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| 1 | Salt Stress in Arabidopsis: Lipid Transfer Protein AZI1 and Its Control by Mitogen-Activated Protein Kinase MPK3显示文摘应付环境挑战的一个植物能力大部分依靠通过 mitogen-activatedprotein kinase (MAPK ) 的传播串联的信号。在 Arabidopsis thaliana, MPK3 强烈特别地与众多的不能生活、关於生命的压力回答被联系。MPK3 substratesis 的鉴定向在植物改进压力抵抗的一个里程碑。这里,我们描绘 AZI1,类脂化合物转移蛋白质(LTP )-relatedhybrid 充满脯氨酸的蛋白质(HyPRP ) , MPK3 的一个新奇目标。AZI1 是由在 vitro 的 MPK3 的 phosphorylated。作为记录 byco-immunoprecipitation 和双分子的荧光互补实验, AZI1 与 MPK3 交往在 planta 形成 proteincomplexes。而且, azi1 的空异种是过分敏感的腌应力,当 AZI1-overexpressing 线是时显著地更容忍。在基因背景部分减轻的 mpk3 的 AZI1 overexpression 这变异,却功能的 MPK3 的盐过分敏感的显型出现为授与 AZI1 的坚韧性的最大程度要求的 tobe。尤其是,这坚韧性不在损坏 normaldevelopment 的情况下来。Immunoblot 和 RTPCR 数据指向 AZI1 abundance.Key 词的 MPK3 同样积极的管理者的一个角色: | Andrea Pitzschke Sneha Datta Helene Persak | 2014 | Molecular Plant2014，7，4： | 13 |
| 2 | New-onset diabetes mellitus after kidney transplantation:Current status and future directions显示文摘A diagnosis of new-onset diabetes after transplantation(NODAT) carries with it a threat to the renal allograft,as well as the same short-and long-term implications of type 2 diabetes seen in the general population.NODAT usually occurs early after transplantation,and is usually diagnosed according to general population guidelines.Non-modifiable risk factors for NODAT include advancing age,African American,Hispanic,or South Asian ethnicity,genetic background,a positive family history for diabetes mellitus,polycystic kidney disease,and previously diagnosed glucose intolerance.Modifiable risk factors for NODAT include obesity and the metabolic syndrome,hepatitis C virus and cytomegalovirus infection,corticosteroids,calcineurin inhibitor drugs(especially tacrolimus),and sirolimus.NODAT affects graft and patient survival,and increases the incidence of post-transplant cardiovascular disease.The incidence and impact of NODAT can be minimized through pre-and post-transplant screening to identify patients at higher risk,including by oral glucose tolerance tests,as well as multi-disciplinary care,lifestyle modification,and the use of modified immunosuppressive regimens coupled with glucose-lowering therapies including oral hypoglycemic agents and insulin.Since NODAT is a major cause of post-transplant morbidity and mortality,measures to reduce its incidence and impact have the potential to greatly improve overall transplant success. | Sneha Palepu G V Ramesh Prasad | 2015 | World Journal of Diabetes2015，6，3： | 8 |
| 3 | Burden of care in caregivers of patients with alcohol use disorder and schizophrenia and its association with anxiety, depression and quality of life显示文摘Background Caregivers play a pivotal role in providing care for mentally ill patients.Increase in caregiver burden can make them vulnerable to mental illness themselves.Aims We assessed the severity of burden of care and its association with depression,anxiety and quality of life among caregivers of patients with alcohol use disorder(AUD)and schizophrenia.Methods This was an observational,cross-sectional,single-centred study of 50 consecutive caregivers of patients with AUD and schizophrenia.Participants were recruited from the psychiatry outpatient department of a tertiary care hospital between January and June 2017.The caregivers were further assessed by demographic details,Hospital Anxiety Depression Scale for assessment of depression and anxiety,Zarit Burden Interview for assessment of caregiver burden and WHO Quality Of Life-BREF for assessment of quality of life.Statistical data were analysed using GraphPad InStat V.3.06(California).Multiple linear regression analysis was applied to identify the predictors of caregiver burden.Results Burden of care experienced by caregivers of patients with AUD is as high as that of caregivers of patients with schizophrenia(U=1142.5,p=0.46).Caregivers experiencing high burden of care are likely to have symptoms of anxiety(U=22,p<0.001),depression(U=32,p<0.001)and poor quality of life(U=84.5,p<0.001).Female caregivers are likely to experience higher burden of care(U=819.5,p=0.006).For caregivers of patients with schizophrenia,anxiety,environmental health,socioeconomic status and patients,occupation can predict burden of care,while for caregivers of patients with AUD,depression and environmental health can predict burden of care.Conclusion Our study suggests that caregivers of patients with AUD experience burden of care as high as that of caregivers of patients with schizophrenia.Caregivers with high burden of care are more likely to have depression,anxiety and poor quality of life.Trial registration number CTRI/2017/03/008224. | Sneha Vadher Rishi Desai Bharat Pancha Ashok Vala Imran Jahangirali Ratnani Mihir P Rupani Kinjal Vasava | 2020 | General Psychiatry2020，33，4： | 7 |
| 4 | Cellulose based polymers in development of amorphous solid dispersions显示文摘Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives as stabilizers, thus highlighting their importance in generation of amorphous solid dispersions. These polymers offer numerous advantages like drug solubilization, crystallization inhibition and improvement in release patterns of drugs. Exploring their potential and exploiting their chemistry and p H responsive behaviour have led to the synthesis of new derivatives that has broadened the scope of the use of cellulose derivatives in amorphous formulation development. The present review aims to provide an overview of different mechanisms by which these cellulose derivatives inhibit the crystallization of drugs in the solid state and from supersaturated solution. A summary of different categories of cellulose derivatives along with the newly explored polymers has been provided. A special segment on strengths, weaknesses, opportunities, and threats(SWOT) analysis and critical quality attributes(CQAs) which affect the performance of the cellulose based amorphous solid dispersion will aid the researchers in identifying the major challenges in the development of cellulose based solid dispersion and serve as a guide for further formulation development. | Rahul B Chavan Sneha Rathi Vaskuri G S Sainaga Jyothi Nalini R Shastri | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 5 |
| 5 | Innate and adaptive T cells in influenza disease显示文摘流行性感冒是一个主要全球健康问题,引起呼吸的道的感染,经常导致急性肺病,威胁生活的复杂并发症甚至死亡。在最后七十年,种痘策略被利用了保护人免受流行性感冒的复杂并发症的伤害,特别在严重疾病的高风险的组。当当前的种痘政体得到紧张特定的抗体回答时,他们没能产生对季节、流行、鸟的病毒跨保护。而且,设计产生流行性感冒特定的 T 房间回答的疫苗还有待于被优化。在自然感染期间,在适应有免疫力的回答(T 细胞和生产抗体的 B 细胞) 完成病毒的清理和宿主恢复以前,病毒的复制被天生的免疫开始控制。适应 T 和 B 房间维持免疫学的记忆并且对随后的感染向保护提供相关流行性感冒病毒。最近的研究也在控制流行性感冒并且连接天生、适应的有免疫力的机制使天生的 T 房间(MAIT 房间, gd T 房间,和 NKT 房间) 的角色清楚些,因此为种痘策略使他们成为吸引人的目标。我们象适应 CD8 + 和 CD4 + T 房间一样在流行性感冒特定的天生的 MAIT 和 gd T 房间上总结当前的知识,并且讨论这些回答怎么能被新奇疫苗的策略利用对不同流行性感冒紧张和子类型得到跨 protective 免疫。 | Simone Nfissing Sneha Sant Marios Koutsakos Kanta Subbarao Thi H.O. Nguyen Katherine Kedzierska | 2018 | Frontiers of Medicine2018，12，1： | 5 |
| 6 | Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of “personalized oncology”显示文摘'Personalized oncology' is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of 'radiomics/radiogenomics'. Diffusionweighted imaging is one such technique which capitalizes on the tendency of water protons to diffuse randomly in a given system. This technique has revolutionized oncological imaging, by giving vital qualitative and quantitative information regarding tumor biology which helps in detection, characterization and post treatment surveillance of the lesions and challenging the notion that 'one size fits all'. It has been applied at various sites with different clinical experience. We hereby present a brief review of this novel functional imaging tool, with its application in 'personalized oncology'. | Abhishek Mahajan Sneha S Deshpande Meenakshi H Thakur | 2017 | World Journal of Radiology2017，9，6： | 3 |
| 7 | Is colonic lavage a suitable alternative for left-sided colonic emergencies?显示文摘BACKGROUND The use of intra-operative colonic lavage(IOCL)with primary anastomosis remains controversial in the emergency left-sided large bowel pathologies,with alternatives including Hartmann’s procedure,manual decompression and subtotal colectomy.AIM To compare the peri-operative outcomes of IOCL to other procedures.METHODS Electronic databases were searched for articles employing IOCL from inception till July 13,2020.Odds ratio and weighted mean differences(WMD)were estimated for dichotomous and continuous outcomes respectively.Single-arm meta-analysis was conducted using DerSimonian and Laird random effects.RESULTS Of 28 studies were included in this meta-analysis,involving 1142 undergoing IOCL,and 634 other interventions.IOCL leads to comparable rates of wound infection when compared to Hartmann’s procedure,and anastomotic leak and wound infection when compared to manual decompression.There was a decreased length of hospital stay(WMD=-7.750;95%CI:-13.504 to-1.996;P=0.008)compared to manual decompression and an increased operating time.Single-arm meta-analysis found that overall mortality rates with IOCL was 4%(CI:0.03-0.05).Rates of anastomotic leak and wound infection were 3%(CI:0.02-0.04)and 12%(CI:0.09-0.16)respectively.CONCLUSION IOCL leads to similar rates of post-operative complications compared to other procedures.More extensive studies are needed to assess the outcomes of IOCL for emergency left-sided colonic surgeries. | Hui Yu Tham Wen Hui Lim Sneha Rajiv Jain Cheng Han Mg Snow Yunni Lin Jie Ling Xiao Fung Joon Foo Kar Yong Wong Choon Seng Chong | 2021 | World Journal of Gastrointestinal Surgery2021，13，4： | 3 |
| 8 | High Risk Factors of Pancreatic Carcinoma显示文摘Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer(PC) is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists. | Soriba Naby Camara 殷涛 杨明 李响 龚琼 周静 赵刚 杨智勇 Tajoo Aroun Martin Kuete Sonam Ramdany Alpha Kabinet Camara Aissatou Taran Diallo 冯珍 宁辛 熊炯新 陶京 钦琪 周伟 崔静 黄敏 郭尧 勾善淼 王博 刘涛 Ohoya Etsaka Terence Olivier Tenin Conde Mohamed Cisse Aboubacar Sidiki Magassouba Sneha Ballah Naby Laye Moussa Keita Ibrahima Sory Souare Aboubacar Toure Sadamoudou Traore Abdoulaye Korse Balde Namory Keita Naby Daouda Camara Dusabe Emmanuel 吴河水 王春友 | 2016 | Journal of Huazhong University of Science and Technology(Medical Sciences)2016，36，3： | 3 |
| 9 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 10 | Study of cyanide removal from contaminated water using zinc peroxide nanomaterial显示文摘The present study highlights the potential application of zinc peroxide(ZnO_2)nanomaterial as an efficient material for the decontamination of cyanide from contaminated water. A process patent for ZnO_2 synthesis has been granted in United States of America(US Patent number 8,715,612; May 2014),South Africa,Bangladesh,and India. The ZnO_2 nanomaterial was capped with polyvinylpyrrolidone(PVP)to control the particle size. The PVP capped ZnO_2nanomaterial(PVP-ZnO_2)before and after adsorption of cyanide was characterized by scanning electron microscope,transmission electron microscope,X-ray diffractometer,Fourier transform infrared spectroscopy and time of flight-secondary ion mass spectrometry. The remaining concentration of cyanide after adsorption by PVP-ZnO_2 was determined using ion chromatograph. The adsorption of cyanide over PVP-ZnO_2 was also studied as a function of p H,adsorbent dose,time and concentration of cyanide. The maximum removal of cyanide was observed in p H range 5.8–7.8 within 15 min. The adsorption data was fitted to Langmuir and Fruendlich isotherm and it has been observed that data follows both the isotherms and also follows second order kinetics. | Himani Uppal S. Swarupa Tripathy Sneha Chawla Bharti Sharma M.K. Dalai S.P. Singh Sukhvir Singh Nahar Singh | 2017 | Journal of Environmental Sciences2017，29，5： | 2 |
| 11 | Multisensory processing in children with cochlear implants显示文摘 | Sneha V. Bharadwaj Patricia L. Matzke Linda L. Daniel | 2012 | International Journal of Pediatric Otorhinolaryngology2012，，6： | 1 |
| 12 | Serum albumin levels in ischemic stroke and its subtypes: Correlation with clinical outcome显示文摘 | Mallemoggala Sai Babu Subhash Kaul Sneha Dadheech Koppula Rajeshwar Akka Jyothy Anjana Munshi | 2013 | Nutrition2013，，6： | 1 |
| 13 | Corynebacterium glutamicum-mediated crystallization of silver ions through sorption and reduction processes 显示文摘 | SNEHA K SATHISHKUMAR M MAO J | 2010 | Chern Eng J2010，162，3： | 1 |
| 14 | Preparation of NiFe_2O_4 nanopowder via EDTA precursor and study of its properties显示文摘An ethylene diamine tetra acetic acid (EDTA) precursor-based chemical method is reported for preparing single-phase nickel ferrite (NiFe 2 O 4 ) nanopowder. The synthesized powder was characterized by thermogravimetric analysis, differential scanning calorimetric analysis, X-ray diffraction, particle size analysis and scanning electron microscopy. DC electrical resistivity and magnetic property of the syn- thesized NiFe 2 O 4 were measured by using a two-probe method and a vibrating sample magnetometer respectively. The DC resistivity behaviour of the NiFe 2 O 4 nanopowder was correlated with the change of microstructure, during sintering. This EDTA precursor-based method is capable of producing nanos- tructured single-phase NiFe 2 O 4 powder at a comparatively low calcination temperature and offers the potential of a simple and cost-effective route, including the preparation of other ferrite nanoparticles. | Amit B.Rajput Subhenjit Hazra Niharika B.Krishna Pavani Chavali Sneha Datla Narendra Nath Ghosh | 2012 | Particuology2012，10，1： | 1 |
| 15 | Convenient synthesis of Cu3 (BTC)2 encapsulated Keggin heteropolyacid nanomaterial for application in catalysis 显示文摘 | LIL H W SNEHA R B NIKKI J | 2010 | Chem Commun2010，46，： | 1 |
| 16 | Durability of a graphite/epoxy woven composite under combined hygrothermal conditions 显示文摘 | Sneha R P Scott W C | 2000 | International Journal of Fatigue2000，22，： | 1 |
| 17 | D-methionine protects against cisplatin -inducedneurotoxicity in the hippocampus of the adult rat 显示文摘 | SNEHA H KARI SK SENTHILVELAN M el al | 2015 | Neurotox Res2015，27，3： | 1 |
| 18 | A framework for enabling patient monitoring via mobile ad hoc network显示文摘 | Sneha S Varshney U | 2013 | Decision Support Systems2013，55，1： | 1 |
| 19 | Cinnamon zeylanicum bark extract and powder mediated green synthesis of nano-crystalline silver particles and its bactericidal activity显示文摘 | M. Sathishkumar K. Sneha S.W. Won C.-W. Cho S. Kim Y.-S. Yun | 2009 | Colloids and Surfaces B: Biointerfaces2009，，2： | 1 |
| 20 | Crude soybean hull peroxidase treatment of phenol in synthetic and real wastewater: En- zyme economy enhanced by Triton X-100 显示文摘 | Aaron Steevensz Sneha Madur Wei Feng | 2014 | Enzyme and Microbi- al Technology2014，55，： | 1 |
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