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| 1 | Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization显示文摘AIM: To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS: A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospectively enrolled. HCC was diagnosed based on the diagnostic guidelines issued by the 2005 American Association for the Study of Liver Diseases. HCC rupture was defined as disruption of the peritumoral liver capsule with enhanced fluid collection in the perihepatic area adjacent to the HCC by dynamic liver computed tomography, and when abdominal paracentesis showed an ascitic red blood cell count of > 50000 mm 3 /mL in bloody fluid. RESULTS: Of the 54 patients, 6 (11.1%) underwent surgery, 25 (46.3%) TAE, and 23 (42.6%) supportive care. The 2-, 4and 6-mo cumulative survival rates at 2, 4 and 6 mo were significantly higher in the surgery (60%, 60% and 60%) or TAE (36%, 20% and 20%) groups than in the supportive care group (8.7%, 0% and 0%), respectively (each, P < 0.01), and tended to be higher in the surgical group than in the TAE group. Multivariate analysis showed that serum bilirubin (HR = 1.09, P < 0.01), creatinine (HR = 1.46, P = 0.04), and vasopressor requirement (HR = 2.37, P = 0.02) were significantly associated with post-treatment mortality, whereas surgery (HR = 0.41, P < 0.01), and TAE (HR = 0.13, P = 0.01) were inversely associated with posttreatment mortality. CONCLUSION: Post-treatment survival after surgery or TAE was found to be better than after supportive care, and surgery tended to provide better survival benefit than TAE. | Young-Joo Jin Jin-Woo Lee Seoung-Wook Park Jung Il Lee Don Haeng Lee Young Soo Kim Soon Gu Cho Yong Sun Jeon Kun Young Lee Seung-Ik Ahn | 2013 | World Journal of Gastroenterology2013，19，28： | 23 |
| 2 | Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis显示文摘AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients. | Soon Kyu Lee Myeong Jun Song Seok Hyun Kim Byung Seok Lee Tae Hee Lee Young Woo Kang Suk Bae Kim Il Han Song Hee Bok Chae Soon Young Ko Jae Dong Lee | 2017 | World Journal of Gastroenterology2017，23，13： | 14 |
| 3 | Retrospective analysis of extra-gastrointestinal stromal tumors显示文摘AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South Korea.METHODS:A total of 51 patients with an EGIST were identified.The clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were analyzed.RESULTS:The median age was 55 years(range:29-80years),and male:female ratio was 1:1.04.The most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon 11mutation.Among 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free survival.Of the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as'high risk'according to the risk criteria.However,the relapse-free survival was not different(P=0.157)between two groups.CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features. | Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park | 2015 | World Journal of Gastroenterology2015，21，6： | 9 |
| 4 | Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature显示文摘Primary hepatic neuroendocrine carcinoma(NEC) with concurrent occurrence of hepatocellular carcinoma(HCC) of the liver is very rare. Only 8 cases have been reported in the literature. Concurrent occurrence of HCC and NEC in the liver is classified as combined type or collision type by histological distributional patterns; only 2 cases have been reported. Herein, we report a case of collision type concurrent occurrence of HCC and NEC, in which primary hepatic NEC was in only a small portion of the nodule, which is different from the 2 previously reported cases. A 72-year-old male with chronic hepatitis C was admitted to our hospital for a hepatic mass detected by liver computed tomography(CT) at another clinic. Because the nodule was in hepatic segment 3 and had proper radiologic findings for diagnosis of HCC, including enhancement in the arterial phase and wash-out in the portal and delay phases, the patient was treated with laparoscopic left lateral sectionectomy. The pathology demonstrated that the nodule was 2.5 cm and was moderately differentiated HCC. However, a 3 mm-sized focal neuroendocrine carcinoma was also detected on the capsule of the nodule. The tumor was concluded to be a collision type with HCC and primary hepatic NEC. After the surgery, for follow-up, the patient underwent a liver CT every 3 mo. Five multiple nodules were found in the right hepatic lobe on the follow-up liver CT 6 mo post-operatively. As the features of the nodules in the liver CT and MRI were different from that of HCC, a liver biopsy was performed. Intrahepatic recurrent NEC was proven after the liver biopsy, which showed the same pathologic features with the specimen obtained 6 mo ago. Palliative chemotherapy with a combination of etoposide and cisplatin has been administered for 4 months, showing partial response. | Gyu Ho Choi Sun Young Ann Soon Il Lee Suk BaeKim Il Han Song | 2016 | World Journal of Gastroenterology2016，22，41： | 8 |
| 5 | Acute idiopathic pancreatitis in pregnancy:A case study显示文摘Acute pancreatitis during pregnancy is a rare event,and can be associated with high maternal mortality and fetal loss.Gallstone disease is thought to be the most common causative factor of acute pancreatitis,but,in many cases,the cause remains unclear.We report a case of a 36-year-old woman at 35 wk of gestation,who presented with severe pain confined to the upper abdomen and radiating to the back.The patient was diagnosed with acute idiopathic pancreatitis,which was managed conservatively;she recovered within several days and then delivered a healthy baby.Therefore it is important to consider acute pancreatitis when a pregnant woman presents with upper abdominal pain,nausea and vomiting in order to improve fetal and maternal outcomes for patients with acute pancreatitis. | Ji Yeon Kim Sung Hoon Jung Hyung Wook Choi Dong Jin Song Cheol Yoon Jeong Dong Hyun Lee Il Soon Whang | 2014 | World Journal of Gastroenterology2014，20，43： | 4 |
| 6 | Antioxidant effects of fermented sea tangle ( Laminaria japonica ) by Lactobacillus brevis BJ20 in individuals with high level of γ-GT: A randomized, double-blind, and placebo-controlled clinical study显示文摘 | Young Mi Kang Bae-Jin Lee Jung Il Kim Byung-Hyouk Nam Jae-Young Cha Young-Mog Kim Chang-Bum Ahn Jae-Suk Choi In Soon Choi Jae-Young Je | 2011 | Food and Chemical Toxicology (-)2011，，3： | 2 |
| 7 | Adding adefovir vs. switching to entecavir for lamivudine‐resistant chronic hepatitis B ( ACE study): a 2‐year follow‐up randomized controlled trial显示文摘 | Hyung Joon Yim Yeon Seok Seo Eileen L. Yoon Chang Wook Kim Chang Don Lee Sang Hoon Park Myung Seok Lee Choong Kee Park Hee Bok Chae Moon Young Kim Soon Koo Baik Yun Soo Kim Ju Hyun Kim Jung Il Lee Jin Woo Lee Sun Pyo Hong Soon Ho Um | 2013 | Liver Int2013，，2： | 2 |
| 8 | Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma显示文摘AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was designed.Thirty-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and 8.Treatment was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent withdrawal.The primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely excluded.Disease control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), respectively.CONCLUSION: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC. | Min-Young Lee Ki Sun Jung Hae Su Kim Ji Yun Lee Sung Hee Lim Moonjin Kim Hyun Ae Jung Sung Min Kim Jong Mu Sun Myung-Ju Ahn Jeeyun Lee Se Hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung Ahn Do Hyoung Lim Soon Il Lee Keon Woo Park | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 9 | Adefovir and Lamivudine Combination Therapy in Patients with Entecavir-Resistant Chronic Hepatitis B: Antiviral Responses and Evolution of Mutations显示文摘 | Yim Hyung Joon Lee Hyun Jung Suh Sang Jun Seo Yeon Seok Kim Chang Wook Lee Chang Don Park Sang Hoon Lee Myung Seok Park Choong Kee Chae Hee Bok Kim Moon Young Baik Soon Koo Kim Yun Soo Kim Ju Hyun Lee Jung Il Lee Jin Woo Hong Sun Pyo Um | 2014 | Intervirology2014，，5： | 1 |
| 10 | Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study显示文摘 | Hyun Joo Jang Jung Han Kim Hun Ho Song Kyung Hee Woo Mi Kim Sea Hyub Kae Jin Lee Ji Wong Cho Jung Hun Kang Soon Il Lee Soo Jung Gong Jung Ae Lee Dae Young Zang | 2008 | Digestive Diseases and Sciences2008，，2： | 1 |
| 11 | Recurrence of hepatitis B is associated with cumulative corticosteroid dose and chemotherapy against hepatocellular carcinoma recurrence after liver transplantation显示文摘 | Nam‐Joon Yi Kyung‐Suk Suh Jai Young Cho Choon Hyuck Kwon Kwang‐Woong Lee Jae Won Joh Suk‐Koo Lee Soon Il Kim Kuhn Uk Lee | 2007 | Liver Transpl2007，，3： | 1 |
| 12 | Pharmacological mechanism responsible for the Atractylodes japonica -induced distal colonic contraction in rats显示文摘 | Keun Han Choi Seung Il Jeong Jun Ho Lee Byung Soon Hwang Sang Jun Kim Seoul Lee Bong Kyu Choi Kyu Yong Jung | 2010 | Phytomedicine2010，，5： | 1 |
| 13 | Phase II study of radiotherapy with three-dimensional conformal boost concurrent with paclitaxel and cisplatin for Stage IIIB non–small-cell lung cancer显示文摘 | Young Seok Kim Sang Min Yoon Eun Kyung Choi Byong Yong Yi Jong Hoon Kim Seung Do Ahn Sang-wook Lee Seong Soo Shin Jung Shin Lee Cheolwon Suh Sang-We Kim Dong Soon Kim Woo Sung Kim Heon Joo Park Charn Il Park | 2005 | International Journal of Radiation Oncology, Biology, Physics2005，，1： | 1 |
| 14 | Antioxidant effects of fermented sea tangle ( Laminaria japonica ) by Lactobacillus brevis BJ20 in individuals with high level of γ-GT: A randomized, double-blind, and placebo-controlled clinical study显示文摘 | Young Mi Kang Bae-Jin Lee Jung Il Kim Byung-Hyouk Nam Jae-Young Cha Young-Mog Kim Chang-Bum Ahn Jae-Suk Choi In Soon Choi Jae-Young Je | 2011 | 2011 (3-4)2011，，3： | 1 |
| 15 | Phase II study of docetaxel and cisplatin combination chemotherapy in metastatic gastric cancer显示文摘 | Keon Woo Park Jin Seok Ahn Young Suk Park Jeeyun Lee Jung Hoon Kang Joon Oh Park Ho Yeong Lim Young-Hyuck Im Won Ki Kang Keunchil Park Soon Il Lee | 2007 | Cancer Chemotherapy and Pharmacology2007，，1： | 1 |
| 16 | A Ds-insertion mutant of OSH6 (Oryza sativa Homeobox 6) exhibits outgrowth of vestigial leaf-like structures, bracts, in rice显示文摘 | Sung Han Park Chul Min Kim Byoung Il Je Su Hyun Park Soon Ju Park Hai Long Piao Yuan-hu Xuan Mi Sook Choe Kouji Satoh Shoshi Kikuchi Kon Ho Lee Young Soon Cha Byung Ohg Ahn Hyeon So Ji Doh Won Yun Myung Chul Lee Seok-cheol Suh Moo Young Eun Chang-deok Han | 2007 | Planta2007，，1： | 1 |
| 17 | Phase II study of docetaxel and cisplatin combination chemotherapy in metastatic gastric cancer显示文摘 | Keon Woo Park Jin Seok Ahn Young Suk Park Jeeyun Lee Jung Hoon Kang Joon Oh Park Ho Yeong Lim Young-Hyuck Im Won Ki Kang Keunchil Park Soon Il Lee | 2007 | Cancer Chemotherapy and Pharmacology2007，，1： | 1 |
| 18 | Gel characterisation and in vivo evaluation of minocycline-loaded wound dressing with enhanced wound healing using polyvinyl alcohol and chitosan显示文摘 | Jung Hoon Sung Ma-Ro Hwang Jong Oh Kim Jeong Hoon Lee Yong Il Kim Jeong Hoon Kim Sun Woo Chang Sung Giu Jin Jung Ae Kim Won Seok Lyoo Sung Soo Han Sae Kwang Ku Chul Soon Yong Han-Gon Choi | 2010 | International Journal of Pharmaceutics2010，，1： | 1 |
| 19 | Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study显示文摘 | Sung Yong Oh Won Seog Kim Jin Seok Kim Seok Jin Kim Suee Lee Dae Ho Lee Jong-Ho Won In Gyu Hwang Min Kyoung Kim Soon Il Lee Yee Soo Chae Deok-Hwan Yang Hye Jin Kang Chul Won Choi Jinny Park Hyo Jung Kim Jung Hye Kwon Ho Sup Lee Gyeong-Won Lee Hyeon Seok E | 2010 | International Journal of Hematology2010，，3： | 1 |
| 20 | Clinical features and predictors of clinical outcomes in K orean patients with C rohn’s disease: A K orean A ssociation for the S tudy of I ntestinal D iseases multicenter study显示文摘 | Chang Mo Moon Dong Il Park Eun Ran Kim Young‐Ho Kim Chang Kyun Lee Suck‐Ho Lee Jae Hak Kim Kyu‐Chan Huh Sung‐Ae Jung Soon Man Yoon Hyun Joo Song Hyun Joo Jang You Sun Kim Kang‐Moon Lee Jeong Eun Shin | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
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