan Song Weijiang He Zijian Guo | 2020 | Science China Chemistry2020，63，5： | 0 |
| 10 | Preparation and evaluation of an enzymatic microreactor based on HILIC matrix for digestion and identification of proteins显示文摘In the present study,a new enzymatic microreactor is developed by immobilizing trypsin on the matrix-HILIC (hydrophilic interaction chromatography).The influences of different types of buffer solutions (borate,Tris·HCl,and phosphate),their concentrations and pH values on the immobilizing rate and the activity of immobilized trypsin were investigated.The optimal condition for off-line immobilization of trypsin on matix-HILIC was Tris·HCl buffer (20 mmol/L,pH 8.0),and then,under the optimal condition,an enzymatic microreactor was prepared by trypsin dynamically immobilized on HILIC matrix which was packed in a Peeksil column.It can be found that the microreactor possessed high hydrolytic activity according to the hydrolysis results of N-α-benzoyl-DL-arginine P-nitroanilide (BAPNA),a substrate of trypsin.Moreover,bovine serum albumin (BSA),cytochrome C and myoglobin as standard proteins were chosen to characterize the enzymolysis of the microreactor demonstrating the high enzymolysis efficiency by this enzymatic microreactor.Besides,the deactivated trypsin can be easily eluted from the matrix-HILIC to re-immobilize trysin,which is highly cost-effective in the experiment.All the results show that the new enzymatic microreactor associated with HPLC-MS techniques can realize online enzymolysis of proteins,and the time to analyze and identify the proteins is greatly shortened. | WANG ShanShan LI Qin LU XueFei LIU Tong ZHANG WeiBo GENG LiNa DENG YuLin | 2010 | Chinese Science Bulletin2010，55，10： | 0 |
| 11 | Characterization of the core microflora and nutrient composition in packaged pasteurized milk products during storage显示文摘Pasteurized milk contains complex microbial communities affected by sterilization and storage conditions.This complex microflora may be the possible reason that pasteurized dairy products are highly prone to spoilage.In this study,packaged pasteurized milk products collected from dairy processing factories in China were stored at 0,4,10,15,and 25℃ for 0−15 days and subjected to microbial identification using high-throughput sequencing.Accordingly,6 phyla and 44 genera were identified as the dominant microbiota.Moreover,the changes in nutritional composition of the pasteurized milk,including in 16 free amino acids,7 taste values,and 8 chemical constituents,were analyzed using principal component and multi-factor analyses.The Pearson correlation analysis identified Pseudomonas,Aeromonas,Paenibacillus,and Serratia genera as the core functional microbiota that significantly affects the nutritional composition of pasteurized milk.Hence,the results provide a comprehensive understanding of the safety and shelf-life of stored pasteurized milk. | Ruixue Ding Shanshan Yang Lijuan Geng Yumeng Liu Baoping He Liyun Liu Xiqing Yue Rina Wu Junrui Wu | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 12 | A dynamically stable self-healable wire based on mechanical-electrical coupling显示文摘The rise in wearable electronics has witnessed the advancement of self-healable wires,which are capable of recovering mechanical and electrical properties upon structural damage.However,their highly fluctuating electrical resistances in the range of hundreds to thousands of ohms under dynamic conditions such as bending,pressing,stretching and tremoring may seriously degrade the precision and continuity of the resulting electronic devices,thus severely hindering their wearable applications.Here,we report a new family of self-healable wires with high strengths and stable electrical conductivities under dynamic conditions,inspired by mechanical-electrical coupling of the myelinated axon in nature.Our self-healable wire based on mechanical-electrical coupling between the structural and conductive components has significantly improved the electrical stability under dynamic scenarios,enabling precise monitoring of human health status and daily activities,even in the case of limb tremors from simulated Parkinson’s disease.Our mechanical-electrical coupling strategy opens a new avenue for the development of dynamically stable electrodes and devices toward real-world wearable applications. | Shuo Wang Zhaofeng Ouyang Shitao Geng Yan Wang Xiaoju Zhao Bin Yuan Xiao Zhang Qiuchen Xu Chengqiang Tang Shanshan Tang Han Miao Huisheng Peng Hao Sun | 2024 | National Science Review2024，11，3： | 0 |
| 13 | Characterization of the cyp19a1a gene from a BAC sequence in half-smooth tongue sole (Cynoglossus semilaevis) and analysis of its conservation among teleosts显示文摘The cyp19a1a gene encodes an aromatase that plays a key role in sex differentiation of the gonad. The first bacterial artificial chromosome (BAC) sequence of half-smooth tongue sole (Cynoglossus semilaevis) containing the intact cyp19a1a gene was reported and the conservation and synteny of the cyp19a1a gene among teleosts were analyzed in the study. The BAC is 107 367 bp in size, with an overall guanine-cytosine (GC) content of 43.44%, and contains 4.38% transposable elements. Nine genes were predicted, including seven functional genes and two hypothetical genes. The cyp19a1a gene of all tested teleosts has nine exons and eight introns, and potential binding sites flanking the transcriptional start site are conserved. The expression pattern among teleosts is also similar during ovarian differentiation. Synteny analysis revealed a conserved gene cluster PKH4B-SL9A5-FHOD3-CEBPG-CEBPA among teleosts. These findings suggest that, among teleosts, cyp19a1a genes not only have similar genomic structures, but also have conserved functions. The genomic environment of cyp19a1a in tongue sole is not universal in teleosts, reflecting the particular evolution of tongue sole cyp19a1a after it diverged from the other teleosts. | SHAO Changwei LIU Geng LIU Shanshan LIU Changlin CHEN Songlin | 2013 | Acta Oceanologica Sinica2013，32，8： | 0 |
| 14 | A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes显示文摘Aging increases the risk ofliver diseases and systemic susceptibility to aging-related diseases.However,cell type-specific changes and the underlying mechanism of liver aging in higher vertebrates remain incompletely characterized.Here,we constructed the first single-nucleus transcriptomic landscape of primate liver aging,in which we resolved cell type-specific gene expression fluctuation in hepatocytes across three liver zonations and detected aberrant cell-cell interactions between hepatocytes and niche cells.Upon in-depth dissection of this rich dataset,we identifed impaired lipid metabolism and upregulation of chronic inflammation-related genes prominently associated with declined liver functions during aging.In particular,hyperactivated sterol regulatory element-binding protein(SREBP)signaling was a hallmark of the aged liver,and consequently,forced activation of SREBP2 in human primary hepatocytes recapitulated in vivo aging phenotypes,manifesting as impaired detoxification and accelerated cellular senescence.This study expands our knowledge of primate liver aging and informs the development of diagnostics and therapeutic interventions for liver aging and associated diseases. | Shanshan Yang Chengyu Liu Mengmeng Jiang Xiaoqian Liu Lingling Geng Yiyuan Zhang Shuhui Sun Kang Wang jian Yin Shuai Ma Si Wang Juan Carlos Izpisua Belmonte Weiqi Zhang Jing Qu Guang-Hui Liu | 2024 | Protein & Cell2024，15，2： | 0 |
| 15 | Human EsC-derived vascular cells promote vascular regeneration in a HIF-1a dependent manner显示文摘Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological conditions.However,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely elusive.Here,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(MsCs),as a platform for discovering cell type-specific hypox-ia-induced response mechanisms.Through comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular regeneration.We found human MSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic processes.Altogether,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage. | Jinghui Lei Xiaoyu Jiang Daoyuan Huang Ying Jing Shanshan Yang Lingling Geng Yupeng Yan Fangshuo Zheng Fang Cheng Weiqi Zhang Juan Carlos Izpisua Belmonte Guang-Hui Liu Si Wang Jing Qu | 2024 | Protein & Cell2024，15，1： | 0 |
| 16 | A focused transcriptomic analysis of the TP53-regulated genes identifies the GPI-anchored molecule-like protein(GML)as a favorable prognostic predictor of lung cancer显示文摘Lung cancer is the most common cause of cancer-related mortality worldwide.1 The current clinical staging systems cannot adequately predict the prognosis of patients with lung cancer,making it difficult to individualize the clinical treatment of the disease,resulting in poorer outcomes. | Yutong Wang Shanshan Wang Yanmei Cui Jie Zhang Shuang Geng Honglei Yin Simiao Zhang Qiufang Li Yunliang Wang | 2023 | Genes & Diseases2023，10，2： | 0 |
| 17 | Multi-factor Effects on Layout of Solar Collector显示文摘Considering the influencing factors of the layout of solar collectors such as the tilt angles,azimuth angles,spacing between collectors and the number of collector rows,a mathematical model of the collected energy of the solar collector with limited area on the horizontal plane is established.Two different optimized models including the cost benefit model and the minimum annual auxiliary heating energy model are conducted in this paper.The results show that,the collected energy in a year could increase with the increase of the number of collector rows.And the collected solar radiation in a year increases firstly and then decreases with the increase of the collector tilt angles.Furthermore,the collected solar radiation in a year increases firstly and then decreases with the continuous increase of the azimuth angles from -90° to 90°.Taking Nanjing city of China as an example,based on the optimized objective of maximum benefit,the optimal layout of the solar collector array in the area of 200 m2 should include:the number of collector rows is 8,the tilt angle is 40° and the azimuth angle is 0°.Meanwhile,the optimal methods for the optimized objective of minimum annual auxiliary heating energy should include:the number of collector rows is 9,the tilt angle is 50°,and the azimuth angle is 0°. | SHI Hong MA Suning GAO Zhigang GENG Shanshan | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，3： | 0 |
| 18 | A Dynamic Memory Allocation Optimization Mechanism Based on Spark显示文摘Spark is a distributed data processing framework based on memory.Memory allocation is a focus question of Spark research.A good memory allocation scheme can effectively improve the efficiency of task execution and memory resource utilization of the Spark.Aiming at the memory allocation problem in the Spark2.x version,this paper optimizes the memory allocation strategy by analyzing the Spark memory model,the existing cache replacement algorithms and the memory allocation methods,which is on the basis of minimizing the storage area and allocating the execution area according to the demand.It mainly including two parts:cache replacement optimization and memory allocation optimization.Firstly,in the storage area,the cache replacement algorithm is optimized according to the characteristics of RDD Partition,which is combined with PCA dimension.In this section,the four features of RDD Partition are selected.When the RDD cache is replaced,only two most important features are selected by PCA dimension reduction method each time,thereby ensuring the generalization of the cache replacement strategy.Secondly,the memory allocation strategy of the execution area is optimized according to the memory requirement of Task and the memory space of storage area.In this paper,a series of experiments in Spark on Yarn mode are carried out to verify the effectiveness of the optimization algorithm and improve the cluster performance. | Suzhen Wang Shanshan Geng Zhanfeng Zhang Anshan Ye Keming Chen Zhaosheng Xu Huimin Luo Gangshan Wu Lina Xu Ning Cao | 2019 | Computers, Materials & Continua2019，，8： | 0 |
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